共查询到20条相似文献,搜索用时 31 毫秒
1.
Huan Long Hans H Bock Ting Lei Xuejun Chai Jihong Yuan Joachim Herz Michael Frotscher Zaiqing Yang 《BMC neuroscience》2011,12(1):17
Background
Disabled-1 (Dab1) is an adaptor protein that is essential for the intracellular transduction of Reelin signaling, which regulates the migration and differentiation of postmitotic neurons during brain development in vertebrates. Dab1 function depends on its tyrosine phosphorylation by Src family kinases, especially Fyn. 相似文献2.
Ursula Fünfschilling Gesine Saher Le Xiao Wiebke M?bius Klaus-Armin Nave 《BMC neuroscience》2007,8(1):1
Background
Cholesterol, an essential component of all mammalian plasma membranes, is highly enriched in the brain. Both during development and in the adult, brain cholesterol is derived from local cholesterol synthesis and not taken up from the circulation. However, the contribution of neurons and glial cells to total brain cholesterol metabolism is unknown. 相似文献3.
Lone B Madsen Bo Thomsen Knud Larsen Christian Bendixen Ida E Holm Merete Fredholm Arne L Jørgensen Anders L Nielsen 《BMC neuroscience》2007,8(1):72
Background
The transmembrane presenilin (PSEN) proteins, PSEN1 and PSEN2, have been proposed to be the catalytic components of the γ-secretase protein complex, which is an intramembranous multimeric protease involved in development, cell regulatory processes, and neurodegeneration in Alzheimer's disease. Here we describe the sequencing, chromosomal mapping, and polymorphism analysis of PSEN1 and PSEN2 in the domestic pig (Sus scrofa domesticus). 相似文献4.
Xinkun Wang Asma Zaidi Ranu Pal Alexander S Garrett Rogelio Braceras Xue-wen Chen Mary L Michaelis Elias K Michaelis 《BMC neuroscience》2009,10(1):12-20
Background
Oxidative stress (OS) is an important factor in brain aging and neurodegenerative diseases. Certain neurons in different brain regions exhibit selective vulnerability to OS. Currently little is known about the underlying mechanisms of this selective neuronal vulnerability. The purpose of this study was to identify endogenous factors that predispose vulnerable neurons to OS by employing genomic and biochemical approaches. 相似文献5.
Hana?Munakata Yukiko?Nakamura Kazumasa?Matsumoto-Miyai Kouichi?Itoh Hironobu?Yamasaki Sadao?Shiosaka
Background
The importance of L1 expression in the matured brain is suggested by physiological and behavioral studies showing that L1 is related to hippocampal plasticity and fear conditioning. The distribution of L1 in mouse brain might provide a basis for understanding its role in the brain. 相似文献6.
Eun S Chung Eugene Bok Sunghyang Sohn Young D Lee Hyung H Baik Byung K Jin 《BMC neuroscience》2010,11(1):74
Background
Gangliosides, sialic acid-containing glycosphingolipids exist in mammalian cell membranes particularly neuronal membranes. The trisialoganglioside (GT1b) is one of the major brain gangliosides and acts as an endogenous regulator in the brain. We previously showed GT1b induces mesencephalic dopaminergic (DA) neuronal death, both in vivo and in vitro. We further investigate the underlying mechanisms of GT1b neurotoxicity. 相似文献7.
Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation 总被引:1,自引:0,他引:1
Tim R Mercer Irfan A Qureshi Solen Gokhan Marcel E Dinger Guangyu Li John S Mattick Mark F Mehler 《BMC neuroscience》2010,11(1):14
Background
Long non-protein-coding RNAs (ncRNAs) are emerging as important regulators of cellular differentiation and are widely expressed in the brain. 相似文献8.
Koji Inui Tomokazu Urakawa Koya Yamashiro Naofumi Otsuru Makoto Nishihara Yasuyuki Takeshima Sumru Keceli Ryusuke Kakigi 《BMC neuroscience》2010,11(1):80
Background
The detection of any abrupt change in the environment is important to survival. Since memory of preceding sensory conditions is necessary for detecting changes, such a change-detection system relates closely to the memory system. Here we used an auditory change-related N1 subcomponent (change-N1) of event-related brain potentials to investigate cortical mechanisms underlying change detection and echoic memory. 相似文献9.
Johann Steiner Hans-Gert Bernstein Hendrik Bielau Annika Berndt Ralf Brisch Christian Mawrin Gerburg Keilhoff Bernhard Bogerts 《BMC neuroscience》2007,8(1):2
Background
S100B is considered an astrocytic in-situ marker and protein levels in cerebrospinal fluid (CSF) or serum are often used as biomarker for astrocytic damage or dysfunction. However, studies on S100B in the human brain are rare. Thus, the distribution of S100B was studied by immunohistochemistry in adult human brains to evaluate its cell-type specificity. 相似文献10.
Zhou Fei Xiang Zhang Hong-min Bai Xiao-fan Jiang Xia Li Wei Zhang Wei Hu 《BMC neuroscience》2007,8(1):96
Background
Our previous studies indicated that metabotropic glutamate receptors (mGluRs) are deeply involved in the secondary processes after diffuse brain injury (DBI). In the present study, we used a rodent DBI model to determine whether hypotension exacerbates neuronal injury as a secondary brain insult (SBI) after traumatic brain injury (TBI) by changing the expression of metabotropic glutamate receptors (mGluRs) in the cerebral cortex. 相似文献11.
Background
Traumatic brain injury (TBI) initiates a complex sequence of destructive and neuroprotective cellular responses. The initial mechanical injury is followed by an extended time period of secondary brain damage. Due to the complicated pathological picture a better understanding of the molecular events occurring during this secondary phase of injury is needed. This study was aimed at analysing gene expression patterns following cerebral cortical contusion in rat using high throughput microarray technology with the goal of identifying genes involved in an early and in a more delayed phase of trauma, as genomic responses behind secondary mechanisms likely are time-dependent. 相似文献12.
Krzysztof R. Gorny Michael F. Presti Stephan J. Goerss Sun C. Hwang Dong-Pyo Jang Inyong Kim Hoon-Ki Min Yunhong Shu Christopher P. Favazza Kendall H. Lee Matt A. Bernstein 《Magnetic resonance imaging》2013
Purpose
To present preliminary, in vivo temperature measurements during MRI of a pig implanted with a deep brain stimulation (DBS) system.Materials and Methods
DBS system (Medtronic Inc., Minneapolis, MN) was implanted in the brain of an anesthetized pig. 3.0-T MRI was performed with a T/R head coil using the low-SAR GRE EPI and IR-prepped GRE sequences (SAR: 0.42 and 0.39 W/kg, respectively), and the high-SAR 4-echo RF spin echo (SAR: 2.9 W/kg). Fluoroptic thermometry was used to directly measure RF-related heating at the DBS electrodes, and at the implantable pulse generator (IPG). For reference the measurements were repeated in the same pig at 1.5 T and, at both field strengths, in a phantom.Results
At 3.0 T, the maximal temperature elevations at DBS electrodes were 0.46 °C and 2.3 °C, for the low- and high-SAR sequences, respectively. No heating was observed on the implanted IPG during any of the measurements. Measurements of in vivo heating differed from those obtained in the phantom.Conclusion
The 3.0-T MRI using GRE EPI and IR-prepped GRE sequences resulted in local temperature elevations at DBS electrodes of no more than 0.46 °C. Although no extrapolation should be made to human exams and much further study will be needed, these preliminary data are encouraging for the future use 3.0-T MRI in patients with DBS. 相似文献13.
Judith Buddensiek Alexander Dressel Michael Kowalski Uwe Runge Henry Schroeder Andreas Hermann Matthias Kirsch Alexander Storch Michael Sabolek 《BMC neuroscience》2010,11(1):48
Background
Neural stem cells (NSCs) are a promising source for cell replacement therapies for neurological diseases. Growing evidence suggests an important role of cerebrospinal fluid (CSF) not only on neuroectodermal cells during brain development but also on the survival, proliferation and fate specification of NSCs in the adult brain. Existing in vitro studies focused on embryonic cell lines and embryonic CSF. We therefore studied the effects of adult human leptomeningeal CSF on the behaviour of adult human NSCs (ahNSCs). 相似文献14.
Birger Scholz Kim Kultima Anna Mattsson Jeanette Axelsson Björn Brunström Krister Halldin Michael Stigson Lennart Dencker 《BMC neuroscience》2006,7(1):12-17
Background
Differentiation of the brain during development leads to sexually dimorphic adult reproductive behavior and other neural sex dimorphisms. Genetic mechanisms independent of steroid hormones produced by the gonads have recently been suggested to partly explain these dimorphisms. 相似文献15.
Wei Shang Wei-Hong Liu Xiu-He Zhao Qin-Jian Sun Jian-Zhong Bi Zhao-Fu Chi 《BMC neuroscience》2008,9(1):67
Background
Glutathione S-transferases (GSTs) play an important role in metabolizing anti-epileptic drugs (AEDs) in liver. Expressions of GSTs in brain, which may result in poor efficacy of AEDs, have not been well studied. Using clinical cortex specimen from 32 intractable epileptic subjects and 8 non-epileptic controls, the present study investigated the correlation between GSTs and intractable epilepsy. 相似文献16.
Background
While gelatinase (MMP-2 and -9) activity is increased after focal ischemia/reperfusion injury in the brain, the relative contribution of neutrophils to the MMP activity and to the development of hemorrhagic transformation remains unknown. 相似文献17.
Chiara Tognoli Federica Rossi Francesco Di Cola Gabriele Baj Enrico Tongiorgi Genciana Terova Marco Saroglia Giovanni Bernardini Rosalba Gornati 《BMC neuroscience》2010,11(1):4
Background
Stress involves alterations of brain functioning that may precipitate to mood disorders. The neurotrophin Brain Derived Neurotrophic Factor (BDNF) has recently been involved in stress-induced adaptation. BDNF is a key regulator of neuronal plasticity and adaptive processes. Regulation of BDNF is complex and may reflect not only stress-specific mechanisms but also hormonal and emotional responses. For this reason we used, as an animal model of stress, a fish whose brain organization is very similar to that of higher vertebrates, but is generally considered free of emotional reactions. 相似文献18.
Background
Attending to a point in space in one modality may facilitate processing to information from the same region in another modality. The involvement of sensory-specific cortical areas in intramodal and crossmodal selective spatial attention can be assessed with event-related brain potentials (ERPs). 相似文献19.
Background
The size of the cerebral cortex varies widely within human populations, and a large portion of this variance is modulated by genetic factors. The discovery and characterization of these genes and their variants can contribute to an understanding of individual differences in brain development, behavior, and disease susceptibility. Here we use unbiased stereological techniques to map quantitative trait loci (QTLs) that modulate the volume of neocortex. 相似文献20.
Shoji Tanaka 《BMC neuroscience》2008,9(1):41