Synthesis and Crystal Structure of 3,3,6,6-Tetramethyl-N-hydroxy-9-ethyl-1,8-dioxo-1,2,3,4,5,6,7,8,9,10-decahydroacridine

1 INTRODUCTION 1,4-Dihydropyridines (1,4-DHPs) are well-knowncompounds because of their pharmacological pro-perty as calcium channel modulators[1, . The che- 2]mical modifications, such as the introduction of dif-ferent substituents[3, or heteroatoms[5], of the DHP 4]ring have allowed the expansion of researches onthe structure-activity relationship to gain new in-sights into the molecular interactions at the receptorlevel. In fact, it is well established th…     

Synthesis and Crystal Structure of 9-Pyridyl-1,8-dioxo-2,3,4,5,6,7-hexahydroxanthene

1 INTRODUCTION The Koevenagel condensation catalyzed by bases or Lewis acid has been the subject of many synthetic applications since its discovery[1] although the pre- sence of catalyst is not always indispensable[2]. Mo- reover, the reaction of aromatic aldehyde with 1,3- cyclohexanedione under different conditions afforded different products[3～6]. In continuing efforts for the application of 1,3-cyclohexanedione derivatives to construct new heterocycles with biological activi- ties[7…     

Synthesis and Crystal Structure of S,S''''-Bis(8-quinolyl)-1,8-dithiaoctane

1INTRODUCTIONPreviously,wehavereportedsomeflexiblemultidentateligands,suchasO,O?bis(8-quinolyl)-1,8-dioxaoctane(ODOQ)[1],1,5-bis(8-quinolylsul-fanyl)-3-oxapentane(OESQ)and1,8-bis(8-quino-lylsulfanyl)-3,6-dioxaoctane(ODSQ)[2,3]formAgcomplexeswitheithersinglestranddouble-helicalstructuresordiscretecageskeletons.SimilarligandscontainingSatomsarelikelytoplayimportantrolesintheformationofdiscretecage-moleculesinwhichthefoldingeffectofsulfuratomsaffordsthebackboneofthespacerperpendicularto…     

Synthesis and Crystal Structure of N-cyclopropyl-9 -（3,4-dicholophenyl）- 1,2,3,4,5,6,7,8,9,10-decahydroacridine -1,8-dione under Microwave Irradiation

1 INTRODUCTION aryl or methyl group to the nitrogen atom of these compounds leads to enhanced activities of fluo- A lot of natural and synthetic compounds con- rescence[7, . Since the pyridine scaffold is included 8] taining acridine skeletons display interesting biolo- in decahydroacridine-1,8-dione, a question is whether gical and physical activities[1]. Acridinedione, for the same modification on the nitrogen atom of de- example, has been identified as antimalarial and cahydroacridine-1…     

Synthesis and Crystal Structure of 9-（ 4-M e tho xylphen yl ）-1,8-dioxo-3,4,5,6,7,9hexahydroxanthene under Microwave Irradiation

1INTRODUCTIONInthepastfewyears,potassiumchannelacti-vatorshavegainedincreasingattentionbecauseoftheirclinicalpotentialapplicationsinvariousdiseases.Oneofthemostpotentcompoundsamongthisnewclassofdrugsisthebenzopyranderivativecroma-kalim[1～4].Benzopyranaswellasitsderivativesex-hibitsextensivepharmacologicalandbiologicalacti-vities[5],suchasantibacterialactivities[6,,antitumor7]activity[8],hypotensiveeffect[9],antiproliferationef-fect[10],etc.Thetitlecompoundbearingabenzo-pyranstructuraluni…     

Synthesis and Crystal Structure of Ethyl 2,7,7-Trimethyl-4-(4''''-methylphenyl)- 5-oxo-1,4,5,6,7,8-hexahydroquinoline-3- carboxylate in Aqueous Medium

1 INTRODUCTION The 1,4-dihydropyridines (1,4-DHPs) are biologi- cally interesting compounds and have been developed extensively in pharmacology. 1,4-DHP derivatives are used therapeutically in the treatment of cardio- vascular disorders, especially hypertension and coro- nary heart disease such as angina pectoris, atheros- clerosis, etc. The DHPs have emerged as one of the most important classes of drugs for the treatment of gastrointestinal disease, Raynaud?s disease, pulmonary hyper…     

Synthesis and Crystal Structure of 9-（4-Dimethylaminophenyl）-l,8-dioxo- 9H-dibenzo [c,h ]-2,7,10-trioxanthene

The title compound 9-(4-dimethylaminophenyl)-1,8-dioxo-9H-dibenzo[c,h]- 2,7,10-trioxanthene (3) was synthesized by the reaction of 4-hydroxycoumarin with 4-dimethyla- minobenzaldehyde, and its chemical structure was determined by X-ray single-crystal diffraction. It crystallizes in triclinic, space group P with a = 7.8753(16), b = 11.029(2), c = 12.913(3) , α = 69.79(3), β = 89.01(3), γ = 81.90(3)°, V = 1041.5(4) 3, Z = 2 , F(000) = 456, Dc = 1.395 Mg/m3, Mr = 437.43, μ = 0.097 mm-1, λ = 0.71073 , the final R = 0.0491 and wR = 0.1314 for 2662 observed reflections with I > 2σ(I).     

Synthesis and Crystal Structure of MnSm_4(SiO_4)_3O

ＳｙｎｔｈｅｓｉｓａｎｄＣｒｙｓｔａｌＳｔｒｕｃｔｕｒｅｏｆＭｎＳｍ_４（ＳｉＯ_４）_３Ｏ￥ＣｈｉＬｉ－Ｓｈｅｎｇ；ＤｅｎｇＳｈｕｉ－Ｑｕａｎ；ＺｈｕａｎｇＨｏｎｇ－Ｈｕｉ；ＨｕａｎｇＪｉｎ－Ｓｈｕｎ；（ＳｔａｔｅＨｅｙｌａｂｏｒａｔｏｒｙｏｆＳｔｒ?..     

Synthesis and Crystal Structure of 4-(N,N-Diphenylamino)styrene- 4′-N-methylpyridinium Iodine

The title compound 4-(N,N-diphenylamino)styrene-4′-N-methylpyridinium iodine (abbreviated to PASMPI) was synthesized by a facile condensation reaction with a high yield. The red crystal including a molecule of CHCl3 was obtained by recrystallization in chloroform/ethanol. Its crystal structure was determined by a four-circle diffractometer. The crystal data: C26H23N2ICHCl3, Mr = 609.73, orthorhombic, space group Pbca, a = 15.422(5), b = 14.042(5), c = 24.693(5) , V = 5347(3) 3, Z = 8, Dc = 1.515 g/cm3, F(000) = 2432, μ(MoKa) = 0.057 mm-1, the final R = 0.0439 and wR = 0.0772. The results reveal that the molecule is a completely reverse system. The molecular rotation from non-coplanar to coplanar may play an important role in increasing the fluorescence intensity under the condition of staining DNA.     

Synthesis and Crystal Structure of N-methyl- 9- （4-bromophenyl）-1,2,3,4,5,6,7,8,9,10- decahydroacridine- 1,8-dione under Microwave Irradiation

1 INTRODUCTION Since the discovery of pharmacological effectsof 1,4-dihydropyridine (1,4-DHPs) as calcium mo-dulators[1], a great deal of work has been directedtowards the synthesis of 1,4-DHPs acting as cal-cium antagonists[2]. The chemical modifications onthe DHP ring, such as the introduction of differentsubstituents on heteroatoms[3], have allowed theexpansion of researches on structure-activity rela-tionship to have new insight into the molecularinteractions at the receptor l…     

Synthesis,Characterization and X-ray Structure of N-(4-bromobutanoyl-N’-(2-3- and 4-methylphenyl)thiourea

N-4-(bromobutanoyl)-N'-(o-, m- and p-tolyl)thioureas 3a, 3b and 3c respectively, were synthesized by the reaction of 4-bromobutanoylisothiocyanate with p-, m- and o-toludine. The products were characterized by IR, and NMR spectroscopic techniques. The two carbonoylthiourea isomers N-(4-bromobutanoyl)-N'-(3-methylphenyl)thiourea(3b) and N-(4-bromobutanoyl)-N'-(4-methylphenyl)thiourea(3c) were obtained in crystalline form by recrystallization from DMSO. Xray crystallographic studies showed that both compounds 3b and 3c crystallize in triclinic system with space group of P1. The molecules adopt trans-cis configuration with respect to the positions of 4-bromobutanoyl and tolyl groups respectively, against the thiono C=S bond across their C–N bonds. The configuration is attributed by the intrahydrogen bond between the carbonyl oxygen and amide hydrogen atoms. Both crystal structures are stabilized by N–H···S intermolecular hydrogen bonds to form dimers and arranged along the b axis.     

Studies on Selena-Macrocyclic Amides Synthesis and Structural Characterization of 7-Phenyl-5, 9-dioxo-1-selena-4, 7, 10-triazacyclododecane and 6-(4-Nitrobenzyl )-5, 9-dioxo-1, 4, 7, 10-selenatriazacyclododecane

lmTR0DUCTI0NSincetheseleniumcoronandswereachivevedin1989tli,thesynthesisandcoor-dinationchemistrystudyofthismacrocycliccomPOundshavereceivedwideattentionowingtotheirstrongcomplexingabilitiestowardssoft.transiti0nandheavymetals.InourprevibuspaPer,wereP0rtedthecrystalstructureoftw0selenacrownethers(2'3)andaPd(1)complexwith10'selenabenzo-15-crown-5t4i.Duetothedifficultyofthepreparationsofselenium-nitr0genmixeddonorc0n-..tainingmacrocycles,thestudyontheseligandsisconsiderablyscarce.Thesynthes…     

Synthesis and Crystal Structure of 3-（4-Bromobenzyloxy）-6-morpholinopyridazine

The title compound 3-(4-bromobenzyloxy)-6-morpholinopyridazine(C15H16BrN3O2) was synthesized,and its crystal structure was studied.It crystallizes in the triclinic system,space group P with a = 8.3408(17),b = 8.8620(18),c = 10.832(2) ,α = 108.09(3),β = 91.28(3),γ = 100.90(3)°,Dc = 1.562 g/cm3,Z = 2,λ = 0.71073 ,μ(MoKα) = 2.769 mm-1,Mr = 350.22,V = 744.5(3) 3,F(000) = 356,the final R = 0.0522 and wR = 0.1366 for 2016 observed reflections with I > 2σ(I).In the crystal structure,the morpholine ring adopts a chair conformation with O(2) and N(3) atoms at the flap positions-0.656(7) and 0.622(6)  out of the mean plane formed by the other four C atoms,respectively.These molecules generate centro-symmetric dimers through intermolecular π-π interaction.     

Synthesis and Crystal Structure of E-4,4’-Bis(N,N-di-n-butylamino)stilbene

1 INTRODUCTION Two-photon absorption is a subject which attracts fast-growing interest in chemistry, photonics, and biological imaging fields in the past decades[1]. The two-photon techniques have wide applications, for example, optical power limiting[2], two-photon opti- cal memory[3], two-photon confocal imaging[4] and up-conversion laser[5]. Especially recently, the inte- rest has gradually been focused on studying two- photon initiated photopolymerization (TPIP) and exploring some pe…     

Synthesis and Crystal Structure of N,N′-4-aminomethyl-pyromellitic diimide

The title compound N,N′-4-aminomethyl-pyromellitic diimide (4-pmpmd) crystallizes in monoclinic, space group P21/c with a = 4.785(1), b = 6.200(1), c = 29.907(2) (A), β =93.583(11)°, V= 885.5(2) (A)3, Dc = 1.494 g/cm3, Z = 2, C22H14N4O4, Mr = 398.37,μ(MoKα) = 0.106mm-1 and F(000) = 412, and its structure was refined to R = 0.0469 and wR = 0.1017 for 1194observed reflections (Fo ＞ 4σ(Fo)). The X-ray diffraction shows the existence of the staggered multi-dimensional supramolecular network based on the Z-mode conformation of the title compound.     

Synthesis and Crystal Structure of N,N′-4-aminomethyl-pyromellitic diimide

1 INTRODUCTION N,N?-4-aminomethyl-pyromellitic diimide (4-pmpmdwas firstly obtained[1] in 1989 as one of the bypro-ducts by refluxing equimolar quantities of pyrome-llitic anhydride, n-hexylamine and 4-aminomethyl py-ridine in dry DMF to assemble electronic donor-spa-cer-acceptor systems, but its structure and coordina-tion chemistry did not receive attention at that time.For 4-pmpmd, the entity of two methylene groups(-CH2-) between the rigid pyromellitic diimide (PMDcore and two fre…     

Synthesis and Crystal Structure of Trichlorotetrakis(tetrahydrofuran) Europium

1INTRODUCTIONTheinvestigationofthestructureoforganolanthanidecompoundshasbeenofin-terestformanyyearsbeacuseitisimportanttointerpretthebondingandchemicalpropertiesoflanthanidecompounds.Toextendourknowledgeofmonoindenyldichlorolanthanides,thecompoundswithgeneralformula(C,H,)LnCI,(Ln~Eu,Ho)weresynthesizedandtheirstructuresweredetermined.Inanattempttoprepare(C,H:)EuCI,,afinecrystalEuCI,(OC.H,).wasobtainedasanunexpectedresult.Itwasfirstfoundthattitlecompoundcancrystallizeindifferentcrys…