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1.
Kirillov N. F. Shchepin V. V. Vakhrin M. I. 《Russian Journal of Organic Chemistry》2004,40(4):578-580
Methyl 1-(2-bromoisobutyryl)cyclopentanecarboxylate and 3-(1-bromocyclopentyl)-2,2-dimethyl-3-oxopropionate react with zinc and aromatic aldehydes to afford 8-aryl-9,9-dimethyl-7-oxaspiro[4.5]decane-6,10-diones and 10-aryl-7,7-dimethyl-9-oxaspiro[4.5]decane-6,8-diones, respectively. 相似文献
2.
Methyl 3-(1-bromocyclobutyl)-2,2-dimethyl-3-oxopropanoates, 1-(1-bromocyclobutyl-carbonyl) cyclopentanoates and 1-(1-bromocyclobutylcarbonyl)cyclobutanoates
react with zinc and aromatic aldehydes to form 5-aryl-8,8-dimethyl-6-oxaspiro[3.5]nonane-7,9-diones, 13-aryl-12-oxadispiro[3.1.4.3]tridecane-5,11-diones
and 12-aryl-11-oxadispiro[3.1.3.3]dodecane-5,10-diones respectively. 相似文献
3.
Alkyl 3-(1-bromocyclohexyl)-2,2-dimethyl-3-oxopropanoates react with zinc and aromatic aldehydes to yield 5-aryl-2,2-dimethyl-4-oxaspiro[5,5]undecane-1,3-diones. 相似文献
4.
N. F. Kirillov V. V. Shchepin V. S. Melekhin 《Russian Journal of Organic Chemistry》2007,43(11):1628-1631
Methyl 1-(2-bromo-2-methyl-1-oxopropyl)-, 1-(1-bromocyclopentylcarbonyl)-, and 1-(1-bromocyclohexylcarbonyl) cyclobutanecarboxylates reacted with zinc and aromatic aldehydes to give, respectively, 7-aryl-2,2-dimethyl-6-oxaspiro[3.5]nonane-5,9-diones, 11-aryl-12-oxadispiro[3.1.4.3]tridecane-5,13-diones, and 12-aryl-13-oxadispiro[3.1.5.3]tetradecane-5,14-diones. 相似文献
5.
Shchepin V. V. Kirillov N. F. Nedugov A. N. 《Russian Journal of General Chemistry》2003,73(8):1264-1266
Methyl esters of 1-(-bromoisobutyryl)cyclohexanecarboxylic or 3-(1-bromocyclohexyl)-2,2-dimethyl-3-oxopropanoic acids react with zinc and arylglyoxals to form 3-aroyl-4,4-dimethyl-2-oxaspiro[5.5]undecane-1,5-diones or 1-aroyl-4,4-dimethyl-2-oxaspiro[5.5]undecane-3,5-diones, respectively. The former products react with phenylhydrazine, yielding 3-[aryl(2-phenylhydrazono)methyl]-4,4-dimethyl-2-oxaspiro[5.5]undecane-1,5-diones. 相似文献
6.
V. V. Shchepin Yu. G. Stepanyan P. S. Silaichev 《Russian Journal of General Chemistry》2008,78(5):929-932
Organozinc compounds prepared from dialkyl dibromomalonates and zinc react with 2-arylmethyl-eneindan-4,6-diones, 5-arylmethylene-2,2-dimethyl-1,3-dioxane-4,6-diones, as well as with 2-[4-(1,3-dioxoindan-2-ylidenemethyl)phenyl]methyleneindan-1,3-dione and 5-[4-(2,2-dimethyl-4,6-dioxo-1,3-dioxane-2-ylidenemethyl)phenyl]methylene-2,2-dimethyl-1,3-dioxane-4,6-diones to form dialkyl 3-aryl-1′3′-dioxaspiro(cyclopropane-2,2′-indan)-1,1-dicarboxylates, dimethyl 3-aryl-6,6-dimethyl-5,7-dioxa-4,8-dioxaspiro[2,5]octan-2,2-dicarboxylates, dialkyl 2-{4-[3,3-bis (alkoxycarbonyl)-1′,3′-dioxaspiro(cyclopropane-2,2′-indan)-1-yl]phenyl}-1′,3′-dioxaspiro[cyclopropane-2,2′-indan]-1,1-dicarboxylates, and dialkyl 2-{4-[2,2-bis(alkoxycarbonyl)-6,6′-dimethyl-4,8-dioxo-5,7-dioxaspiro[2,5]oct-1-yl]phenyl}-6,6-dimethyl-4,8-dioxo-5,7-dioxaspiro[2,5]octan-1,1-dicarboxylate respectively. 相似文献
7.
V. V. Shchepin Yu. G. Stepanyan P. S. Silaichev M. A. Ezhikova M. I. Kodess 《Russian Journal of Organic Chemistry》2010,46(4):499-502
Bromine-containing organozinc compounds generated from 1,1-dibromo-3,3-dimethylbutan-2-one reacted with 2-arylmethylideneindan-1,3-diones
and 5-arylmethylidene-2,2-dimethyl-1,3-dioxane-4,6-diones to give 3-aryl-2-(2,2-dimethylpropanoyl)spiro[cyclopropane-1,2′-indan]-1′,3′-diones
and 1-aryl-6,6-dimethyl-2-(2,2-dimethylpropanoyl)-5,7-dioxaspiro[2.5]octan-4,8-diones, respectively. Reactions of 2-arylmethylideneindan-1,3-diones
with bromine-containing zinc enolates derived from 1-aryl-2,2-dibromopropan-1-ones and 2,2-dibromo-1,2,3,4-tetrahydronaphthalen-1-one
resulted in the formation of 2-aroyl-3-aryl-2-methylspiro-[cyclopropane-1,2′-indan]-1′,3′-diones and 2,3: 8,9-dibenzo-12-phenyldispiro[4.0.5.1]dodecane-1,4,7-trione,
respectively. 相似文献
8.
N. F. Kirillov A. G. Gavrilov M. I. Vakhrin V. P. Feshin 《Russian Journal of General Chemistry》2011,81(6):1195-1197
Methyl 1-bromocyclopentane-, 1-bromocyclohexane- and 1-bromocycloheptanecarboxylates react with zinc and 1,5-diarylpenta-1,4-dien-3-ones
to form 10-aryl-8-(2-arylethenyl)-7-oxaspiro[4.5]dec-8-en-6-ones, 5-aryl-3-(2-arylethenyl)-2-oxaspiro[5.5]undec-3-en-1-ones,
and 5-aryl-3-(2-arylethenyl)-2-oxaspiro[5.6]-dodec-3-en-1-ones, respectively. 相似文献
9.
N. F. Kirillov E. A. Nikiforova P. A. Slepukhin M. I. Vakhrin 《Russian Journal of General Chemistry》2012,82(5):891-894
Methyl 1-bromoalkanecarboxylates react with zinc and ethyl 5-aryl-3-oxo-2,2-diethylpent-4-enoates to form ethyl 2-(10-aryl-6-oxo-7-oxaspiro[4.5]dec-8-en-8-yl)-2-ethylbutanoates and ethyl 2-(5-aryl-1-oxo-2-oxaspiro[5.5]undec-3-en-3-yl)-2-ethylbutanoates. 相似文献
10.
N. F. Kirillov V. V. Shchepin L. A. Vedernikova 《Russian Journal of Organic Chemistry》2004,40(7):953-956
Reformatsky reactions of methyl 1-bromocyclohexanecarboxylate and methyl 1-bromocyclo-pentanecarboxylate with 2-aryl-2-oxoacetaldehydes involve both carbonyl groups of the latter and result in formation of 3a-aryl-3,3 : 6,6-bis(pentamethylene)- and 3a-aryl-3,3 : 6,6-bis(tetramethylene)tetrahydrofuro-[3,2-b]furan-2,5-diones. The reaction with 2-(2,4-dimethylphenyl)-2-oxoacetaldehyde gives acyclic products, methyl 1-[1-hydroxy-2-(2,4-dimethylphenyl)-2-oxoethyl]cyclohexanecarboxylate and methyl 1-[1-hydroxy-2-(2,4-dimethylphenyl)-2-oxoethyl]cyclopentanecarboxylate, while with benzil methyl 1-(4-hydroxy-1-oxo-3,4-diphenyl-2-oxaspiro[4.5]dec-3-yl)cyclohexanecarboxylate and methyl 1-(4-hydroxy-1-oxo-3,4-diphenyl-2-oxaspiro[4.4]non-3-yl)cyclopentanecarboxylate are obtained. 相似文献
11.
V. V. Lipson S. M. Desenko M. G. Shirobokova O. V. Shishkin S. V. Shishkina 《Russian Journal of Organic Chemistry》2006,42(7):1022-1027
Cyclocondensation of 5-methylpyrazol-3-amine with methyl cinnamate and arylmethylidenemalonic acids in DMF and methanol leads to the formation of 7-aryl-2-methyl-6,7-dihydropyrazolo[1,5-a]-pyrimidin-5(4H)-ones. Arylmethylidenemalonic acids react with the title amine at a ratio of 1:2 in nitrobenzene to give 4-aryl-3,5-dimethyl-1,7-dihydrodipyrazolo[3,4-b:4′,3′-e]pyridines. Heterocyclizations of 5-methylpyrazol-3-amine with 5-arylmethylidene-2,2-dimethyl-1,3-dioxane-4,6-diones or their precursors, para-substituted benzaldehydes and 2,2-dimethyl-1,3-dioxane-4,6-dione (Meldrum’s acid) in all solvents (methanol, DMF, and nitrobenzene) give the corresponding 4-aryl-3-methyl-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-6-ones. The structure of 3-methyl-4-(4-nitrophenyl)-2,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-6-one was proved by X-ray analysis. 相似文献
12.
T. V. Kochikyan E. V. Harutyunyan V. S. Harutyunyan A. A. Avetisyan 《Chemistry of Heterocyclic Compounds》2006,42(1):109-114
By reaction of 8-substituted 3-bromoacetyl-3,8-dimethyl-2,7-dioxaspiro[4,4]nonane-1,6-diones with thiourea and substituted
thioureas under Hansch reaction conditions, we have obtained the novel heterocycles 3-[2′-amino(arylamino)thiazol-4-yl]-3,8-dimethyl-2,7-dioxaspiro[4,4]nonane-1,6-diones.
By reacting the above-indicated bromoacetyl spirodilactones with 5-aryl-3-mercapto-1,2,4-triazoles, we obtained 8-substituted
3-(aryl-3,8-dimethyl-1′,2′,4′-triazol-3′-yl)thioacetyl-2,7-dioxaspiro[4,4]nonane-1,6-diones.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 123–129, January, 2006. 相似文献
13.
V. V. Khalturina Yu. V. Shklyaev Z. G. Aliev A. N. Maslivets 《Russian Journal of Organic Chemistry》2010,46(4):539-542
5-Arylfuran-2,3-diones react with (Z)-2-[3,3-dimethyl-3,4-dihydroisoquinolin-1(2H)-ylidene]acetamides to give (3E,5Z)-5-(2-aryl-2-oxoethylidene)-3-[3,3-dimethyl-3,4-dihydroisoquinolin-1(2H)-ylidene]-pyrrolidine-2,4-diones. The crystalline and molecular structures of one of the products were determined by X-ray
analysis. 相似文献
14.
N. F. Kirillov V. S. Melekhin S. N. Shurov A. V. Plotnikov M. I. Vakhrin O. A. Maiorova 《Russian Journal of Organic Chemistry》2010,46(3):368-371
Dimethyl 2-(1-bromocyclohexylcarbonyl)-, 2-(1-bromocyclopentylcarbonyl)-, and 2-(1-bromocyclobutylcarbonyl)-2-methylmalonates
reacted with zinc and aromatic aldehydes to give the corresponding methyl 1-aryl-4-methyl-3,5-dioxo-2-oxaspiro[5.5]undecane-4-,
6-aryl-9-methyl-8,10-dioxo-7-oxaspiro[4.5]-decane-9-, and 5-aryl-8-methyl-7,9-dioxo-6-oxaspiro[3.5]nonane-8-carboxylates. 相似文献
15.
E. S. Denislamova Z. G. Aliev A. N. Maslivets 《Russian Journal of Organic Chemistry》2014,50(7):1012-1016
Methyl 1-aryl-3-benzoyl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates reacted with N′-(5,5-dimethyl-3-oxocyclohex-1-en-1-yl)benzohydrazides and N′-(5,5-dimethyl-3-oxocyclohex-1-en-1-yl)-2,2-diphenylacetohydrazide to give substituted N-[1′-aryl-3′-benzoyl-4′-hydroxy-6,6-dimethyl-2,4,5′-trioxo-1′,4,5,5′,6,7-hexahydrospiro[indole-3,2′-pyrrol]-1(2H)-yl]benz- and -diphenylacetamides. 相似文献
16.
Z. R. Valiullina N. P. Akhmetdinova N. A. Ivanova O. V. Shitikova M. S. Miftakhov 《Russian Journal of Organic Chemistry》2011,47(2):180-184
Proceeding from the [2+2]-adduct of dichloroketene and dimethylfulvene a synthesis was developed of methyl (5Z)-7-(2,2-dimethyl-4-oxo-1-oxaspiro[2.4]hept-6-en-5-yl)hept-5-enoate, the key block in the new synthetic approach to 15-deoxy-Δ12,14-prostaglandin J2. 相似文献
17.
Reaction of methyl 1-bromocyclopentanecarboxylate with zinc and 1-aryl-5-phenylpenta-1,4-dien-3-ones
N. F. Kirillov P. A. Slepukhin A. A. Gorbunov A. G. Gavrilov M. I. Vakhrin 《Russian Journal of Organic Chemistry》2012,48(8):1090-1093
Methyl 1-bromocyclopentanecarboxylate reacted with zinc and 1-aryl-5-phenylpenta-1,4-dien-3-ones with the formation of isomeric 10-aryl-8-(2-arylethenyl)-7-oxaspiro[4.5]dec-8-en-6-ones. 相似文献
18.
Andreev G. N. Shul’ts E. E. Volkov A. A. Shakirov M. M. Bagryanskaya I. Yu. Gatilov Yu. V. Tolstikov G. A. 《Russian Journal of Organic Chemistry》2004,40(6):854-865
5-Arylmethylene-2,2-dimethyl-1,3-dioxane-4,6-diones reacted with 5-isopropenyl-2,3-dihydrothio-phene 1,1-dioxide to give the corresponding ortho-addition products, 5-aryl-2',2',7-trimethyl-3,3a,5,6-tetra-hydro-2H-spiro[1-benzothiophene-4,5'-[1,3]dioxane]-4',6'-dione 1,1-dioxides. Their aminolysis resulted in opening of the 1,3-dioxane ring and formation of 4-carbamoyl-7-methyl-2,3,3a,4,5,6-hexahydro-1-benzo-thiophene-4-carboxylic acid 1,1-dioxide whose structure was determined by X-ray analysis. Reactions of the spiro adducts with amines and hydrazine hydrate afforded the corresponding mono- or dicarboxylic acid monoamides (hydrazide). 相似文献
19.
V. V. Shchepin P. S. Silaichev Yu. G. Stepanyan M. M. Kalyuzhnyi N. Yu. Russkikh M. I. Kodess 《Russian Journal of Organic Chemistry》2006,42(7):973-980
Zinc enolates derived from 1-aryl-2,2-dibromoalkanones react with N-substituted 3-aryl-2-cyanoprop-2-enamides and 5,5-dimethyl-2-oxo-2,5-dihydrofuran-3-carboxylic and 2-oxochromene-3-carboxylic acid derivatives to give, respectively, N-substituted 2-alkyl-3-aryl-2-aroyl-1-cyanocyclopropane-1-carboxamides, 6-(4-bromobenzoyl)-4,4,6-trimethyl-2-oxo-3-oxabicyclo[3.1.0]hexane-1-carboxylic acid ethyl ester and morpholide, and 1-alkyl-1-aroyl-2-oxo-1a,7b-dihydrocyclopropla[c]chromene-1a-carboxylic acids as a single geometric isomer. Treatment of 1-alkyl-1-aroyl-2-oxo-1a,7b-dihydrocyclopropa[c]chromene-1a-carboxylic acids with carboxylic acid anhydrides leads to the formation of the corresponding 9c-alkyl-1-aryl-3,4-dioxo-9b,9c-dihydro-2,5-dioxacyclopenta[2,3]cyclopropa[1,2-a]naphthalen-1-yl carboxylates. 相似文献
20.
T. G. Simonova S. P. Epshtein Yu. G. Putsykin Yu. A. Baskakov 《Chemistry of Heterocyclic Compounds》1980,16(7):761-764
Treatment of 2-ethylamino-2-methylpropanol oxime with aryl isocyanates leads to 4-[N-(arylcarbamoyl) hydroxyamino [-1-ethyl-3-aryl-5,5-dimenthyl-2-imidazolidionones, which are acylated by acid chlorides and methyl isocyanate to give the corresponding O-acyl derivatives and are converted to 2-(2-oxo-1-ethyl-3-aryl-5,5-dimethyl-4-imidazolidinyl)-4-aryl-1,2,4-oxadiazolidine-3,5-diones by the action of methyl chlorocarbonate.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 980–983, July, 1980. 相似文献