A study of the alkaloids of Kirghiz opium

Summary Morphine, codeine, narcotine, thebaine, papaverine, protopine, xanthaline, prophyroxine, bases with mp 267 and 263°C,l-canadine, and cryptopine have been isolated from Kirghiz opium.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 711–713, November–December, 1970.     

Qualitative mass spectrometric analysis of the total diterpene bases from the roots ofAconitum kusnezoffi

A quantitative analysis of the roots ofAconitum kusnezoffi has been made by a group of mass-spectrometric methods. Twelve diterpene bases have been studied of which ten have been identified as beiwutine, aconitine. mesaconitine, 3-deoxyaconitine, hypaconitine, neoline, songorine, isotalatisidine, talatisidine, and 10-hydroxyneoline.Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 89–92, January–February, 1996. Original article submitted August 7, 1995.     

Robustaminecis-N-oxide and merenderine fromMerendera robusta

The structure and configuration of a new homoproaporphine, robustamine cis-N-oxide, isolated fromMerendera robusta (fam. Liliaceae) have been established by spectral characteristics and chemical transformations. It was found that the fraction of alkali-soluble bases from this plant consists mainly of the homoaporphine compound merenderine, the amount of which increases considerably towards the end of the vegetation period.Tashkent State University, fax (3712) 46 24 72. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 734–738, September–October, 1996. Original article submitted February 26, 1996.     

Alkaloids ofCorydalis

Summary Fifteen bases have been isolated from three species ofCorydalis. Dihydrosanguinarine has been isolated from a plant of the genusCorydalis for the first time.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 612–615, September–October, 1975.     

Structure of isoregelinone

From a fraction of the bases ofColchicium kesselringii Rgl., growing in the Tashkent Province, a new compound which has been called isoregelinone has been isolated. On the basis of spectral characteristics, especially the INDOR spectrum, and chemical transformations, a structure epimeric with that of regelinone has been proposed for it.V. I. Lenin Tashkent State University. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 195–199, March–April, 1981.     

Tropane alkaloids of two species of plants of theConvolvulus genus

Eighteen alkaloids have been isolated from two species ofConvolvulus, ten of which were new. The structures of nine of the latter, including two dimeric bases, have been established. Transitions between them have been effected.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, fax (3712) 89 14 75. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 687–689, September–October, 1986. Original article submitted February 19, 1996.     

Potentiometric Studies of Copper(II) Complexes of Some Substituted Benzylidene-2-Hydroxyanilines in Dioxane–Water Media

The formation and protonation constants of 17 Schiff bases-derived 2-hydroxyaniline with some substituted benzaldehydes, and the stability constants of Cu(II) complexes of these Schiff bases, have been determined potentiometrically in 20, 40, and 60% dioxane–water media. The data from the potentiometric titrations were evaluated with the BEST computer program. For all Schiff bases studied, it was observed that the log K_OH values related to the protonation equilibria of the phenolic oxygen are increased, and the log K_NH values related to the protonation equilibria of the azomethine nitrogen are decreased, as the dioxane content is increased. The variation of these constants is discussed on the basis of specific solute–solvent interactions and structural changes of Schiff bases from water to the dioxane–water media. Also, titrimetric-pH investigation of substituted benzilidene-2-hydroxyaniline systems has revealed the formation of stable mono-Schiff base complexes with the metal ion Cu(II).     

Alkaloids ofThalictrum sachalinense. V

Summary Glaucine, N-methylnantenine, thalrugosine, magnoflorine, berberine, and the unidentified bases (II) and (III) have been obtained from the roots and rhizomes ofThalictrum sachalinense. The main alkaloid in the combined bases of the roots and rhizomes was magnoflorine.Intitute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Pacific Ocean Institute of Bioorganic Chemistry, Far Eastern Scientific Center of the Academy of Sciences of the USSR, Vladivostok. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 594–597, September–October, 1978.     

Alkaloids of the epigeal part ofConvolvulus krauseanus

The epigeal part ofConvolvulus krauseanus collected in two vegetation periods — flowering and fruit-bearing — has been studied for the first time. Five bases have been isolated. Convolvine, convolamine, and convolidine proved to be known, phyllalbine was isolated from this species for the first time, and colvolicine proved to be a new base for which the structure of (±)-N-acetoxy-3-veratroyl-nortropine has been established.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 527–529, July–August, 1979.     

Palladium(II) Schiff base complexes derived from sulfanilamides and aminobenzothiazoles

Schiff bases (HL) derived from sulfanilamides or aminobenzothiazoles add to Pd(OAc)₂ to give complexes of the type PdL₂ (1–7) in moderate to excellent yields. Reactions of Schiff bases containing pyrimidine groups, however, gave several products arising from competing coordination of the pyrimidine nitrogen. Palladium complexes and Schiff bases have been investigated as antifungal agents against Aspergillus niger and Aspergillus flavus.     

Unsymmetrical bis-Schiff bases derived from ethylenediamine,dehydroacetic acid and another aldehyde/ketone and the preparation and characterisation of their copper(II) and nickel(II) complexes

Summary Partial displacement of the symmetrical bis-Schiff bases (1)–(4) of ethylenediamine and salicyladehyde, o-hydroxyacetophenone, acetylacetone or benzoylacetone by dehydroacetic acid have led to the formation and isolation of the unsymmetrical bis-Schiff base ligands (6)–(9). Attempted partial displacements of the symmetrical bis-Schiff base (5) of dehydroacetic acid or (1)–(4) by each of the other four carbonyl compounds have been unsuccessful. The Ni^(II) and Cu^(II) complexes of (6)–(9) have been prepared and characterized.     

New copper (II) complexes of tridentate dibasic ONO donor ligands derived from salicylaldehyde or substituted salicylaldehydes ando-hydroxybenzylamine

Summary Copper(II) complexes with the Schiff bases derived from Salicylaldehyde and its 5-chloro-, 5-bromo-, 5-nitro-, 3-ethoxy- and 3,5-dichloro derivatives, or from 2-hydroxy-1-naphthaldehyde ando-hydroxybenzylamine, have been synthesized and characterized on the basis of elemental analysis, i.r. and electronic spectra and magnetic susceptibility measurements. The Schiff bases behave as tridentate dibasic O, N and O donor ligands and form complexes with 11 metal: ligand stoichiometry which exhibit subnormal magnetic moments ( _eff=0.88–0.98 B.M.) and are involved in strong antifer-romagnetic exchange (–J=482–525 cm^–1). The complexes exhibit a d-d band atca. 1600 cm^–1. A dimeric structure with aminophenolic oxygen atoms as the bridging atoms is proposed on the basis of i.r. and magnetic data.     

Alkaloids of Merendera iolantae

Summary The alkaloids ofMerendera iolantae E. Czerniak have been studied for the first time. The total alkaloids consist of tropolone compounds and bases without a tropolone ring. From this plant we isolated the known alkaloids colchicine, colchamine, -lumicolchicine, colchameine, and 2-demethylcolchiceine, and four new, nontropolone, bases — MI-1 (iolantamine), MI-2, MI-3, and MI-4. The presence of colchiceine, 3-demethylcolchamine, and two unknown bases with R _f 0.49 and 0.53 was shown by chromatographic methods.A developed formula has been put forward for iolantamine on the basis of its spectral characteristics.V. I. Lenin Tashkent State University. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 487–493, July–August, 1972.     

Dynamics of the accumulation of the alkaloids ofReseda luteola structure of lutine and lutinine

Summary The qualitative and quantitative changes in the composition of the combined bases inReseda luteola during the vegetation periods have been studied. From the epigeal part of the plant we have isolated cinnamamide and two new alkaloids: lutine and lutinine. A study of the spectral characteristics and the mechanism of fragmentation has shown that lutine has the structure of 2-anilino-1,4-naphthoquinone and lutidine that of 4-anilino-2-phenylamino-1,2-dihydronaphthalen-1-one.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. M. I. Kalinin Andizhan Medical Institute. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 826–830, November–December, 1977.     

Alkaloids ofDelphinium dictyocarpum

Summary From the plantDelphinium dictyocarpum DC, in addition to alkaloids described previously, we have isolated N-methyllaurotetanine, isoboldine, and the new bases dictyzine, dictyonine, delectinine and delporphine. The structure of 1,2,10-trimethoxy-3,9-dihydroxy-aporphine has been established for delporphine.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 235–241, March–April, 1978.     

Alkaloids ofNitraria komarovii. X. Structures of tetrahydronitramarine,tetrahydrokomarovinine, dihydroisokomarovine,and tetrahydroisokomarovine

The alkaloid nitraraine and four new bases have been isolated for the first time from the epigeal part ofNitraria komarovii. Their structures have been established with the aid of chemical transformations and spectral characteristics: tetrahydronitramarine, tetrahydrokomarovinine, dihydroisokomarovine, and tetrahydroisokomarovine. Passages have been effected to nitramarine, komarovinine, isokomarovinine, and komarovidinine. Tetrahydroisokomarovine is a new alkaloid, while this is the first time that tetrahydronitroamarine, tetrahydrokomarovinine, and dihydroisokomarovine have been found in nature. Nitrarine, isonitrarine, and schoberidine have been isolated from the seeds with fruit.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 61–67, January–February, 1990.     

Syntheses of new oxovanadium(IV) complexes with some new Schiff bases derived from salicylaldehyde or substituted salicylaldehyde and 3-aminothiophenol

Summary The syntheses of several new oxovanadium(IV) complexes of new Schiff bases derived from Salicylaldehyde, 5-ch orosalicylaldehyde, 5-bromosalicylaldehyde, 5-nitrosalicylaldehyde, 4-methoxysalicylaldehyde, 2-hydroxy-l-naphthaldehyde and 3-aminothiophenol are described. The complexes, which are of the VOL₂ type, have been characterized on the basis of elemental analysis, i.r. and electronic absorption spectra, and magnetic susceptibility measurements. The Schiff bases behave as bidentate ligands and a five-coordinate square-pyramidal structure is suggested for the complexes which exhibit two or three spin-allowed d-d bands atca. 12000, 17000 and 22000 cm^–1. The v(V=0) vibration occurs in the 940–980 cm^–1. range. The complexes exhibit normal magnetic moments (µ_eff = 1.71-1.73 B.M.) at room temperature.     

Phytoglycolipids of the grape

The qualitative and quantitative compositions of the grape and its component parts — flesh, skin, seeds — have been studied. Ten fractions have been identified, the main ones being cerebrosides and monogalactosyldiglycerides. The compositions of the fatty acids, of the sphingosine bases, of the sterols, and of the carbohydrates of the individual fraction of phytoglycolipids have been determined.Physicochemical Institute of the Academy of Sciences of the Ukrainian SSR, Odessa. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 296–300, May–June, 1984.     

Polybuffer separation of the alkaloids ofNitraria schoberi

Summary It has been established that the epigeal part of the plantNitraria schoberi L. in the budding stage contains 0.5% of alkaloids.By a combination of the fractionation of the mixture of alkaloids by polybuffer separation with other methods of separation, nine alkaloids have been isolated and studied.Fractions with a high pH value yielded the following strong bases: nitramine (pH 9 and 8), schoberidine and base A (pH 8), and nitrarine, isonitrarine, and nitramidine (pH 7). The following alkaloids were also isolated: nitraramine (pH 6.5 and 6) and schoberine and base B (pH 4 and the combined chloroform phases of the fractions with pH 7-2).Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 84–87, January–February, 1977.     

Berberis alkaloids. XXXVII. Investigation of the alkaloids ofB. oblongata andB. integerrima. Crystal structure of 8-trichloromethyldihydroberberine

Two species of Berberis have yielded 10 isoquinoline alkaloids. In addition to known bases, two artifacts have been isolated — 8-trichloromethyldihydroberberine (I) and 8-trichloromethyldihydropalmatine. An x-ray structural analysis has been made of (1).Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 889–893, November–December, 1996. Original article submitted April 15, 1996.