离散可激发介质激发性降低的几种起因

采用简单的可激发介质元胞自动机模型,通过在均匀介质中引入死亡细胞、疲劳细胞以及让元胞的激发阈值作周期变化使螺旋波漫游.通过监测元胞的激发比率,发现不同原因导致的螺旋波漫游有一个共同的特点：螺旋波漫游情况下的元胞的激发比率较螺旋波不漫游情况下的元胞激发比率减小许多,表明介质的激发性降低与死亡细胞、疲劳细胞的数量以及元胞的激发阈值作周期变化有关;研究结果还表明：介质激发性的降低始终伴随螺旋波频率的减小.这些结果对心脏病的预防与治疗可能会提供有益的帮助. 关键词： 元胞自动机 可激发介质 螺旋波 漫游     

时空调制对可激发介质螺旋波波头动力学行为影响及控制研究

本文首先研究了时空调制对可激发介质中周期螺旋波波头动力学行为的影响. 随着时空调制的增大, 螺旋波经历了周期螺旋波、外滚螺旋波、旅行螺旋波和内滚螺旋波的显著变化. 通过定义序参量来定量的描述由时空调制引起的螺旋波在不同态之间非平衡跃迁的临界条件, 及漫游螺旋波波头圆滚圆半径随调制参数的变化情况. 当时空调制增大到某个临界值时, 螺旋波发生了破碎; 再增加时空调制, 螺旋波则发生了衰减, 系统最终演化为空间均匀静息态. 在文中给出了螺旋波发生破碎和衰减的机理和原因. 最后将时空调制方法运用于漫游螺旋波, 实现了将漫游螺旋波控制成周期螺旋波, 或将其控制为空间均匀静息态.     

Motion of spiral waves induced by local pacing

The motion of spiral waves in excitable media driven by a weak pacing around the spiral tip is investigated numerically as well as theoretically. We presented a Bifurcations diagram containing four types of the spiral motion induced by different frequencies of pacing: rigidly rotating, inward-petal meandering, resonant drift, and outward-petal meandering spiral. Simulation shows that the spiral resonantly drifts when the frequency of pacing is close to that of the spiral rotation. We also find that the speed and direction of the drift can be efficiently controlled by means of the strength and phase of the local pacing, which is consistent with analytical results based on the framework of the weak deformation approximation.      

Dynamics of spiral waves under phase feedback control in a Belousov-Zhabotinsky reaction

Feedback control of spiral waves by the phases of the spiral tip is investigated experimentally in a light-sensitive Belousov-Zhabotinsky reaction. The phases of rotation (Psi(r)) and meandering (Psi(m)) of the spiral tip are obtained in real time during experiments. It is found that, for both meandering and rigid rotating spirals, one can manipulate the spirals to move with any arbitrary paths by the feedback signals derived from Psi(r). Synchronization between meandering and rotation dynamics can be induced when both Psi(m) and Psi(r) are used simultaneously as control signals. Experimental findings are compared well with numerical simulations of the Oregonator model.     

激发介质相对不应态对螺旋波动力学行为的影响

采用元胞自动机模型研究激发介质相对不应态对螺旋波动力学行为的影响。数值模拟表明：元胞激发阈值存在一临界区间,该区间的螺旋波周期会突然增加,并存在一最大周期,在合适的系统尺寸和状态数下,螺旋波周期不再受相对不应态的影响而只取决于系统的激发阈值;相对不应态导致螺旋波“Z”型漫游、小范围无规律漫游、花瓣状漫游、锯齿状漫游、风车状漫游等复杂的波头运动。观察到稳定螺旋波、漫游螺旋波和螺旋波消失,并对产生这些现象的机制作简要的解释。     

Meandering Spiral Waves Induced by Time-Periodic Coupling Strength

Effects of time-periodic coupling strength (TPCS) on spiral waves dynamics are studied by numerical computations and mathematical analyses. We find that meandering or drifting spirals waves, which are not observed for the case of constant coupling strength, can be induced by TPCS. In particular, a transition between outward petal and inward petal meandering spirals is observed when the period of TPCS is varied. These two types of meandering spirals are separated by a drifting spiral, which can be induced by TPCS when the period of TPCS is very close to that of rigidly rotating spiral. Similar results can be obtained if the coupling strength is modulated by a rectangle wave. Furthermore, a kinetic model for spiral movement suggested by Di et al., [Phys. Rev. E 85 (2012) 046216] is applied for explaining the above findings. The theoretical results are in good qualitative agreement with numerical simulations.     

Dynamics of Meandering Spiral Waves Driven by Two-Point Feedback

We numerically study the dynamics of meandering spiral waves in theexcitable system subjected to a feedback signal coming from two measuring points located on a straight line together with the initial spiral core. The core location and size radius of the final attractors are computed, and they change with the position of the moving measuring point in a unique way. By the Fourier Spectral analysis, we find the frequency-locked behaviors different from the
driving scheme of the external periodic force. It is also found that the meandering spiral wave can be eliminated when the moving measuring point approaches closely the boundary and its feedback gain is large enough. This offers an effective and convenient method for eliminating meandering spiral waves.     

Meandering Spiral Waves Induced by Time-Periodic Coupling Strength

Effects of time-periodic coupling strength （TPCS） on spiral waves dynamics are studied by numerical computations and mathematical analyses. We find that meandering or drifting spirals waves, which are not observed for the case of constant coupling strength, can be induced by TPCS. In particular, a transition between outward petal and inward petal meandering spirals is observed when the period of TPCS is varied. These two types of meandering spirals are separated by a drifting spiral, which can be induced by TPCS when the period of TPCS is very close to that of rigidly rotating spiral. Similar results can be obtained if the coupling strength is modulated by a rectangle wave. Furthermore, a kinetic model for spiral movement suggested by Diet al., [Phys. Rev. E 85 （2012） 046216] is applied for explaining the above findings. The theoretical results are in good qualitative agreement with numerical simulations.     

随机相位扰动抑制激发介质中漂移的螺旋波

研究了一类二维变量描述的激发系统中漂移螺旋波的抑制问题.通过在整个系统中局部注入带随机相位的电信号，如在系统256×256格点的边界或中心区域中选取4×4或者5×5格点区域施加一个带随机相位的外部激励电信号，在系统内部产生一个持续的靶波信号，实现靶波对螺旋波的动态竞争.数值计算表明：该方法对于Barkley模型中螺旋波有很强的抑制作用，与简单的局部周期信号驱动比较，具有暂态过程比较短的特点，而且对于时空噪声具有一定的抗干扰性.在一定的噪声范围内，即使系统出现不均匀性，也可以观测到靶波，新出现的靶波对螺旋波有抑制作用. 关键词： 螺旋波 靶波 Barkley模型 随机相位     

无扩散功能的缺陷对螺旋波动力学行为的影响

采用Br 模型,在二维激发介质中引入无扩散功能的缺陷,研究了均匀分布的缺陷对螺旋波动力学行为的影响.研究发现,缺陷导致介质的激发性降低、波传播速度减少,在一定数量的缺陷均匀分布下,缺陷可以使原来稳定的螺旋波发生漫游或破碎,缺陷使原来不稳定的螺旋波稳定或漫游,首次在激发介质中观察到螺旋波因Doppler效应破碎形成小螺旋波和时空混沌共存现象.对产生这些现象的物理机理做了简要的讨论. 关键词： 激发介质 螺旋波 缺陷     

Spiral tip meandering induced by excitability modulation

In this work, we introduce a spatiotemporal modulation for excitability into an excitable medium, the Barkley model. The modulation can make the spiral wave tip meandering. Various types of periodic spiral and quasiperiodic meandering spiral motions can be observed numerically by varying the modulation. And the theoretical analysis for the conditions of Hopf bifurcation, based on an ordinary-differential-equation (ODE) model, is applied to well explain the rich behaviors of numerical simulations.     

激发介质中去极化对螺旋波动力学影响的数值研究

考虑可激发介质的不应态可以被激发,在Bar模型中引入去极化行为,研究去极化对稳定螺旋波的影响.数值模拟结果显示,适当选择去极化阈值、去极化激发时间,可以使螺旋波漂移、漫游,甚至使螺旋波漫游出系统边界,还可以使系统出现宽臂螺旋波、双臂螺旋波、双峰波、多个螺旋波共存、时空混沌等现象.对产生这些现象的机理进行了分析.     

心肌组织机械形变的元胞自动机模拟

采用Greenberg-Hastings元胞自动机模型研究机械形变对心肌组织中螺旋波动力学行为的影响.数值模拟表明：对于规则网格下的稳定螺旋波,在生理性机械形变作用下,螺旋波发生漫游但不破碎;在病理性机械形变作用下,螺旋波会发生持续漫游、漫游后消失和破碎进入螺旋波湍流态三种变化.通过对比发现机械形变的振幅变化率对螺旋波的影响较大,而机械形变的角频率对螺旋波的影响较小.结合数值模拟,对心前区受到猛烈撞击会出现心颤致死及耐力运动员在发生心动过速后比一般人员更容易恢复正常进行解释.     

Spiral wave drift induced by stimulating wave trains

We investigate the drift of a spiral wave core in a homogeneous excitable medium under the influence of a periodic stimulation by wave trains close to the core. Two important results were found. First, as opposed to existing theories of spiral wave drift, we observe drift induced by wave trains with periods larger than the period of the freely rotating spiral wave. Second, when investigating the drift of meandering spirals we found that the property of meandering of spirals is not robust against periodic stimulations. Simple phenomenological arguments are provided to explain these observations. (c) 2001 American Institute of Physics.     

用低通滤波方法终止心脏组织中的螺旋波和时空混沌

通过让心肌细胞钠离子通道的触发门变量延迟打开, 使介质具有激发延迟能力, 介质延迟激发时间随控制电压和刺激频率增加而增加, 当控制电压超过一个阈值时, 延迟激发介质具有低通滤波作用:低频波可以连续通过, 而高频波不能连续通过. 本文用Luo-Rudy相I模型研究了介质延迟激发对螺旋波和时空混沌的影响, 数值模拟结果表明: 当控制电压超过阈值时, 介质的延迟激发可有效消除螺旋波和时空混沌; 从小逐渐增大控制电压, 在钙最大电导率较小情况下, 延迟激发会导致介质激发性降低, 使螺旋波漫游幅度增大, 直至传导障碍导致螺旋波消失; 当钙最大电导率较大时, 延迟激发会导致螺旋波失稳变弱, 这样当控制电压增加到一定值时, 时空混沌可以演化成漫游螺旋波, 当控制参数被适当选取时, 观察到漫游幅度大的螺旋波漫游出系统边界消失现象, 继续增大控制电压将导致时空混沌直接消失.     

Stabilization of spiral wave and turbulence in the excitable media using parameter perturbation scheme

This paper proposes a scheme of parameter perturbation to suppress the stable rotating spiral wave, meandering spiral wave and turbulence in the excitable media, which is described by the modified Fitzhug-Nagumo （MFHN） model. The controllable parameter in the MFHN model is perturbed with a weak pulse and the pulse period is decided by the rotating period of the spiral wave approximatively. It is confirmed that the spiral wave and spiral turbulence can be suppressed greatly. Drift and instability of spiral wave can be observed in the numerical simulation tests before the whole media become homogeneous finally.     

时空调制引起的漫游螺旋波与旅行螺旋波共存现象

以Barkley模型为研究对象, 研究了在时空调制作用下螺旋波时空动力学行为特性. 发现在适当的调制参数的作用下, 能够在同一系统中同时观察到漫游螺旋波与旅行螺旋波. 通过数值模拟研究分析, 给出了能产生漫游螺旋波与旅行螺旋波共存现象的潜在机理, 并详细讨论了在Barkley 模型中要产生这种共存现象的两个必要条件. 关键词： 时空调制 漫游螺旋波 旅行螺旋波     

Patterns of spiral tip motion in cardiac tissues

In support of the spiral wave theory of reentry, simulation studies and animal models have been utilized to show various patterns of spiral wave tip motion such as meandering and drifting. However, the demonstration of these or any other patterns in cardiac tissues have been limited. Whether such patterns of spiral tip motion are commonly observed in fibrillating cardiac tissues is unknown, and whether such patterns form the basis of ventricular tachycardia or fibrillation remain debatable. Using a computerized dynamic activation display, 108 episodes of atrial and ventricular tachycardia and fibrillation in isolated and intact canine cardiac tissues, as well as in vitro swine and myopathic human cardiac tissues, were analyzed for patterns of nonstationary, spiral wave tip motion. Among them, 46 episodes were from normal animal myocardium without pharmacological perturbations, 50 samples were from normal animal myocardium, either treated with drugs or had chemical ablation of the subendocardium, and 12 samples were from diseased human hearts. Among the total episodes, 11 of them had obvious nonstationary spiral tip motion with a life span of >2 cycles and with consecutive reentrant paths distinct from each other. Four patterns were observed: (1) meandering with an inward petal flower in 2; (2) meandering with outward petals in 5; (3) irregularly concentric in 3 (core moving about a common center); and (4) drift in 1 (linear core movement). The life span of a single nonstationary spiral wave lasted no more than 7 complete cycles with a mean of 4.6+/-4.3, and a median of 4.5 cycles in our samples. Conclusion: (1) Patently evident nonstationary spiral waves with long life spans were uncommon in our sample of mostly normal cardiac tissues, thus making a single meandering spiral wave an unlikely major mechanism of fibrillation in normal ventricular myocardium. (2) A tendency toward four patterns of nonstationary spiral tip motion was observed. (c) 1998 American Institute of Physics.     

Exploring the role of inhibitory coupling in duplex networks

The electrical coupling of myocytes and fibroblasts can play a role in inhibiting electrical impluse propagation in cardiac muscle. To understand the function of fibroblast–myocyte coupling in the aging heart, the spiral-wave dynamics in the duplex networks with inhibitory coupling is numerically investigated by the Br–Eiswirth model. The numerical results show that the inhibitory coupling can change the wave amplitude, excited phase duration and excitability of the system. When the related parameters are properly chosen, the inhibitory coupling can induce local abnormal oscillation in the system and the Eckhaus instability of the spiral wave. For the dense inhibitory network, the maximal decrement(maximal increment) in the excited phase duration can reach 24.3%(13.4%), whereas the maximal decrement in wave amplitude approaches 28.1%. Upon increasing the inhibitory coupling strength, the system excitability is reduced and even completely suppressed when the interval between grid points in the inhibitory network is small enough. Moreover, the inhibitory coupling can lead to richer phase transition scenarios of the system, such as the transition from a stable spiral wave to turbulence and the transition from a meandering spiral wave to a planar wave. In addition, the self-sustaining planar wave, the unique meandering of spiral wave and inward spiral wave are observed. The physical mechanisms behind the phenomena are analyzed.     

Controlling intracellular Ca2+ spiral waves by the local agonist in the cell membrane

A modified spatially extended Tang-Othmer Ca2+ model is used to study intracellular Ca2+ spiral waves numerically.It is found that,as a local stimulation,the local agonist-binding on the cell membrane,which enhances the local concentration of the messenger molecule inositol 1,4,5-trisphosphate(IP 3),can influence the dynamics of the spiral waves.1) Strong enough stimuli can change the spiral wave from a meandering to a rigidly rotating one.2) On the other hand,strong enough stimuli can suppress the spiral wave from the system.It provides the theoretical clue for controlling the spiral waves by stimulating the cell membrane.