共查询到20条相似文献,搜索用时 0 毫秒
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Elizabeth C. Frye Dr. Cornelius J. O' Connor David G. Twigg Bryony Elbert Luca Laraia Dr. David G. Hulcoop Prof. Ashok R. Venkitaraman Dr. David R. Spring 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(28):8774-8779
The Hiyama cross‐coupling reaction is a powerful method for carbon–carbon bond formation. To date, the substrate scope of this reaction has predominantly been limited to sp2–sp2 coupling reactions. Herein, the palladium‐catalysed Hiyama type cross‐coupling of vinyldisiloxanes with benzylic and allylic bromides, chlorides, tosylates and mesylates is reported. A wide variety of functional groups were tolerated, and the synthetic utility of the methodology was exemplified through the efficient total synthesis of the cytotoxic natural product bussealin A. In addition, the antiproliferative ability of bussealin A was evaluated in two cancer‐cell lines. 相似文献
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Oleg Vechorkin Xile Hu Prof. Dr. 《Angewandte Chemie (International ed. in English)》2009,48(16):2937-2940
Reacting in the 'Ni'ck of time : The title reaction is realized by using an isolated NiII complex ( 1 ). The catalysis tolerates a wide range of important functional groups that are often incompatible with Grignard reagents in cross‐coupling reactions.
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Jinping Chen Dr. Naoki Aratani Dr. Hiroshi Shinokubo Prof. Dr. Atsuhiro Osuka Prof. Dr. 《化学:亚洲杂志》2009,4(7):1126-1133
Skillfully attached! meso–meso‐Linked diporphyrins can be efficiently and selectively functionalized with multiple unsaturated carboxylic acid groups through iridium and rhodium catalyses. This post‐modification strategy allows fine‐tuning of energy levels of each porphyrin unit.
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A copper‐catalyzed migratory oxidative‐coupling reaction between nitrones and various ethers/amines exhibited high functional‐group tolerance. Even in aqueous media, the reaction proceeded efficiently. For practical use of this catalysis, a unique sequential Huisgen cycloaddition was demonstrated. Mechanistic investigations revealed that the reaction proceeded through oxidative catalytic activation of ethers/amines to afford iminium/oxonium intermediates by concurrent dual one‐electron abstractions by copper(II) and oxyl radicals. 相似文献
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