共查询到20条相似文献,搜索用时 46 毫秒
1.
2.
3.
4.
倒数示波计时电位滴定法测定鞣液中铬 总被引:1,自引:0,他引:1
倒数示波计时电位滴定法测定鞣液中铬郑建斌,白育伟,胡娟,朱俊杰,高鸿(西北大学化学系西安,710069)(南京大学化学系南京,210008)关键词倒数示波计时电位滴定,皮革鞣液,铬在皮革鞣制过程中,鞣液中铬含量的高低直接影响成革或毛皮板的质量和规格。... 相似文献
5.
采用K_2S_2O_8-NaHSO_3引发体系,研究了丙烯酸乙酯(EA)、甲基丙烯酸丁酯(BMA)及其二元混合单体(EA-BMA)在铬鞣猪皮中的聚合过程,考察了反应温度、时间、单体浓度和铬鞣猪皮的部位不同对反应的影响,初步探讨了改性过程的反应机理。 相似文献
6.
电位滴定法测定工业废水中铬 总被引:6,自引:0,他引:6
报道了以氨三乙酸(NTA,活化剂)存在下,Mn(Ⅱ)催化高碘酸钾氧化孔雀绿的反应指示终点,孔雀绿电极作指示电极用催化电位滴定法测定工业废水中铬的方法。该法不需对样品进行复杂分离,操作简单方便,终点灵敏、准确度高,重现性较好。试验对鞣革废水及电镀废水中的铬进行测定并与火焰原子吸收光谱法比较,结果满意。用标准加入法测得的平均回收率为99.62%,RSD为0.94%。 相似文献
7.
8.
催化电位滴定法测定铬鞣中铬(III) 总被引:1,自引:0,他引:1
报道了以氨三乙酸存在下锰(II)催化KIO4氧化结晶紫的反应指示终点,结晶紫电极作指示电极用催化电位滴定法测定的铬鞣剂中Cr(III)的方法,该法终点灵敏,准确度高,重现性好,结果满意,用标准加入法测得的平均回收率为100.03%,RSD为0.24%。 相似文献
9.
10.
11.
Two 1H-2,3-dihydropyrrolizine derivatives bearing a nitro group at the 6 position have been synthesized and an improved method for nitrating pyrroles using potassium nitrate in trifluoroacetic acid was developed. An efficient, two-step synthesis of the butterfly pheromone, Danaidone, was also developed with an overall 33% yield. 相似文献
12.
Perspectives in nonsteroidal anti-inflammatory agents 总被引:1,自引:0,他引:1
T Y Shen 《Angewandte Chemie (International ed. in English)》1972,11(6):460-472
Among numerous nonsteroidal anti-imflammatory agents synthesized in the past few years, various analogs of indomethacin, phenylacetic acid and heteroarylacetic acid have reached the stage of clinical evaluation. Their biochemical mechanisms of action are exemplified by the broad activity profile of indomethacin which includes inhibition of mediators and enzymes, effects on cell membranes, and, most recently, inhibition of prostaglandin biosynthesis. The importance of pharmacodynamic properties to clinical efficacy was clearly demonstrated in some cases. Several candidates were eliminated because of their side-effects. A group of α-methylarylacetic acids showed a high degree of stereospecificity in their potency and metabolisms in vivo, as well as inhibition of prostaglandin synthetase and albumin binding in vitro. Extrinsic Cotton effect provides a sensitive technique in the study of interactions of these drugs with biopolymers. Competitive binding and antagonistic interactions between nonsteroidal drugs, particularly salicylate, were observed in vitro and in vivo. Progress in salicylate research was marked by the synthesis of flufenisal as a new derivative with enhanced potency and longer duration of action. Several fenamate analogs and new chemical types have shown promise in preliminary clinical trials. Various immunological approaches are under investigation for the treatment of rheumatoid arthritis. Newer concepts are still needed to achieve more effective control of arthritic disorders. 相似文献
13.
Scalia S 《Journal of chromatography. A》2000,870(1-2):199-205
A rapid supercritical fluid extraction (SFE) procedure for the isolation of five of the most common sunscreen agents (2-ethylhexyl-p-dimethylaminobenzoate, 2-hydroxy-4-methoxybenzophenone, 2-ethylhexyl-p-methoxycinnamate, 4-methylbenzylidene camphor and 4-tert.-butyl-4′-methoxydibenzoylmethane) from cosmetic products is described. Investigation of the factors affecting the extraction efficiency in SFE indicated that sunscreen recoveries were affected mainly by the supercritical CO2 pressure and by the trapping method. The sunscreens were analyzed by reversed-phase high-performance liquid chromatography after a 10-min extraction of the cosmetic product with CO2 at 250 bar and 40°C, using sequential glass surface and C18 sorbent as collection system. A quantitative comparison of SFE with a liquid extraction procedure was performed on commercial cosmetics. The SFE method yielded recoveries higher than 94.8% compared with conventional liquid extraction and exhibited a precision better than 5.3% relative standard deviation. Moreover, SFE minimized sample handling, reduced the consumption of harmful solvents and afforded a more effective purification of the cosmetic matrices. 相似文献
14.
Zhang AH Jiang N Gu W Ma J Wang YR Song YC Tan RX 《Chemistry (Weinheim an der Bergstrasse, Germany)》2010,16(48):14479-14485
(-)-Alternarlactam [(-)-1], a new promising cytotoxin against two human cancer cell lines, was isolated from an endophyte culture and synthesized (along with (+)-1) from readily available starting materials. The absolute configuration, chirality-activity relevance and self-aggregation of (-)-1 were assigned by a combination of synthetic, spectroscopic and computational approaches. The full characterization of the new fungal cytotoxin may provide valuable information in the discovery of new antitumor agents. 相似文献
15.
In Situ Proteome Profiling and Bioimaging Applications of Small‐Molecule Affinity‐Based Probes Derived From DOT1L Inhibitors 下载免费PDF全文
Biwei Zhu Dr. Hailong Zhang Sijun Pan Chenyu Wang Dr. Jingyan Ge Prof. Dr. Jun‐Seok Lee Prof. Dr. Shao Q. Yao 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(23):7824-7836
DOT1L is the sole protein methyltransferase that methylates histone H3 on lysine 79 (H3K79), and is a promising drug target against cancers. Small‐molecule inhibitors of DOT1L such as FED1 are potential anti‐cancer agents and useful tools to investigate the biological roles of DOT1L in human diseases. FED1 showed excellent in vitro inhibitory activity against DOT1L, but its cellular effect was relatively poor. In this study, we designed and synthesized photo‐reactive and “clickable” affinity‐based probes (AfBPs), P1 and P2 , which were cell‐permeable and structural mimics of FED1 . The binding and inhibitory effects of these two probes against DOT1L protein were extensively investigated in vitro and in live mammalian cells (in situ). The cellular uptake and sub‐cellular localization properties of the probes were subsequently studied in live‐cell imaging experiments, and our results revealed that, whereas both P1 and P2 readily entered mammalian cells, most of them were not able to reach the cell nucleus where functional DOT1L resides. This offers a plausible explanation for the poor cellular activity of FED1 . Finally with P1 / P2 , large‐scale cell‐based proteome profiling, followed by quantitative LC‐MS/MS, was carried out to identify potential cellular off‐targets of FED1 . Amongst the more than 100 candidate off‐targets identified, NOP2 (a putative ribosomal RNA methyltransferase) was further confirmed to be likely a genuine off‐target of FED1 by preliminary validation experiments including pull‐down/Western blotting (PD/WB) and cellular thermal shift assay (CETSA). 相似文献
16.
17.
Platinum(II)–Gadolinium(III) Complexes as Potential Single‐Molecular Theranostic Agents for Cancer Treatment 下载免费PDF全文
Zhenzhu Zhu Prof. Dr. Xiaoyong Wang Dr. Tuanjie Li Prof. Dr. Silvio Aime Prof. Dr. Peter J. Sadler Prof. Dr. Zijian Guo 《Angewandte Chemie (International ed. in English)》2014,53(48):13225-13228
Theranostic agents are emerging multifunctional molecules capable of simultaneous therapy and diagnosis of diseases. We found that platinum(II)–gadolinium(III) complexes with the formula [{Pt(NH3)2Cl}2GdL](NO3)2 possess such properties. The Gd center is stable in solution and the cytoplasm, whereas the Pt centers undergo ligand substitution in cancer cells. The Pt units interact with DNA and significantly promote the cellular uptake of Gd complexes. The cytotoxicity of the Pt–Gd complexes is comparable to that of cisplatin at high concentrations (≥0.1 mM ), and their proton relaxivity is higher than that of the commercial magnetic resonance imaging (MRI) contrast agent Gd–DTPA. T1‐weighted MRI on B6 mice demonstrated that these complexes can reveal the accumulation of platinum drugs in vivo. Their cytotoxicity and imaging capabilities make the Pt–Gd complexes promising theranostic agents for cancer treatment. 相似文献
18.
Keelara Abiraj Dr. Rosalba Mansi Dr. Maria‐Luisa Tamma Flavio Forrer Dr. Renzo Cescato Dr. Jean Claude Reubi Prof. Kayhan G. Akyel Helmut R. Maecke Prof. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2010,16(7):2115-2124
Owing to its optimal nuclear properties, ready availability, low cost and favourable dosimetry, 99mTc continues to be the ideal radioisotope for medical‐imaging applications. Bifunctional chelators based on a tetraamine framework exhibit facile complexation with Tc(V)O2 to form monocationic species with high in vivo stability and significant hydrophilicity, which leads to favourable pharmacokinetics. The synthesis of a series of 1,4,8,11‐tetraazaundecane derivatives ( 01 – 06 ) containing different functional groups at the 6‐position for the conjugation of biomolecules and subsequent labelling with 99mTc is described herein. The chelator 01 was used as a starting material for the facile synthesis of chelators functionalised with OH ( 02 ), N3 ( 04 ) and O‐succinyl ester ( 05 ) groups. A straightforward and easy synthesis of carboxyl‐functionalised tetraamine‐based chelator 06 was achieved by using inexpensive and commercially available starting materials. Conjugation of 06 to a potent bombesin‐antagonist peptide and subsequent labelling with 99mTc afforded the radiotracer 99mTc‐N4‐BB‐ANT, with radiolabelling yields of >97 % at a specific activity of 37 GBq μmol?1. An IC50 value of (3.7±1.3) nM was obtained, which confirmed the high affinity of the conjugate to the gastrin‐releasing‐peptide receptor (GRPr). Immunofluorescence and calcium mobilisation assays confirmed the strong antagonist properties of the conjugate. In vivo pharmacokinetic studies of 99mTc‐N4‐BB‐ANT showed high and specific uptake in PC3 xenografts and in other GRPr‐positive organs. The tumour uptake was (22.5±2.6) % injected activity per gram (% IA g?1) at 1 h post injection (p.i.). and increased to (29.9±4.0) % IA g?1 at 4 h p.i. The SPECT/computed tomography (CT) images showed high tumour uptake, clear background and negligible radioactivity in the abdomen. The promising preclinical results of 99mTc‐N4‐BB‐ANT warrant its potential candidature for clinical translation. 相似文献
19.
综述了核磁共振技术对映体纯度测定中的应用,它包括三个方面:(1)手性衍生剂法;(2)手性镧系位移试剂法;(3)手性溶剂法,对三种方法的测定机理和特点也做了讨论,全文共65篇参考文献。 相似文献
20.
Krutagn Patel Bhavesh Bharatiya Tulsi Mukherjee Tejal Soni Atindra Shukla B. N. Suhagia 《Journal of Dispersion Science and Technology》2017,38(5):626-631
The stability of silver nanoparticles is controlled mainly by two major factors, namely, aggregation and oxidation. In the present study, silver nanoparticles were synthesized by using different series of reducing agents like a strong reducing agent (sodium borohydride), a mild reducing agent (tri-sodium citrate), and a weak reducing agent (glucose) with different capping agents, namely, polyvinyl pyrrolidone (PVP K 30), starch, and sodium carboxyl methyl cellulose (NaCMC). The synthesized silver nanoparticles were characterized by UV-Visible absorption spectroscopy, dynamic light scattering (DLS), atomic force microscopy (AFM), and anti-microbial activity. The particle size of silver nanoparticles varies in the following order: sodium borohydride < tri-sodium citrate < glucose. Combination of sodium borohydride–polyvinyl pyrrolidone and tri-sodium citrate-polyvinyl pyrrolidone yields stable silver nanoparticles compared to other combinations of reducing agents and capping agents. The stability results confirmed that a refrigerated condition (8°C) was more suitable for storage of silver nanoparticles. Anti-microbial activity of silver nanoparticles synthesized in a sodium borohydride–polyvinyl pyrrolidone mixture shows a larger zone of inhibition compared to other silver nanoparticles. Anti-microbial results confirmed that the anti-microbial activity is better with smaller particle size. The size and stability of silver nanoparticles in the presence of different combinations of stabilizing and capping agents are reported. 相似文献