共查询到20条相似文献,搜索用时 31 毫秒
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Arun K. Sarkar Sushama M. Pawar Khushi L. Matta 《Journal of carbohydrate chemistry》2013,32(2):269-278
ABSTRACT Synthesis of three tetrasaccharides, namely, 0-α-L-fucopyranosyl-(1→3)-0-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-(1→3)-0-(β-D-galactopyranosyl)-(1→4)-β-D-glucopyranose (7), 0-α-L-fucopyranosyl-(1→4)-0-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-(1→3)-0-(β-D-galactopyranosyl)-(1→4)-D-glucopyranose (9), and 0-α-L-fucopyransoyl-(1→3)-0-(2-acetamido-2-deoxy-β-D-glucopyransoyl)-(1→6)-0-(β-D-galactopyranosyl)-(1→4)-D-glucopyranose (15) has been described. Their structures have been established by 13C NMR spectroscopy. 相似文献
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WAN Jun LI Chun-li LI Xue-mei ZHANG Shu-sheng~ College of Chemistry Molecular Engineering Qingdao University of Science Technology Qingdao P.R. China 《高等学校化学研究》2006,22(4)
IntroductionTriazole derivatives have become the most rapidlyexpanding group of antifungal compounds with advanta-ges of lowtoxicity, high oral bioavailability and broad-spectrum antifungal activity, which can be used againstfungi including most yeasts an… 相似文献
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通过不同的胺对烯唑醇前体1的1,4-亲核加成反应,合成了目标化合物2,并将其还原得到了其还原产物3.生物活性测试结果发现,化合物3表现出较好的杀菌活性及一定程度的植物生长调节活性. 相似文献
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Abstract A series of enantiomerically pure (Z)-(?)-4-(1′-alkyloxy-1′-alkyloxycarbonyl-methylidene)-5(R)-[(1R)-menthyloxy]-γ-butyrolactones were synthesized and characterized in good to excellent yields via O-alkylation of (4R,5R)-(?)-4-ethoxyoxalyl-5-[(1R)-menthyloxy]-γ-butyrolactone with alkyl halides in the presence of K2CO3 in acetone at room temperature. 相似文献
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《合成通讯》2013,43(22):3413-3417
ABSTRACT Conditions for efficient resolution of (±)-1-(9-anthryl)ethylamine ((±)-1) by fractional crystallization of its salts with (S)-(+)-mandelic acid (2) are reported. When crystallization was performed by fast addition of chloroform solution of an equivalent of (±)-1 to the hot chloroform solution of (+)-2, crystals of mandelate of (+)-1-(9-anthryl)ethylamine ((R,S)-3) are collected in 56% yield. (R)-(+)-1 (98.6% e.e.) is isolated by extraction from bicarbonate solution of mandelate salt. Ulterior collection of four crops afforded (R,S)-3 with 71.5% cumulative yield and >98% e.e. of (+)-1 in a any single crop. With only 0.5 equivalents of (+)-2 crystallization afforded (R,S)-3 in 47.4% yield and (+)-1 with 98.1% e.e. 相似文献
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Narayan S. Hosmane Hongming Zhang Kai -Juan Lu John A. Maguire Alan H. Cowley Miguel A. Mardones 《Structural chemistry》1992,3(3):183-190
The reaction between thecloso-gallacarborane, 1-(t-C4H9)-1-Ga-2,3-(SiMe3)2-2,3-C2B4H4 (1), and 2,2-bipyrimidine in a molar ratio of 11 in dry benzene produced the unbridged donor-acceptor complex 1-(2,2-C8H6N4)-1-(t-C4H9)-1-Ga-2,3-(SiMe3)2-2, 3-C2B4H4 (2) as a pale-yellow crystalline solid in 81% yield. The spectroscopic data of2 are almost identical to those of the bridged species 1,1-(2,2-C8 H6N4)-[1-(t-C4H9)-1-Ga-2,3-(SiMe3)2-2,3-C2 B4H4]2 (3). However, the single-crystal X-ray structure of2 reveals that the complex consists of only one distorted gallacarborane unit and a bipyrimidine molecule, that acts as a bidentate ligand. The apical gallium in2 is displaced further away from the centroidal position above the carborane than it is in 1. Despite the steric hindrance imposed by the bulky trimethylsilyl groups on the cage carbons, the Ga-C(t-buty) bond is tilted toward the cage carbon atoms. Complex2 crystallizes in the monoclinic space groupP21 witha=11.279 (3),b=10.060 (3),c=11.911 (3) Å,=94.94 (2)°,V=1346.5 (6) Å3,Z=2,D
x=1.24g cm–3, (MoK) F(000)= 528, andT=220 K. Full-matrix least-squares refinement for2 converged at R=0.036 andRw= 0.045 for 3032 observed reflections. Molecular orbital calculations showed that antibonding interactions between the gallium and carborane cage carbons, induced by base complexation, are a contributing factor to the gallium's slip distortion that is found in2. 相似文献
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John Nicolson Low Justo Cobo Manuel Nogueras Adolfo Sánchez Jairo Quiroga Diana Mejía 《Acta Crystallographica. Section C, Structural Chemistry》2001,57(11):1356-1358
Molecules of the title compound, C28H27ClN4O4·C2H6O, form a C(6) chain via an N—H⋯O hydrogen bond along the c axis by the operation of a c-glide plane, with N⋯O = 2.761 (3) Å and N—H⋯O = 165°. The molecules are further linked by a weak C—H⋯O interaction, with C⋯O = 3.344 (4) Å and C—H⋯O = 150°. Pendant hydrogen-bonded ethanol solvent molecules are attached to the chains by O—H⋯N hydrogen bonds, with O⋯N = 2.904 (3) Å and O—H⋯N = 175°. 相似文献
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T. M. Seilkhanov L. A. Nazarenko N. N. Poplavskii O. T. Seilkhanov T. K. Iskakova K. D. Praliev A. A. Abzhapparov T. N. Zharkinbekov 《Russian Journal of General Chemistry》2016,86(1):110-115
A comparative analysis of 1H and 13C NMR spectra of 1-(2-ethoxyethyl)-4-(pentyn-1-yl)-4-hydroxypiperidine, 1-(2-ethoxyethyl)-4-(pentyn-1-yl)-4-benzoyloxypiperidine oxalate and their inclusion complexes with β-cyclodextrin was performed. The differences in values of chemical shifts of 1H and 13C nuclei of the substrates and the receptor in the inclusion complexes were determined. It was found that the formation of complexes of 1-(2-ethoxyethyl)-4-(pentyn-1-yl)-4-hydroxypiperidine and 1-(2-ethoxyethyl)-4-(pentyn-1-yl)-4-benzoyloxypiperidine oxalate with β-cyclodextrin was accompanied by insertion of one N-ethoxyethyl fragment of the substrate molecule into the inner sphere of one molecule of the receptor. 相似文献
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2-(2,4-二氟苯基)-1-(4-烃基派嗪-1-基)-3-(1,2,4-三唑-1-基)-2-丙醇类化合物的合成及抗真菌活性 总被引:1,自引:0,他引:1
近20年来,真菌感染特别是深部真菌感染日益引起人们的广泛关注[1]。三唑类抗真菌药物对真菌的选择性较高,代谢稳定,体内动态、安全性都较好,已成为目前抗真菌药物研究开发的重点[2]。三唑类抗真菌药物是细胞色素P450 14α 去甲基酶的抑制剂,可影响该酶所催化的真菌麦角甾醇的生物合成,导致真菌细胞膜破损而死亡[3,4]。1998年,SynPhar实验室及Taiho制药公司[5]研制开发的化合物Syn 2869采用了取代哌嗪作为侧链。体外实验表明,该化合物抗菌谱广,对多种念珠菌、隐球菌及曲莓菌均有效,体内实验中,与目前临床上治疗真菌感染的主要用药伊曲… 相似文献
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<正> 将低分子药物或有药理活性的基团,通过高分子化,所得的高分子药物,具有较高的为细胞吞噬或胞饮等活性,并期望它们在体内崩解缓释,与相应的低分子药物相比,可以发挥长效、低毒的优点。 1,2双-(3,5-二氧哌嗪-1)乙烷和(±)1,2双(3,5-二氧哌嗪-1)丙烷,是临床使用 相似文献
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Propyl O-(α-L-rhamncpyranosyl)-(1→3)-[2,4-di-O-(2s-methylbutyryl)-α-L-rham-nopyranosyl]-(1→2)-(3-O-acetyl-β-D-glucopyranosyl)-(1→2)-β-D-fucopyranoside (1), the tetrasac-charide moiety of Tricolorin A, was synthesized in total 23 steps with a longest linear sequence of 10 steps, and overall yield of 3.7% from D-Glucose. The isomerization of the dioxolane-type berzyli-dene in the presence of NIS/AgOTf was observed. Tetrasaccharide 1 exhibited no activity against the cultured P388 cell as Tricolorin A did. 相似文献
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合成了一种新的有机非线性光学(NLO)材料1-(芘-1-基)-3-(4-甲氧基苯基)丙烯酮(PMPAK),通过1H NMR、IR、HR-MS和元素分析表征其结构。 以Nd:YAG-Laser System作为光源,激光波长450 nm,脉冲宽度4 ns(FWHM),采用4f相位相干成像技术测定了PMPAK的三阶NLO性质并确定了相关参数:非线性折射率n2=-1.84×10-16 m2/W,非线性吸收系数β=2.53×10-9 m/W,非线性极化率χ(3)=1.137×10-10 esu。 相似文献