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1.
I. V. Ukrainets L. V. Sidorenko O. V. Gorokhova S. V. Slobodzyan 《Chemistry of Heterocyclic Compounds》2006,42(7):882-885
Short term treatment of 3-ethoxycarbonyl-4-morpholino-2-oxo-1,2-dihydroquinoline with aqueous solutions of hydrohalogen acids
leads to the formation of the ethyl esters of 4-halo-substituted 2-oxo-1,2-dihydroquinoline-3-carboxylic acids. Hydrolysis
in HF is possible on extended boiling only to the 4-hydroxy derivative.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1022–1025, July, 2006. 相似文献
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L. Brandsma N. A. Nedolya A. C. T. H. M. van der Kerk W. Heerma E. T. H. G. Lutz R. -J. de Lang A. V. Afonin B. A. Trofimov 《Russian Chemical Bulletin》1997,46(4):832-833
The reaction of lithiated 1,1-dimethylallene with isopropyl isothiocyanate gives 3a,4,5,5a-tetrahydro-4,4,5a-trimethyl-2-methylthio-3H-cyclobuta[b]pyrrole resulting from cyclization of the intermediate 2,7-dimethyl-4-methylthio-3-azaocta-2,4,6-triene.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 865–867, April, 1997. 相似文献
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G. A. Obanin A. S. Fokin Ya. V. Burgart O. V. Ryzhkov Z. E. Skryabina V. I. Saloutin O. N. Chupakhin 《Russian Chemical Bulletin》2000,49(7):1231-1236
Methods for the synthesis of the earlier unknownN-substituted 2-(5,6,7,8-tetrafluoro-4-oxo-1,4-dihydroquinolin-3-yl)glycoxylic acids their esters from copper chelate of ethyl
pentafluorobenzoylpyruvate were developed. The structure of intermediate ethyl 4-(R-amino)-2-oxo-3-pentafluorobenzoylbut-3-enoates
is discussed.
Published inIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1234–1239, July, 2000. 相似文献
5.
D. I. D'yachenko A. G. Mustafin V. V. Shereshovets N. N. Kabal'nova V. P. Kazakov I. B. Abdrakhmanov G. A. Tolstikov 《Russian Chemical Bulletin》1998,47(8):1611-1612
An unusual direction of the reaction of 2-(cyclopent-2-enyl)aniline hydrochloride with dimethyldioxirane was found: the formation
of two isomeric products,viz., 3- and 6-chloro-2-(cyclopent-2-enyl)anilines, was observed.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1654–1655, August, 1998. 相似文献
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4-Amino-5-(4,6-diphenyl-2-pyrimidinyl)-3,4-dihydro-2H-1,2,4-trazole-3-thione is formed from the reaction of 4,6-diphenylpyrimidinecarboxylic
acid or its ethyl ester with thiocarbonyl hydrazide. Alkylation of the product leads to S-alkyl derivaties or 6-substituted
3-(4,6-diphenyl-2-pyriimidinyl)-7H-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine. Acetylation of 4-amino-5-(4,6-diphenyl-2-pyrimidinyl)-3,4-dihydro-2H-1,2,4-triazole-3-thione
gave under different conditions monoacetyl-, diacetyl, and triacetyl derivatives at the amino group and the N(2) atom, whereas benzoylation gave a benzoyl group at the amino group and 3-(4,6-diphenyl-2-pyrimidinyl)-6-phenyl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, 1088–1094, July, 2007. 相似文献
8.
N. Z. Tugusheva L. M. Alekseeva A. S. Shashkov V. G. Granik 《Russian Chemical Bulletin》2006,55(8):1470-1474
The reactions of 3-cyano-3(5)-formyl-2-oxo-4-(phenylamino)-1,2-dihydropyridines with CH acids were studied. The previously
unknown fused 2-pyridone derivatives containing the 4-aminopyridine fragment were synthesized by the Knoevenagel reaction.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1416-1420, August, 2006. 相似文献
9.
Aavo Aaviksaar 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-4):47-50
Abstract Structure-activity relationships in inhibition of acetylcholinesterase by organophosphorus compounds (YO)(Z)P(O)SX have been analyzed using the equation log ki = C + ρσ + ?π with Taft σ* for substituent elehtronegativity and Hansch Π for hydrophobicity. The obtained relationships have been used for optimizing the structures of organophosphorus inhibitors for their maximum anticholinesterase activity. 相似文献
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P. M. Kushakova Yu. V. Basan A. I. Yulisova V. V. Lifontova S. M. Ramsh A. V. Garabadgiu L. N. Belobrzeckaja Costa 《Chemistry of Heterocyclic Compounds》2006,42(8):1078-1085
Alkylation of 1-methyltetrahydropyrimidine-2(1H)-thione (N-methylpropylenethiourea) with chloro-and bromoacetic acids and
their esters have given the 8-methyl-3-oxo-2,3,6,7-tetrahydro-5H-[1,3]thiazolo[3,2-a]pyrimidin-8-ium chloride or bromide.
The former is readily hydrolyzed in 95% ethanol to 3-[(3-methylamino)propyl]-1,3-thiazolidine-2,4-dione hydrochloride while
the second is more stable towards hydrolysis such that the corresponding hydrobromide is not separated. A paradoxical trend
in the extent of the hydrolysis decreasing with the content of the water in the alcoholic solution comes to a complete stop
in water. A possible explanation of this phenomenon is given.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1242–1251, August, 2006. 相似文献
11.
N-Methyl-2-benzoylmethylsulfanyl-4-phenylnicotinamide and N-methyl-2-(4-phenyl-1,3-thiazol-2-yl)-acetamide have been obtained
as alternative products to the desired N-methyl-2,3-dihydro-7H-thiazolo[3,2-a]pyridine-8-carboxamide by a one-pot cyclocondensation
of benzylidenemalononitrile, N-methyl-2-thiocarbamoylacetamide, piperidine, and ω-bromoacetophenone. 2-Amino-1-methyl-6-oxo-4-phenyl-5-(4-phenyl-1,3-thiazol-2-yl)-1,6-dihydropyridine-3-carbonitrile
has been obtained as main product by treatment of benzylidenemalononitrile with N-methyl-2-(1,3-thiazol-2-yl)acetamide.
Dedicated to Professor I. Kalvinsh on his 60th birthday
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 777–781, May, 2007. 相似文献
12.
The reaction of 1-aryl-2-(dimethylaminomethylene)butane-1,3-diones with diethyl oxalate in the presence of sodium hydride in THF gave ethyl 5-aroyl-4-oxo-4H-pyran-2-carboxylates, from which 4-oxo-6-aryl-4H-pyran-2-carboxylic acids (6-arylcomanic acids) were obtained in high yields via acid-catalyzed deformylative rearrangement. 5-Aroyl-4-oxo-4H-pyran-2-carboxylic acids (5-aroylcomanic acids) were prepared via а ring-opening/ring-closure sequence by the reaction of 5-aroyl-2-carbethoxy-4-pyrones with piperidine and subsequent basic hydrolysis and acidification. 相似文献
13.
V. N. Nesterov S. G. Krivokolysko V. V. Dotsenko V. P. Litvinov 《Russian Chemical Bulletin》1997,46(5):990-996
The reaction of arylcyanomethylenethiocetamides with Meldrum, acid gave Michael adducts as ammonium salts. When heated in
alcohol, these salts undergo cyclization to ammonium 4-aryl-5-cyano-2-oxo-1,2,3,4-tetrahydropyridine-6-thiolates. The structure
ofN-methylmorpholinium 4-(2′-chlorophenyl)-5-cyano-2-oxo-1,2,3,4-tetrahydropyridine-6-thiolate was established by X-ray structural
analysis.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 1029–1034, May, 1997. 相似文献
14.
I. V. Ukrainets L. V. Sidorenko L. A. Petrushova O. V. Gorokhova 《Chemistry of Heterocyclic Compounds》2006,42(1):64-69
Several variants were studied for the synthesis of esters of halogen derivatives of 4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylic
acids, whose reaction with 2-amino-4-methylthiazole gives the corresponding hetarylamides. Results are given for a study of
the antitubercular activity of these products.
Communication 89, see ref. [1].
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 71–76, January, 2006. 相似文献
15.
A. Strakovs N. N. Tonkikh M. Petrova K. V. Ryzhanova E. Palitis 《Chemistry of Heterocyclic Compounds》2002,38(4):449-455
The reaction of 2-formyl-1,3-cyclohexanedione, its 5,5-dimethyl, 5-phenyl and 5-(2-furyl) derivatives and of 2-formyl-1,3-indanedione and dehydroacetic acid with histamine, 3-(1-imidazolyl)propylamine, 3-(4-morpholyl)propylamine, 3-(2-pyrrolidon-1-yl)propylamine, 2-(1-piperazinyl)ethylamine, tryptamine, and 2-(aminomethyl)pyridine gave fifteen 2-aminomethylene derivatives. The reaction of these amines with 2-methyl-4-oxo-3,1-benzoxazine gave the 3-substituted 2-methyl-4(3H)-quinazolinones and with 4-oxo-2-phenyl-3,1-benzoxazine the monosubstituted N-benzoylanthranilic acid amides. 相似文献
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V. F. Mironov R. A. Mavleev L. A. Burnaeva I. V. Konovalova P. P. Chernov A. N. Pudovik 《Russian Chemical Bulletin》1993,42(3):528-530
The reaction of 2-substituted 4-oxo-5, 6-benzo-1, 3, 2-dioxaphosphorinanes with ethyl pyruvate affords ring-expansion products, i.e., diastereomeric 2-substituted 2, 5-dioxo-6, 7benzo-1, 3, 2-dioxaphosphepanes.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 565–567, March, 1993.The authors are grateful to Ye.I.Gol'dfarb for recording the 31P-(1H) NMR spectra. 相似文献
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3-(2-氧代环烷基)丙酸与(R)-2-硫代四氢噻唑-4-羧酸乙酯的反应李叶芝,田颜清,黄化民(吉林大学化学,长春,130023)关键词(R)-2-硫代四氢噻唑-4-羧酸乙酯,N-3-(2-氧代环烷基)丙酰-2-硫代四氢噻唑-4-羧酸乙酯,环合反应,... 相似文献
20.
2-Hydroxy-4-oxo-4-(2,3,5,6-tetrafluoro-4-methoxyphenyl)-but-2-enoic acid methyl ester (1) was synthesized by the reaction of pentafluoroacetophenone with dimethyl oxalate in the presence of sodium methylate. Subsequently, reactions of compound 1 with aniline, o-phenylenediamine, and o-aminophenol were investigated. In addition, the thermal cyclization of ester 1 was studied and led to the formation of 5,6,8-trifluoro-7-methoxy-4-oxo-4H-chromene-2-carboxylic acid methyl ester (6) due to nucleophilic substitution of the 3-fluoro group. Hydrolysis of compound 1 and subsequent cyclization by treatment with SOCl2 gave 5-(2,3,5,6-tetrafluoro-4-methoxyphenyl)-furan-2,3-dione (3). Thermal decarbonylation of compound 3 under mild conditions resulted in the formation of 3-(2,3,5,6-tetrafluoro-4-methoxyphenyl)-propene-1,3-dione (4) which dimerized to pyranone 5. 相似文献