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1.
I. Strakova A. Strakovs M. Petrova S. Belyakov 《Chemistry of Heterocyclic Compounds》2007,43(12):1512-1518
The [3+2] cycloaddition reactions of a series of 1,3-substituted 5-diazo-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydroindazoles with
maleic anhydride and dimethyl acetylenedicarboxylate gave 1′,3′-substituted 3-spiro[4,6-dioxo-4,6,3a,6a-tetrahydro-3H-furo[3,4-c]pyrazole]-5′-[6′,6′-dimethyl-4′-oxo-4′,5′,6′,7′-tetrahydroindazoles]
and 1′,3′-substituted 3-spiro[4,5-di(methoxycarbonyl)-3H-pyrazole]-5′-[6′,6′-dimethyl-4′-oxo-4′,5′,6′,7′-tetrahydroindazoles]
respectively. When heated the former eliminate nitrogen and are transformed into 1′,3′-substituted 6-spiro[2,4-dioxo-3-oxabicyclo[3.1.0]hexane]-5′-[6′,6′-dimethyl-4′-oxo-4′,5′,6′,7′-tetrahydroindazoles].
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1784–1791, December, 2007. 相似文献
2.
L. G. Delyatitskaya M. V. Petrova S. Grinberga N. N. Tonkikh A. Ya. Strakov 《Chemistry of Heterocyclic Compounds》2000,36(6):728-732
Treatment of 3,6,6-trimethyl-4-oxo-1-(2-pyridyl)-4,5,6,7-tetrahydroindazole with sodium azide in acids gives 3,7,7-trimethyl-5-oxo-1-(2-pyridyl)-5,6,7,8-tetrahydro(4H)pyrazolo[4,3-b]azepine. Heating 1-(2-pyridyl)-3,6,6-trimethyl- and 1-phenyl-6,6-dimethyl-4-hydroxyimino-4,5,6,7-tetrahydroindazoles in polyphosphoric acid gives 1-phenyl-5,6-dimethyl- and 1-(2-pyridyl)-3,5,6-trimethyl-4-aminoindazole respectively: The reactions of the latter with 4-dimethylaminobenzaldehyde gave the 4-(4-dimethylaminobenzalamino) derivative and with 2-formyldimedone the 4-(4,4-dimethyl-2,6-dioxocyclohexylidenemethylamino) derivative.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 830–834, June, 2000. 相似文献
3.
I. A. Strakova A. Ya. Strakov M. V. Petrova L. G. Delyatitskaya 《Chemistry of Heterocyclic Compounds》2000,36(4):459-464
Reaction of the potassium salt of 2-formyldimedone with hydrochlorides of 4-chloro-, 3-chloro-, 2-chloro-, 2,4-dichloro-, and 2,4-difluorophenylhydrazines gave the corresponding 2-arylhydrazinomethylene-dimedones which cyclized in acid media to 1-substituted 6,6-dimethyl-4-oxo-4,5,6,7-tetrahydroindazoles. Oxidation of the latter with selenious acid gave the corresponding 4,5-dioxo-4,5,6,7-tetrahydroindazoles which were further converted into 3-aryl-5,5-dimethyl-4,5-dihydro-3H-pyrazolo[4,3-a]phenazines and 2,6-diaryl-4,4-dimethyl-4,5-dihydro-1H(3H)-indazolo[4,5-g]imidazoles.Riga Technical University, Riga LV-1658, Latvia; e-mail: marina@osi.lv. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, 533–539, April, 2000. 相似文献
4.
The synthesis of new condensed indoline bis-spiropyrans from isomeric hexamethyldihydroindolo-[4,5-e]-and -[7,6-g]indoles,
and also from hexamethyldihydrobenzo[e]pyrrolo[3,2-g]indole in three stages has been generalized. By condensation of the isomeric
bis-analogs of Fischer's bases obtained at the second stage with salicylic aldehydes, the following bis-spiro compounds have
been synthesized: 6,6"-dinitro-, 6,6",8,8"-tetranitro-, 6,6",8,8"-tetrabromo-1',3',3',6',8',8'-hexamethyldispiro[chromene-2,2'-indolino[7,6-g]indoline-7',2"-chromenes],
6,6"-dinitro-, 6,6",8,8"-tetranitro-, 6,6",8,8"-tetrabromo-1',1',3',8',10',10'-hexamethyldispiro[chromene-2,2'-indolino[4,5-e]indoline-9',2"-chromenes],
6,6"-di-nitro-, 6,6"-dibromo-, and 6,6",8,8"-tetrabromo-1',1',8,8'-tetramethyl-1',4',5',8'-tetrahydrodispiro-[chromene-2,2'-dipyrrolo[1,2,3-d,e:3,2,1-i,j]benzo[g]quinoxaline-7',2"-chromenes]. 相似文献
5.
A. Ya. Strakov M. V. Petrova A. Dishs Yu. Popelis N. N. Tonkikh 《Chemistry of Heterocyclic Compounds》1997,33(2):202-207
The reactions of 2-cyano-3-ethoxy-5,5-dimethyl-2-cyclohexen-1-one with 2-amino- and 2-hydrazinobenzimidazoles gave 1-oxo-3,3-dimethyl-11-amino-1,2,3,4-tetrahydroquinazolino[3,2-a]benzimidazole and 2-(2-benzimidazolyl)-3-amino-4-oxo-6,6-dimethyl-4,5,6,7-tetrahydroindazole, respectively.Riga Technical University, Riga LV-1658. Latvian Institute of Organic Synthesis, Riga LV-1006. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 235–240, Feburary, 1997. 相似文献
6.
V. V. Shchepin Yu. G. Stepanyan P. S. Silaichev 《Russian Journal of General Chemistry》2008,78(5):929-932
Organozinc compounds prepared from dialkyl dibromomalonates and zinc react with 2-arylmethyl-eneindan-4,6-diones, 5-arylmethylene-2,2-dimethyl-1,3-dioxane-4,6-diones, as well as with 2-[4-(1,3-dioxoindan-2-ylidenemethyl)phenyl]methyleneindan-1,3-dione and 5-[4-(2,2-dimethyl-4,6-dioxo-1,3-dioxane-2-ylidenemethyl)phenyl]methylene-2,2-dimethyl-1,3-dioxane-4,6-diones to form dialkyl 3-aryl-1′3′-dioxaspiro(cyclopropane-2,2′-indan)-1,1-dicarboxylates, dimethyl 3-aryl-6,6-dimethyl-5,7-dioxa-4,8-dioxaspiro[2,5]octan-2,2-dicarboxylates, dialkyl 2-{4-[3,3-bis (alkoxycarbonyl)-1′,3′-dioxaspiro(cyclopropane-2,2′-indan)-1-yl]phenyl}-1′,3′-dioxaspiro[cyclopropane-2,2′-indan]-1,1-dicarboxylates, and dialkyl 2-{4-[2,2-bis(alkoxycarbonyl)-6,6′-dimethyl-4,8-dioxo-5,7-dioxaspiro[2,5]oct-1-yl]phenyl}-6,6-dimethyl-4,8-dioxo-5,7-dioxaspiro[2,5]octan-1,1-dicarboxylate respectively. 相似文献
7.
A. A. Akhrem F. A. Lakhvich V. A. Khripach I. B. Klebanovich 《Chemistry of Heterocyclic Compounds》1979,15(2):194-198
A mixture of 4,4-dimethyl-9-(3-methylglutarlmidyl)-2-oxo-7-oxa-8-azabicyclo[4.3.0] non-8-ene and 3-(3-methylglutarimidyl)-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydrobenz-[d]isoxazole was obtained by in situ 1,3-dipolar cycloaddition of 3-glutarimidyl-acetonitrile oxide to 5,5-dimethylcyclohex-2-en-1-one. Reductive cleavage of these compounds by catalytic hydrogenation over Pd catalysts gives 3-[2-amino-2,2-(4,4-dimethyl-2-oxocyclohexylene)ethyl]glutarimide and the known 3-[2-amino-2,2-(4,4-dimethyl-2,6-dioxocyclohexylene)ethyl]glutarimide, respectively, in quantitative yield. Hydrolysis of the latter leads to 3-[2-oxo-2-(4,4-dimethyl-2,6-dioxocyclo-hexyl)ethyl]glutarimide. The ketones obtained are analogs of glutarimide antibiotics and polyfunctional intermediates in their synthesis.See [1] for a preliminary communication.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 230–234, February, 1979. 相似文献
8.
The corresponding 1-(2-quinoxalyl)-, 1-[3,5-di(trifluoromethyl)phenyl]-, and 1-ethoxycarbonyl-3-methyl-4-oxo-4,5,6,7-tetrahydroindazoles have been obtained from reactions of 2-acetyl-1,3-cyclohexanedione, its 5,5-dimethyl and 5-(2-furyl) derivatives, with 2-hydrazinoquinoxaline, 3,5-di(trifluoromethyl)phenylhydrazine, and ethoxycarbonylhydrazine. On interaction with ethoxycarbonylhydrazine the intermediate 2-[1-(-ethoxycarbonyl)hydrazino]ethylidene-1,3-cyclohexanediones were also isolated. From the potassium salt of 2-formyldimedone and 2-carboxyphenylhydrazine hydrochloride, 2-(2-carboxyphenyl)hydrazinomethylene-5,5-dimethyl-1,3-cyclohexanedione was obtained, the cyclization of which in ethanol in the presence of HCl led to 1-(2-carboxyphenyl)- and 1-(2-ethoxycarbonylphenyl)-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydroindazole. 相似文献
9.
10.
A. Ya. Strakov N. N. Tonkikh M. V. Petrova I. A. Strakova 《Chemistry of Heterocyclic Compounds》1997,33(4):441-444
Reactions of 4-hydrazinobenzoic acid with 2-formyl- and 2-acetyldimedones were utilized to synthesize 6,6-dimethyl- and 3,6,6-trimethyl-1-(4-hydroxycarbonylphenyl)-4-oxo-4,5,6,7-tetrahydroindazoles
corre-spondingly, and the reaction with 2-cyano-3-ethoxy-5,5-dimethylcyclohex-2-en-1-one gave 2-(4-hydroxy-carbonylphenyl)-3-amino-4-oxo-6,6-dimethyl-4,5,6,7-tetrahydroindazole.
Riga Technical University, Riga LV-1658. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 516–519, April,
1997. 相似文献
11.
The oxidation of 2,3-diphenyl-, 3-(4-chlorophenyl)-2-phenyl-, 3-(4-dimethylaminophenyl)-2-phenyl-, 3-(4-methoxyphenyl)-2-phenyl-,
2-phenyl-3-(3-pyridyl)-, 3-phenyl-2-(2-pyridyl)-, and 3-(4-dimethylaminophenyl)-6,6-dimethyl-4-oxo-2-(2-pyridyl)-4,5,6,7-tetrahydroindazoles
using H2SeO3 in acetic acid in the presence of sulfuric acid gave the corresponding 4,5-dioxo derivatives. Reaction of these with tosylhydrazine
gave 4-oxo-5-tosylhydrazino derivatives which were decomposed by alkali to give the corresponding 2,3-diaryl-5-diazo-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydroindazoles.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1829–1833, December, 2005 相似文献
12.
V. V. Dabaeva M. R. Bagdasaryan A. S. Noravyan 《Chemistry of Heterocyclic Compounds》2011,47(5):639-643
The reactions of 2-methyl (propyl) substituted 8,8-dimethyl-7,10-dihydro-4H,8H-pyrano[3",4":5',6']pyrido[3',2':4,5]thieno[3,2-d][1,3]oxazines
with primary amines give 2-methyl (propyl) substituted 8,8-di- methyl-7,10-dihydro-8H-pyrano[3",4":5',6']pyrido[3',2':4,5]thieno[3,2-d][1,3]pyrimidin-4(3H)-ones
or 3-acetyl-N-alkyl- and N-alkyl-3-butyrylamino-7,7-dimethyl-7,8-dihydro-5H-pyrano[4,3-b]thieno[3,2-e]- pyridine-2-carboxamides depending on steric hindrance in the amines. 相似文献
13.
Noland WE Konkel MJ Konkel LM Pearce BC Barnes CL Schlemper EO 《The Journal of organic chemistry》1996,61(2):451-454
Four of the previously reported compounds obtained from the acid-catalyzed condensation of indole with acetone are now assigned the following structures: cis-4,4a,9,9a-tetrahydro-2-(1H-indol-3-yl)-4,4-dimethyl-3H-carbazole (2a), 1,1',4,4'-tetrahydro-1,1,1',1'-tetramethyl-3,3'(2H,2'H)-spirobi[cyclopent[b]indole] (4), 4,4a-dihydro-2-(3-1H-indolyl)-4,4-dimethyl-3H-carbazol-4a-ol (7), and 5-(2-aminophenyl)-1,3,4,5-tetrahydro-1,1,4,4-tetramethylcyclopent[kl]acridine (8). The structure of the novel rearrangement product 8 was solved by an X-ray crystal structure determination. The two previously reported autoxidation products of 4 are now assigned the following structures: 1,3',4,4'-tetrahydro-1,1,4',4'-tetramethyl-cis-dispiro[cyclopent[b]indole-3(2H),2'(5'H)-furan-5',3"-[3H]-indol]-2"(1"H)-one (5) and 1,4-dihydro-1,1,5',5'-tetramethylspiro[cyclopent[b]indole-3(2H),3'(4'H)-1-benzazocine]-2'(1'H),6'(5'H)-dione (6). 相似文献
14.
V. V. Dotsenko S. G. Krivokolysko V. P. Litvinov 《Chemistry of Heterocyclic Compounds》2003,39(1):110-112
The reaction of N-methylmorpholinium 4-(2-chlorophenyl)-5-cyano-2-oxo-1,2,3,4-tetrahydropyridine-6-thiolate with chloroacetamide in DMF in the presence of an excess of KOH gave 3-amino-2-carbamoyl-4-(2-chlorophenyl)-6-oxo-4,5,6,7-tetrahydrothieno[2,3-b]pyridine. Refluxing the latter with acyl chlorides in AcOH or heating in formic acid gave hexahydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine derivatives and reaction with cyclohexanone gave a spiro-linked octahydropyrido[3',2':4,5]thieno[3,2-d]pyrimidine. 相似文献
15.
Two new xanthones, 3-hydroxy-6-methoxy-5'-isopropyl-4',5'-dihydrofuro[2',3'?:?7, 8]-6″,6″-dimethyl-4″,5″-dihydropyrano[2″,3″?:?1,2]xanthone (1) and 1,6-dihydroxy-7-methoxy-8-(3-methylbut-3-enyl)-6',6'-dimethyl-4',5'-dihydropyrano[2'3'?:?3,2]xanthone (2), were isolated from the pericarp of Garcinia mangostana. Their structures were elucidated by spectral means (1-D and 2-D NMR, MS). 相似文献
16.
A. Ya. Strakov N. N. Tonkikh M. V. Petrova I. A. Strakova 《Chemistry of Heterocyclic Compounds》1997,33(12):1443-1449
From 2-formyldimedone and 4-bromo-, 4-fluoro-, and 4-trifluoromethylphenylhydrazines we have obtained the corresponding 2-arylhydrazinomethylenedimedones, which in acid medium undergo ring closure to form 1-substituted 6,6-dimethyl-4-oxo-4,5,6,7-tetrahydroindazoles. Oxidation of the latter by selenous acid leads to the corresponding 4,5-dioxo-4,5,6,7-tetrahydroindazoles, which then were converted to derivatives of 4,5-dihydro-3H-pyrazolo[4,3-a]phenazine and 4,5-dihydro-1H(3H)-indazolo[4,5-d]imidazole.Riga Technical University, Riga LV-1658. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1669–1675, December, 1997. 相似文献
17.
Isaka K Nagatsu A Ondognii P Zevgeegiin O Gombosurengyin P Davgiin K Kojima K Ogihara Y 《Chemical & pharmaceutical bulletin》2001,49(9):1072-1076
Nine novel prenyl-dihydrofurocoumarin-type sesquiterpenoid derivatives, 2,3-dihydro-7-hydroxy-2R*,3R*-dimethyl-2-[4,8-dimethyl-3(E),7-nonadienyl]-furo[3,2-c]coumarin, 2,3-dihydro-7-hydroxy-2S*,3R*-dimethyl-2-[4,8-dimethyl-3(E),7-nonadien-6-onyl]-furo[3,2-c]coumarin, 2,3-dihydro-7-hydroxy-2S*,3R*-dimethyl-2-[4-methyl-5-(4-methyl-2-furyl)-3(E)-pentenyl]-furo[3,2-c]coumarin, 2,3-dihydro-7-hydroxy-2R*,3R*-dimethyl-2-[4-methyl-5- (4-methyl-2-furyl)-3(E)-pentenyl]-furo[3,2-c]coumarin, 2,3-dihydro-7-methoxy-2S*,3R*-dimethyl-2-[4,8-dimethyl-3(E),7-nonadienyl]-furo[3,2-c]coumarin, 2,3-dihydro-7-methoxy-2R*,3R*-dimethyl-2-[4,8-dimethyl-3(E),7-nonadienyl]-furo[3,2-c]coumarin, 2,3-dihydro-7-methoxy-2S*,3R*-dimethyl-2-[4,8-dimethyl-3(E),7-nonadien-6-onyl]-furo-[3,2-c]coumarin, and 2,3-dihydro-7-methoxy-2S*,3R*-dimethyl-2-[4-methyl-5-(4-methyl-2-furyl)-3(E)-pentenyl]-furo[3,2-c]coumarin, were isolated from the roots of Ferula ferulaeoides [corrected]. The structures were established by comprehensive spectral analysis. The biosynthetic pathway leading to these prenyl-furocoumarin-type sesquiterpenoids is proposed based on their structures. 相似文献
18.
A. N. Grinev I. A. Kharizomenova M. V. Kapustina Yu. N. Sheinker L. M. Alekseeva N. M. Rubtsov 《Chemistry of Heterocyclic Compounds》1987,23(4):384-386
Bromination of 2-acylamino-3-ethoxycarbonyl-7-oxo-4,5,6,7-tetrahydrobenzo[b]-thiophenes has been studied. This reaction affords 2-acylamino-6,6-dibromo-3-ethoxycarbonyl-7-oxo-4,5,6,7-tetrahydrobenzo[b]thiophene, which on dehydrobro-mination gives 6-bromo-7-oxybenzo[b]thiophene derivatives. The 4,6-dibromo- and 4,6-dinitro-7-oxybenzo[b]thiophenes were also obtained.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 460–462, April, 1987. 相似文献
19.
A. P. Mkrtchyan A. S. Noravyan V. M. Petrosyan 《Chemistry of Heterocyclic Compounds》2002,38(2):238-241
A method has been developed for the preparation of 2-R-substituted 3-amino-6,6-dimethyl-5,6-dihydro-8H-pyrano[4'3':4,5]thieno[2,3-d]pyrimidin-4-ones based on 2-R-amino-3-ethoxycarbonylpyrano[2,3-c]thiophenes. It has been established that their cyclization with hydrazine hydrate requires vigorous conditions. 相似文献
20.
Yu. N. Bannikova A. N. Maslivets Z. G. Aliev 《Russian Journal of Organic Chemistry》2007,43(9):1334-1337
Methyl 1-aryl-3-benzoyl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates reacted with 3-arylamino-5,5-dimethylcyclohex-2-en-1-ones in boiling benzene to give the corresponding 1,1′-diaryl-3′-benzoyl-4′-hydroxy-6,6-dimethyl-1,1′,2,4,5,5′,6,7-octahydrospiro[indole-3,2′-pyrrole]-2,4,5′-triones and 1′-aryl-4-arylamino-3-benzoyl-6′,6′-dimethyl-1′,2′,4′,5′,6′,7′-hexahydro-5H-spiro[furan-2,3′-indole]-2′,4′,5-triones whose structure was proved by X-ray analysis. 相似文献