基于问卷调查的ATDE创造性思维教学模式探讨

ATDE创造性思维教学模式是以学生为主体,以教师为主导,通过“问、想、做、评”四个环节引导学生共同完成教学任务,旨在培养学生创造性思维的一种创新的教学模式。为了解学生对“大学化学”及实验教学中教学模式的态度,探讨应用ATDE教学模式的教学效果及影响因素。对九江学院2010级应用化学本科41名学生进行了回顾性问卷调查。结果表明,实施ATDE教学模式对培养大学生综合素质有显著的积极影响,大部分学生对ATDE教学模式很感兴趣,并且认为应用ATDE教学模式教学很有必要。同时针对实施过程中尚存的有关问题,提出了建议性的解决策略。     

基于翻转课堂-PBL的混合式“金课”教学*——以“药物分析”为例

以创新应用能力及岗位需求重构课程标准,更新教学方法和教学手段,从教学设计、教学实施、教学评价、教学效果等4个方面系统地探索了基于翻转课堂-PBL教学的药物分析课程教学模式建设与应用,旨在形成多元化、多层次的药物分析教学新体系,将“以教师教为主”的教学模式转变为“以学生学为主”,让学生化“被动”为“主动”学习,锻炼学生自主学习能力,增强学生团队协作及分析解决问题的能力,启发学生创新应用能力。     

线上线下互动教学模式在医学院校基础化学教学中的应用——以“缓冲溶液及其作用机制”为例

为提高基础化学的教学效果,以“UMU互动”为平台,开展线上线下混合式教学模式改革。以“缓冲溶液及其作用机制”教学设计为例, 阐述线上线下混合教学模式的应用。结果表明,混合式教学模式可以激发学生的学习兴趣,提升学生自主学习的能力,有效提高了教学质量和教学效果。     

基于雨课堂平台的化工基础“对分课堂”教学模式的探索与实践*

依托雨课堂教学平台,应用现代信息技术,在化工基础课堂教学中引入“对分课堂”教学理念和教学模式。以流体流动教学内容为教学案例,具体说明“对分课堂”教学模式的具体实施过程。实践结果表明,该教学模式激发了学生的学习兴趣和主观能动性,提高了课堂教学效果,有利于学生对化工基础知识的掌握、学生综合能力的培养和后续生产实践的应用。     

化学制药工艺学在线教学实践与思考

以化学制药工艺学课程为例,从在线教学技术、教学设计等方面探讨了以学生为中心的在线教学模式与方法,对比分析了在线教学与线下教学的优缺点.实践表明,与线下教学相比,以学生为中心的在线教学模式更有利于学生自主学习能力的培养和课程目标的达成.     

线上线下混合式教学结合翻转课堂进行酯缩合反应的教学*

采用“线上线下混合式教学”开展有机化学课程的教学工作,利用APP “学习通”将在线课堂教学和线下讲授相结合。以知识点酯缩合反应的教学为例,介绍了该教学模式的实施过程和教学效果。实践结果表明,线上线下混合式教学与翻转课堂相结合的教学模式,能够拓展化学专业学生知识面,提升学生的自主学习能力和学习的积极性,取得了较好的教学效果。     

在化学教学中以Blending Learning为理念尝试"双主-探究"教学模式的研究与实践

阐述了以Blending Learning为教学理念,通过构建学科教学网站实施"双主—探究"教学模式的研究。"Blending Learning"是当前国际教育理念发展的最新动向。而在教学中实施教师主导作用和学生主体地位的有机统一、以学生自主探究为主线的教学模式,是我们在经历了对传统教学模式的批判与继承及对建构主义教学理论的发扬与引申后建立起的一种科学的教学模式。     

“一体三翼”教学模式在工科无机化学教学中的应用与实践*

为适应当前复合型人才培养需求和提高学生自主学习能力和创新意识,在对大学一年级新生进行无机化学教学时需坚持以学生为主体的教学理念,并努力同时提高他们的思想政治素质、理论联系实际能力和科学研究素养。为此,提出“一体三翼”教学模式。然而,大多数工科院校无机化学课程的授课学时有所压缩,这对任课教师来讲是一种巨大挑战。通过“线上-线下”混合式教学解决学时不足问题,并通过学生课程参与度、学生学习成绩及教学反思等形式检验“一体三翼”教学模式的教学实践成效。     

应用型本科院校有机化学实验教学改革实践与探索

以建构主义理论为指导,牢固树立以学生为主体、教师为主导的教学理念,对教学内容、教学方法、教学手段、教学模式和考核评价等进行全方位的教学改革和探索实践,建立“校企融合”“工学交替”和“产学研用”一体化教学模式,充分调动了学生的实验积极性、主动性和创造性。同时,通过强化实验基本操作技能训练,不断提高学生的综合实验设计能力、创新能力和科研能力,取得了良好的实践效果,为学生就业、创业奠定了坚实的技术基础,较好地满足了企业对高素质技术技能型人才的需求。     

观摩美国田纳西大学物理化学教学得到的启示

阐述美国田纳西大学物理化学课程教学的教学内容、教学方式、学生成绩的评估方式以及对教师教学工作的评估方式,并对比我国华南理工大学的物理化学教学,提出了借鉴美国高校物理化学教学的先进经验,将以教师为中心的教学模式转变为以学生为中心的教学模式是提高物理化学教学效果的一个有效途径。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

Synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives

Different approaches for the synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives from simple amino acids have been investigated. A library of 33 precursors for the preparation of N-hydroxy pyrazinones was obtained in moderate to good yields.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.     

Chemistry of heterocyclic compounds at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, over 50 years (Review)

The review contains a concise historical account and information on the most significant researches undertaken by the staff at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences on the Chemistry of Heterocyclic Compounds. Dedicated to Academician of the Russian Academy of Sciences B. A. Trofimov on his 70th jubilee. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1443–1502, October, 2008.     

A general and convenient synthesis of 4-(tosylmethyl)semicarbazones and their use in amidoalkylation of hydrogen,heteroatom, and carbon nucleophiles

A general synthesis of previously unknown semicarbazone-based α-amidoalkylating reagents, 4-(tosylmethyl)semicarbazones, has been developed. The synthesis involved three-component condensation of semicarbazones of aliphatic or aromatic aldehydes with the same or other aldehydes and p-toluenesulfinic acid. The scope and limitations of this reaction were investigated. The compounds obtained were demonstrated to be an efficient α-(4-semicarbazono)alkylating agents. They were reacted with H- (sodium borohydride), O- (sodium methylate), S- (sodium phenylthiolate), N- (pyrrolidine, sodium succinimide), P- (trialkyl phosphites), and C-nucleophiles (sodium diethyl malonate) to give the corresponding products of the tosyl group substitution, 4-substituted semicarbazones, including analogues of nitrofurazone. Among the prepared compounds tested in vitro for antibacterial and antifungal activity, three nitrofuryl-containing semicarbazones exhibited high biological activities with minimum inhibitory concentration (MIC) values of 8–32 μg/mL.     

Sulfur-directed metal-free and regiospecific methyl C(sp3)–H imidation of thioanisoles

Regiospecific and direct imidation of the methyl C(sp³)–H bond of thioanisoles is realized under mild and metal-free conditions with N-fluorobis(benzenesulfonyl)imide as an oxidant and nitrogen source. Proposed mechanism suggests that thionium ion intermediates and a Pummerer-type reaction are involved. The imidation has advantages such as high step-economy, excellent functionality tolerance, and regiospecificity, giving structurally diverse imidation products.     

Synthesis of novel chiral bidentate hydroxyalkyl-N-heterocyclic carbene ligands and their application in palladium-catalyzed Mizoroki–Heck couplings and asymmetric addition of diethylzinc to benzaldehyde

A small library of new chiral bidentate hydroxyalkyl-imidazolium salts 1 is conveniently synthesized on multi-gram scale from inexpensive and commercially available chiral pool amino acids. The corresponding carbenes, generated by deprotonation of imidazolium salts 1, in combination with palladium(II) chloride were tested in the Mizoroki–Heck coupling reaction. The most significant results in terms of yields and reactivities were achieved with low catalyst loading. The catalytic activities of these imidazolium salts were also investigated in the asymmetric addition of diethylzinc to benzaldehyde. The use of MgO nanoparticles as an additive in conjunction with these ligands played a crucial role in increasing the efficiency of these reactions.