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I. V. Ukrainets P. A. Bezuglyi O. V. Gorokhova V. I. Treskach A. V. Turov 《Chemistry of Heterocyclic Compounds》1993,29(1):92-94
Condensation of 1-R-3-carbethoxy-4-hydroxy-2-quinolones with o-phenylene diamine gives the corresponding 1-R-3-(2-benzimidazolyl)-4-hydroxy-2-quinolones. Data on a study of the antithyroid activity of the synthesized compounds is presented.For Communication 6, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 105–108, January, 1993.We express our sincere thanks to A. A. Kirichenko and T. S. Bozhko for the study of the antithyroid activity. 相似文献
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The addition of substituted anilines to methyl propiolate produces labile cis-trans mixtures of enamines which can be isomerized by acid, solvent variation, and thermal techniques. Thermal cyclization of these enamines provides a synthesis of 4( lH)-quinolones. 相似文献
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Veinberg G. A. Petrulyanis L. N. Lukevits É. Ya. 《Chemistry of Heterocyclic Compounds》1982,18(2):111-123
The principal pathways of modification of -lactam antibiotics by means of silyl methods, including silylation, the preparation of N-acyl and amide analogs of penicillin and cephalosporin, the deacylation of N-protective groups, the epimerization of the side chain, the transformation of penicillin to cephalosporin, and other transformations, are examined.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 147–162, February, 1982. 相似文献
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I. V. Ukrainets L. A. Grinevich A. A. Tkach O. V. Gorokhova V. N. Kravchenko G. Sim 《Chemistry of Heterocyclic Compounds》2011,46(11):1364-1370
A series of benzimidazol-2-ylamides of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids was prepared in a search for
biologically active compounds. These compounds exist in the crystal exclusively in the amide form, while in solution amide↔imide
tautomerism is observed. The results of a study of the antithyroid and antituberculosis activities of these compounds are
given. 相似文献
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A review of the isolation, biological activity and synthesis of pyranonaphthoquinones and closely related compounds is provided. 相似文献
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I. V. Ukrainets A. A. Davidenko E. V. Mospanova L. V. Sidorenko E. N. Svechnikova 《Chemistry of Heterocyclic Compounds》2010,46(5):559-568
We have carried out the synthesis and a comparative analysis of the acidic properties of a large group of 4-R-2-oxo-1,2-dihydroquinoline-3-carboxylic
acids. Features of the recorded NMR spectra of these compounds are discussed together with their analgesic properties. 相似文献
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I. V. Ukrainets N. L. Bereznyakova V. A. Parshikov O. V. Gorokhova 《Chemistry of Heterocyclic Compounds》2008,44(12):1493-1499
A simple and efficient method for preparing 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkyl amides is proposed.
The results of a study of the diuretic activity of the compounds synthesized are reported.
*For communication 149 see [1].
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1841-1848, December, 2008. 相似文献
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The cycloacylation of aniline derivatives to 4-quinolones in the presence of Eaton's reagent is described. This high-yielding methodology is applicable to a wide variety of functionalized anilines and requires milder conditions than those traditionally employed. This cyclization protocol is used to prepare a host of heterocycles and bis-quinolones and is characterized by relatively low reaction temperature and ease of product isolation. 相似文献
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Russian Chemical Bulletin - The review addresses the synthetic potential of cations or hydrols of (aza,thio)xanthenes in reactions with primary and secondary amines and imines. The diversity of... 相似文献
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I. V. Ukrainets N. L. Bereznyakova O. V. Gorokhova S. V. Shishkina 《Chemistry of Heterocyclic Compounds》2009,45(10):1241-1247
Independently of the reaction conditions N-allylisatin forms only the 2,3-dibromo derivative upon treatment with molecular
bromine in contrast to N-allyl-substituted quinolin- or pyrid-2-ones which readily undergo halocyclization to the corresponding
2-bromomethyl oxazoles. 相似文献
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Thomas Kappe Abdel S. Karem Wolfgang Stadlbauer 《Journal of heterocyclic chemistry》1988,25(3):857-862
Malondianilides 3 derived from dichloro substituted anilines 2 undergo cyclization to afford 4-hydroxy-2(1H)-quinolones 4 in very good yields using methane sulfonic acid-phosphorus pentoxide as catalyst. 3,4-Dichloro anilines 5 can be shown to yield two isomers, 7 and 8 , whereas 3-substituted anilines 9 afford merely 7-substituted 4-hydroxy-2(1H)-quinolones 11. 相似文献
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Singh BK Bhojak N Mishra P Garg BS 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》2008,70(4):758-765
Complexes of Cu(II) with bioactive carboxyamide ligands N',N'-bis(3-carboxy-1-oxoprop-2-enyl)2-amino-N-arylbenzamidine, N',N'-bis(3-carboxy-1-oxopropanyl)2-amino-N-arylbenzamidine and N',N'-bis(3-carboxy-1-oxophenelenyl)2-amino-N-arylbenzamidine have been synthesized and characterized by various physico-chemical techniques. Mass spectrum explains the successive degradation of the molecular species in solution and justifies ML complexes. Vibrational spectra indicate coordination of amide and carboxylate oxygen of the ligands along with water molecules. Electronic spectra and magnetic susceptibility measurements reveal octahedral geometry for Cu(II) complexes. The EPR of the reported complex show g( parallel)>g( perpendicular)>2.0023 and G value within the range 2.08-4.49 are consistent with [Formula: see text] ground state in an octahedral geometry. The voltammogram of the copper(II) complex shows a quasi-reversible redox process and a simple one electron process assignable to the Cu(II)/Cu(I) couple. Kinetic and thermodynamic parameters were computed from the thermal data using Coats and Redfern method, which confirm first order kinetics. The bio-efficacy of the ligands and its copper complexes have been examined against the growth of bacteria and pathogenic fungi in vitro to evaluate their antimicrobial potential. The results indicate that the ligand and its metal complexes possess notable antimicrobial properties. 相似文献
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Aubry C Jenkins PR Mahale S Chaudhuri B Maréchal JD Sutcliffe MJ 《Chemical communications (Cambridge, England)》2004,(15):1696-1697
The first biologically active non-planar analogues of the toxic anti-cancer agent, fascaplysin, have been produced; we present the design, synthesis and biological activity of three tryptamine derivatives. 相似文献