Kernel estimators of the ROC Curve with censored data

Receiver operating characteristic (ROC) curves are often used to study the two sample problem in medical studies. However, most data in medical studies are censored. Usually a natural estimator is based on the Kaplan-Meier estimator. In this paper we propose a smoothed estimator based on kernel techniques for the ROC curve with censored data. The large sample properties of the smoothed estimator are established. Moreover, deficiency is considered in order to compare the proposed smoothed estimator of the ROC curve with the empirical one based on Kaplan-Meier estimator. It is shown that the smoothed estimator outperforms the direct empirical estimator based on the Kaplan-Meier estimator under the criterion of deficiency. A simulation study is also conducted and a real data is analyzed.     

A KERNEL-TYPE ESTIMATOR OF A QUANTILE FUNCTION UNDER RANDOMLY TRUNCATED DATA

A kernel-type estimator of the quantile function Q(p) = inf {t : F(t)≥p}, 0≤p≤1, is proposed based on the kernel smoother when the data are subjected to random truncation. The Bahadur-type representations of the kernel smooth estimator are established, and from Bahadur representations the authors can show that this estimator is strongly consistent, asymptotically normal, and weakly convergent.     

A generalized log-normal distribution and its goodness of fit to censored data

In life testing experiments, the skewed distributions like log-normal, Weibull, gamma and generalized gamma are the most suitable models for recording the failure time measurements. In this paper, a generalized version of log-normal distribution is proposed and its goodness-of-fit for a randomly censored data set representing the remission times of bladder cancer patients has been demonstrated and compared with other lifetime models considered in the literature. The P-P plots of Kaplan-Meier estimator against the survival functions of the considered models are used to show the goodness-of-fit. A simulation study is also performed to estimate the parameters in both the classical and Bayesian setups.     

The Bahadur representation for kernel-type estimator of the quantile function under strong mixing and censored data

In this paper, we consider the kernel-type estimator of the quantile function based on the kernel smoother under a censored dependent model. The Bahadur-type representation of the kernel smooth estimator is established, and from the Bahadur representation we can show that this estimator is strongly consistent.     

On estimation of survival function under random censoring model

We study an estimator of the survival function under the random censoring model. Bahadur-type representation of the estimator is obtained and asymptotic expression for its mean squared errors is given, which leads to the consistency and asymptotic normality of the estimator. A data-driven local bandwidth selection rule for the estimator is proposed. It is worth noting that the estimator is consistent at left boundary points, which contrasts with the cases of density and hazard rate estimation. A Monte Carlo comparison of different estimators is made and it appears that the proposed data-driven estimators have certain advantages over the common Kaplan-Meier estmator.     

Smooth estimation of survival and density functions for a stationary associated process using Poisson weights

Let {X_n,n≥1} be a sequence of stationary non-negative associated random variables with common marginal density f(x). Here we use the empirical survival function as studied in Bagai and Prakasa Rao (1991) and apply the smoothing technique proposed by Gawronski (1980) (see also Chaubey and Sen, 1996) in proposing a smooth estimator of the density function f and that of the corresponding survival function. Some asymptotic properties of the resulting estimators, similar to those obtained in Chaubey and Sen (1996) for the i.i.d. case, are derived. A simulation study has been carried out to compare the new estimator to the kernel estimator of a density function given in Bagai and Prakasa Rao (1996) and the estimator in Buch-Larsen et al. (2005).     

Stahel-Donoho kernel estimation for fixed design nonparametric regression models

This paper reports a robust kernel estimation for fixed design nonparametric regression models. A Stahel-Donoho kernel estimation is introduced, in which the weight functions depend on both the depths of data and the distances between the design points and the estimation points. Based on a local approximation, a computational technique is given to approximate to the incomputable depths of the errors. As a result the new estimator is computationally efficient. The proposed estimator attains a high breakdown point and has perfect asymptotic behaviors such as the asymptotic normality and convergence in the mean squared error. Unlike the depth-weighted estimator for parametric regression models, this depth-weighted nonparametric estimator has a simple variance structure and then we can compare its efficiency with the original one. Some simulations show that the new method can smooth the regression estimation and achieve some desirable balances between robustness and efficiency.     

Multiple imputations and the missing censoring indicator model

Semiparametric random censorship (SRC) models (Dikta, 1998) provide an attractive framework for estimating survival functions when censoring indicators are fully or partially available. When there are missing censoring indicators (MCIs), the SRC approach employs a model-based estimate of the conditional expectation of the censoring indicator given the observed time, where the model parameters are estimated using only the complete cases. The multiple imputations approach, on the other hand, utilizes this model-based estimate to impute the missing censoring indicators and form several completed data sets. The Kaplan-Meier and SRC estimators based on the several completed data sets are averaged to arrive at the multiple imputations Kaplan-Meier (MIKM) and the multiple imputations SRC (MISRC) estimators. While the MIKM estimator is asymptotically as efficient as or less efficient than the standard SRC-based estimator that involves no imputations, here we investigate the performance of the MISRC estimator and prove that it attains the benchmark variance set by the SRC-based estimator. We also present numerical results comparing the performances of the estimators under several misspecified models for the above mentioned conditional expectation.     

Model-based likelihood ratio confidence intervals for survival functions

We introduce an adjusted likelihood ratio procedure for computing pointwise confidence intervals for survival functions from censored data. The test statistic, scaled by a ratio of two variance quantities, is shown to converge to a chi-squared distribution with one degree of freedom. The confidence intervals are seen to be a neighborhood of a semiparametric survival function estimator and are shown to have correct empirical coverage. Numerical studies also indicate that the proposed intervals have smaller estimated mean lengths in comparison to the ones that are produced as a neighborhood of the Kaplan-Meier estimator. We illustrate our method using a lung cancer data set.     

纵向数据非参数混合效应模型的一个局部不变估计

非参数核回归方法近年来已被用于纵向数据的分析(Lin和Carroll,2000)．一个颇具争议性的问题是在非参数核回归中是否需要考虑纵向数据间的相关性．Lin和Carroll (2000)证明了基于独立性(即忽略相关性)的核估计在一类核GEE估计量中是(渐近)最有效的．基于混合效应模型方法作者提出了一个不同的核估计类,它自然而有效地结合了纵向数据的相关结构．估计量达到了与Lin和Carroll的估计量相同的渐近有效性,且在有限样本情形下表现更好．由此方法可以很容易地获得对于总体和个体的非参数曲线估计．所提出的估计量具有较好的统计性质,且实施方便,从而对实际工作者具有较大的吸引力．     

On the limit points of the Kaplan-Meier estimator

In this paper the limit points of the Kaplan-Meier estimator is discussed. We use the method of strong approximation to get the unit ball of the reproducing kernel Hilbert space.     

Ghost Point Diffusion Maps for Solving Elliptic PDEs on Manifolds with Classical Boundary Conditions

In this paper, we extend the class of kernel methods, the so-called diffusion maps (DM) and its local kernel variants to approximate second-order differential operators defined on smooth manifolds with boundaries that naturally arise in elliptic PDE models. To achieve this goal, we introduce the ghost point diffusion maps (GPDM) estimator on an extended manifold, identified by the set of point clouds on the unknown original manifold together with a set of ghost points, specified along the estimated tangential direction at the sampled points on the boundary. The resulting GPDM estimator restricts the standard DM matrix to a set of extrapolation equations that estimates the function values at the ghost points. This adjustment is analogous to the classical ghost point method in a finite-difference scheme for solving PDEs on flat domains. As opposed to the classical DM, which diverges near the boundary, the proposed GPDM estimator converges pointwise even near the boundary. Applying the consistent GPDM estimator to solve well-posed elliptic PDEs with classical boundary conditions (Dirichlet, Neumann, and Robin), we establish the convergence of the approximate solution under appropriate smoothness assumptions. We numerically validate the proposed mesh-free PDE solver on various problems defined on simple submanifolds embedded in Euclidean spaces as well as on an unknown manifold. Numerically, we also found that the GPDM is more accurate compared to DM in solving elliptic eigenvalue problems on bounded smooth manifolds. © 2021 Wiley Periodicals LLC.     

On the modal resolution of kernel density estimators

The ability of a kernel density estimator to resolve modes of the underlying density is investigated. For various bimodal densities and three different kernels, the smallest sample size required for the expectation of an optimally smoothed kernel estimator to be bimodal is determined. The optimality criterion employed is equivalent to asymptotic mean integrated squared error for sufficiently smooth densities.     

Nonlinear wavelet density estimation with censored dependent data

In this paper, we provide an asymptotic expansion for the mean integrated squared error (MISE) of nonlinear wavelet estimator of survival density for a censorship model when the data exhibit some kind of dependence. It is assumed that the observations form a stationary and α‐mixing sequence. This asymptotic MISE expansion, when the density is only piecewise smooth, is same. However, for the kernel estimators, the MISE expansion fails if the additional smoothness assumption is absent. Also, we establish the asymptotic normality of the nonlinear wavelet estimator. Copyright © 2011 John Wiley & Sons, Ltd.     

Asymptotically Local Minimax Estimation of Infinitely Smooth Density with Censored Data

The problem of the nonparametric minimax estimation of an infinitely smooth density at a given point, under random censorship, is considered. We establish the exact asymptotics of the local minimax risk and propose the efficient kernel-type estimator based on the well known Kaplan-Meier estimator.     

Improved confidence intervals for quantiles

We derive the Edgeworth expansion for the studentized version of the kernel quantile estimator. Inverting the expansion allows us to get very accurate confidence intervals for the pth quantile under general conditions. The results are applicable in practice to improve inference for quantiles when sample sizes are moderate.     

Comparative Analysis of Cubic Spline and Kernel Estimation of a Probit Function

The least-squares cubic spline and the kernel estimators produce comparable mean squared errors, although the kernel produces smaller mean squared errors when the variable increases away from 0. Mean squared error increases with an increase in the number of knots (for the cubic spline) or reduced band width (for the kernel estimator). The cubic spline produces smaller mean squared errors when all observations are made at knots than when they are spaced out between knots. Irrespective of the exact form of the probit function g(x), the cubic spline estimator is asymptotically unbiased, while the kernel estimator only converges to g(x) under certain conditions. Moreover, the cubic spline is a smooth function, which is twice differentiable on the interval [0,1].     

On a nonparametric estimator for the finite time survival probability with zero initial surplus

In this paper, we consider the estimation of the finite time survival probability in the classical risk model when the initial surplus is zero. We construct a nonparametric estimator by Fourier inversion and kernel density estimation method. Under some mild assumptions imposed on the kernel, bandwidth and claim size density, we derive the order of the bias and variance, and show that the estimator has asymptotic normality property. Some simulation studies show that the estimator performs quite well in the finite sample setting.     

Moderate deviations for deconvolution kernel density estimators with ordinary smooth measurement errors

In this paper, we establish the pointwise and uniform moderate deviations limit results for the deconvolution kernel density estimator in the errors-in-variables model, when the measurement error possesses an ordinary smooth distribution. The results are similar to the moderate deviations theorems for the classical kernel density estimators, but a factor related to the ordinary smooth order is needed to account for the measurement errors.     

NA样本概率密度函数核估计的相合性

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