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1.
A mild, simple and efficient procedure for the preparation of 3,4-dihydropyrimidin-2(1H)-ones and -thiones is described using N-sulfonic acid poly(4-vinylpyridinium) chloride (NSPVPC) as a heterogeneous and efficient catalyst under solvent-free conditions. Simple methodologies, easy work-up procedure, easy preparation of the catalyst, excellent yields and very short reaction times are among the other advantages of this work. Further, the catalyst can be reused and recovered for several times without significant decrease in its activity.  相似文献   

2.
An efficient, highly product selective, eco-friendly, one-pot multicomponent synthesis of dihydropyrimidine derivatives via Biginelli reaction has been described. The reaction was developed by greener nanoparticle-catalyzed organic synthesis enhancement (NOSE) chemistry and solvent free reaction condition (SFRC) approaches, which helped us in making the procedure greener. The reaction went smoothly with a diverse range of aromatic, aliphatic, hetero-aromatic aldehydes, different amine sources, as well as various β-dicarbonyl compounds, showing the flexibility of this methodology. Magnetically separable nano-Fe3O4@SiO2@SO3H, which acts as a potent solid acid catalyst, was characterized by FT-IR, SEM, EDX and TEM, VSM, and TGA analyses. The catalyst was recycled from the reaction mixture easily by an external magnet and reused in five more consecutive runs without much decrease in catalytic activity. Its catalytic efficiency was compared to other nano and bulk solid acid catalyst in order to ascertain the best combination for the conversion.  相似文献   

3.
The present work describes eco-friendly multicomponent protocol for the synthesis in excellent yields of structurally diverse benzylpyrazolyl coumarin 5 (a–s) involving the reaction of 4-hydroxycoumarin, ethyl acetoacetate, hydrazine hydrate/phenyl hydrazine hydrate and aldehydes, also novel pyrano[2,3-c]pyrazole derivatives 8 (a–k) integrated by isonicotinic acid hydrazide from reaction of aldehyde, ethyl acetoacetate, malononitrile with isoniazid, employing water as a reaction medium and 2-aminoethanesulfonic acid (taurine) as the catalyst. This new methodology endowed the advantages such as short reaction time, recovery of catalysts after catalytic reaction and reusing them without losing their activity and alleviate of operation.  相似文献   

4.
A method to study the valence state of Fe, Cu and Ni on the surface of a multicomponent catalyst by X-ray photoelectron spectroscopy (XPS) under reduction and action of reaction medium is proposed.  相似文献   

5.
6.
Abstract

A simple, rapid, and highly efficient method has been attempted for the three-component condensation of benzil/benzoin, aldehydes, and ammonium acetate under microwave irradiation in the presence of a catalytic amount of bio-supported cellulose sulfuric acid under solvent-free conditions to afford the 2,4,5-triarylimidazole derivatives. The catalyst is easily prepared, inexpensive, separated simply by filtration, gives excellent yield of products with shorter reaction times, and is recyclable several times.  相似文献   

7.
The change in the carbon content on the surface of Fe, Cu, Ni containing catalysts has been studied by X-ray Photoelectron Spectroscopy (XPS) under different treatments. It has been concluded that the superficial carbon content affects the content of an active element,e.g. copper, on the catalyst surface.  相似文献   

8.
An efficient, high yielding, and expeditious method has been developed for the synthesis of diversity oriented pyrrole derivatives via a four component, one-pot cyclocondensation reaction of amines, aldehydes, α-methylene ketones, and nitroalkanes using silica supported tungstic acid as a heterogeneous catalyst for the first time. The scope of the domino reaction is successfully explored toward synthesis of highly aryl-substituted pyrroles. The reaction was conveniently promoted by silica supported tungstic acid and the catalyst could be recovered easily after the reaction and reused without any loss of its catalytic activity. The advantageous features of this methodology are high atom-economy, operational simplicity, shorter reaction time, convergence, and facile automation.  相似文献   

9.
A new approach is applied for the synthesis of novel acridine-calix[4]arene derivatives via a multicomponent reaction. These compounds have been characterised by 1H NMR, 13C NMR and HR-MS. Our binding studies between acridine-functionalised calix[4]arenes and calf thymus DNA (CT-DNA) via fluorescence titration show that these compounds have a good affinity to CT-DNA.  相似文献   

10.
In this paper, Fe3O4 nanoparticles were coated with 3-mercaptopropanoic acid (MPA) through a simple in-situ method and subsequently oxidized by H2O2/H2SO4 to obtain a novel acid magnetic catalyst (Fe3O4/SMPA). This catalyst exhibited high catalytic activity in the one-pot synthesis of different 3,4-dihydropyrimidin-2(1H)-ones under mild and solvent-free conditions, along with excellent level of reusability.  相似文献   

11.
Taichi Kano 《Tetrahedron letters》2006,47(42):7423-7426
A biphenyl-based axially chiral amino acid (S)-2 has been designed and synthesized. The new amino acid (S)-2 has been found to be a more efficient catalyst than (S)-1 in the direct asymmetric aldol reaction of acetone with aldehydes. For instance, the use of only 0.1 mol % of (S)-2 was sufficient to complete the reaction between acetone and 4-nitrobenzaldehyde, giving the corresponding aldol adduct in good yield with an excellent enantioselectivity.  相似文献   

12.
固体铁系超强酸的制备及催化水杨酸异丙酯的合成   总被引:15,自引:0,他引:15  
卢泽楷  朱万仁 《有机化学》2002,22(6):450-452
报道固体铁系超强酸作为酯化催化剂,并研究了用此催化剂催化合成水杨酸异 丙酯,实验结果表明:水杨酸与异丙醇的投料比n酸:n醇=1:6,催化剂的用量占 反应物总投料质量的6%,反应时间为4h,得产物水杨酸异丙酯,其产率达到94.5 %,同时对催化剂的催化性能进行了讨论。  相似文献   

13.
MCM-41-anchored sulfonic acid (MCM-41-SO3H) used as a solid acid catalyst has been reported in recent years for various synthetic protocols. The superior advantage of MCM-41-SO3H is that it can be recovered and reused several times without loss of its efficiency. In this tutorial review, we attempt to give an overview of the use of MCM-41-SO3H as a solid and heterogeneous catalyst in the synthesis of various organic compounds that have industrial and pharmaceutical applications.  相似文献   

14.
Radiation crosslinked poly(ethylene oxide)s (PEO) modified with two tetraalkylammonium salts: allyldimethyldodecylammonium bromide and ethylmethacrylate dimethyldodecylammonium bromide were prepared. They have been characterized by elemental analysis, IR, 1H-NMR spectra, and DSC measurements. Their activity as phase transfer catalysts (PTC) in the model displacement reaction of 1-bromooctane with aqueous sodium cyanide were studied. The reaction kinetics were followed under pseudo-first-order conditions. Small amounts of onium salt inserted into the PEO network gave rise to a five time increase in the rate constant. The recovered catalysts could be re-used without loss of activity. © 1995 John Wiley & Sons, Inc.  相似文献   

15.
N-Sulfonic acid poly(4-vinylpyridinum) hydrogen sulfate has been developed as a recyclable solid acid catalyst for the acetylation of alcohols, phenols, thiols, and amines, as well as the 1,1- diacetylation of aldehydes under solvent-free conditions at room temperature. The acetylated products were formed in good to excellent yields over short reaction times, and the catalyst could be readily recovered by filtration and used several times without any discernible loss in activity. The hydrogen sulfate anion of the catalytic system was found to play a critical role in enhancing the reaction time and yield of the acetylation reaction.  相似文献   

16.
17.
Abstract

A new protocol for Biginelli (or like) reaction has been developed under solvent-free grinding method using catalytic amount of hydrated ferric nitrate or clayfen. The advantage of this novel protocol lies in the avoidance of organic solvent, high yield, energy efficiency, variation of substrates, and use of inexpensive catalyst. The recycling of catalyst is also possible with clayfen for more than three times. Furthermore, the catalytic activity of ferric nitrate retains its efficiency in methanol and acetone as reaction medium.  相似文献   

18.
Phosphated tungstate as a new, reusable and efficient solid phosphoric acid catalyst was synthesized and used to promote the reaction of diaminoglyoxime with various aromatic aldehydes. The prepared phosphated tungstate was characterized using various techniques including X‐ray diffraction, scanning electron microscopy, energy‐dispersive X‐ray spectroscopy, Fourier transform infrared spectroscopy and thermal analysis. A wide variety of heterocyclic nitrones were obtained under mild reaction conditions and in high yields by using the prepared catalyst.  相似文献   

19.
Hojat Veisi 《Tetrahedron letters》2010,51(16):2109-3695
A variety of N-substituted pyrroles have been synthesized by reacting γ-diketones with amines, diamines or triamine in the presence of silica sulfuric acid (SSA) at room temperature under solvent-free conditions. The experiment protocol features simple operations, and the products are isolated in high to excellent yields (70-98%).  相似文献   

20.
An efficient synthesis of 3,4-dihydropyrimidinones or thiones (DHPMs) is described, using silica-supported heteropoly acid H3PW12O40/SiO2 (PW/SiO2) for the first time as the catalyst from an aldehyde, β-keto ester and urea or thiourea in acetonitrile. Compared to the classical Biginelli reaction conditions, this method consistently has the advantage of excellent yields, mild reaction conditions, ease of workup, survival of different functional groups, and short reaction times.  相似文献   

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