Metal clamping in operation! Deprotonation of [η6‐2‐(9‐triptycyl)indene]tricarbonylchromium induces a haptotropic shift of the organometallic fragment from the six‐membered to the five‐membered ring, as in a→b . In the anion, rotation of the molecular paddlewheel is blocked by the bulky tripod. X‐ray crystal structures provide pictures of the system in both its “ON” and “OFF” states.
Do the twist : The reaction of in situ generated phosphinidenes with phosphaalkynes is a facile route to the new metal‐coordinated η3‐diphosphavinylcarbene 1 , which shows facile ligand‐exchange reactions and undergoes an unprecedented rearrangement that involves phosphinidene complex 2 and η3‐phosphaalkenylphosphinidene complex 3 , the 1,3 isomer of 1 .
Bridging pyrrole and selenophene chemistries : Molecular assemblies have been developed that allow scrutiny of the electronic communication between pyrrole and selenophene nuclei. Divergent syntheses of 2‐(selenophen‐2‐yl)pyrroles and their N‐vinyl derivatives from available 2‐acylselenophenes and acetylenes in a one‐pot procedure have been devised (see scheme), which provide access to these exotic heterocyclic ensembles.
Fast and furious : Cribrostatin 6, an antimicrobial and antineoplastic agent, was the target of a total synthesis where the longest linear sequence was only four steps. The key step involves a tandem 4π electrocyclic ring opening, radical cyclization, and homolytic aromatic substitution sequence to afford the tricyclic core of the natural product.
Enriching peptides : Novel TiO2‐modified macroporous materials (Ti‐MOSF, see figure) have been synthesized with high surface area, large pore volume, and functional surfaces that are rich in coordinatively unsaturated TiIV species, which can be applied in the specific extraction of phosphopeptides and which show a preferential capture of multi‐phosphorylated peptides with low detection limits and high selectivity.
Guest Effect : The differences of nitrogen atom positions and the bridge bonds linked to two pyridine rings of some bipyridine guests can significantly affect the binding abilities and inclusion geometries of β‐cyclodextrin with the guests in both the solution and solid states.
Clicking iron : Cheap and environmentally friendly [Fe(OAc)2] is used for the catalysis of cycloadditions between aryl nitriles and trimethylsilyl azide to prepare substituted 1H‐tetrazoles in good yield (see scheme).
Finding a clear route to new structures : The design of an adaptable time warping (ATW) methodology (see figure) for automatically, quickly, and reliably deciphering X‐ray diffraction patterns is described.
