A new flavonol glycoside from the aerial parts of Astragalus vulneraria

A new flavonol glycoside, isorhamnetin 3-O-beta-D-apiofuranosyl-(1-->2)-alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-galactopyranoside, and the known diglycoside, isorhamnetin 3-O-alpha-L-rhamnopyranosyl-(1-->6)-beta-D-galactopyranoside were isolated from the aerial parts of Astragalus vulneraria. Characterization of the two compounds was done by spectroscopic methods (1D and 2D NMR, and FAB-MS).     

Two new phenolic glycosides from the aerial parts of Androsace umbellata

Two new phenolic glycosides,2-hydroxy-4-O-β-D-glucopyranosylphenylacetic acid methyl acetate(1) and 2-hydroxy-4-O-β-D-glucopyranosylphenylacetic acid(2) were isolated from the aerial parts of Andwsace umbellata.Their structures were elucidated by spectral techniques.     

Three new flavonol glycosides from the aerial parts of Rodgersia podophylla

Three new flavonol glycosides were isolated together with five known flavonoids and six bergenin derivatives from the aerial parts of Rodgersia podophylla. The structures of these new compounds were elucidated by spectral methods as kaempferol-3-O-alpha-L-5'-acetyl-arabinofuranoside (1), kaempferol 3-O-alpha-L-3'-acetyl-arabinofuranoside (2), and quercetin-3-O-alpha-L-3',5'-diacetyl-arabinofuranoside (3).     

Three new acyclic diterpene glycosides from the aerial parts of paprika and pimiento

Paprika and pimiento are used as vegetables and spices. We have obtained three new acyclic diterpene glycosides, called capsianosides XVII (1), V methyl ester (2) and XIV (3) together with capsianosides I and II from the aerial parts of paprika and pimiento. The structures of these compounds have been established by (1)H- and (13)C-NMR spectra and two-dimensional NMR methods.     

New cardenolide and acylated lignan glycosides from the aerial parts of Asclepias curassavica

Three new cardenolide glycosides and six new acylated lignan glycosides were obtained along with nineteen known compounds from the aerial parts of Asclepias curassavica L. (Asclepiadaceae). The structure of each compound was determined based on interpretations of NMR and MS measurements and chemical evidence.     

8-O-4’ Neolignan glycosides from the aerial parts of Matteuccia struthiopteris

Two new 8-O-4’ neolignan glycosides, named matteustruthiosides A(1) and B(2) were isolated from the aerial parts of Matteuccia struthiopteris. Their chemical structures were characterized on the basis of various spectroscopic techniques. The absolute configurations of them were determined by experimental circular dichroism(CD) spectra. Compounds 1 and 2 were inactive against influenza A(H1N1) virus in vitro.     

Two new saponins from the aerial part of Astragalus membranaceus var. mongholicus

Two new saponins named mongholicoside A (1) and mongholicoside B (2) were isolated from the aerial part of Astragalus membranaceus var. mongholicus. Their structures were determined by 1D and 2D NMR, ESI-MS techniques and chemical methods.     

Three new pterocarpans from the aerial parts of Abrus Precatorius

Abstract

Three new pterocarpans, named abrusprecatins A-C (1–3), along with three known ones, namely medicarpin (4), maackiain (5), and 4-hydroxy-3-methoxy-8,9-methylenedioxypterocarpan (6) were isolated from the aerial parts of Abrus precatorius. The structures of these compounds were established by extensive analysis of mass spectrometric data, 1?D and 2?D NMR spectroscopic data. In addition, the absolute configurations were determined by a combination of single crystal X-ray diffraction analysis and circular dichroism spectroscopy.     

A new isocoumarin from the aerial parts of Aconitum gymnandrum

A new isocoumarin, along with 10 known compounds, was isolated from the aerial parts of Aconitum gymnandrum. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Among the known compounds, compound 11 was obtained as a natural product for the first time, which was previously reported as a synthetic product. In addition, compounds 1–5, 7 and 9 were tested for their cytotoxicity against four human cancer cell lines. The results showed that compounds 3, 4 and 7 displayed cytotoxicity against lung cancer A549 and gastric cancer MGC80, respectively, whereas 5 and 9 showed selective cytotoxicity against hepatocellular carcinoma HepG2.     

Two new neolignans from the aerial parts of Rodgersia podophylla

Two new neolignans (1, 2) were isolated from the aerial parts of Rodgersia podophylla, along with four known neolignans, and their structures were elucidated using spectral experiments and comparison with literature data.     

Larrealignans A and B, novel lignan glycosides from the aerial parts of Larrea tridentata

Two new lignan glycosides, named larrealignans A (1) and B (2), and a known lignan (3) were isolated from the aerial parts of Larrea tridentata (Zygophyllaceae). The structures of 1 and 2 were determined on the basis of spectroscopic analysis and the results of hydrolytic cleavage. The isolated compounds (1-3) and aglycones (1a, 2a) of 1 and 2 were evaluated for their cytotoxic activities against HL-60 human leukemia cells.     

A new sesquiterpene glycoside from the aerial parts of Saussurea triangulata

Column chromatographic separation of a MeOH extract of the aerial parts of Saussurea triangulata led to the isolation of a new sesquiterpene glycoside 6, together with three quinic acid derivatives, two phenolics, two sesquiterpene glycosides and two flavonoids. The new compound 6 was identified as amarantholidol A glycoside by spectroscopic and chemical methods.     

Two new cycloartane glycosides from the underground parts of Aquilegia vulgaris

Two new cycloartane glycosides, named aquilegiosides K and L, have been isolated from the dried underground parts of Aquilegia vulgaris. Their structures were determined by two dimensional (2D) NMR spectroscopic analysis and chemical evidence.     

Triterpene glycosides from the seeds of Astragalus sinicus L.

From the seeds of Astragalus sinicus L. (Leguminosae), seven triterpene glycosides were isolated and identified as soyasaponin I-III methyl esters (1-3) which were treated with CH2N2 during the separation procedure, soyasaponin IV (4), soyasapogenol B 3-O-beta-D-glucuronopyranoside (5), 3-O-alpha-L-rhamnopyranosyl(1-->2)-beta-D-xylopyranosyl(1-->2)-beta-D- glucuronopyranosyl 3 beta, 22 beta, 24-trihydroxy-11-oxoolean-12-ene (6), whose sapogenol (8) was obtained by enzymatic hydrolysis using glycyrrhizinic acid hydrolase, unambiguously characterized and designated as complogenin, and 3-O-alpha-L-rhamnopyranosyl(1-->2)-beta-D-galactopyranosyl(1-->2)-beta-D - glucuronopyranosyl complogenin (7).     

Three new steroid glycosides from the underground parts of Trillium kamtschaticum

Three new steroid glycosides named trikamsterosides C, D and E were isolated from the underground parts of Trillium kamtschaticum PALL. (Liliaceae) along with two known 18-norspirostanol glycosides trillenosides A and B. Their chemical structures were determined on the basis of spectroscopic data and chemical evidence.     

A new ent-clerodane diterpene from the aerial parts of Baccharis gaudichaudiana

A new ent-clerodane diterpene, named bacchariol (1) was isolated from the aerial parts of Baccharis gaudichaudiana DC. (Compositae), together with known ent-clerodane diterpenes (2, 3), eight known flavonoids (4-11) and 3, 5-dicaffeoylquinic acid (12). Their structures were determined by spectroscopic analyses. Flavonoids (7, 8, 11) and 12 showed moderate scavenging activities toward 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radicals.     

Three minor new compounds from the aerial parts of Leonurus japonicus

Phytochemical investigation of the aerial parts of Leonurus japonicus led to the isolation of one new labdane diterpenoid, leojaponin D(1) and two new ionone derivatives, leojaponones A and B(2 and 3),together with seven known diterpenoids(4–10). Their structures were elucidated by extensive 1D and2 D NMR spectroscopic data and by comparison with data reported in the literature. Selected isolates were evaluated their effects on Jurkat IL2 secretion.