共查询到20条相似文献,搜索用时 821 毫秒
1.
Hans Blom Daniel Rönnlund Lena Scott Zuzana Spicarova Jerker Widengren Alexander Bondar Anita Aperia Hjalmar Brismar 《BMC neuroscience》2011,12(1):16
Background
The Na+,K+-ATPase plays an important role for ion homeostasis in virtually all mammalian cells, including neurons. Despite this, there is as yet little known about the isoform specific distribution in neurons. 相似文献2.
Background
It is well known that neurons of the peripheral nervous system have the capacity to regenerate a severed axon leading to functional recovery, whereas neurons of the central nervous system do not regenerate successfully after injury. The underlying molecular programs initiated by axotomized peripheral and central nervous system neurons are not yet fully understood. 相似文献3.
Background
Development of a functional retina depends on regulated differentiation of several types of neurons and generation of a highly complex network between the different types of neurons. In addition, each type of retinal neuron includes several distinct morphological types. Very little is known about the mechanisms responsible for generating this diversity of retinal neurons, which may also display specific patterns of regional distribution. 相似文献4.
Bahman N Shokouhi Bernadette ZY Wong Samir Siddiqui A Robert Lieberman Gregor Campbell Koujiro Tohyama Patrick N Anderson 《BMC neuroscience》2010,11(1):13
Background
Microglia/macrophages and lymphocytes (T-cells) accumulate around motor and primary sensory neurons that are regenerating axons but there is little or no microglial activation or T-cell accumulation around axotomised intrinsic CNS neurons, which do not normally regenerate axons. We aimed to establish whether there was an inflammatory response around the perikarya of CNS neurons that were induced to regenerate axons through a peripheral nerve graft. 相似文献5.
Background
The capsaicin (vanilloid) receptor, VR1, is an agonist-activated ion channel expressed by sensory neurons that serves as a detector of chemical and thermal noxious stimuli. 相似文献6.
Background
Iron is necessary for neuronal function but in excess generates neurodegeneration. Although most of the components of the iron homeostasis machinery have been described in neurons, little is known about the particulars of their iron homeostasis. In this work we characterized the response of SH-SY5Y neuroblastoma cells and hippocampal neurons to a model of progressive iron accumulation. 相似文献7.
Daron Geldwert Madison J Norris Igor G Feldman Joshua J Schulman Myra P Joyce Stephen Rayport 《BMC neuroscience》2006,7(1):53-16
Background
The striatal complex is the major target of dopamine action in the CNS. There, medium-spiny GABAergic neurons, which constitute about 95% of the neurons in the area, form a mutually inhibitory synaptic network that is modulated by dopamine. When put in culture, the neurons reestablish this network. In particular, they make autaptic connections that provide access to single, identified medium-spiny to medium-spiny neuron synaptic connections. 相似文献8.
Background
Synchronization of action potentials between neurons is considered to be an encoding process that allows the grouping of various and multiple features of an image leading to a coherent perception. How this coding neuronal assembly is configured is debated. We have previously shown that the magnitude of synchronization between excited neurons is stimulus-dependent. In the present investigation we compare the levels of synchronization between synchronizing individual neurons and the synchronizing pool of cells to which they belong. 相似文献9.
Li Nan Zhang Su Wen Su Fang Guo Hui Cai Guo Xiao Lu Shi Wen Ya Li Xu Liu Yong Li Wang 《BMC neuroscience》2012,13(1):10
Background
The aim of this study was to investigate whether serotonin (5-hydroxytryptamine, 5-HT) can modulate Na+/K+ pump in rat hippocampal CA1 pyramidal neurons. 相似文献10.
Xinkun Wang Asma Zaidi Ranu Pal Alexander S Garrett Rogelio Braceras Xue-wen Chen Mary L Michaelis Elias K Michaelis 《BMC neuroscience》2009,10(1):12-20
Background
Oxidative stress (OS) is an important factor in brain aging and neurodegenerative diseases. Certain neurons in different brain regions exhibit selective vulnerability to OS. Currently little is known about the underlying mechanisms of this selective neuronal vulnerability. The purpose of this study was to identify endogenous factors that predispose vulnerable neurons to OS by employing genomic and biochemical approaches. 相似文献11.
Hiroko N Beck Karen Drahushuk David B Jacoby Dennis Higgins Pamela J Lein 《BMC neuroscience》2001,2(1):12-11
Background
BMP-5 is expressed in the nervous system throughout development and into adulthood. However its effects on neural tissues are not well defined. BMP-5 is a member of the 60A subgroup of BMPs, other members of which have been shown to stimulate dendritic growth in central and peripheral neurons. We therefore examined the possibility that BMP-5 similarly enhances dendritic growth in cultured sympathetic neurons. 相似文献12.
Mallika Somayajulu-Ni?u Jagdeep K Sandhu Jerome Cohen Marianna Sikorska TS Sridhar Anca Matei Henryk Borowy-Borowski Siyaram Pandey 《BMC neuroscience》2009,10(1):88
Background
Parkinson's disease, for which currently there is no cure, develops as a result of progressive loss of dopamine neurons in the brain; thus, identification of any potential therapeutic intervention for disease management is of a great importance. 相似文献13.
Heinrich JG Matthies Qiao Han Angela Shields Jane Wright Jessica L Moore Danny G Winder Aurelio Galli Randy D Blakely 《BMC neuroscience》2009,10(1):65-19
Background
Reuptake of synaptic norepinephrine (NE) via the antidepressant-sensitive NE transporter (NET) supports efficient noradrenergic signaling and presynaptic NE homeostasis. Limited, and somewhat contradictory, information currently describes the axonal transport and localization of NET in neurons. 相似文献14.
Background
Genetically manipulated embryonic stem (ES) cell derived neurons (ESNs) provide a powerful system with which to study the consequences of gene manipulation in mature, synaptically connected neurons in vitro. Here we report a study of focal adhesion kinase (FAK), which has been implicated in synapse formation and regulation of ion channels, using the ESN system to circumvent the embryonic lethality of homozygous FAK mutant mice. 相似文献15.
Background
Mutations, toxic insults and radiation exposure are known to slow or arrest the migration of cortical neurons, in most cases by unknown mechanisms. The movement of migrating neurons is saltatory, reflecting the intermittent movement of the nucleus (nucleokinesis) within the confines of the plasma membrane. Each nucleokinetic movement is analogous to a step. Thus, average migration speed could be reduced by lowering step frequency and/or step distance. 相似文献16.
Background
Propriospinal neurons, with axonal projections intrinsic to the spinal cord, have shown a greater regenerative response than supraspinal neurons after axotomy due to spinal cord injury (SCI). Our previous work focused on the response of axotomized short thoracic propriospinal (TPS) neurons following a low thoracic SCI (T9 spinal transection or moderate spinal contusion injury) in the rat. The present investigation analyzes the intrinsic response of cervical propriospinal neurons having long descending axons which project into the lumbosacral enlargement, long descending propriospinal tract (LDPT) axons. These neurons also were axotomized by T9 spinal injury in the same animals used in our previous study. 相似文献17.
Hong Sun Jian Xu Kimberly B Della Penna Robert J Benz Fumi Kinose Daniel J Holder Kenneth S Koblan David L Gerhold Hao Wang 《BMC neuroscience》2002,3(1):11-12
Background
Neurons in the dorsal spinal cord play important roles in nociception and pain. These neurons receive input from peripheral sensory neurons and then transmit the signals to the brain, as well as receive and integrate descending control signals from the brain. Many molecules important for pain transmission have been demonstrated to be localized to the dorsal horn of the spinal cord. Further understanding of the molecular interactions and signaling pathways in the dorsal horn neurons will require a better knowledge of the molecular neuroanatomy in the dorsal spinal cord. 相似文献18.
Background
The mammalian suprachiasmatic nucleus (SCN) is composed of heterogeneous sub-groups of neurons that are organized into a neural system for the control of circadian physiology and behaviour. Molecular circadian 'clocks' are not an exclusive property of SCN neurons but the unique role of the SCN as a central integrative pacemaker is associated with specialized aspects of neuronal organization. Current studies are aimed at identifying the functional components of this hypothalamic integrative centre. 相似文献19.
Carola Krüger Rico Laage Claudia Pitzer Wolf-Rüdiger Schäbitz Armin Schneider 《BMC neuroscience》2007,8(1):88
Background
Granulocyte-macrophage colony stimulating factor (GM-CSF) is a hematopoietic growth factor involved in the generation of granulocytes, macrophages, and dendritic cells from hematopoietic progenitor cells. We have recently demonstrated that GM-CSF has anti-apoptotic functions on neurons, and is neuroprotective in animal stroke models. 相似文献20.