共查询到20条相似文献,搜索用时 15 毫秒
1.
Masahiko Isaka Nuntawan Rugseree Palangpon Kongsaeree Yodhathai Thebtaranonth 《Tetrahedron》2005,61(23):5577-5583
Five new alkaloids, hirsutellones A-E, were isolated from the insect pathogenic fungus Hirsutella nivea BCC 2594. Their structures were elucidated by spectroscopic analysis and X-ray crystallography. Hirsutellones displayed significant growth inhibitory activity against Mycobacterium tuberculosis H37Ra. 相似文献
2.
E. Łodyga-Chruścińska S. Ołdziej D. Sanna G. Micera L. Chruściński K. Kaczmarek R.J. Nachman J. Zabrocki A. Sykuła 《Polyhedron》2009
Spectroscopic data, including electronic absorption, CD and EPR results, as well as theoretical calculations have shown that the insertion of 4-aminopyroglutamate, a novel cis-peptide bond mimic, in the insect kinin peptide leads to an effective ligand towards Cu(II) ions at basic pH ranges. The 4-aminopyroglutamate motif induces a specific peptide conformation which favors the formation of one or two five-membered chelating rings stabilizing a bent structure, with the coordination of 3N-type or 4N-type in the metallopeptide molecule involving in metal bonding C-terminal of modified peptide. It is worth noting that the copper(II) bonding does not undergo hydrolysis even at a very high pH range. 相似文献
3.
Siriporn Saepua Jittra Kornsakulkarn Wiwat Somyong Pattiyaa Laksanacharoen Masahiko Isaka Chawanee Thongpanchang 《Tetrahedron》2018,74(8):859-866
Eleven new compounds, including two quinone derivatives of bioxanthracene, conoideocrellones A (1) and B (2), two bioxanthracenes 3 and 4, four isocoumarins and isocoumarin glycosides 7–10, two phenolic compounds 16 and 17, and a diterpenoid compound, conoideocin A (18), were isolated from culture of the scale-insect pathogenic fungus Conoideocrella tenuis BCC 44534. Seventeen known compounds, compounds 5 and 6, ES-242-2 and its atropisomer, isocoumarins and isocoumarin glycosides 11–15, 3,4,6-trihydroxymellein, cis-4,6-dihydroxymellein, metarhizins A (19) and B (20), BR-050 (21), 5α,8α-epidioxy-24(R)-methylcholesta-6,22-dien-3β-ol, zeorin, and conoideocrellide A, were also isolated from this fungus. Structures of these compounds were elucidated by NMR and MS data analyses. Compound 4 was active against Plasmodium falciparum K1 (IC50 6.6?μg/mL), while it did not show cytotoxicity. Conoideocrellone A (1) and compounds 3 and 7 exhibited cytotoxic activity, while conoideocin A (18) showed broad range of biological activities including antimalarial, antibacterial, and cytotoxic activities. 相似文献
4.
Jittra Kornsakulkarn Siriporn Saepua Kitlada Srichomthong Sumalee Supothina Chawanee Thongpanchang 《Tetrahedron》2012,68(40):8480-8486
Nine new mycotoxins; five xanthones 1–5, hydroxanthone 6, and three anthraquinones 7–9, together with nine known compounds; sterigmatocystin (10), demethylsterigmatocystin (11), dihydrodemethylsterigmatocystin (12), sterigmatin (13), austocystin F (14), averufin (15), aflatoxin B1, paeciloquinone A, and zeorin, were isolated from the scale insect fungus Aschersonia coffeae Henn. BCC 28712. The structures of these compounds were elucidated using NMR spectroscopic and MS spectrometric analyses. Compounds 1–3 and 6–9 displayed cytotoxic activity while the xanthone 2 and anthraquinones 8 and 9 also showed antimalarial activity. 相似文献
5.
Pattama Pittayakhajonwut Atit Usuwan Chakapong Intaraudom Punsa Khoyaiklang Sumalee Supothina 《Tetrahedron》2009,65(31):6069-789
Investigation of the insect pathogenic fungus Torrubiella luteorostrata led to the isolation of three new macrocyclic torrubiellutins A-C (1-3) and the known pyrone diterpene 4. Structures were elucidated by spectroscopic data including 1D, 2D NMR, and MS spectral data. The absolute stereochemistry was determined by chemical means using Mosher reactions and Marfey's reagent, together with NOESY spectral data. Torrubiellutin C showed biological activities against KB, MCF-7, NCI-H187, and Vero cell lines with IC50 varying from 0.78 to 4.36 μg/mL, while compound 4 exhibited antimalaria and anti-inflammatory activity with IC50 values of 3.49 and 1.21 μg/mL, respectively. 相似文献
6.
Masahiko Isaka Pitchapa Berkaew Kamolphan Intereya Somjit Komwijit Thiptiwa Sathitkunanon 《Tetrahedron》2007,63(29):6855-6860
Four new cyclohexadepsipeptides, pullularins A-D, were isolated from the endophytic fungus Pullularia sp. BCC 8613. Structures of these compounds were elucidated by interpretation of NMR spectroscopic and mass spectrometric data. The absolute configurations of amino acid and hydroxy acid residues were determined by HPLC analysis of depsipeptide acid hydrolyzates using a chiral column and Marfey's method. Pullularin A exhibited activities against the malarial parasite Plasmodium falciparum K1 (IC50 3.6 μg/mL) and herpes simplex virus type 1 (HSV-1; IC50 3.3 μg/mL), whereas it showed weak cytotoxicity to Vero cells (IC50 36 μg/mL). 相似文献
7.
《Tetrahedron》2019,75(45):130646
A benzophenone derivative, orbiophenone A, and its homodimer, orbiocrellone A, a chromone derivative, orbiochromone A, four benzophenone–chromone heterodimers, orbiocrellones B–E, and a benzophenone–tetrahydroxanthone dimer, ent-secalonic acid I, were isolated from cultures of the scale-insect pathogenic fungus Orbiocrella petchii BCC 51377. Their structures were elucidated by spectroscopic analyses and chemical correlations. Orbiochromone A was isolated for the first time as an optically active natural product, and its absolute configuration was determined by the ECD spectrum combined with TD-DFT calculations. Four of the dimeric compounds, orbiocrellones B–D and ent-secalonic acid I, exhibited antimalarial activity against Plasmodium falciparum K1 with IC50 values of 5.7, 5.6, 14, and 5.5 μM, respectively. 相似文献
8.
Berkleasmins A-E, five new eremophilane sesquiterpenoids were isolated from the saprobic fungus Berkleasmium nigroapicale BCC 8220. The structures of the new compounds were elucidated by analyses of NMR spectroscopic and mass spectrometry data in combination with chemical means. Berkleasmins A and C exhibited cytotoxic activity against cancer cell-lines (NCI-H187, MCF-7, and KB) as well as nonmalignant Vero cells with IC50 values of 1.1-7.5 μg/mL, and these compounds also showed antimalarial activity with respective IC50 of 3.1 and 2.8 μg/mL. 相似文献
9.
Masahiko Isaka Panida Chinthanom Sukitaya Veeranondha Sumalee Supothina J. Jennifer Luangsa-ard 《Tetrahedron》2008,64(49):11028-11033
Two novel cyclopropyl diketones, hamavellone A (1) and B (2), and two new 14-membered nonaketide macrolactones, hamigeromycin A (3) and B (4), together with six known compounds, 89-250904-F1 (radicicol analogue A, 5), pseurotin A (6), emodin (7), ω-hydroxyemodin (8), and emodin bianthrones (9 and 10) were isolated from the soil fungus Hamigera avellanea BCC 17816. The structures of the new compounds were defined by analysis of NMR and MS data. The absolute stereochemistry of 3 was addressed by chemical correlation to 5. Hamavellone B (2) exhibited antimalarial activity with an IC50 of 5.2 μg/mL, whereas it also showed comparable cytotoxicity. 相似文献
10.
Jittra Kornsakulkarn Siriporn Saepua Rapheephat Suvannakad Sumalee Supothina Nattawut Boonyuen Masahiko Isaka Samran Prabpai Palangpon Kongsaeree Chawanee Thongpanchang 《Tetrahedron》2017,73(25):3505-3512
Twelve new compounds, including nine tropolones, nemanolones A?I (1–9), three 7-isochromenones, nemanecins A?C (10–12), and a new naturally isolated 4-isochromanone (13), along with two known compounds, 7,8-dihydroxy-3-methyl isochroman-4-one (XJP), and chaetoquadrin F, were isolated from culture broth of the fungus Nemania sp. BCC 30850. Structures of these compounds were elucidated by NMR and MS spectroscopic analyses. Nemanolones exhibited cytotoxic activities and two of them, compounds 1 and 2, also showed antibacterial activity against Bacillus cereus and antifungal activity against Candida albicans. 相似文献
11.
Masahiko Isaka Somporn PalasarnSomjit Komwijit Sayanh SomrithipolSujinda Sommai 《Tetrahedron letters》2014
Cyclodepsipeptides SCH 217048 (1), SCH 218157 (2), and a new analog, pleosporin A (3), were isolated from cultures of an unidentified elephant dung fungus of the family Pleosporaceae. The structure of 3 was elucidated on the basis of detailed spectroscopic interpretation. The absolute configurations of 1–3 were determined by chiral column HPLC analysis and Marfey’s method. Cyclodepsipeptides 1–3 exhibited antimalarial activity against Plasmodium falciparum K1 with respective IC50 values of 1.6, 6.4, and 1.6 μg/mL, while they did not show cytotoxicity against KB, MCF-7 and NCI-H187 cell-lines or non-cancerous Vero cells at 50 μg/mL. 相似文献
12.
Masahiko Isaka Somporn Palasarn Wilunda Choowong Suchada Mongkolsamrit 《Tetrahedron letters》2019,60(2):154-156
Conoideoxime A (1), a prenyl-tryptophan dimer possessing bis-oxime functionality, was isolated from cultures of the whitefly pathogenic fungus Conoideocrella luteorostrata BCC 76664. The structure was elucidated by spectroscopic analyses. It displayed antibacterial activity against Gram-positive bacteria, Bacillus cereus, Enterococcus faecium, and Staphylococcus aureus, with MIC values of 3.13, 6.25, and 6.25?μg/mL, respectively. 相似文献
13.
Wen Yan HU Wen Ping XU Jian Gong SHI* Yong Chun YANG Guang Xiong ZHOU Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Bejing Hospital of Jiu Quan District Gansu Province Jiuquan Dis 《中国化学快报》2001,(9)
Alangium, the sole genus in the family Alangiaceae, has a variety of about 20 species distributed in the tropical and subtropical area of the Eastern Hemisphere, and 13 species are known to occur in the south of China1. A. plantanifolium and A. chinense are used in chinese traditional medicine for the treatment of rheumatalgia, paralysis, cardianeuria, and wound2. Pharmacological studies of the extracts of these two species showed muscular relaxing activity, and anabasine was considered as t… 相似文献
14.
Bachir BenniniAlbert J. Chulia Mourad KaouadjiPatrice Fondanèche Daovy P. Allais 《Tetrahedron letters》2011,52(14):1597-1600
The reinvestigation of Erica cinerea fresh aerial parts led to the isolation of two new diarylnonanoid aglycones along with their glucosides. From spectroscopic data, their structures were elucidated as rel-(3R,7R)-1,9-bis(p-hydroxyphenyl)-3,7-dihydroxynonan-5-one named ericanone, ericanone 3-β-d-glucoside, (3S)-3,7-anhydro-6,7-dehydroericanone and (3S)-3,7-anhydro-6,7-dehydroericanone 4′-β-d-glucoside. Contrary to the numerous diarylheptanoids more frequently distributed in the plant kingdom, the rare diarylnonanoids were previously restricted to the genus Myristica of the Myristicaceae plant family. 相似文献
15.
Jittra Kornsakulkarn Siriporn SaepuaSomjit Komwijit Pranee RachtaweeChawanee Thongpanchang 《Tetrahedron》2014
Five new compounds, phthalide 1, dihydroisocoumarin 2, and 3, pyrone 4, and benzophenone 5, together with nine known compounds, 3,4-dihydro-4,5,8-trihydroxy-3-methylisocoumarin, sclerotinin A, methyl-8-hydroxy-6-methylxanthone-1-carboxylate, sydowinin A, conioxanthone A, 1,3,8-trihydroxy-6-methylxanthone, 1,8-dihydroxy-3-methoxy-6-methylxanthone, coniochaetone B, and xylaranol B, were isolated from the fungus Astrocystis sp. BCC 22166. Structures of these compounds were elucidated using NMR spectroscopic and MS spectrometric analyses. Compound 1 exhibited antibacterial activity against Bacillus cereus (IC50=12.5 μg/mL) while compound 2 showed cytotoxicity to KB and Vero cells (IC50=22.6 and 48.2 μg/mL). 相似文献
16.
Jittra KornsakulkarnKulvadee Dolsophon Nattawut BoonyuenTanapong Boonruangprapa Pranee RachtaweeSamran Prabpai Palangpon Kongsaeree Chawanee Thongpanchang 《Tetrahedron》2011,67(39):7540-7547
Eleven new dihydronaphthalenones 1-11, together with five known compounds; 5-hydroxydihydrofusarubin C (12), javanicin, bostrycoidin, anhydrofusarubin, and 3-O-methylfusarubin, were isolated from the endophytic fungus Fusarium sp. BCC14842. Structures were elucidated by analyses of the NMR spectroscopic and mass spectrometry data. Javanicin, 3-O-methylfusarubin, compounds 3 and 7 exhibited antimycobacterial and cytotoxic activities. Javanicin also displayed antifungal activity with IC50 of 6.16 μg/mL, while compounds 2, 4, 5, 8, and 12 showed only cytotoxic activity. 相似文献
17.
Masahiko Isaka Somporn Palasarn Sujinda Sommai Pattiyaa Laksanacharoen Kitlada Srichomthong 《Natural product research》2018,32(13):1506-1511
A maleic anhydride derivative, botryoanhydride (1), and a chromone derivative, botryochromone (2), together with three known chromones, eugenitin (3), 6-hydroxymethyleugenin (4) and 6-methoxymethyleugenin (5), were isolated from cultures of the endophytic fungus BCC 54265 of the family Botryosphaeriaceae. The structures were elucidated on the basis of NMR, HRMS and CD data. Compound 2 showed weak cytotoxic activity to cancer cell-lines. 相似文献
18.
Masahiko Isaka Rachada Haritakun Suchada Mongkolsamrit Sumalee Supothina Tao Feng Ji-Kai Liu 《Tetrahedron letters》2018,59(7):620-623
Hypocrellutins A–C (1–3), 2- and 4-pyridone alkaloids, were isolated from cultures of the scale-insect pathogenic fungus Hypocrella discoidea BCC 71382. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. The absolute configuration of hypocrellutin B (2) was determined by ECD calculation. Their plausibly biosynthetic pathways are proposed. All isolated compounds were inactive in the antifungal, antimalarial, antitubercular, and cytotoxic activity assays. 相似文献
19.
Masahiko Isaka Rachada HaritakunSumalee Supothina Wilunda ChoowongSuchada Mongkolsamrit 《Tetrahedron》2014
Six new compounds, an N-hydroxypyridone glucoside, orbiocrellin A (1), its aglycone orbiocrellin B (2), chromone glucosides 3 and 4, a dihydrochromone 5a/5b, and a chromone 6, were isolated from the scale-insect pathogenic fungus Orbiocrella sp. BCC 33248. Orbiocrellin A (1) exhibited antimalarial activity against Plasmodium falciparum K1 (IC50 3.1 μg/mL) while it was non-cytotoxic. In contrast, orbiocrellin B (2) showed both antimalarial (IC50 2.1 μg/mL) and cytotoxic (NCI-H187 cells, IC50 0.70 μg/mL) activities. 相似文献
20.
Masahiko Isaka Arunrat Yangchum Kanokarn Kocharin Palangpon Kongsaeree Samran Prabpai 《Tetrahedron》2009,65(22):4396-475
Reinvestigation of the secondary metabolites from the marine mangrove fungus Aigialus parvus BCC 5311 led to the isolation of six new nonaketide metabolites, aigialomycins F (4) and G (5a/5b), 7′,8′-dihydroaigialospirol (7), 4′-deoxy-7′,8′-dihydroaigialospirol (8), and rearranged macrolides 9 and 10, along with six previously described compounds, hypothemycin (1), aigialomycins A (2) and B (3), aigialospirol (6), 4-O-demethylhypothemycin (11), and aigialone (12). The structures of the new compounds were elucidated by analyses of the NMR spectroscopic and mass spectrometry data in combination with chemical means. 相似文献