激光辐照下皮肤组织光热响应有限元分析

为了更好地选择临床激光医疗曝光参量,采用有限元数值计算方法,模拟了脉冲激光与连续激光对人皮肤组织的光热作用及导致的温度变化效应,比较了两者的不同,得到了热响应时间及热弛豫时间与组织深度的关系,即组织越深(0～60 μm),其热响应时间(0～4 ms)与热弛豫时间(0.4～12.1 ms)越长;分析了激光脉宽长短对组织升温的影响;建立了评价脉冲间热损失的评价函数δ,并以此对脉冲间隔的选取作了探讨.     

1064 nm激光不同辐照时间对小鼠皮肤热损伤的实验与理论研究

通过实验和理论分析的方法研究1064 nm激光不同辐照时间对小鼠皮肤的热损伤规律。利用皮肤镜图像和光学相干断层图像评估小鼠皮肤组织热损伤程度,利用Arrhenius热损伤方程计算热损伤参数,建立激光诱导皮肤组织热损伤模型,并与实验结果进行对比。结果表明,在靶功率密度为30 W/mm2的1064 nm激光辐照下,0～100 ms辐照时间内,小鼠皮肤组织损伤可恢复;150～280 ms辐照时间内,小鼠皮肤组织出现水肿现象和热凝固损伤;280～550 ms辐照时间内,小鼠皮肤表皮层出现汽化现象,损伤斑周围出现焦痂,真皮层发生变性;660 ms辐照时间以上,小鼠皮肤表皮层和真皮层出现汽化现象,伤口渗出组织液,皮下组织发生变性。理论分析与实验结果一致,建立的热损伤模型能够验证小鼠皮肤热损伤程度。     

A numerical simulation of photothermal response in laser medicine

In this paper, we reported a numerical solution of laser induced thermal effect in the bio-tissue. The model of photothermal effect and classical Pennes bio-heat transfer equation were introduced. Finite element method (FEM), which was realized by Matlab software, was used to calculate the temperature distribution. He-Ne laser (633 nm) was used to simulate the physical therapy in in vivo skin tissue. Under the cylinder coordinates, the three-dimension(3-D) geometry of tissue was reduced to two-dimension(2-D)computation. The results contained the radial, axial and temperature 3-D color plot. Combining the time animation display was possible. By changing the laser and tissue parameters we can get different results.This will be the initial and indispensable work of the non-destructive evaluation of the laser induced injury.     

不同功率密度1064 nm激光辐照下小鼠皮肤热损伤研究

通过实验和理论分析研究1064 nm激光不同输出功率对小鼠皮肤的热损伤规律。利用皮肤镜与光学相干断层成像(OCT)评估小鼠皮肤组织热损伤程度;参考Arrhenius热损伤方程进行理论分析,并与实验结果对比。结果显示,当激光连续辐照时间为400 ms时,激光输出功率密度小于958 W/cm²时,激光辐照处泛红;激光输出功率密度为958～1160 W/cm²时,损伤呈白色水疱状;激光输出功率密度为1160～1370 W/cm²时,损伤呈浅坑状焦黄斑,损伤斑周围伴一圈鼓起的白色皮肤水疱;激光的功率密度在1370～2190 W/cm²,损伤呈红色坑状斑,损伤斑周围伴黑黄色焦痂。     

高能激光系统内光路热效应建模与仿真

高能激光系统内光路热效应是影响系统性能的重要因素,介绍了内光路中光学元件、介质气体热效应物理模型,分析了影响热效应的主要因素,并开展了热效应变化规律研究。针对光学元件,重点研究了元件吸收率、元件材料特性、光斑分布对反射镜、窗口镜、分光镜热像差的影响规律,指出吸收率主要影响热像差的大小,而元件基底材料特性和激光分布影响热像差时间和空间变化。针对介质气体,指出介质气体升温后重力引起的自然对流是影响气体热像差的主要物理因素,细致研究了热像差随时间的变化规律,介绍了降低封闭与开放式内光路介质气体热像差的措施与方法。介绍了激光仿真软件平台Easylaser多物理仿真模块,搭建了包含反射镜、窗口镜、分光镜和介质气体的内光路计算模型,通过光-热-力-控多物理耦合仿真,研究了反射镜与窗口镜、介质气体与窗口镜热像差补偿效应,给出了激光传输远场光斑特征,表明了Easylaser的多物理仿真模块具备对内光路热效应综合仿真分析能力。     

激光窗口热透镜效应对光束质量的影响

 分析了高功率激光通过窗口时，引起的窗口热透镜效应及其对激光光束质量的影响。用冲量定理方法，推导了二维热传导方程的广义傅里叶级数解，然后按照平面热应力问题，运用有限元方法数值计算热变形。考虑热变形、折射率随温度变化，忽略光弹性效应，解出出光面的波前相差分布，讨论了远场光束质量。以空心环形光束为例，计算了熔融石英(SiO₂)和白宝石(Al₂O₃)两种常用窗口的温升分布、热变形、波前相差和光束质量，分析了冷却、辐照时间、光强分布的空间梯度和各种材料参数对光束质量的影响。     

Theoretical analysis and experimental verification of AZO/i-ZnO/CdS/CIGS multilayer stack isolation using 1064 nm and 355 nm laser wavelengths

This study analyzed the thermal field effect and experimental verification of laser scribing of stainless foil based copper indium gallium selenide solar cells of the AZO/i-ZnO/CdS/CIGS multilayer stack films (P3 layer) using Nd:YAG (1064 nm) and ultraviolet (355 nm) lasers. To prevent breakdown of molybdenum films of the solar cell, the laser processing temperature must be lower than the ablation temperature (2896 °C) of the Mo layer, but higher than the ablation temperature (2248 °C) of aluminum doped zinc oxide layer. Therefore, the scribing depth of the P3 layer is limited to the range 1.5–1.7 μm. First, the ANSYS Parameter Design Language program in the ANSYS finite element software is used to establish the simulation mathematical thermal model of the laser scribing process. To simulate the actual laser scribing process, a three-dimensional FE model for laser scribing process with a moving laser beam was constructed. Comparison the theoretical analysis and experimental results indicated that two sets of simulation parameters could not completely remove the P3 layer when the Nd:YAG laser was used. However, when the UV laser was used, the theoretical and experimental results were in favorable agreement. The findings of this study indicate that simulation analysis results can be helpful as reference data for experimental parameters during the actual scribing process.     

Comparison of Cut Path Deviation Between CO2 and Diode Lasers in Float-Glass Cutting

Laser cutting of glass using the controlled fracture technique leads to cut path deviation at the leading and trailing edges of the float glass sheet. In this technique, thermal stresses are used to induce the crack, and the material is separated along the cutting path by extending the crack. We show that the cut path deviation is partly due to high magnitudes of thermal stresses generated near the sheet edges. The absorption of intense radiation from the CO₂ and diode laser beams in the glass causes local temperature increases and consequently generates different thermal fields and stress distributions due to surface and volumetric heat absorption. In this paper, we report the effect of the CO₂ and diode laser wavelength interaction with the float glass and its effect on the magnitudes of thermal stresses generated near the edges of the glass sheet. We simulate the distribution of the thermal stress and temperature using finite-element analysis software Abaqus and validate it against the experimental data. We show that the CO₂ laser produces a lower surface quality and a larger cut path deviation at the leading and trailing edges of the glass sheet as compared to the diode laser.     

Spectral enhancement of thermal radiation by laser fabricating grating structure on nickel surface

Previous studies have shown some correlations between the optical properties of objects and their surface patterns. We fabricate tens of micrometer period gratings by femtosecond laser direct writing technology on polished nickel targets and measure their thermal radiation spectra at a temperature of 623 K by Fourier transform infrared(FTIR) spectrometry. The results show an obvious major enhanced peak in which the wavelength is slightly larger than the grating period. Surface plasmon resonance(SPR) and Kirchhoff's law of thermal radiation are applied to give this phenomenon a preliminary explanation. In addition, we utilized rigorous coupled wave analysis(RCWA) to simulate the absorption spectrum of the grating surface. The experiment results show good agreement with the simulation results.     

Simulation of temperature distribution in skin under laser irradiation with different wavelengths

With the help of numerical calculations of the finite element method, we simulate the distributions of the temperature in skin after laser irradiation with four wavelengths, 532 nm, 694 nm, 755 nm, and 800 nm, respectively. Combined metabolism of the organism with the traditional Pennes equation, the induced thermal effect in tissue is expressed. The simulated results show that the temperature in the irradiation center decreases as the increase of the wavelength for the same irradiation duration, and the relationships of the distribution of temperature and the wavelength along the radial and longitudinal directions are different.     

A two-layer model of laser interaction with skin: A photothermal effect analysis

In order to understand the photothermal effect mechanism of laser interaction with skin, we employed a two-layer model to describe the heat generation, transportation, and dispersion in the procedure of laser interaction with skin. A skin temperature distribution corresponding to the laser interaction direction is calculated to describe the time of skin gasification and the possible thermal injury. The magnitude of time is ms. This basic process provides a possible quantitative recognition of the applications of laser in clinical skin care.     

二极管双侧抽运横流连续液体激光系统性能模拟

为解决无机液体激光系统的热效应问题,采用激光二极管双侧抽运横向流动的Nd3 :POCl3:ZrCl4溶液以很好地减小热效应,实现液体激光系统高功率高光束质量输出。建立了液体激光理论模型,分析了工作参量对系统能量转换效率与介质热效应的影响;模拟了系统在不同吸收系数和不同流速下的能量转换效率,远场光斑分布以及激光束亮度分布。模拟结果表明:采用二极管作为抽运源可以获得很高的能量转换效率,而且光束质量较好;在给定抽运体积和抽运强度为800 W/cm2时,介质的吸收系数位于2.5~3.0 cm-1,流速约为25 m/s时,输出功率与光束质量实现最佳匹配,激光束亮度最高,系统性能达到最佳。     

Modeling of laser transmission contour welding process using FEA and DoE

In this research, a systematic investigation on laser transmission contour welding process is carried out using finite element analysis (FEA) and design of experiments (DoE) techniques. First of all, a three-dimensional thermal model is developed to simulate the laser transmission contour welding process with a moving heat source. The commercial finite element code ANSYS^® multi-physics is used to obtain the numerical results by implementing a volumetric Gaussian heat source, and combined convection–radiation boundary conditions. Design of experiments together with regression analysis is then employed to plan the experiments and to develop mathematical models based on simulation results. Four key process parameters, namely power, welding speed, beam diameter, and carbon black content in absorbing polymer, are considered as independent variables, while maximum temperature at weld interface, weld width, and weld depths in transparent and absorbing polymers are considered as dependent variables. Sensitivity analysis is performed to determine how different values of an independent variable affect a particular dependent variable.     

Modeling of laser induced breakdown spectroscopy for very low-pressure conditions

Laser Induced Breakdown Spectroscopy (LIBS) can be considered as a prominent technology for compositional analysis of materials in low-pressure space applications. In space applications, usually LIBS is conducted in a low-pressure environment and proper understanding of the plasma parameters is significant for any improvement in the system. A model is developed to describe the heating and subsequent melting, vaporization and ionization of a target material during LIBS process. A numerical model based on one-dimensional thermal conductivity equation is being used to simulate the target evaporation and a hydrodynamic model is used to simulate plume expansion. Further, an experimental approach of measuring spectral emission from the ablation plume using emission spectroscopy and estimating the plasma state, such as the ionization species, and average plasma temperature, is investigated. An important result of this work is that for different ambient conditions, laser ablation plume dynamics can be estimated.     

Study of the temperature distribution in Si nanowires under microscopic laser beam excitation

The use of laser beams as excitation sources for the characterization of semiconductor nanowires (NWs) is largely extended. Raman spectroscopy and photoluminescence (PL) are currently applied to the study of NWs. However, NWs are systems with poor thermal conductivity and poor heat dissipation, which result in unintentional heating under the excitation with a focused laser beam with microscopic size, as those usually used in microRaman and microPL experiments. On the other hand, the NWs have subwavelength diameter, which changes the optical absorption with respect to the absorption in bulk materials. Furthermore, the NW diameter is smaller than the laser beam spot, which means that the optical power absorbed by the NW depends on its position inside the laser beam spot. A detailed analysis of the interaction between a microscopic focused laser beam and semiconductor NWs is necessary for the understanding of the experiments involving laser beam excitation of NWs. We present in this work a numerical analysis of the thermal transport in Si NWs, where the heat source is the laser energy locally absorbed by the NW. This analysis takes account of the optical absorption, the thermal conductivity, the dimensions, diameter and length of the NWs, and the immersion medium. Both free standing and heat-sunk NWs are considered. Also, the temperature distribution in ensembles of NWs is discussed. This analysis intends to constitute a tool for the understanding of the thermal phenomena induced by laser beams in semiconductor NWs.     

脉冲激光辐照光学薄膜的缺陷损伤模型

建立了缺陷吸收升温致薄膜激光损伤模型,该模型从热传导方程出发,考虑了缺陷内部的温度分布以及向薄膜的传导过程,通过引入散射系数简化了Mie散射理论得出的吸收截面.对电子束蒸发沉积的ZrO₂:Y₂O₃单层膜进行了激光破坏实验,薄膜样品的损伤是缺陷引起的,通过辉光放电质谱法对薄膜制备材料的纯度分析发现材料中的主要杂质元素为铂,其含量为0.9％.利用缺陷损伤模型对损伤过程进行了模拟,理论模型和实验结果取得了较好的一致性.     

Simulation on laser-induced surface acoustic wave on isotropic cylinders by finite element method

Based on the thermoelastic theory, a finite element model is developed to simulate the process of laser inducing ultrasonic field in isotropic cylinders, which can take the temperature dependence of thermal parameters into account. Using the finite element model, we have simulated the ultrasonic fields induced by a pulse laser line source impacting on the generatrix of aluminum cylinders with different diameters. And the intact waveforms of surface acoustic wave (SAW including cylindrical Rayleigh and Whispering gallery (WG) modes) are presented, which are in very good agreement with the calculated and experimental waveforms in other literatures. Furthermore, the dispersion properties of cylindrical Rayleigh waves are analyzed by the method of phase spectral analysis, and the results show that with the increasing frequency, the phase velocity of cylindrical Rayleigh wave rapidly increases to the maximum value, and then gradually decreases to that of plane Rayleigh wave. With the diameter of cylinder decreasing, the maximum value of phase velocity and the corresponding frequency increase.     

固体激光器热透镜效应的调控

利用工作腔的热透镜模型, 分析了有激光发射下固体激光器的谐振腔配置对热透镜效应和稳定区的影响, 论述了通过改变谐振腔配置调控热效应的可行性.实验上, 使用一台Nd: YAG激光器对理论作了验证, 实现了对热透镜光焦度及稳定区分布的调控.     

Thermal modeling of laser-annealing-induced crystallization of amorphous NiTi thin films

Laser annealing of shape memory alloy thin films provides new opportunities in actuator design and fabrication for microelectromechanical systems applications. In this paper, we present a three-dimensional thermal model to simulate the crystallization process when a laser beam is swept across an amorphous NiTi thin film. Experimental crystallite nucleation and growth rates are included in the model to enable prediction of the size of the crystallized region as a function of laser annealing parameters. The model can also be used to study the crystallization of other material systems by means of laser annealing. PACS 42.62.-b; 81.20.-n; 81.30.Kf     

钛合金纳秒激光打孔数值模拟和实验研究

为了描述纳秒激光对钛合金打孔过程中孔的形貌及温度场的变化规律,建立激光打孔的物理模型,利用ANSYS中APDL语言进行编程,对温度场进行仿真分析,并利用单元生死技术模拟孔形貌的变化过程。从有限元数值模拟和实验两方面综合分析比较了激光工艺参数(脉冲能量和脉冲数量)对打孔质量(孔深和孔径)的影响,系统论述了钛合金纳秒激光打孔的一般规律,以达到工艺参数优化,提高打孔质量的目的。