Versatile synthetic strategies for PBCA-based hybrid fluorescent microbubbles and their potential theranostic applications to cell labelling and imaging

This research reports the versatile synthetic strategies for hybrid PBCA microbubbles as contrast agents and drug carriers loaded with fluorescent dyes and magnetic nanoparticles serving in vitro cell labelling and in vivo target imaging. These multifunctional probes therefore prove their potential biomedical applications in cancer diagnostics and treatment.     

Recent progress in capillary isotachophoresis

This article is a continuation of previous reviews and summarizes the progress of analytical capillary isotachophoresis since 2000. Papers reviewed include methodological and instrumental aspects as well as analytical applications. Included are also papers using isotachophoresis and/or isotachophoretic principles as part of multidimensional separation schemes.     

Recent progress in capillary ITP

ITP has been attracting constant attention for many years due to its principal capability to concentrate trace analytes by several orders of magnitude. In the current capillary format, it is able to concentrate trace analytes diluted to several microliters of an original sample into concentrated zones having volumes in the range of picoliters. Due to this reason, ITP holds an important position in many current multistage and multidimensional separation schemes. This article links up previous reviews on the topic and summarizes the progress of analytical capillary ITP since 2002. Almost 100 papers are reviewed that include methodological novelties, instrumental aspects, and analytical applications. Papers using ITP and/or isotachophoretic principles as part of multistage and/or multidimensional separation schemes are also included.     

Recent progress in SERS biosensing

This perspective gives an overview of recent developments in surface-enhanced Raman scattering (SERS) for biosensing. We focus this review on SERS papers published in the last 10 years and to specific applications of detecting biological analytes. Both intrinsic and extrinsic SERS biosensing schemes have been employed to detect and identify small molecules, nucleic acids, lipids, peptides, and proteins, as well as for in vivo and cellular sensing. Current SERS substrate technologies along with a series of advancements in surface chemistry, sample preparation, intrinsic/extrinsic signal transduction schemes, and tip-enhanced Raman spectroscopy are discussed. The progress covered herein shows great promise for widespread adoption of SERS biosensing.     

碳锂化反应的研究进展

介绍了近年来碳锂化反应在分子间和分子内以及不对称反应方面的研究进展。     

Recent progress in titration calorimetry

Research developments in titration calorimetry over the past ten years by personnel at the Thermochemical Institute have resulted in new techniques and instrumentation that have greatly increased the usefulness of calorimetry in the study of chemical problems. During this time, problems associated with the components of the calorimeter (i.e., constant temperature bath, constant rate buret, reaction vessel, temperature sensing circuit, and data analysis procedure) have been solved so that the continuous titration method now gives results comparable in accuracy to those obtained with conventional solution calorimeters. These developments have opened new avenues of research in the fields of biochemistry, microbiology, and environmental analysis.

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Zusammenfassung Die Fortschritte der Forschung auf dem Gebiete der Titrationskalorimetrie, welche in den vergangenen Jahren von Mitarbeitern des Thermochemischen Instituts erreicht worden sind, führten zu neuen Techniken und neuer Instrumentation, die die Einsatzfähigkeit der Kalorimetrie zur Untersuchung chemischer Probleme wesentlich erhöhten. Während dieser Zeit wurden Probleme in Zusammenhang mit den Bestandteilen des Kalorimeters (d.h. Konstanttemperaturbad, Burette mit konstanter Geschwindigkeit, Reaktionsbehälter, Temperatur, Wärmefühler-Stromkreis und Datenverarbeitungsvorgang) gelöst, so daß die kontinuierliche Titrationsmethode jetzt Ergebnisse von einer Genauigkeit liefert, welche mit der in herkömmlichen Lösungskalorimetern erhaltenen vergleichbar ist. Diese Entwicklungsarbeit eröffnet neue Wege der Forschung auf den Gebieten der Biochemie, Mikrobiologie und Umweltschutzanalyse

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Résumé Les recherches effectuées durant les dix dernières années par le personnel de l'Institut de Thermochimie ont eu pour résultat la mise au point d'appareils nouveaux qui augmentent, considérablement l'applicabilité de la calorimétrie à l'étude des problèmes chimiques. Ainsi les problèmes associés aux composants d'un calorimètre (c'est-à-dire bain à température constante, burette à vitesse constante, récipient réactionnel, circuit détecteur de température et procédés d'analyse des données) ont été résolus. C'est pourquoi la technique du titrage en continu donne maintenant des résultats d'une exactitude comparable à celle obtenue avec les calorimètres en solutions conventionnels. Ces développements ont ouvert de nouvelles perspectives de recherche dans les domaines de la biochimie, de la microbiologie et des analyses liées à la protection de l'environnement.

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Recent progress in capillary isotachophoresis

This article is a continuation of previous reviews and summarizes the progress of analytical capillary isotachophoresis in the years 1997-1999. Papers reviewed include theoretical and methodological aspects as well as analytical applications. Included are also papers using isotachophoresis and/or isotachophoretic principles as part of multidimensional separation schemes.     

Recent progress in capillary electrochromatography

Capillary electrochromatography (CEC) continues to captivate many separation scientists. A remarkable activity is apparent from the numerous publications in the literature using CEC. A review of the most recent progress in CEC is presented herein, covering an extensive fraction of the literature on CEC published from the year 1997 until the beginning of 2000. Most of the recent developments have concentrated on column technology.     

Recent progress on nanovehicles

Nanovehicles are a new class of molecular machines consisting of a molecular scale chassis, axles, and wheels, that can roll across solid surfaces with structurally defined directions making them of interest to synthetic chemists, surface scientists, chemical engineers, and the general car enthusiast. In this tutorial review, following a brief introduction to the development of nanomachines, our recent progress on the nanovehicle project is presented including the design, synthesis, and testing of a series of nanocars, nanotrucks, and motorized nanocars.     

Lamellarin H(LMH)的研究进展

Lamellarin及其类似物是一类从海洋软体动物中分离出来的具有生物活性的吡咯生物碱,截至2008年已发现70多种,其中Lamellarin H(LMH)具有高效的抑制拓扑异构酶1,抑制HIV-1整合酶等活性,而且对各种肿瘤细胞特别是人类宫颈癌传代细胞(HeLa)具有很好的细胞毒性,从而在医学上有很大的价值.本文综述...     

亲电氟化反应的新进展

介绍了自八十年代以来亲电氟化反应的最新进展, 其中包括众多的N-F类电氟化试剂的制备, 它们和各种底物的反应以及此类亲电氟化反应可能的机理。     

Recent progress in actinide borate chemistry

The use of molten boric acid as a reactive flux for synthesizing actinide borates has been developed in the past two years providing access to a remarkable array of exotic materials with both unusual structures and unprecedented properties. [ThB(5)O(6)(OH)(6)][BO(OH)(2)]·2.5H(2)O possesses a cationic supertetrahedral structure and displays remarkable anion exchange properties with high selectivity for TcO(4)(-). Uranyl borates form noncentrosymmetric structures with extraordinarily rich topological relationships. Neptunium borates are often mixed-valent and yield rare examples of compounds with one metal in three different oxidation states. Plutonium borates display new coordination chemistry for trivalent actinides. Finally, americium borates show a dramatic departure from plutonium borates, and there are scant examples of families of actinides compounds that extend past plutonium to examine the bonding of later actinides. There are several grand challenges that this work addresses. The foremost of these challenges is the development of structure-property relationships in transuranium materials. A deep understanding of the materials chemistry of actinides will likely lead to the development of advanced waste forms for radionuclides present in nuclear waste that prevent their transport in the environment. This work may have also uncovered the solubility-limiting phases of actinides in some repositories, and allows for measurements on the stability of these materials.     

Recent progress in environmental catalytic technology

Recent progress and trends in environmental catalytic technology in Japan are described with emphasis on the catalysts having hybridized functions. In addition to automobile exhaust cleaning, use of environmental catalysts such as titanium oxide photocatalysts is rapidly growing for the control of residential environments, e.g., antimicrobial activity and odor control, as life styles change gradually and the living environment is deteriorating considerably. Many new catalysts are evolving through hybridization of functions. The market of environmental catalyst products in 2005 is estimated 2,000 billion yen/year (photocatalyst: 1,100 billion yen/year).     

有机荧光材料研究进展

对三类主要的有机荧光材料－－具刚性结构的芳香稠环化合物，具共轭结构的分子内电荷转移化合物及某些金属配合物尤其是稀土金属配合物近二十年来的研究与应用进行了综述，引用文献48篇。     

Recent progress in supramolecular chiral photochemistry

Chiral photochemistry appears to be a highly challenging topic and still very much in its infancy, especially if comparing to its well-developed thermochemical counterpart.Significant efforts have been devoted in order to improve stereoselectivity of chiral photoreactions,among which,the supramolecular strategy proven the most promising.The present review,motivated by the rapid progress in the supramolecular chiral photochemistry,concentrates on advancements achieved mainly in the last decade.The features and advantages of supramolecular chiral photochemistry are exemplified by representative photoreactions in terms of the chiral hosts/assemblies.     

Recent progress in heterogeneous Ziegler-Natta catalysts

This paper summarizes the results on regio- and stereochemical control of heterogeneous Ziegler-Natta catalysts which we have obtained for the last several years. Convenient converting methods of active species from aspecific into isospecific are first shown with the use of a completely aspecific catalyst. Effects of catalyst isospecificity on the polymerization of various olefins as well as olefin copolymerizations are then described in some detail. Finnaly, the preparation method of Ti-based regioirregular catalyst and its application to ethylene-propene copolymerization are reported in brief.     

Recent progress in tumor photodynamic immunotherapy

Photodynamic therapy(PDT) is a promising alternative approach for effective cancer treatment,which can directly destroy local tumor cells due to the generation of cytotoxic singlet oxygen and reactive oxygen species(ROS) in the tumor cells.Intriguingly,PDT-mediated cell death is also associated with anti-tumor immune response.Howeve r,immunosuppre s sion of tumor microe nvironment is able to limit the immune response induced by PDT,it is therefore necessary to combine with immunocheckpoint inhib...     

Recent progress in polymer hydrogel bioadhesives

Adhesive hydrogels have broad applications in tissue adhesives, hemostatic agents, and biomedical sensors. Various bio-inspired glues and synthetic adhesives are clinically used as conventional hemostatic agents and auxiliary tools for wound closure. Medical adhesives are needed to effectively and quickly control bleeding, thereby reducing the risk of complications caused by severe blood loss. Medical sensors need to have excellent skin compliance, mechanical properties, sensitivity, and biological safety. This review focuses on recent progress in adhesive hydrogel systems, their structures, adhesion mechanisms, construction strategies, and emerging applications in the biomedical field.     

Recent progress in hybrid materials science

This themed issue of Chemical Society Reviews reviews recent progress made in hybrid materials science. Guest editors Clément Sanchez, Susumu Kitagawa and Ken Shea introduce the issue and the academic and industrial importance of the field.     

Recent progress in high-performance capillary bioseparations

Bioanalysis is a fast growing domain with new technological developments in the field of mass spectrometry, separation science, and bioinformatics. The central role of separation prior to detection and evaluation of analytes is indisputable. In fact, since the decipherment of the human genome via multichannel capillary electrophoresis in combination with laser-induced fluorescence [1], the analysis of the proteome, i.e., the type and amount of all proteins expressed at a certain time by the genome in a cell or tissue [2] became of central interest. Therefore, new fast and sensitive capillary liquid chromatographic, electrophoretic, and electrochromatographic separation techniques, suitable for high-throughput analysis of proteins, peptides and nucleic acids, are required.