师范类专业认证视域下的课程与教学改革探索*——以化学教学论课程为例

课程与教学是师范类专业认证的基础。以化学教学论课程为例,针对课程所存在的问题,以师范类专业认证标准要求为导向,进行课程与教学改革:以“产出导向”定位课程目标与内容,通过“U-S双向建构”动态更新课程内容,构建线上线下协同的案例教学模式突出“学生中心”,通过“教、学、评”一体化设计改进教学。结果表明,学生学习主动性、参与度高,课程目标达成度高。     

“双一流”背景下化学本科人才培养创新路径探索*

人才培养是高校的核心使命和必然要求。在“双一流”建设背景下,国家对高校人才培养提出了新要求。西北大学化学与材料科学学院围绕“培养什么人”“怎样培养人”,对本科人才培养不断进行探索和创新,搭建 “以本科生导师制为核心”的科研训练体系,“以拓展学术视野为核心”的国际化培养体系,“以调动教师教学投入为核心”的评价激励体系,“以提升创新意识为核心”的实践育人体系等措施,实现高校理科人才培养的创新发展。     

贯彻“三全育人”理念实现高素质化学创新人才培养

吉林大学化学学院建院(系)70年来,始终把立德树人作为人才培养的根本任务,坚持教育为人民服务、为中国共产党治国理政服务、为巩固和发展中国特色社会主义制度服务、为改革开放和社会主义现代化建设服务,不断提升化学专业人才培养水平。“三全育人”,核心是“育”,目标是 “才”,关键是“全”,其核心目标就是培养德才兼备、全面发展的社会主义建设人才。吉林大学化学学院始终坚持育人和育才相统一、“第一课堂”和“第二课堂”相融合、专业教师和思政教师相互协同的人才培养模式,赓续“又红又专”的红色血脉,强化、提升学生技能、科研素养和综合能力的同时,培养了一代又一代德才兼备、可堪大用的时代新人。     

师范专业认证背景下有机化学“三段式”教学法的构建与实践*

针对应用型本科院校化学专业的培养目标和师范专业认证标准,以“发现学习”和“建构主义学习”理论为依据,结合课程内容特点提出了基于学生为中心和产出导向的有机化学“三段式”教学法,并在糖类化合物、蛋白质和核酸章节中进行了具体的教学实施,对实施效果进行了问卷调查和分析。“三段式”教学法对有机化学教学模式的改革提供了一定的借鉴作用。     

理工复合型人才联合培养实践与探索*

南开大学化学学院和天津大学化工学院利用各自办学优势和特点,按照“独立办学,紧密合作”要求,坚持“高起点、高标准、创特色、建一流”原则,创办“分子科学与工程”专业。两校每年各招收30人,配备优势师资力量,前两年在南开大学后两年在天津大学集中培养、统一管理,毕业时授予理学和工学双学士学位,培养适应国家发展需要,拥有宽广深厚的化学化工基础,同时具有科学研究、产品研发与产业化能力的“顶天立地”高水平复合型人才。“分子科学与工程”专业培养的学生同时具有理科与工科背景,理论基础扎实、实践创新能力强,就业前景广阔,并得到业界的普遍赞誉。2020年“分子科学与工程专业”入选国家一流专业建设点,已经成为复合型人才培养的专业标杆。     

全国食品药品职业教育基础数据采集与数据库建设研究

为了全面了解全国食品药品职业教育人才培养的基本情况，通过对散见于“全国职业院校专业设置管理与公共信息服务平台”“教育部高等职业院校人才培养工作状态数据采集与管理平台”“高等职业教育人才培养质量年度报告”等各大平台中的数据进行采集、调研、分析，总结了全国食品药品职业教育的整体情况，整理了全国高等职业教育食品药品类专业布点与结构、各专业的教学条件情况、各专业的人才培养质量状况等基础数据，期望为我国职业教育体系的优化与完善及食品药品行业人才培养与开发政策的制定提供必要的数据支撑。     

应用型本科院校化学实验课程体系优化与教学模式改革

根据应用型本科院校人才培养要求,结合本校实际和多年教学经验,从化学基础实验课程内容设置、教学方法和成绩评定等3方面提出对实验课程体系进行优化设计,同时探索新型的实验教学模式,构建“4课一体、3个阶段、4个层次”的实验课程新体系,并将“可视化”教学模式引进实验教学中,同时制定“多元加权”的“过程质量评价”体系。     

产教融合下高职“三三结合式”人才培养模式*——以药品生产技术专业为例

针对高职产教融合存在的问题,构建了“三三结合式”人才培养模式,即通过“企业指导、行业引导、学校督导”三结合,改革人才培养模式;通过“核心课程、核心问题、核心能力”三结合,深化“教师、教材、教法、教学评价”四教改革;通过“基础实验、专业实验,实习实训”三结合,优化实践教学体系。该模式的构建与实施能提升学生的职业素养,提高毕业生的就业质量,打造出优秀的双师型教师团队。     

“化学游戏教学”的“学教评产”混合式教学模式实践

基于师范类专业认证理念与毕业要求的教学前端分析,建构“学教评产”混合式教学模式,通过整合教学内容、重构教学安排与优化教学评价,对“化学游戏教学”课程进行创新性改革,并从学生学习成果、教学目标达成与学生满意度等3个方面评价教学成效。结果表明:该教学模式有助于学生学习成果质量的提升,能够有效促进教学目标的达成,并取得较高的学生满意度。     

高职“石油化工专业群”复合型技术技能人才“五跨”培养模式的探索与实践

为培养一批符合社会需求、企业欢迎的“宽基础、多技能、高素质”的复合型技术技能人才,借鉴国内外先进职教经验,以高职石油化工专业群为试点,创建了跨专业复合人才培养体系。通过采取“理实一体化”教学改革,建立现代学徒制试点,推广校企“双主体”协同育人方案,开展跨学院、跨国境交流,打造复合型师资队伍等策略,探索并实践了复合型技术技能人才“跨专业、跨理实、跨校企、跨学院、跨国境”的“五跨”培养模式。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.     

Sulfur-directed metal-free and regiospecific methyl C(sp3)–H imidation of thioanisoles

Regiospecific and direct imidation of the methyl C(sp³)–H bond of thioanisoles is realized under mild and metal-free conditions with N-fluorobis(benzenesulfonyl)imide as an oxidant and nitrogen source. Proposed mechanism suggests that thionium ion intermediates and a Pummerer-type reaction are involved. The imidation has advantages such as high step-economy, excellent functionality tolerance, and regiospecificity, giving structurally diverse imidation products.     

Selective syntheses of 2H-1,3-oxazines and 1H-pyrrol-3(2H)-ones via temperature-dependent Rh(II)-carbenoid-mediated 2H-azirine-ring expansion

The Rh(II)-catalyzed reaction of 2-carbonyl-substituted 2H-azirines with ethyl 2-cyano-2-diazoacetate or 2-diazo-3,3,3-trifluoropropionate provides an easy access to 2H-1,3-oxazines and 1H-pyrrol-3(2H)-ones. These compounds can be selectively prepared from the same starting material using temperature as the only varied parameter. The 2-azabuta-1,3-diene intermediate, a common precursor for both heterocyclic products, isomerizes into 2H-1,3-oxazine under kinetic control, while 1H-pyrrol-3(2H)-one is the sole product of the reaction at elevated temperatures. According to DFT-calculations a one-atom oxazine ring contraction involving ring-opening to a 2-azabuta-1,3-diene intermediate, followed by a 1,5- and 1,2-prototropic shift leads to the consecutive formation of imidoylketene and azomethine ylide, which then further undergo cyclization to the pyrrole derivative.     

Copper catalyzed/mediated synthetic methodology for ebselen and related isoselenazolones

Scope of the copper catalyzed/mediated selenium-nitrogen coupling reaction has been studied for the synthesis of isoselenazolones. It is noticed that the 2-chloro, 2-bromo-, and 2-iodo-aryl amides substrates can be exploited in the selenium-nitrogen coupling reaction by employing 25-100 mol % of CuI/1,10-phenanthroline (L) and potassium carbonate as a base in DMF. Furthermore, electron rich 2-chloro-arylamides also underwent selenium-nitrogen coupling reaction to give biologically important selenium-nitrogen heterocycles. Also, copper-catalyzed selenium-nitrogen coupling reaction has been meticulously applied for the synthesis of diaryl diselenides having methoxy, amine, and amide functionality from respective aryl iodides in the presence of stoichiometric amount of succinimide as an external Se-N coupling partner.     

Knoevenagel condensation catalyzed by novel Nmm-based ionic liquids in water

A series of novel N-methyl morpholine (Nmm) based ionic liquids with 1,2-propanediol group were synthesized and used as catalysts for Knoevenagel condensation at room temperature in water. Under the effect of the catalyst, various aldehydes or aliphatic ketones could react with a wide range of activated methylene compounds well, including malononitrile, alkyl cyanoacetate, cyanoacetamide, β-diketone, barbituric acid, 2-arylacetonitrile and thiazolidinedione. Furthermore, most of the products could be separated just by filtrating and washing with water. Additionally, the catalyst is recyclable and applicable for the large-scale synthesis.     

Construction of polyheterocyclic spirotetrahydrothiophene derivatives via sulfa-Michael/aldol cascade reaction

A series of polyheterocyclic spirotetrahydrothiophene derivatives were obtained in moderate to excellent yields via a catalyst-free sulfa-Michael/aldol cascade reaction of chalcones 1 and commercially available 1,4-dithiane-2,5-diol 2 under mild conditions. We also present the first asymmetric sulfa-Michael/aldol cascade reaction of chalcones 1 and commercially available 1,4-dithiane-2,5-diol 2 with moderate to good enantioselectivities catalyzed by readily available chiral phase-transfer catalysts (PTCs).     

Suzuki-Miyaura reactions of the soluble guanylate cyclase inhibitor NS2028: a non-product specific route to C-8 substituted analogues

Both soluble guanylate cyclase (sGC) inhibitors ODQ 1 and NS2028 2 are synthesized via improved protocols. In the former case treating 3,4-dihydroquinoxalin-2(1H)-one oxime 8, which can be prepared in two steps from 1,2-benzenediamine, with 1,1′-carbonyldiimidazole (CDI) gives the dihydro-ODQ 10 that in the presence of KMnO₄ oxidises to give ODQ 1 in an overall yield of 46% starting from 1,2-benzenediamine. In the latter case, the synthesis affords NS2028 2 from 2-amino-4-bromophenol 3 in three steps with an overall yield of 85% and avoids the need for chromatography. Furthermore, Suzuki-Miyaura reaction conditions are described that enable the preparation of 8-aryl and 8-heteroaryl derivatives of NS2028 directly from NS2028 2. Finally, demethylation of the 8-(methoxyphenyl) substituted analogues afforded the 8-(hydroxyphenyl) derivatives 40-42. All new products are fully characterised.