国内外酶免疫试剂检测乙肝病毒标志物的比较

报道了国产与美国Ａｂｂｏｔｔ公司生产的ＨＢＶＥＬＩＳＡ诊断试剂盒,对３０例来自昆明医学院传染科门诊及住院部标本同时进行ＨＢｓＡｇ、抗－ＨＢｓ、ＨＢｅＡｇ、抗－ＨＢｅ及抗－ＨＢｃＩｇＭ检测,对两试剂阳性符合率进行了比较研究,并采用滴定ＨＢｓＡｇ及抗－ＨＢｓ阳性血清的方法,表明两试剂敏感性极为相似,而国产试剂对抗－ＨＢｃＩｇＭ阳性检出率大大提高于Ａｂｂｏｔｔ试剂。     

Reaction of boron compounds with hydroxyquinones: A colour test of diagnostic value

The reactions of esters of boric acid, the wilson reagent, the DIMROTH reagent and the modified DIMROTH reagent have been studied with a wide variety of hydioxy-carbonyl compounds. The modified DIMROTH reagent and triphenyl borate behave very similarly and these reagents have the advantage of convenience, sensitivity and selectivity over the original DIMROTH test. The wilson reagent has been found to react with suitable hydroxy and methoxy acridones and xanthones as well as flavonees, flavonols and chalkones.     

Isoquinolinium bromochromate： An efficient and stable reagent for bromination of hydroxylated aromatic compounds and oxidation of alcohols

The new chromium(Ⅵ) oxidizing reagent isoquinolinium bromochromate(IQBC) was prepared and characterized.The IQBC has been found to be stable and an efficient solid reagent which can be easily prepared in good yield.It act as an efficient brominating reagent for hydroxylated aromatic compounds as well as good oxidizing reagent for the conversion of alcohols to carbonyl compounds in good to excellent yield.The synthesized isoquinolinium bromochromate is more ideal reagent,with number of specification inclu...     

Direct detection of polyaromatic hydrocarbons, estrogenic compounds and pesticides in water using desorption chemical ionisation membrane inlet mass spectrometry

This paper describes the use of desorption chemical ionisation membrane inlet mass spectrometry (DCI-MIMS) for the detection of a broad range of common contaminants in water. In addition, we discuss the advantages/disadvantages of two different types of chemical ionisation reagent gases, i-butene (a Broensted acid reagent) and argon (a charge exchange reagent). We found that polyaromatic hydrocarbons was detectable at ppt levels, the estrogenic compounds diethyl phthalate and octylphenol at high ppt levels, steroid hormones at ppb levels, hydrophobic pesticides at low ppb levels, whereas hydrophilic pesticides and bisphenol A were not detectable at all. With the exception of the polyaromatic hydrocarbons and pentachlorophenol, none of the reported compounds have to our knowledge been detected previously by other MIMS systems. In most cases the Broensted acid reagent gave characteristic ions at high mass/charge ratio, whereas the charge exchange reagent gave less characteristic ions at low m/z ratio. However, the sensitivity was generally not as good with the Broensted acid reagent as with the charge exchange reagent, since the Broensted acid reagent, i-butene, gave a large chemical background.     

4-(2-Pyridylazo)-resorcinol as a possible analytical reagent for the colorimetric estimation of cobalt,lead, and uranium ,

4-(2-Pyridylazo)-resorcinol has been synthesized, and its uses as an analytical reagent for the colorimetric estimation of cobalt, uranium and lead have been investigated. It has been shown to be the most sensitive reagent for the colorimetric estimation of cobalt, the most sensitive watersoluble reagent for the colorimetric estimation of uranium, and the first published water-soluble reagent for the colorimetric estimation of lead.     

氯铬酸甲铵/硅胶载体氧化剂的制备及其对醇的氧化研究

利用硅胶作载体，负载氯铬酸甲铵盐制备了一种新的载体铬(Ⅵ)氧化剂。该试剂制备方法简单、性质稳定。可在多种反应介质中对伯醇和仲醇氧化，高收率得到相应的醛和酮，反应操作简单，提纯方便。     

Study of the behaviour of the absorbent blanks in analytical procedures by using the H-Point standard additions method (HPSAM)

This paper studies the behaviour of reagent blank in different extractive-colorimetric procedures (determination of sympathomimetic amines with NQS reagent) by using the H-Point Standard Additions Method (HPSAM) in order to study and characterize the different possibilities that the blank can introduce in an analytical procedure. We define two kinds of blanks: the external blank (from reagent alone solutions data) and the internal blank (from extrapolation of reagent plus analyte solutions data). Comparison between both gives the information about the reproducibility of the behaviour of the reagent blank. A procedure to evaluate, and characterize, errors (if they exist) is described, and a guide for optimizing the measuring procedure is presented.     

Chemically removable derivatization reagent for liquid chromatography I. 2-(N-Phthalimido)ethyl 2-(dimethylamino)ethanesulfonate

A sulfonate derivatization reagent, 2-(N-phthalimido)ethyl 2-(dimethylamino)ethanesulfonate, was synthesized and examined for use in liquid chromatography. The reagent contains two key moieties, a chromophore (phthalimido) necessary for detection and a dimethylamino function that is chemically removable after derivatization. The reagent was applied to the derivatization of 2,4,6-trichlorophenol as a model analyte. The results indicated that the reagent can be readily removed after derivatization by simple acid treatment.     

One-pot synthesis of 1,3,4-thiadiazoles using Vilsmeier reagent as a versatile cyclodehydration agent

A simple and efficient synthetic method for the one-pot synthesis of 1,3,4-thiadiazoles utilizing Vilsmeier reagent was developed. In this method carboxylic acids and hydrazine were converted to 1,3,4-thiadiazoles in the presence of Vilsmeier reagent and Lawesson's reagent. The influence of the thionation reagent, solvent, temperature and time, in this reaction was discussed. The developed methodology for 1,3,4-thiadiazole synthesis has the advantage of simplicity, ambient reaction conditions, easy purification and good to excellent yield of products.     

氯铬酸三甲铵/氧化铝的制备及其对醇和苯偶姻类化合物的氧化

本文报道了氯铬酸三甲铵/氧化铝的制备方法及其对醇和苯偶姻类化合物的氧化反应。 该试剂制备简单、性质稳定。氧化反应条件温和、操作简单、提纯方便、收率良好。     

REALISIS: a medicinal chemistry-oriented reagent selection, library design, and profiling platform

REALISIS is a software system for reagent selection, library design, and profiling, developed to fit the workflow of bench chemists and medicinal chemists. Designed to be portable, the software offers a comprehensive graphical user interface and rapid, integrated functionalities required for reagent retrieval and filtering, product enumeration, and library profiling. REALISIS is component-based, consisting of four main modules: reagent searching; reagent filtering; library enumeration; and library profiling. Each module allows the chemist to access specific functionalities and diverse filtering and profiling mechanisms. By implementing the entire process of reagent selection, library design, and profiling and by integrating all the necessary functionalities for this process, REALISIS cuts the time required to design combinatorial and noncombinatorial libraries from several days to a few hours.     

A flow injection analysis technique for the determination of chloride using reflectance detection

A flow injection (FI) determination for chloride has been developed using the light reflectance of the precipitate formed by the reaction of chloride with silver(I) as the method of detection rather than turbidimetry, as in the previous FI method using this reaction. The dynamic range of the analysis is increased to 0-10 mM chloride with a 10 mM silver(I) reagent and to 0-50 mM chloride with a 50 mM silver(I) reagent by using this mode of detection. The ability to select the injected reagent from an option of two concentrations via the control program is incorporated into the FI system, enhancing the versatility of the analysis. The dynamic range is further extended to 100 mM chloride by measuring the signal levels at the trailing portion of the response curve. The consumption of reagent is kept to a minimum by merging injected zones of sample and reagent instead of using a constant reagent stream.     

Pulsed reagent introduction through a membrane reactor for flow-injection systems

A method of intermittent reagent introduction, functionally equivalent to stop-go pumping, is described. A pneumatically pressurized reagent reservoir is used to deliver liquid through a high-speed on/off valve to the outer channel of an annular tube assembly. Except for this single entry point, the outer channel is otherwise sealed. The inner flow channel bearing the principal flow stream contains a short microporous membrane tube. When the reagent delivery valve is activated, reagent flows radially inward through the membrane into the principal flow stream.     

o-Diamines as reagents for selenium : Part I. 4-dimethylamino-1,2-phenylenediamine

4-Dimethylamino-1,2-phenylenediamine is investigated as a photometric and qualitative reagent for selenium. With this reagent selenium (IV) forms 5-dimethylamino-2,1,3-benzoselenadiazole, a red colored compound, with an absorption maximum in the visible region at 500 mμ. Variables such as reagent stability, extinction stability, reaction rate, influence of acidity, foreign ions, validity of Beer's law are discussed. The reagent is highly selective for selenium, has good sensitivity and recproducibility, and is also useful for qualitative purposes.     

用于水中矿物油测定的新型萃取剂

探讨了用于水中矿物油测定的新型萃取剂的筛选和超纯新型萃取剂的制备方法,对选定的新型萃取剂与目前我国常用萃取剂的萃取能力进行了较详细的对比研究.     

A soluble polymer-supported triflating reagent: a high-throughput synthetic approach to aryl and enol triflates

[reaction: see text] The high-yielding synthesis and application of the first example of a polymer-supported reagent for the preparation of trifluoromethanesulfonates (triflates) is described. This new reagent efficiently triflates aryl alcohols and lithium enolates in high yield (>90%). A simple precipitation and filtration to remove the excess reagent and byproduct facilitate purification of the triflate products. The PEG-supported approach is highly efficient, as the PEG-supported byproduct can be quantitatively recovered and recycled into reagent 1.     

Strained silacycles in organic synthesis: a new reagent for the enantioselective allylation of aldehydes

A new reagent for the enantioselective allylation of aliphatic aldehydes has been developed. The reagent is easily prepared in a single step from commercially available materials and may be stored without significant decomposition. The reactivity of the reagent is attributed to strain-release Lewis acidity.     

硅烷化剂-苯基二甲基氯硅烷的合成研究

苯基二甲基氯硅烷是一种空间位阻封闭剂,保护剂。由于分子中的Si-Cl键很活泼所以能与有机化合物中含活泼氢的官能团（如羟基、羰基、羧基、氨基等）反应,取代其中的活泼氢,其衍生物在酸及碱条件下比三甲基醚类更为稳定。有机化合物中的活泼氢被硅烷基取代后,变成化学稳定性很高的中间产物,且其它基团的反应活性不受影响;反应结束后,通过催化水解或醇解反应,可在不影响分子中其余部分前提下脱去硅烷基,恢复被保护的活泼氢。     

逆流色谱分离中选择性试剂的应用研究进展

逆流色谱中添加选择性试剂可有效提高分离度,常用选择性试剂主要有金属离子、多糖衍生物、阴离子表面活性剂、离子对、手性试剂、p H-区带逆流色谱中酸碱试剂等6类。该文综述了国内外选择性试剂在逆流色谱分离中的应用研究进展,介绍了其基本原理,阐述了不同选择性试剂的适用范围,并展望了选择性试剂发展的新趋势。     

Studies in the analytical chemistry of sodium : 6:8-Dichlorobenzoylene urea as a reagent for sodium

6:8-Dichlorobcnzoylene urea has been. examined as a reagent for sodium. The reagent cannot be recommended for this purpose. Precipitation is incomplete and the reagent tends to hydrolyse so that it is impossible to differentiate sodium in the presence of potassium.