共查询到17条相似文献,搜索用时 109 毫秒
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贫电子环丙烷衍生物1以精制四氢呋喃为溶剂, 与2-巯基苯骈噻唑(2)封管加热反应, 得到产物3和4. 产物3经IR, MS, 1H NMR, 13C NMR和元素分析等数据确定其结构为: (R)-β-取代-(R)-γ-(2-巯基)苯骈噻唑基-γ-对位取代苯基丁酸或(S)-β-取代-(S)-γ-(2-巯基)苯骈噻唑基-γ-对位取代苯基丁酸(3); 产物4通过IR, MS, 1H NMR, 13C NMR, 2D-NOESY谱和元素分析等数据确定其结构为: 反式-β-取代-γ-对位取代苯基-3-丁烯酸(4). 对生成产物的机理也进行了推测. 相似文献
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本文报道稳定胂叶立德与异氰酸苯酯反应时,在胂叶立德的亚甲基碳原子上发生N-苯胺甲酰化,并得到相应的稳定双羰基胂叶立德.经元素分析,IR和^1HNMR鉴定,确证了产物的结构. 相似文献
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Min CHEN Rong QIAN Hai‐Yan JIANG Xiang ZHANG Jing ZHOU Wei‐Guo CAO Yin‐Long GUO 《中国化学》2008,26(5):923-928
Electrospray ionization mass spectrometry (ESI‐MS) was utilized to perform monitoring of the intermediates in the reaction of 1,2,3‐trisubstituted electron‐deficient cyclopropane derivatives, cis‐1‐thien‐2′‐oyl‐2‐(p‐subustituted phenyl‐6,6‐dimethyl)‐5,7‐dioxaspiro[2.5]‐4,8‐octadiones, with methanol. Key intermediates, either cationic or protonated forms of neutral species, were intercepted and characterized by ESI‐MS and its tandem version (ESI‐MS/MS). Therefore, the mechanism of the ring‐opening process for electron‐deficient cyclopropane derivatives was fully confirmed by the intermediates monitored. 相似文献
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Abstract N-Aryl-trans,trans-α-carboxyl-β-benzoyl-γ-aryl-γ-butyrolactams were synthesized in high yields with high stereoselectivity by the reaction of electron-deficient cyclopropane derivatives, cis-1-benzoyl-2-aryl-6,6-dimethyl-5,7-dioxo-spiro-[2 5]-4,8-octadiones, with aromatic amines. The reaction mechanism was proposed. 相似文献
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Reaction of electron deficient cyclopropane derivatives cis‐1‐methoxycarbonyl‐2‐aryl‐6, 6‐dimethyl‐5, 7‐dioxa‐spiro‐[2,5]‐4,8‐octadiones (1a‐d) (X = CH3, H, Cl, NO2) with anilines (2a‐e) (Y = p‐CH3, H, p‐Br, p‐NO2, o‐CH3) at room temperature gives N‐aryl‐trans, trans‐α‐carboxyl‐β‐methoxycarbonyl‐γ‐aryl‐γ‐butyrolactams (3a‐p) in high yields with high stereoselectivity. For example, 1a (X= CH3) reacts with ammonia 4 or benzyl amine 5 at room temperature to give inner ammonium salt 6 or 7 in the yield of 83% or 97% respectively. The reaction mechanisms for formation of the products are proposed. 相似文献
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In the presence of KF·2H2O, furoylmethyltriphenylarsonium bromide (1a) or thienoylmethyltriphenylarsonium bromide (1b) reacted with 2-[(un)substituted benzylidene]malononitrile (2) in chloroform at room temperature to give trans-3,3-dicyano-1-furoyl-2-[(un)substituted phenyl]cyclopropane (3a) or trans-3,3-dicyano-1-thienoyl-2- [(un)substituted phenyl]cyclopropane (3b) respectively in good yield with high stereoselectivity. The structures of product 3 were confirmed by IR, MS, 1^H NMR, 1^H-1^H COSY and microanalysis. The relative configuration of product 3 was determined by 1^H-1^H NOESY technique. The mechanism for the formation of product 3 was also proposed. 相似文献
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A facile and highly stereoselective methodology for the preparation of highly functionalized trans-1,2-cyclopropanes containing benzoimidazolyl, cyano, aryl, and carbonyl groups 3 is described. Arsonium bromides 2 reacted with electron-deficient olefins 1 in the presence of KF·2H2O to provide 3 exclusively with high stereoselectivity in moderate to good yields. 相似文献
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溴化(a-噻吩甲酰基)甲基三苯鉮1与3-取代苯甲叉基-2,4-戊二酮 2以碳酸钾为碱,在苯中55℃条件下反应,可以较好的收率、高立体选择性地生成反-2-(a-噻吩甲酰基)-3-取代苯基-4-乙氧羰基-5-甲基-2,3-二氢呋喃3。产物结构均经波谱予以确定。本文还提出了生成产物的可能机理。 相似文献