汉语儿童情感语声合成

情感语声合成技术对于人机交互具有重要的意义。面对儿童情感语声合成所需汉语语声数据资源缺乏以及模型训练时长较长等问题,该文提出利用迁移学习实现汉语儿童情感语声合成的方法。首先基于汉语语声数据库训练深度学习模型实现中文语声端到端合成模型,再使用高质量大样本的中文情感语料库完成情感语声合成模型,最后利用自行采样的小样本汉语儿童情感语料对模型进行迁移学习实现低资源的语声合成。客观实验结果中梅尔倒谱失真指标为4.91,主观听辨实验指标分别为3.61和4.17。通过实验对比表明,该文的方法在情感语声合成技术的应用上具有良好的性能表现,并且优于现有先进的低资源情感语声合成方法。     

综合法在反应堆物理中的应用

本文着重介绍了综合法,并用加权剩余法对于R-Z几何的中子扩散方程推导了综合方程,同时叙述了综合方程的解法,并作了实例计算,与有限差分法比较,可大大地节省计算时间。     

Analysis and synthesis of fractal antenna radiation patterns

A problem of fractal antenna radiation pattern synthesis is considered. The problem of synthesis of fractal antenna radiation patterns is solved for two kinds of antennas (discrete and linear) in one- and two- dimensional cases. With the use of the theory of fractal synthesis, new modes with new properties are obtained in fractal electrodynamics. Fractal radiation pattern synthesis was conducted by means of the Weierstrass function.     

Comparative study on graphene growth mechanism using Ni films,Ni/Mo sheets,and Pt substrates

We demonstrate a comparative study on graphene growth mechanism using various catalytic metal substrates such as Ni thin films, Ni-deposited Mo (Ni/Mo) sheets, and Pt sheets during chemical vapor deposition (CVD). Depending on the substrates, two kinds of graphene growth mechanisms that involve either precipitation or surface adsorption of carbon have been reported. We synthesized graphene, focusing especially on the initial growth stage during CVD, by varying synthesis parameters such as synthesis time, amount of feedstock, and cooling rate after synthesis. We concluded that precipitation-driven synthesis is dominant in the case of Ni substrates whereas adsorption-driven growth is dominant in the Ni/Mo system. In the case of the Pt substrate, which is generally believed to grow by carbon precipitation, graphene growth by adsorption was found to be dominant. We believe that our results will contribute to a clearer understanding of the graphene synthesis mechanism, and development of manufacturing routes for controllable synthesis of high-quality graphenes.     

Sonoproduction of nanobiomaterials – A critical review

Ultrasound (US) demonstrates remarkable potential in synthesising nanomaterials, particularly nanobiomaterials targeted towards biomedical applications. This review briefly introduces existing top-down and bottom-up approaches for nanomaterials synthesis and their corresponding synthesis mechanisms, followed by the expounding of US-driven nanomaterials synthesis. Subsequently, the pros and cons of sono-nanotechnology and its advances in the synthesis of nanobiomaterials are drawn based on recent works. US-synthesised nanobiomaterials have improved properties and performance over conventional synthesis methods and most essentially eliminate the need for harsh and expensive chemicals. The sonoproduction of different classes and types of nanobiomaterials such as metal and superparamagnetic nanoparticles (NPs), lipid- and carbohydrate-based NPs, protein microspheres, microgels and other nanocomposites are broadly categorised based on the physical and/or chemical effects induced by US. This review ends on a good note and recognises US-driven synthesis as a pragmatic solution to satisfy the growing demand for nanobiomaterials, nonetheless some technical challenges are highlighted.     

Real-time synthesis of clarinet-like instruments using digital impedance models

A real-time synthesis model of wind instruments sounds, based upon a classical physical model, is presented. The physical model describes the nonlinear coupling between the resonator and the excitor through the Bernoulli equation. While most synthesis methods use wave variables and their sampled equivalent in order to describe the resonator of the instrument, the synthesis model presented here uses sampled versions of the physical variables all along the synthesis process, and hence constitutes a straightforward digital transposition of each part of the physical model. Moreover, the resolution scheme of the problem (i.e., the synthesis algorithm) is explicit and all the parameters of the algorithm are expressed analytically as functions of the physical and the control parameters.     

Detonation diamonds in Ukraine

Some information on the history of dynamic synthesis of diamond in Ukraine is considered. Basic characteristics of ASM5 0.1/0 and ASM1 0.1/0 nanodiamond powders produced by static synthesis are described. The characteristics and surface properties of nanodiamond powders produced by detonation synthesis in Ukraine are presented. It is shown that the chemical activity of the particle surface can be controlled. Applications of nanopowders produced by detonation synthesis in various technologies are considered.     

高压合成立方氮化硼用的新触媒材料的研究

 本文研究了合成立方氮化硼用新触媒材料Mg₃B₂N₄及Ca₃B₂N₄的制备方法，并对它们的稳定性及其催化作用进行了讨论。氮化硼原料的结晶状态及合成温度、合成时间、气流量等对新触媒的合成有着重要的影响。本文还在高温高压下利用新触媒进行了立方氮化硼的合成实验，结果表明，与碱土金属触媒相比新触媒具有合成压力低、转化率高、合成温度和压力范围宽、产物杂志含量低、破碎强度高等优点，是一种应用前景很大的触媒材料。     

Phase synthesis of a holographic metrological diffraction grating of unlimited length

A breakthrough in the technology of measuring systems of submicrometre and subsecond precision was made possible by the invention of holographic phase aperture synthesis of highly regular interference structures. The practical fulfilment of holographic phase aperture synthesis requires development of the following new optical methods: (1) synthesis of the aperture by out of phase auxiliary holographic diffraction gratings; (2) high-precision analysis of the phase structure of the interference field; (3) automatic control of the aperture synthesis process using two-frequency modulation of the interference field; (4) an adaptive interferometer for aperture synthesis. This paper is devoted to the above methods.     

国产六面顶压机多晶种法合成宝石级金刚石单晶

对国产六面顶压机平台下使用多晶种法合成宝石级金刚石单晶进行了系统的研究. 通过合理调整温度梯度法的合成腔体组装, 采用多晶种法, 探索多晶种法金刚石合成的压力和温度区间, 在单个合成腔体内放置3–5颗金刚石晶种, 成功合成出多颗(3–5)优质Ib型宝石级金刚石单晶. 多颗晶种的引入, 单次实验合成的多个金刚石晶体晶形及品质一致; 同时, 晶体的整体生长速度也有明显的增大. 多晶种法金刚石单晶合成的研究, 可以有效地利用腔体空间、提高单次金刚石单晶合成的效率, 解决压机大型化下高温高压资源利用率低的问题; 同时, 为宝石级金刚石单晶商业化生产提供重要的依据. 关键词： 金刚石 国产六面顶 多晶种 温度梯度法     

High density peptide microarrays. In situ synthesis and applications

The technologies enabling the creation of large scale, miniaturized peptide or protein microarrays are emerging. The focuses of this review are the synthesis and applications of peptide and peptidomimetic microarrays, especially the light directed parallel synthesis of individually addressable high density peptide microarrays using a novel photogenerated reagent chemistry and digital photolithography (Gao et al., 1998, J. Am. Chem. Soc. 120, 12698; Pellois et al. 2002, Nat. Biotechnol. 20, 922). Concepts related to the synthesis are discussed, such as the reactions of photogenerated acids in the deprotection step of peptide synthesis or oligonucleotide synthesis, and the applications of high density peptide chips in antibody binding assays are discussed. Peptide chips provide versatile tools for probing antigen-antibody, protein-protein, peptide-ligand interactions and are basic components for miniaturization, automation, and system integration in research and clinical diagnosis applications.     

Combination of microwave reactions with fluorous separations in the palladium-catalyzed synthesis of aryl sulfides

Coupling of microwave reactions with fluorous separations can dramatically increase the efficiency of high-speed synthesis. Described in this paper is a fluorous synthesis of aryl sulfides by palladium-catalyzed cross-coupling of aryl perfluoroalkylsulfonates (C8F17O2SOAr) with thiols (RSH) under microwave irradiation. Fluorous solid-phase extractions (F-SPE) are employed for the purification of reaction mixtures. No fluorous solvents are involved in reaction and separation processes. The fluorous synthesis is further extended to the multi-step synthesis of substituted hydantoin and amide scaffolds.     

Molecular shift register and its utilization as an autonomous DNA synthesizer

A novel algorithmic approach to the synthesis of fairly long DNA molecules with nonrecurring sequences is demonstrated. The scheme exploits chemical embodiment of shift registers (SR) to execute algorithms similar to those used to generate pseudorandom numbers on a computer. Single stranded DNA molecules guide the synthesis of double stranded DNA according to the SR truth table. The SR logic facilitates an exponentially smaller synthesis effort compared with all other strategies. A redundancy based scheme, similar to those used in communication, is utilized to suppress synthesis errors.     

The role of ultrasound-induced cavitation in the ‘in vitro’ stimulation of collagen synthesis in human fibroblasts

Collagen synthesis by human embryonic fibroblasts in vitro was estimated using a collagenase-sensitivity assay. Collagen synthesis was stimulated by irradiation with ultrasound at a frequency of 3 MHz, a space-time peak intensity of 0.5 Wcm^?2, pulsed at a mark-space ratio of 2:8 ms for 5 min at ambient pressure. This stimulation was suppressed by the application of a positive pressure of 2 atmospheres during irradiation of the cells. Increasing the pressure in the absence of ultrasound had no effect on the rate of collagen synthesis in control cells. This stimulation, therefore, appears to be due to ultrasound-induced cavitation, since it is unlikely that increasing the pressure could modify any other ultrasonic parameter. Collagen synthesis is apparently stimulated to the same extent as general protein synthesis.     

Microwave synthesis solutions from personal chemistry

By fulfilling the specific design criteria required for safe and reproducible microwave synthesis, Personal Chemistry introduced the first microwave system designed for organic chemistry in 2000. The principle of microwave synthesis offers 3 major benefits to chemistry development: speed, reproducibility, and a scalable approach to compound synthesis. Additionally, significant advantages of our technical solution are ease of use, safety, verified synthesis methods to enable new users, and an efficient workflow that fits the drug discovery process. To gain the greatest advantages offered by microwave synthesis, Personal Chemistry has implemented a system called Coherent Synthesis. Incorporating planning systems, automation, distributed system access, searchable databases and reaction optimisation kits, the technology has already proved itself to dramatically improve the quality of output from medicinal chemistry for lead optimisation in all the major pharmaceutical and biotech companies.     

The Effect of the Protein Synthesis Entropy Reduction on the Cell Size Regulation and Division Size of Unicellular Organisms

The underlying mechanism determining the size of a particular cell is one of the fundamental unknowns in cell biology. Here, using a new approach that could be used for most of unicellular species, we show that the protein synthesis and cell size are interconnected biophysically and that protein synthesis may be the chief mechanism in establishing size limitations of unicellular organisms. This result is obtained based on the free energy balance equation of protein synthesis and the second law of thermodynamics. Our calculations show that protein synthesis involves a considerable amount of entropy reduction due to polymerization of amino acids depending on the cytoplasmic volume of the cell. The amount of entropy reduction will increase with cell growth and eventually makes the free energy variations of the protein synthesis positive (that is, forbidden thermodynamically). Within the limits of the second law of thermodynamics we propose a framework to estimate the optimal cell size at division.     

The effects of stoichiometric changes in LaMnO<Subscript>3</Subscript>

The preparation of LaMnO₃ from various precursors via a solid-state reaction combined with codeposition and sorption is found to form perovskite phases with different stoichiometric deviations, depending on the temperature of synthesis. This favors the coexistence of orthorhombic (in solid-phase synthesis) and rhombohedral (in wet synthesis) phases at room temperature.     

A new route for the synthesis of nitrides: The solvothermal preparation of GaN

Abstract

A new solvothermal route for the synthesis of nitrides is proposed using liquid NH3 as solvent in supercritical conditions, Such a preparation method was applied to the synthesis of GaN using gallium metal as starting material.

GaN is a wide band-gap semi-conductor (3.4eV). It is a very attractive nitride due to its various applications in micro- and opto-electronics [1,2]. Consequently, many research groups are interested in synthesising GaN. Two methods have been principally developed:

(i) synthesis of thin films by epitaxy [3,4]

(ii) synthesis of bulk GaN by high pressure method [5,6].

The new proposed process leads to fine microcrystallites of GaN with the wurtzite-type structure. The chemical purity can be optimised versus the synthesis mechanism. The size and shape of the crystallites would be influenced by the nature of the nitriding additive and the thermodynamical conditions (pressure and temperature) used for the synthesis.     

The dominant deformation mechanism of nanocrystalline materials with the finest grains: grain boundary sliding or grain boundary migration?

We report an efficient room-temperature synthesis of Au nanoparticles (NPs) using carbon dots (C-dots) as mediator in poly(ethylene glycol). The synthesis does not require any irradiation or heating for the reduction of the metal precursor and it yields smaller sized particles of ~15 nm, mostly octahedron in shape. The effect of varying concentrations of the Au precursor and C-dots on the synthesis was studied, which demonstrated the variation in particle size and shape with change in either the precursor or C-dots concentration. Time-resolved absorbance study for the synthesis of Au NPs showed the sigmoidal behavior for the autocatalytic growth having the lagging phase of induction period. The optimum concentration of the precursor and the C-dots were determined for the synthesis of well-dispersed Au NPs. The stability of the prepared Au NPs was also determined, showing that at optimum concentration of the precursor and C-dots, the particles were stable and did not precipitate for several days.     

Hierarchical and Complex ZnO Nanostructures by Microwave-Assisted Synthesis: Morphologies,Growth Mechanism and Classification

Zinc Oxide is an important and multi-purpose material in various industries due to its particular chemical and physical properties. Discovering a cheap, fast, clean, safe, and easy to use method, to synthesize this oxide nanoparticle has attracted a lot of attention in recent applications. The unique properties of the microwave and its special heating capabilities have yielded desirable outcomes by combining different synthesis methods. In the recent years, the vast majority of studies focus on the microwave-assisted synthesis of zinc oxide nanoparticles. This review article attempts to go over the recent advancements on the synthesis of zinc oxide nanoparticles with the aid of microwave, different morphologies and applications obtained by this method. Various microwave-assisted synthesis methods are classified, including the solution-based methods such as hydrothermal, sol-gel, and combustion methods. Morphology of the nanoparticles can affect the properties, and subsequently, applications of these nanoparticles. On the other hand, there is great diversity of morphological and synthesis conditions of zinc oxide nanoparticles. Thus, categorizing the synthesis techniques and providing features of them, facilitates the selection of appropriate method for designing new hierarchical structures with potential properties for future applications. Also it is endeavored to focus on the formation mechanisms of these methods. Finally, the various morphologies obtained under microwave radiation and their formation mechanisms are discussed and the effective factors in the synthesis are analyzed and presented. The potential and suitable fields of development and progress in the future studies are also proposed.