共查询到20条相似文献,搜索用时 15 毫秒
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多光谱光声层析成像(MSOT)技术是一种将多光谱成像与光声层析成像(PACT)技术相结合的新技术,该技术利用不同生物组织的光谱吸收特性,用多组不同波长的短脉冲激光照射组织以产生组织特异性的光声信号,从而更好地进行光声成像和组分识别。MSOT兼具光学成像的高灵敏度、高分辨率优势和超声成像可对数厘米深组织成像的长处,同时又能弥补光学成像深度有限和超声成像对比度差的短处,能够实现深层组织的高分辨率、高对比度、高穿透深度的实时无损伤成像。迄今为止,MSOT已应用于肿瘤内光吸收粒子的检测、血管结构和血液氧合作用的评价、生物荧光蛋白的成像以及乳腺癌患者检测的初步研究。随着光声成像系统的不断改进,MSOT与生物标记物(如荧光试剂、金纳米颗粒等)结合对体内分子进行成像,在生物医学中得到了广泛的应用。本文简要综述了MOST的成像原理、实验装置及其性能特点,着重总结了其在生物医学领域的最新应用进展,尤其是在新生血管成像、肿瘤的早期诊断及肿瘤的原位成像方面。 相似文献
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Folding Up of Gold Nanoparticle Strings into Plasmonic Vesicles for Enhanced Photoacoustic Imaging 下载免费PDF全文
Yijing Liu Dr. Jie He Kuikun Yang Dr. Chenglin Yi Dr. Yi Liu Dr. Liming Nie Prof. Niveen M. Khashab Dr. Xiaoyuan Chen Prof. Zhihong Nie 《Angewandte Chemie (International ed. in English)》2015,54(52):15809-15812
The stepwise self‐assembly of hollow plasmonic vesicles with vesicular membranes containing strings of gold nanoparticles (NPs) is reported. The formation of chain vesicles can be controlled by tuning the density of the polymer ligands on the surface of the gold NPs. The strong absorption of the chain vesicles in the near‐infrared (NIR) region leads to a much higher efficiency in photoacoustic (PA) imaging than for non‐chain vesicles. The chain vesicles were further employed for the encapsulation of drugs and the NIR light triggered release of payloads. This work not only offers a new platform for controlling the hierarchical self‐assembly of NPs, but also demonstrates that the physical properties of the materials can be tailored by controlling the spatial arrangement of NPs within assemblies to achieve a better performance in biomedical applications. 相似文献
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《Macromolecular rapid communications》2017,38(12)
Semiconducting polymer nanoparticles (SPNs) have evolved into a new class of photonic materials with great potential for biomedical applications. Depending on the polymer structures, SPNs can be developed into optical agents for fluorescence and chemiluminescence imaging, photosensitizers for photodynamic therapy, and heat converters for photothermal therapy. In this feature article, recent work is summarized on the development of SPNs for in vivo photoacoustic (PA) imaging, a state‐of‐the‐art imaging modality that converts light energy into mechanical acoustic waves to provide deep tissue penetration. The structure–property relationship and doping approaches are discussed to reveal the importance of promoting nonradiative decay in amplifying the PA brightness of SPNs. Moreover, their imaging applications, including lymph node mapping, tumor imaging, and monitoring of pathological indexes, are highlighted. These studies demonstrate that SPNs can serve as versatile PA agents for advanced molecular imaging applications.
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Back Cover: Folding Up of Gold Nanoparticle Strings into Plasmonic Vesicles for Enhanced Photoacoustic Imaging (Angew. Chem. Int. Ed. 52/2015) 下载免费PDF全文
Yijing Liu Dr. Jie He Kuikun Yang Dr. Chenglin Yi Dr. Yi Liu Dr. Liming Nie Prof. Niveen M. Khashab Dr. Xiaoyuan Chen Prof. Zhihong Nie 《Angewandte Chemie (International ed. in English)》2015,54(52):15916-15916
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BSA‐IrO2: Catalase‐like Nanoparticles with High Photothermal Conversion Efficiency and a High X‐ray Absorption Coefficient for Anti‐inflammation and Antitumor Theranostics 下载免费PDF全文
Wenyao Zhen Yang Liu Lin Lin Jing Bai Xiaodan Jia Prof. Huayu Tian Prof. Xiue Jiang 《Angewandte Chemie (International ed. in English)》2018,57(32):10309-10313
Intrinsically integrating precise diagnosis, effective therapy, and self‐anti‐inflammatory action into a single nanoparticle is attractive for tumor treatment and future clinical application, but still remains a great challenge. In this study, bovine serum albumin–iridium oxide nanoparticles (BSA‐IrO2 NPs) with extraordinary photothermal conversion efficiency, good photocatalytic activity, and a high X‐ray absorption coefficient were prepared through one‐step biomineralization. The nanoparticles allow tumor phototherapy and simultaneous photoacoustic/thermal imaging and computed tomography. More importantly, BSA‐IrO2 NPs can also act as a catalase to protect normal cells against H2O2‐induced reactive oxygen pressure and inflammation while significantly enhancing photoacoustic imaging through microbubble‐based inertial cavitation. These remarkable features may open up the exploration iridium‐based nanomaterials in theranostics. 相似文献
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Dr. Wanwan Li Pengfei Rong Dr. Zhe Wang Dr. Shouju Wang Xiaoping Wang Dr. Xiaolian Sun Dr. Maria Aronova Dr. Gang Niu Prof. Richard D. Leapman Prof. Zhihong Nie Prof. Xiaoyuan Chen 《Angewandte Chemie (International ed. in English)》2013,52(52):13958-13964
The hierarchical assembly of gold nanoparticles (GNPs) allows the localized surface plasmon resonance peaks to be engineered to the near‐infrared (NIR) region for enhanced photothermal therapy (PTT). Herein we report a novel theranostic platform based on biodegradable plasmonic gold nanovesicles for photoacoustic (PA) imaging and PTT. The disulfide bond at the terminus of a PEG‐b‐PCL block‐copolymer graft enables dense packing of GNPs during the assembly process and induces ultrastrong plasmonic coupling between adjacent GNPs. The strong NIR absorption induced by plasmon coupling and very high photothermal conversion efficiency (η=37 %) enable simultaneous thermal/PA imaging and enhanced PTT efficacy with improved clearance of the dissociated particles after the completion of PTT. The assembly of various nanocrystals with tailored optical, magnetic, and electronic properties into vesicle architectures opens new possibilities for the construction of multifunctional biodegradable platforms for biomedical applications. 相似文献
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Magneto‐Plasmonic Janus Vesicles for Magnetic Field‐Enhanced Photoacoustic and Magnetic Resonance Imaging of Tumors 下载免费PDF全文
Dr. Yijing Liu Xiangyu Yang Zhiqi Huang Prof. Peng Huang Yang Zhang Dr. Lin Deng Zhantong Wang Zijian Zhou Dr. Yi Liu Dr. Heather Kalish Prof. Niveen M. Khachab Dr. Xiaoyuan Chen Prof. Zhihong Nie 《Angewandte Chemie (International ed. in English)》2016,55(49):15297-15300
Magneto‐plasmonic Janus vesicles (JVs) integrated with gold nanoparticles (AuNPs) and magnetic NPs (MNPs) were prepared asymmetrically in the membrane for in vivo cancer imaging. The hybrid JVs were produced by coassembling a mixture of hydrophobic MNPs, free amphiphilic block copolymers (BCPs), and AuNPs tethered with amphiphilic BCPs. Depending on the size and content of NPs, the JVs acquired spherical or hemispherical shapes. Among them, hemispherical JVs containing 50 nm AuNPs and 15 nm MNPs showed a strong absorption in the near‐infrared (NIR) window and enhanced the transverse relaxation (T2) contrast effect, as a result of the ordering and dense packing of AuNPs and MNPs in the membrane. The magneto‐plasmonic JVs were used as drug delivery vehicles, from which the release of a payload can be triggered by NIR light and the release rate can be modulated by a magnetic field. Moreover, the JVs were applied as imaging agents for in vivo bimodal photoacoustic (PA) and magnetic resonance (MR) imaging of tumors by intravenous injection. With an external magnetic field, the accumulation of the JVs in tumors was significantly increased, leading to a signal enhancement of approximately 2–3 times in the PA and MR imaging, compared with control groups without a magnetic field. 相似文献
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Dr. Jiaguo Huang Prof. Kanyi Pu 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(29):11813-11827
Optical imaging plays a crucial role in biomedicine. However, due to strong light scattering and autofluorescence in biological tissue between 650–900 nm, conventional optical imaging often has a poor signal-to-background ratio and shallow penetration depth, which limits its ability in deep-tissue in vivo imaging. Second near-infrared fluorescence, chemiluminescence, and photoacoustic imaging modalities mitigate these issues by their respective advantages of minimized light scattering, eliminated external excitation, and ultrasound detection. To enable disease detection, activatable molecular probes (AMPs) with the ability to change their second near-infrared fluorescence, chemiluminescence, or photoacoustic signals in response to a biomarker have been developed. This Minireview summarizes the molecular design strategies, sensing mechanisms, and imaging applications of AMPs. The potential challenges and perspectives of AMPs in deep-tissue imaging are also discussed. 相似文献
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Ananthakrishnan Soundaram Jeevarathinam Jeanne E. Lemaster Fang Chen Eric Zhao Jesse V. Jokerst 《Angewandte Chemie (International ed. in English)》2020,59(12):4678-4683
We report a new approach to monitor drug release from nanocarriers via a paclitaxel–methylene blue conjugate (PTX‐MB) with redox activity. This construct is in a photoacoustically silent reduced state inside poly(lactic‐co‐glycolic acid) (PLGA) nanoparticles (PTX‐MB@PLGA NPs). During release, PTX‐MB is spontaneously oxidized to produce a concentration‐dependent photoacoustic signal. An in vitro drug‐release study showed an initial burst release (25 %) between 0–24 h and a sustained release between 24–120 h with a cumulative release of 40.6 % and a 670‐fold increase in photoacoustic signal. An in vivo murine drug release showed a photoacoustic signal enhancement of up to 649 % after 10 hours. PTX‐MB@PLGA NPs showed an IC50 of 78 μg mL?1 and 44.7±4.8 % decrease of tumor burden in an orthotopic model of colon cancer via luciferase‐positive CT26 cells. 相似文献
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Near‐Infrared‐Light‐Mediated Imaging of Latent Fingerprints based on Molecular Recognition 下载免费PDF全文
Jie Wang Ting Wei Xinyang Li Binhao Zhang Jiaxi Wang Chi Huang Prof. Dr. Quan Yuan 《Angewandte Chemie (International ed. in English)》2014,53(6):1616-1620
Photoluminescence is one of the most sensitive techniques for fingerprint detection, but it also suffers from background fluorescence and selectivity at the expense of generality. The method described herein integrates the advantages of near‐infrared‐light‐mediated imaging and molecular recognition. In principle, upconversion nanoparticles (UCNPs) functionalized with a lysozyme‐binding aptamer were used to detect fingerprints through recognizing lysozyme in the fingerprint ridges. UCNPs possess the ability to suppress background fluorescence and make it possible for fingerprint imaging on problematic surfaces. Lysozyme, a universal compound in fingerprints, was chosen as the target, thus simultaneously meeting the selectivity and generality criteria in photoluminescence approaches. Fingerprints on different surfaces and from different people were detected successfully. This strategy was used to detect fingerprints with cocaine powder by using UCNPs functionalized with a cocaine‐binding aptamer. 相似文献
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Optical imaging plays a crucial role in biomedicine. However, due to strong light scattering and autofluorescence in biological tissue between 650–900 nm, conventional optical imaging often has a poor signal‐to‐background ratio and shallow penetration depth, which limits its ability in deep‐tissue in vivo imaging. Second near‐infrared fluorescence, chemiluminescence, and photoacoustic imaging modalities mitigate these issues by their respective advantages of minimized light scattering, eliminated external excitation, and ultrasound detection. To enable disease detection, activatable molecular probes (AMPs) with the ability to change their second near‐infrared fluorescence, chemiluminescence, or photoacoustic signals in response to a biomarker have been developed. This Minireview summarizes the molecular design strategies, sensing mechanisms, and imaging applications of AMPs. The potential challenges and perspectives of AMPs in deep‐tissue imaging are also discussed. 相似文献
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