共查询到19条相似文献,搜索用时 78 毫秒
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薄层色谱—质谱联用技术及其进展 总被引:1,自引:0,他引:1
概述了薄层色谱同质谱的联用(TLC-MS)技术及其进展,着重介绍了TLC-MS联用技术中的多种接口及已经开始广泛使用的几种较先进的电离方法。 相似文献
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毛细管电泳质谱联用技术及其应用 总被引:9,自引:0,他引:9
本文介绍了用于毛细管电泳质谱联用仪器的多种接口技术,描述了CZE,CIEF,CGE,MEKC和CITP等毛细管电泳技术和四极质谱,离子阱质谱,傅 叶变换离子回旋共振质谱,飞行时间质谱,磁质谱,解吸质谱等联用的现状及发展前景,对近年来CE-MS在酶解产物。蛋白质和肽,核苷酸,药物及代谢产物等领域中的应用作了详细述评。 相似文献
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介绍了毛细管电泳-电致化学发光联用技术(CE-ECL)的检测原理,重点评述了1983-2010年间CE-ECL在药物制品、生物样品、环境和食品、农产品分析中的应用(引用文献66篇)。 相似文献
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毛细管电泳-电感耦合等离子质谱联用的接口设计 总被引:1,自引:0,他引:1
描述了毛细管电泳电感耦合等离子体质谱(CE-ICP-MS)联用技术的单T型接口,自行设计了双T型接口,并对两接口的分析性能作了比较。解决了接口中的常见问题,使用节流阀减小自吸作用并降低了CE分离物的稀释倍数,排气阀使提升量保持稳定。经考察得知,采用自吸作用提升液流流量稳定,其重现性RSD小于5%;双T型接口较单T型接口对CE分离更有利。采用双T型接口联用时,CE分离La、Ce、Nd混合离子迁移时间RSD小于2%,MS信号RSD小于15%,且不同浓度样品经CE分离后其MS信号基本呈线性关系。 相似文献
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毛细管电泳-质谱(CE-MS)联用技术具有高灵敏度、高分析效率、低样品损耗等优点,在强极性和带电荷的物质分析中具有明显优势,已广泛应用于生命科学、医学、药学等多个领域。在过去的十几年,影响其应用的主要因素包括系统的稳定性、实验的可重复性、数据的准确性等。为解决现有问题,进一步拓展其应用,研究人员在技术设计和改进等方面做了大量工作。医学和分析化学领域的相关研究证明了CE-MS在代谢组学和蛋白质组学中的实用性。这篇文章综述了2015年以来,CE-MS在技术和应用方面的最新进展,为未来的技术发展及应用提供借鉴。为提高CE-MS的分析效率和数据可比性,该文对多个方面的研究进行了讨论,包括涂层与样品的相互作用、接口技术、运行参数和数据处理方法。文中关于复杂样品(组织、细胞、体液等)代谢组学/蛋白质组学的综述研究,使癌症病理分析、药物开发和疾病监测等分析数据更加可视化,为CE-MS临床分析应用提供借鉴。除了对CE-MS的最新发展进行综合评述外,还提出未来应加强3个方面的研究:(i)从样品前处理和分离技术方面优化分析方法;(ii)从毛细管涂层和接口技术方面调整分析技术;(iii)从临床研究和数据分析... 相似文献
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毛细管电色谱研究进展 总被引:7,自引:2,他引:7
毛细管电色谱是一种新兴的具有高效,高选择性的微分离技术。本文评述了毛细管电色说的发展状况和相关的技术,并对其发展前景进行了展望,引用文献24篇 。 相似文献
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Werner Ahrer Isolde Hagenauer Wolfgang Buchberger 《Monatshefte für Chemie / Chemical Monthly》2000,131(2):155-163
Summary. The separation of pyrimidine derivatives by capillary electrochromatography (CEC) using either UV or mass spectrometric detection
is described. For UV detection an aqueous phosphate carrier electrolyte containing acetonitrile is employed. The results are
compared to the analysis of the same compounds by micellar electrokinetic chromatography in terms of selectivity, migration
times, linearity, and detection limits.
For the combination of CEC and mass spectrometry (MS) an inexpensive way to couple commercially available instruments is presented;
the interface consists of an electrically grounded stainless steel connector (containing a stainless steel frit) serving as
the electrode and coupling the CEC capillary with a fused silica transfer capillary to the MS instrument. Alternatively, a
PEEK adapter combining the CEC capillary and a grounded stainless steel transfer capillary serving as the electrode is employed.
To avoid the formation of hydrogen gas at the coupling piece or the transfer capillary, p-benzoquinone is added to the carrier electrolyte consisting of aqueous ammonium acetate and acetonitrile.
Received July 21, 1999. Accepted July 29, 1999 相似文献
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毛细管电色谱(Capillary electrochromatography,CEC)是一种新兴的以电渗流为驱动力的微柱分离分析新技术和新方法[1].它主要依靠电渗流驱动流动相,流动相的流型为塞状平推流,具有与毛细管电泳(Capillary electrophoresis,CE)类似的高效性. 相似文献
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毛细管离子交换电色谱的分离行为 总被引:7,自引:0,他引:7
在离子交换毛细管色谱柱上实施电色谱,并对其分离行为进行了研究,采用75μm(i.d.)20cm的毛细管强阳离子交换柱(3μm)以NaH2PO4-H3PO4缓冲液为淋洗剂,紫外柱上检测(214nm)考察了流动相的pH值,有机改性剂及分离电压等因素对分离的影响,研究表明,不同的pH溶质的流出次序发生改变,随着有机改性剂含量增加,溶质的保留时间减小,而电渗流却增大,同时,对分离的柱效和方法的重现性进行了 相似文献
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Richard A. Carney Mark M. Robson Keith D. Bartle Peter Myers 《Journal of separation science》1999,22(1):29-32
The formation of bubbles in capillary electrochromatography (CEC) is well documented: possible origins include Joule heating and variations in EOF velocity on passing from the stationary phase through the frit and into the open tube. Methods for the prevention of bubble formation are discussed which are confirmed by experimental results. Using frit lengths varying from 1 mm to 6 mm it is shown how frit length is directly related to the likelihood of bubble formation and how this is affected by applied voltage. It is shown that the change in applied voltage across a capillary affects the formation of bubbles and also that rebonding octadecylsilane (ODS) onto the silica frit after formation of the frit can minimize the formation of bubbles and how this effects the chromatography. A method is also described for increasing the robustness of silica capillaries using a column coupler along with modifications made to conventional capillary electrophoresis equipment to cater for CEC. 相似文献
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With surfactant P123 as structure directing reagent, 1, 2-bis (trimethoxysilyl) ethane was hydrolyzed under acid condition. The resulting ethane-bridged silica was coated onto the inner
walls of fused silica capillaries and used as the stationary phase for capillary electrochromatography. The bridged ethyl
silica provided hydrophobic groups for reversed-phase separation. A comparative coated capillary was fabricated without the
use of surfactant in the preparation of the bonded silica. Separation of model neutral compounds was compared between these
two kinds of capillaries. Surfactant-assisted organosilica-coated capillaries displayed much superior retention efficiency
without obviously decreased electroosmotic flow. The existence of surfactant in the synthesis of the sol results in higher
surface areas of the coating. Such ethane-bridged organosilica stationary phases can be used under basic conditions. 相似文献