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1.
Under the catalysis of small amount of concentrated hydrochloric acid, the Mannich reaction of butanone, aromatic aldehydes and aromatic amines can be carried out directly at 0–20°C. Twelve corresponding Mannich bases (1), 1-aryl-1-arylamino-3-pentanones, were prepared in high yields. 相似文献
2.
《Comptes Rendus Chimie》2014,17(9):952-957
In water, Al powder becomes a powerful reducing agent, transforming in cyclohexyl either one or both benzene rings of aromatic compounds such as biphenyl, fluorene and 9,10-dihydroanthracene under mild reaction conditions in the presence of noble metal catalysts, such as Pd/C, Rh/C, Pt/C, or Ru/C. The reaction is carried out in a sealed tube, without the use of any organic solvent, at low temperature. Partial aromatic ring reduction was observed when using Pd/C, the reaction conditions being 24 h and 60 °C. The complete reduction process of both aromatic rings required 12 h and 80 °C with Al powder in the presence of Pt/C. 相似文献
3.
Jian Li Wenxian Lv Danfeng Huang Ke‐Hu Wang Teng Niu Yingpeng Su Yulai Hu 《应用有机金属化学》2014,28(4):286-289
A convenient and facile method for the synthesis of homoallylic amines was disclosed. The one‐pot reaction of aldehydes, aromatic amines and allylic bromide with tin powder at room temperature could afford the homoallylic amines in good to excellent yield without any promoter or additive. The method is highly efficient and environmentally benign with low cost and concise manipulation. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
4.
Direct reductive amination of aldehydes and ketones were accomplished efficiently using high-capacity, ionene-based, polymer-supported borohydride reagent in isopropyl alcohol at reflux under neutral conditions. The reagent is easily prepared by mixing aqueous solution of 2,4-ionene bromide with an alkaline solution of sodium borohydride at room temperature. The generality of reaction was established using both aliphatic and aromatic aldehydes, ketones, and amines. 相似文献
5.
Epoxides undergo a rapid ring‐opening reaction with aromatic amines catalyzed by niobium pentachloride under mild reaction conditions. All the reactions were carried out at room temperature to afford the corresponding β‐amino alcohols in excellent yields and with high regioselectivity. 相似文献
6.
无溶剂条件下N-磺酸琥珀酰亚胺催化乙酰化反应(英文) 总被引:1,自引:0,他引:1
A small amount of succinimide-N-sulfonic acid efficiently catalyzed the acetylation of a variety alcohols, phenols, thiols, amines and aldehydes with acetic anhydride at room temperature under solvent free conditions. This catalyst has the advantages of excellent yields and short reaction times and the reaction can be carried out on a large scale, which makes it potentially useful for industrial applications. 相似文献
7.
<正>A simple and convenient procedure for the preparation of amines from aldehydes and ketones with sodium borohydride activated by silica chloride as a catalyst under solvent-free conditions is described.A variety of aliphatic and aromatic aldehydes,ketones and amines when mixed with NaBH_4/silica chloride at room temperature,afforded excellent yield of the corresponding amines. 相似文献
8.
One-pot three-component Mannich reactions of ketones with aromatic aldehydes and aromatic amines are effectively catalyzed
by molecular iodine at room temperature under solvent-free conditions to afford the corresponding β-amino carbonyl compounds
with moderate to excellent yields. The method has the following advantages: no use of solvent, mild condition, high reaction
speed and small quantity of catalyst. 相似文献
9.
Gurusamy Harichandran Savarimuthu David Amalraj Ponnusamy Shanmugam 《Journal of heterocyclic chemistry》2013,50(3):539-543
A facile and efficient one‐pot, solid supported synthesis of functionalized piperidine derivatives catalyzed by Amberlite IRA400‐Cl resin/I2/KI via a multicomponent reaction of various aldehydes, aromatic amines, and 1,3‐dicarbonyl compounds has been achieved. The reaction has been carried out in a one‐pot reaction and Amberlite resin as a solid supported catalyst at room temperature. Shorter reaction time, easy workup, yield, and mild reaction condition make the novel synthetic strategy both practical and attractive. 相似文献
10.
11.
One‐pot Synthesis of Highly Functionalized Tetrahydropyridines: A Camphoresulfonic Acid Catalyzed Multicomponent Reaction 下载免费PDF全文
A simple and straight forward solvent free method for the synthesis of a series of highly functionalized tetrahydropyridine derivatives has been achieved via multicomponent reaction of aromatic aldehydes, various amines, and β‐keto esters at room temperature using readily available (±)‐camphor‐10‐sulfonic acid as an organocatalyst. The current protocol offers an atom economic and environmentally benign method for the synthesis of the title compounds under solvent free conditions in good yields with high substrate scope and avoids column chromatographic purification. 相似文献
12.
Heshmatollah Alinezhad Mahmood Tajbakhsh Fatemeh Salehian 《Monatshefte für Chemie / Chemical Monthly》2005,43(9):2029-2033
A variety of aliphatic and aromatic aldehydes and ketones were efficiently reduced to their corresponding amines when treated
with primary and secondary amines and NaBH4 in micellar media at room temperature under neutral conditions. 相似文献
13.
Summary. A variety of aliphatic and aromatic aldehydes and ketones were efficiently reduced to their corresponding amines when treated
with primary and secondary amines and NaBH4 in micellar media at room temperature under neutral conditions. 相似文献
14.
Venkata Bhavanarushi Pendem 《Phosphorus, sulfur, and silicon and the related elements》2020,195(6):485-490
AbstractWe have established a facile and versatile synthesis for the construction of isothiocyanates from their respective amines in the presence of an eco-friendly, inexpensive, easily available Iron catalyst under mild conditions. This reaction provides the target products through the formation of thiocarbamate salt as an intermediate. Both aromatic amines and aliphatic amines provided the respective target products in moderate to high yield under optimized reaction conditions. However, electron withdrawing substituents were difficult to give target product at room temperature, whereas, they obtained final products in good yield at moderate temperature. In addition, mechanistic studies were revealed that the synthetic route involved iron based subsequent reactions of addition and removal of sulfur. 相似文献
15.
[reaction: see text] A simple, selective, rapid, and efficient procedure for the synthesis of secondary amines from the reductive alkylation of either aliphatic or aromatic nitro compounds and the corresponding amines is reported. Ammonium formate is used as the hydrogen source and Pd/C as the hydrogen transfer catalyst. The reaction is carried out at room temperature. The rate differences for the preferential formation of secondary over tertiary products are due to both steric and electronic factors. 相似文献
16.
The trimethylgallium reagent was found to promote the addition of phenylacetylene to various aromatic and aliphatic aldehydes. This reaction was efficiently carried out in anhydrous CH2Cl2 at room temperature under mild conditions and the corresponding propargylic alcohols were obtained in good to excellent yields up to 98%. 相似文献
17.
A simple, economical, and convenient synthesis of a new series of 4‐thiazolidinone derivatives using one‐pot three‐component condensation of aromatic amines, thioglycolic acid and aromatic aldehydes or cyclohexanone in polypropylene glycol (PPG), a recyclable and inexpensive solvent medium is reported. All the reactions are carried out at 110°C without using catalyst or additives. The products are obtained in good to excellent yields (60–97%) after easy workup and purification. 相似文献
18.
19.
Philip A. Conway 《Tetrahedron》2009,65(15):2935-7189
We have recently developed a novel and efficient method for synthesising Erlenmeyer azlactones under mild and rapid conditions. The reaction is performed by reacting 2-phenyl-5-oxazolone with an aldehyde in dichloromethane using alumina as a catalyst. The materials react instantly at room temperature, negating the need for high temperatures and long reaction times. We have successfully used this method for both aliphatic, aromatic and heteroaromatic aldehydes, synthesising previously unmade Erlenmeyer azlactones in moderate to high yields. 相似文献
20.
JianHong Jia WeiJian Sheng Liang Han YuJin Li JianRong Gao JunFei Tu 《中国科学B辑(英文版)》2009,52(12):2171-2175
A series of N-monoalkyl aromatic amines are synthesized in high yields from corresponding nitroarene derivatives, aldehydes, and ammonium
formate in the presence of Pd/C as a catalyst through one-pot operations at room temperature. Both the conversion and selectivity
of the process are above 80%. Optimum reaction conditions are investigated, and it is found that the optimum molar ratio of
nitroarene derivatives to ammonium formate and the optimum weight ratio of nitroarene derivatives to Pd/C are 1/4 and 1/0.10,
respectively. These experiments provide a novel access for N-monoalkyl aromatic amines with advantages of simplicity, high selectivity, and environmental benignity. 相似文献