药学专业留学生分析化学实验全英文教学的体会

留学生教育已成为我国高等教育的重要组成部分,而全英文教学是无中文基础的留学生的最佳选择。分析化学实验为药学专业本科生的必修课,本文针对药学专业留学生分析化学实验课的全英文教学过程,从课程的教学安排、教材选用、教学师资、授课方式和考评方式等方面讲述了教学实践中的体会,希望为开设同类课程的全英文教学提供借鉴和参考。     

化学分析课程的全英文教学实践

归纳了化学分析课程的全英文教学特点,探索了全英文课程的教学方法,总结了化学分析(全英)课程建设过程的经验与不足,并展望了在化学国际合作办学中推广化学分析课程全英文教学的前景。     

慕课时代翻转课堂在药物化学教学中的应用

针对药物化学课程的自身特点, 就如何开展翻转课堂进行了思考, 包括制作教学视频、课堂组织、课后辅导和教学评价等诸多环节。慕课和翻转课堂的结合, 调动了学生的学习主动性和积极性, 使学生成为教学主体, 有利于药物化学课程的教学和培养适合大药学背景下的药学人才。     

基于药物化学课程内容的新药研发前沿案例构建——循环系统药物章节案例教学举例

药物化学是药学本科专业基础课程,也是创新药物研究的重要基石。如何提高药物化学教学内容的时效性、创新性和高阶性,以满足新时代药学创新人才培养的需求,是值得深入思考与探索的问题。本文以循环系统药物章节教学内容为基础,构建了学科前沿、学科交叉和课程思政三个方面的课程案例,期望能为药物化学相关专业教学提供新素材和新思考。     

药物化学课程思政教学模式的探索与实践*——青霉素抗生素专题

药物化学是药学专业核心课程,拥有丰富的思政资源。以药物化学课程为研究对象,在明确课程思政育人目标基础上,将药物化学课程思政教学主线设置为“定目标、拆内容、寻热点、挖元素、隐融入、明效果、做评价”等7个环节。进一步以青霉素专题为例,展示思政内容有机融入课程教学的全过程,为其他理工类专业课程思政教学提供一种参考模式。     

全英文研究型教学效果探讨 ——基于有机材料化学课学生问卷调查分析

全英文研究型教学是值得探索的旨在提高人才培养质量的教学形式,因此多年来我们针对材料化学专业的专业必修课有机材料化学开展了全英文研究型教学的尝试与实践。为了解学生的英语学习现状、需求及教学效果,设计了开课前问卷和结课调查问卷。调查结果表明,学生有较好的英语水平,有学习用全英文讲授的专业课的内在动力和需求,对该课程的教材选择、英语讲授、教学内容及安排、教学方法和形式等方面的满意程度很高,全英文研究型教学不仅可行,而且可以取得很好的教学效果。     

药学教育中应加强结构化学的教学

从药学教育中结构化学的教学现状,结构化学的基本概念和原理在药学中的应用,具备较系统的结构化学知识对于药学专业人员进行药物研究的作用等方面,论述了在药学教育中加强结构化学教学的重要性和必要性,并提出了加强结构化学教学的途径。     

利用Bachman语言能力模型重塑全英文教学的化学课堂

针对全英文授课中的一些普遍问题,结合作者近年来在相关化学课程全英文教学的实践和思考,借鉴了Bachman语言能力模型,提出一种全英文化学课堂的设计新方法。课堂上积极主动、丰富的交流和反馈是形成有效教学的关键。鉴于此,全英文课堂中要特别关注五个要素:专业知识、语言知识、策略能力、语言环境和个人特征。因此在课程准备的过程中就需要从这五个方面入手,对教学方法和策略进行重新设计。同时,设计中必须意识到全英文教学中专业知识和英语能力培养的两个维度应该是相互支持和依赖的。实践表明,这一新的教学模式通过活跃课堂气氛、正向激励、及时反馈和促进主动学习显著提高了教学质量和课程满意度。     

“药物化学”与“药理学”课程整合教学的探索

分析了"药物化学"与"药理学"2门课程整合教学的基础,从师资队伍、教学大纲、理论教学内容、实验教学内容和试题库建设等方面具体阐述了课程整合教学改革的实施方案,并对药学本科课程整合进行了总结思考与展望,为药学人才培养探索了新的模式和方向。     

药物化学全英教学中的思考和创新实践

药物化学全英教学对培养国际化创新药学人才起到重要的支撑作用。本文结合药物化学全英教学工作实践中发现的痛点问题——教学内容局限和抽象化、师资队伍本土化等方面的不足,秉承“以生为本、接轨国际”的教学理念,从教学师资、教学内容和教学方式改革等角度对药物化学全英教学进行创新实践研究。提出药物化学全英教学应以国际化教学为中心的前提下,从教学团队建设、教学方法、教学课程体系和教材四个方面建设创新课程教学体系,提高教学质量。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

Synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives

Different approaches for the synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives from simple amino acids have been investigated. A library of 33 precursors for the preparation of N-hydroxy pyrazinones was obtained in moderate to good yields.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.     

Chemistry of heterocyclic compounds at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, over 50 years (Review)

The review contains a concise historical account and information on the most significant researches undertaken by the staff at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences on the Chemistry of Heterocyclic Compounds. Dedicated to Academician of the Russian Academy of Sciences B. A. Trofimov on his 70th jubilee. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1443–1502, October, 2008.     

A general and convenient synthesis of 4-(tosylmethyl)semicarbazones and their use in amidoalkylation of hydrogen,heteroatom, and carbon nucleophiles

A general synthesis of previously unknown semicarbazone-based α-amidoalkylating reagents, 4-(tosylmethyl)semicarbazones, has been developed. The synthesis involved three-component condensation of semicarbazones of aliphatic or aromatic aldehydes with the same or other aldehydes and p-toluenesulfinic acid. The scope and limitations of this reaction were investigated. The compounds obtained were demonstrated to be an efficient α-(4-semicarbazono)alkylating agents. They were reacted with H- (sodium borohydride), O- (sodium methylate), S- (sodium phenylthiolate), N- (pyrrolidine, sodium succinimide), P- (trialkyl phosphites), and C-nucleophiles (sodium diethyl malonate) to give the corresponding products of the tosyl group substitution, 4-substituted semicarbazones, including analogues of nitrofurazone. Among the prepared compounds tested in vitro for antibacterial and antifungal activity, three nitrofuryl-containing semicarbazones exhibited high biological activities with minimum inhibitory concentration (MIC) values of 8–32 μg/mL.     

Sulfur-directed metal-free and regiospecific methyl C(sp3)–H imidation of thioanisoles

Regiospecific and direct imidation of the methyl C(sp³)–H bond of thioanisoles is realized under mild and metal-free conditions with N-fluorobis(benzenesulfonyl)imide as an oxidant and nitrogen source. Proposed mechanism suggests that thionium ion intermediates and a Pummerer-type reaction are involved. The imidation has advantages such as high step-economy, excellent functionality tolerance, and regiospecificity, giving structurally diverse imidation products.     

Synthesis of novel chiral bidentate hydroxyalkyl-N-heterocyclic carbene ligands and their application in palladium-catalyzed Mizoroki–Heck couplings and asymmetric addition of diethylzinc to benzaldehyde

A small library of new chiral bidentate hydroxyalkyl-imidazolium salts 1 is conveniently synthesized on multi-gram scale from inexpensive and commercially available chiral pool amino acids. The corresponding carbenes, generated by deprotonation of imidazolium salts 1, in combination with palladium(II) chloride were tested in the Mizoroki–Heck coupling reaction. The most significant results in terms of yields and reactivities were achieved with low catalyst loading. The catalytic activities of these imidazolium salts were also investigated in the asymmetric addition of diethylzinc to benzaldehyde. The use of MgO nanoparticles as an additive in conjunction with these ligands played a crucial role in increasing the efficiency of these reactions.