N,N—二（邻硝基苯氨基乙基）甘氨酸糖酯的合成

在氢氧化钠和四丁基溴化铵存在下，将Ｎ，Ｎ－二（邻硝基苯氨基乙基）甘氨酸分别与Ｏ－乙酰基代葡萄糖，Ｏ－乙酰基溴代半乳糖，Ｏ－乙酰基溴代乳糖和Ｏ－乙酰基溴代木糖作用，制得Ｎ，Ｎ－二取代甘氨酸的对应乙酰基糖酯。由元素分析，ＩＲ，ＭＳ和Ｈ＾１Ｈ ＮＭＲ确认了４个的糖酯的结构。     

环戊二烯基氟尿嘧啶基钛（Ⅳ）,锆（Ⅳ）配合物的合成及其…

用（ＲＣｐ）２ＭＣｌ２和（ＲＣｐ）ＴｉＣｌ３（Ｒ＝Ｈ，Ｍｅ；Ｍ＝Ｔｉ，Ｚｒ）分别与具有生物活性的２－甲氧基－５－氟尿嘧啶、２－甲硫基－５－氟尿嘧啶在甲苯剂中１１０℃下反应，合成了２０个未见报道的（ＲＣｐ）．Ｍ（ＯＲｍ）２Ｃｌ（ＲＣＰ）２Ｍ（ＯＰｍ）Ｃｌ和（ＲＣｐ）Ｍ（ＯＰｍ）Ｃｌ２（ＯＰｍ＝２－甲氧基－５－氟尿嘧啶基，２－甲硫基－５－氟尿嘧啶基）型钛配合物，这些配合物均经元素分析、＾１ＨＭＲ、ＩＲ     

α—氧代烯酮环二硫代缩酮化学：α,α—二氧代烯酮环二硫代缩酮与乙二…

由α，α－二氧代烯酮环二硫代缩酮与乙二胺反应制得五种α，α－二氧代烯酮环二氮代缩酮化合物，所有产物均经元素分析，ＩＲ＾１ＨＮＭＲ和＾１３ＣＮＭＲ确证。     

锗甲基丙酰—α—氨基酸酯系列倍半氧化物的合成与表征

锗甲基丙酰氯与α－氨基酸酯反应继而水解得到４个新的锗甲基丙酰－α－氨基酸乙酯倍半氧化物，研究了其ＩＲ，＾ＨＮＭＲ和１３ＣＮＭＲ与氨基酸代基结构效应的关系。     

金属键有机化合物的研究—非对称型η^5—取代环戊二烯…

通过η＾５－Ｒ＾１Ｃ５Ｈ４（ＣＯ）３ＭＨａ与η＾５－Ｒ＾２Ｃ５Ｈ４（ＣＯ）２ＭＮａ（Ｍ＝Ｍｏ，Ｗ）以及η＾５－Ｒ＾１Ｃ５Ｈ４（ＣＯ）３ＭｏＮａ与η＾５－Ｒ＾２Ｃ５Ｈ４（ＣＯ）３ＷＮａ在Ｆｅ２（ＳＯ４）３醋酸水溶液作用下的交叉氧化偶联反应，合成了７个新的非对称型金属单键化合物η＾５－Ｒ＾１Ｃ５Ｈ４（ＣＯ）３Ｍｏ－Ｍｏ（ＣＯ）３Ｃ５Ｈ４Ｒ＾２－η＾５（Ｒ＾１，Ｒ＾２：Ｃ（Ｏ）Ｍｅ，ＣＯ２Ｅｔ），η＾５     

4—取代苯基—6—甲基—5—硫代—1,2,4—三嗪—3—酮的合成

合成了一系列新的４，６－二取代－５－硫代－１，２，４－三嗪－３－酮类化合物，并用元素分析、ＩＲ、＾１Ｈ ＮＭＲ及ＭＳ对其结构进行了表征。     

尖晶石型铁酸盐的制备和表征研究

本文采用空气氧化湿法制备尖晶石铁酸盐，得到最佳生成条件为：Ｒ－２ＯＨ＾－／（Ｍ＾２＋＋Ｆ２＋）≥１．０；Ｍ＾２＋／Ｆｅ＾２＋＝０．５摩尔比；氧化温度３４３－３５８Ｋ；氧化时间１０－２５小时。通过ＸＲＤ、ＴＰＲ和ＴＰＤ等方法对其进行表征，讨论了尖晶石型铁酸盐的氧化－还原活及其化学组成和结构的变化。     

不对称环磷化合物的合成及立体化学（I）：—环磷酰氯和3…

研究了２－氧代－２－氯－４－取代苯基－５，５－二甲基－１，３，２－二氧磷杂环己烷与３－羟基异恶唑的反应，得到的氧磷酰化产物含有顺反两种异构体，用＾１Ｈ ＮＭＲ，＾３１Ｐ ＮＭＲ，Ｘ射线衍射确定了它们的构型，并讨论了亲核取代反应中手性磷原子构型保持和翻转的机理，测定了异构体的生物活性。     

2,3—二取代—5—氟脲嘧啶的合成及其抗肿瘤活性研究

以相转移催化法或在无水体系中合成了十个未见文献报道了２，３－二取代５－氟脲嘧啶化合物，它们的结构经ＩＲ、＾ＨＮＭＲ元素分析或ＭＳ等确证。其中有些化合物具有一定的抗肿瘤活性。     

1—酰氧（胺）—2,8,9—三氧杂—5—氮杂—1—锡杂三环（3.3.3.0^1. …

合成了１４个新化合物，１－酰氧（胺）基－２，８，９－三氧杂－５－氮杂－１－锡杂三环（３．３．３．０＾１．５）十一烷，由ＩＲ，＾１ＨＮＭＲ，＾１３ＣＮＭＲ和＾１１９ＳｎＮＭＲ及元素分析确定其结构，该类化合物在ＣＤＣｌ３中可能形成六配位化合物，而在ＤＭＳＯ中，溶剂分子参与Ｓｎ原子配位，聚合体解聚为六配位化合物。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.     

Chemistry of heterocyclic compounds at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, over 50 years (Review)

The review contains a concise historical account and information on the most significant researches undertaken by the staff at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences on the Chemistry of Heterocyclic Compounds. Dedicated to Academician of the Russian Academy of Sciences B. A. Trofimov on his 70th jubilee. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1443–1502, October, 2008.     

Sulfur-directed metal-free and regiospecific methyl C(sp3)–H imidation of thioanisoles

Regiospecific and direct imidation of the methyl C(sp³)–H bond of thioanisoles is realized under mild and metal-free conditions with N-fluorobis(benzenesulfonyl)imide as an oxidant and nitrogen source. Proposed mechanism suggests that thionium ion intermediates and a Pummerer-type reaction are involved. The imidation has advantages such as high step-economy, excellent functionality tolerance, and regiospecificity, giving structurally diverse imidation products.     

Selective syntheses of 2H-1,3-oxazines and 1H-pyrrol-3(2H)-ones via temperature-dependent Rh(II)-carbenoid-mediated 2H-azirine-ring expansion

The Rh(II)-catalyzed reaction of 2-carbonyl-substituted 2H-azirines with ethyl 2-cyano-2-diazoacetate or 2-diazo-3,3,3-trifluoropropionate provides an easy access to 2H-1,3-oxazines and 1H-pyrrol-3(2H)-ones. These compounds can be selectively prepared from the same starting material using temperature as the only varied parameter. The 2-azabuta-1,3-diene intermediate, a common precursor for both heterocyclic products, isomerizes into 2H-1,3-oxazine under kinetic control, while 1H-pyrrol-3(2H)-one is the sole product of the reaction at elevated temperatures. According to DFT-calculations a one-atom oxazine ring contraction involving ring-opening to a 2-azabuta-1,3-diene intermediate, followed by a 1,5- and 1,2-prototropic shift leads to the consecutive formation of imidoylketene and azomethine ylide, which then further undergo cyclization to the pyrrole derivative.     

Synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives

Different approaches for the synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives from simple amino acids have been investigated. A library of 33 precursors for the preparation of N-hydroxy pyrazinones was obtained in moderate to good yields.