Diterpenoids from Isodon sculponeatus

Further investigation on the leaves of Isodon sculponeatus afforded two new ent-kaurane diterpenoids,sculponeatins J and K .Their sturctures were elucidated on the basis of their spectral properties,as well as X-ray crystallographic analysis ,The cytotoxicities of these two new compounds against human tumor cells K562 and T24 were also tested ,and sculponeation J showed significant inhibitory effects with IC50 values less than 1.0 μg/mL。     

Diterpenoids from Isodon Eriocalyx

Two new diterpenoids, Maoecrystal U and epi‐maoecrystal P , together with nine known diterpenoids and eight other known compounds were isolated from Isodon eriocalyx ( ). The structures of two new diterpenoids were elucidated as 6β‐acetoxy‐15β‐hydroxy‐3α,20‐epoxy‐ent‐kaur‐16‐ene‐1,7‐dione and 16(S)‐methoxymethy‐6β,7β‐dihydroxy‐7α,20‐epoxy‐ent‐kaur‐2,3‐ethenylene‐1,15‐dione on the basis of spectroscopic evidence, especially by 2D NMR techniques.     

Three New Diterpenoids from Isodon nervosus

Three new ent‐kaurane diterpenoids, rabdonervosins D–F ( 1 – 3 ), were isolated from the leaves and stems of Isodon nervosus. Their structures were elucidated on the basis of spectroscopic methods including 1D‐ and 2D‐NMR analyses. Compounds 1 – 3 were evaluated for their cytotoxicity against HepG2, CNE2, PC‐9/ZD, HeLa, MCF‐7, and HCT116 cell lines. No compounds exhibited potent cytotoxicity.     

Two New Diterpenoids from Isodon rubescens

In order to further study on minor diterpenoid constituents of lsodon rubescens, wereinvestigated this species, which was collected in Taibai mountain, Shaanxi Province.TWo new diterpenoids, taibairubescensins A (l) and B (2), were isolated. In this paper,we present the structure elucidation of these two new diterpenoids.Taibairubescensin A (l ), C,.H,#O, (FABMS m/z 435[M 11 ), an amorphous powder,showed UV and iR absorption bands for the existence of hydroxyl, acetoxyl and a fivemembe…     

Four New Diterpenoids from Isodon leucophylla

IsodonleucoPhyll(Dunn)Hara(Labiatae),distributedinthenorthwestareaofYunnanProvince,isusedasfolkmedicineforitsantibacterialandanti-inflanimatoryactivitybylocalpractitioners'.Fromtheleavesofthisplant,fournewent-kauranetypediterPenoids,baiyecrystalA'C1'3andePi-baiyecrystalC4,wereisolated.Thispaperpresentstheirsimctureelucidation.BaiyecrystalA1C26H34O1owasdeterminedbyHRMS(5O6.2157,calc5o6.2l52).Itsmassspectrumshowedthatthemolecularion(wt5O6)was58amumorethanthatofeffusaninD5',aknownkaureno…     

Three New Diterpenoids from Isodon Eriocalyx

Isodoneriocalyxisknowntoberichinent-kaurenoids.Inspiteofthatmanyent-kaurenoidswereisolated,newent-kaurenoidswerestillisolatedfromcollectionindifferentregions'-,o.FromthedriedleavesofthisspeciescollectedinHeqingcounty,Yunnan,threenewcompounds,eriocalyxinsC-El-3,wereisolated.Inthispaper,wereportthestructureelucidationofthesenewcompoundsbyspectralanalysis.EriocaIyxinClC22H2sO7(HRMS4O4.l825calc4O4.1835),ElMS(7OeV)In/z(reI.Int%)t4O4[M1 (lO),386[M-H2O] 'lO),368IM-2H,O] (2O),344(l00),32…     

Two New ent-Kaurane Diterpenoids from Isodon xerophilus

In continuation of our research on diterpenoids in the Isodon species, several newcompounds"' were obtained from the leaves oflsodon xerophilus (C. Y. Wu et H. W. Li)H. Hara (Labiatae), a perennial shrub native to Yunnan province. Further fractionation ofthe EtOAc extract led to the isolation of tWo new enl-kauranoids, xerophilusin E (l) andxerophilusin F (2). This paper deals with the structUral elucidation of the newcompounds.Xerophilusin E (l), a minor constitUent, was obtained as p…     

Diterpenoids from the gum resin of Boswellia carterii and their biological activities

Seven new diterpenoids, classified as three cembrane-type diterpenoids boscartins I-K (1–3) and four prenylaromadendrane-type diterpenoids boscartols K-N (4–7), respectively, along with nine known diterpenoids, were isolated from the gum resin of Boswellia carterii. Their structure elucidations were achieved by spectroscopic examination. All isolates were evaluated for anti-inflammatory activity against nitric oxide (NO) production and antiproliferative activity against MCF-7 human breast cancer cell in vitro. 4 and 5 exhibited potent inhibitory effects on NO production (IC₅₀ of 2.22 and 1.10?μM, respectively), with 11 showing moderate inhibition (IC₅₀ of 8.63?μM), and 12 and 15 demonstrated moderate antiproliferative effects against MCF-7?cell (IC₅₀ of 9.5, and 6.3?μM, respectively).     

Diterpenoids of Isodon macrophylla

Two new ent‐abietane diterpenoids, macrophynin E ( 1 ) and macrophynin F ( 2 ), and a known related ent‐abietanoid (?)‐lambertic acid ( 3 ), together with four known ent‐kauranoids, were isolated from the roots and aerial parts of Isodon macrophylla, respectively. The structures of the new compounds were elucidated on the basis of spectroscopic‐data analysis and chemical correlations.     

Two New ent—Kaurane Diterpenoids from Isodon japonica

Two new ent-kauranoids,named maoyecrystals A (1) and B(2),were isolated from the EtOAc extract of the dried leaves of Isodon japonica (Burman f.) Hara collected in Tongbai mountains ,Henan Province,Their structures were determined on the basis of spectral data,especially by 2D NMR.     

Two New ent-Kaurane Diterpenoids from Isodon adenantha

As a medicinal herb locally used for the treatment of enteritis and dysentery in Yunnan province2, Isodon adenantha (Diels) Hara has been previously studied, which led to the isolation of several ent-kaurane diterpenoids including a new one3-5. In continuation of our research on the bio-active constituents from Isodon species6, two new ent-kaurane diterpenoids, adenanthins B (1) and C (2), were isolated from I. adenantha collected in Dali, Yunnan. In this paper, we report the structural el…     

ent‐Kaurane Diterpenoids from Isodon japonicus

Two new 6,7‐seco‐ent‐kaurane diterpenoids, isojaponins A ( 1 ) and B ( 2 ), together with 18 known ent‐kaurane diterpenoids were isolated from the aerial parts of Isodon japonicus. The structures of the two new compounds were elucidated by extensive 1D‐ and 2D‐NMR spectroscopic methods in combination with MS experiments.     

ent‐Kaurane Diterpenoids from Isodon phyllostachys

Phytochemical investigation of the medicinal plant Isodon phyllostachys led to the isolation of four new ent‐kaurane diterpenoids, phyllostacins F–I ( 1 – 4 , resp.), together with 11 known compounds, rosthorin A ( 5 ), rabdoternin C ( 6 ), enmenol ( 7 ), oridonin ( 8 ), lasiocarpanin ( 9 ), xerophilusin B ( 10 ), ponicidin ( 11 ), macrocalin B ( 12 ), phyllostachysin A ( 13 ), sculponeatin C ( 14 ), and macrocalyxoformin E ( 15 ). The structures of the new compounds were established by spectroscopic methods, including extensive 1D‐ and 2D‐NMR analyses. Compounds 1, 2, 7, 10 , and 13 were evaluated for their inhibitory activity against K562 and HepG2 cell lines.     

Two New Diterpenoids and other Constituents from Isodon Nervosus

Two new ent‐kaurane diterpenoids, 15β‐hydroxy‐6,7‐seco‐6,11β:6,20‐diepoxy‐1α,7‐olide‐ent‐kaur‐16‐ene ( 1 ), 11α,15α‐dihydroxy‐6β‐methoxy‐6,7‐seco‐6,20‐epoxy‐1α,7‐olide‐ent‐kaur‐16‐ene ( 2 ), together with four known diterpenoids, nodosin ( 3 ), isodocarpin ( 4 ), odonicin ( 5 ) and maoyecrystal F ( 6 ) were isolated from the aerial parts of Isodon nervosus. The structures of the new compounds were elucidated on the basis of their spectral evidence, especially on 2D NMR.     

Two New Diterpenoids and Other Constituents from Isodon japonicus

Two new ent‐kaurene diterpenoids, 15α,20‐dihydroxy‐6,7‐seco‐entkaur‐16‐ene‐7,1α(6,11α)‐diolide ( 1 ), 6β‐butyroxy‐3β‐hydroxy‐6,7‐seco‐6,20‐epoxy‐7,1α‐olide‐entkaur‐16‐en‐15‐one ( 2 ), together with 25 known compounds, 3 – 27 , were isolated from the leaves of Isodon japonicus. Their structures were established by spectroscopic methods, including 2D‐NMR techniques.     

Immunosuppressive ent‐Kaurene Diterpenoids from Isodon serra

Three new enmein‐type ent‐kaurenoids, i.e., the two pairs 1 and 2 of 20‐epimers and the (20R)‐isomer 3 , besides the seven known diterpenoids 4 – 10 , were isolated from the aerial parts of Isodon serra. Their structures were elucidated by spectroscopic techniques and X‐ray diffraction. The immunosuppressive effect for T‐lymphocytes proliferation induced by Con A in BALB/c mouse was evaluated for the isolates 1 – 10 . They all displayed a remarkable inhibitory effect, with multi‐glycosides of Tripterygium wilfordii as positive reference substance (Table 3).     

贵州冬凌草的对映－贝壳杉烷二萜化合物

从贵州产冬凌草[Isodon rubescens (Hemsl.) Hera]中分离得到12个6，7－断 裂－7，20－内酯－对映－贝壳杉烷二萜化合物，经波谱分析鉴定了它们的结构， 其中有7个新化合物，分别命名为贵州冬凌草乙素～辛素（guidongnins B～H, 1～ 7)，以及卢氏冬凌草甲素（8）、卢氏冬凌草乙素（9）、贵州冬凌草素（10）、狭 叶香茶菜素(angustifolin, 11)和6－表香茶菜素（6-epiangustifolin, 12)等5个 已知化合物。另外，将作者原命名的贵州冬凌草素（guidongnin, 10）更名为贵州 冬凌草甲素(guidongnin A, 10)，并利用二维核磁区振波谱技术修订了卢氏冬凌草 乙素的结构。     

Two Novel ent‐Kaurene Diterpenoids from Isodon rubescens

A novel 20‐nor‐ent‐kaurene diterpenoid, rubescensin N ( 1 ), and a new 7,20‐epoxy‐ent‐kaurene diterpenoid, rubescensin O ( 2 ), along with the seven known diterpenoids rabdoternins A–F and xerophilusin N, were isolated from Isodon rubescens collected in Jiyuan prefecture, Henan Province, China. Their structures were established by extensive spectroscopic analysis. Compound 1 is the first example of a naturally occurring 20‐nor‐ent‐kaurene diterpenoid from the Isodon genus plants.     

Novel ent ‐Kaurane Diterpenoids from Isodon xerophilus

Further investigation on the leaves of Isodon xerophilus afforded three novel ent‐kaurane diterpenoids, xerophilusins D‐F (1–3), together with seven known compounds, phyllostachysin A (4), oleanolic acid, caffeic acid, rosmarinic acid, rutin, quercetin‐3‐O‐β‐D‐glucopyranoside, and quercetin. Structures of 1–3 were elucidated on the basis of their spectral properties and X‐ray crystallographic analysis. Compound 1 showed broad spectra inhibiting human tumor cells and significant cytotoxicity.