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1.
Knoevenagel condensate Schiff base ligands [L = 3‐cinnamalideneacetylacetone‐thiosemicarbazone (CAT)/3‐cinnama‐ lideneacetylacetoneethylthiosemicarbazone (CAET)/3‐cinnamalideneacetylacetonephenylthiosemicarbazone (CAPT)] and their copper/zinc complexes were synthesized. They were characterized by analytical and spectral techniques. From these data it was found that the ligands adopt square‐planar geometry on metalation with Cu2+ and Zn2+. To evaluate the antitumor and cytotoxic activity of the synthesized complexes in mice and human cancer cell lines, the antitumor activity of the complexes was evaluated against an Ehrlich ascites carcinoma (EAC) tumor model. The activity was assessed using survival time and short‐term in vitro cytotoxic activity. Oral administration of complexes (100 mg/kg) increased the survival time. The cytotoxic activity of complexes was evaluated using human breast cancer (MDA‐MB‐231), colon cancer (HCT‐116) and nonsmall lung cancer (NCI‐H‐23) cell lines. Both the complexes possessed significant antitumor and cytotoxic activity on EAC and human cancer cell lines. The in vitro antimicrobial screening effect of the investigated compounds was also tested against the various organisms by well diffusion method. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
2.
《Journal of Coordination Chemistry》2012,65(14):2091-2101
AbstractDinuclear ruthenium complexes [Ru2(bpy)4BL](ClO4)2 (Ru-1), where bpy = 2,2′-bipyridine and BL = 2,2′-((1E,1′E)-((E)-diazene-1,2-diyl-bis(2,1-phenylene))-bis(azanylylidene))bis(methanylylidene))diphenol (a bidentate bridging ligand), and mononuclear ruthenium complexes [Ru(bpy)2L](ClO4) (Ru-2), where L = (E)-2-((phenylimino)methyl)phenol, were synthesized and characterized by elemental analysis and electrospray ionization mass spectrometry. Their photophysical and electrochemical properties were also studied. The cytotoxicity of the two complexes in vitro was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The results indicated that Ru-1 and Ru-2 exhibited significant dose-dependent cytotoxicity to human breast cancer (MCF-7), gastric cancer (SGC-7901), cervical cancer (Hela), and lung cancer (A549) tumor cell lines. Ru-1 showed excellent antitumor effects in a cellular study (IC50 values of 3.61 μM for MCF-7 human breast cancer cells in vitro). However, Ru-2 exhibited the highest cytotoxicity to Hela cells; the IC50 value is 3.71 μM. The results reveal that Ru-1 and Ru-2 have obvious selectivity and might be a potential anticancer agent that could improve the efficacy of common anticancer therapies. 相似文献
3.
Paul Grocki Mark Woollam Luqi Wang Shengzhi Liu Maitri Kalra Amanda P. Siegel Bai-Yan Li Hiroki Yokota Mangilal Agarwal 《Molecules (Basel, Switzerland)》2022,27(13)
Volatile organic compounds (VOCs) in urine are potential biomarkers of breast cancer. Previously, our group has investigated breast cancer through analysis of VOCs in mouse urine and identified a panel of VOCs with the ability to monitor tumor progression. However, an unanswered question is whether VOCs can be exploited similarly to monitor the efficacy of antitumor treatments over time. Herein, subsets of tumor-bearing mice were treated with pitavastatin at high (8 mg/kg) and low (4 mg/kg) concentrations, and urine was analyzed through solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC-MS). Previous investigations using X-ray and micro-CT analysis indicated pitavastatin administered at 8 mg/kg had a protective effect against mammary tumors, whereas 4 mg/kg treatments did not inhibit tumor-induced damage. VOCs from mice treated with pitavastatin were compared to the previously analyzed healthy controls and tumor-bearing mice using chemometric analyses, which revealed that mice treated with pitavastatin at high concentrations were significantly different than tumor-bearing untreated mice in the direction of healthy controls. Mice treated with low concentrations demonstrated significant differences relative to healthy controls and were reflective of tumor-bearing untreated mice. These results show that urinary VOCs can accurately and noninvasively predict the efficacy of pitavastatin treatments over time. 相似文献
4.
Neslihan Şahin Serap Şahin-Bölükbaşı Halis Marşan 《Journal of Coordination Chemistry》2019,72(22-24):3602-3613
AbstractIn this study, two novel benzimidazole-based N-heterocyclic carbene ligands (1a-b) and their silver(I) complexes (2a-b) were synthesized. All new compounds were characterized by FT-IR, LC-MS, 1H NMR, and 13C NMR spectroscopies. The in vitro antitumor activities of NHC ligands (1a-b) and their silver(I) complexes (2a-b) against DU-145 human prostate cancer cells, MDA-MB-231 and MCF-7 human breast cancer cells and L-929 (normal cells adipose from mouse) were also determined using MTT analysis for 24?h, 48?h, and 72?h. The results showed that while NHC ligands did not have in vitro antitumor activity on MCF-7, MDA-MB-231 and DU-145 cells, Ag(I)-NHC complexes have in vitro antitumor activities. The in vitro antitumor activity of 2a was found to be lower than that of 2b. Ag(I)-NHC complexes were observed to have higher IC50 values for non-cancerous cell lines than cancer cells. 相似文献
5.
Nand K. Singh Nagendra Singh Ajit Sodhi Anju Shrivastava Guru C. Prasad 《Transition Metal Chemistry》1996,21(6):556-559
Summary The new potential tetradentate ligand N-salicyl-N-thiobenzohydrazide (H2SBTH) and its Cu complex, [Cu(SBTH)], have been prepared and characterized by physico-chemical studies. In vivo antitumour activity of [Cu(SBTH)] has been tested against breast tumour in C3H/J strain mice; LD
50 values were also calculated. The cytotoxicity and antitumour effect of [Cu(SBTH)] is a maximum at 100 mg kg-1 body weight injected intraperitoneally in mice carrying breast tumour. In vitro results of the ligand and the complex on P-815 (murine mastocytoma) and K-562 (human erythroleukemia cells) indicate that these compounds show significant inhibition on 3H-thymidine and 3H-uridine incorporation in DNA and RNA in these tumour cells. Light microscopic study of the treated tumour mass demonstrated that certain cellular degradation, such as disappearance of mitotic figures, loss in cellular compactness, distortion of nucleus and disruption of cytoplasmic boundaries, take place in complex-treated mice with tumours. 相似文献
6.
A Palladium‐Catalyzed Carbonylation Approach to Eight‐Membered Lactam Derivatives with Antitumor Activity
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Dr. Raffaella Mancuso Dr. Dnyaneshwar S. Raut Dr. Nadia Marino Dr. Giorgio De Luca Dr. Cinzia Giordano Prof. Dr. Stefania Catalano Dr. Ines Barone Prof. Dr. Sebastiano Andò Prof. Dr. Bartolo Gabriele 《Chemistry (Weinheim an der Bergstrasse, Germany)》2016,22(9):3053-3064
The reactivity of 2‐(2‐alkynylphenoxy)anilines under PdI2/KI‐catalyzed oxidative carbonylation conditions has been studied. Although a different reaction pathway could have been operating, N‐palladation followed by CO insertion was the favored pathway with all substrates tested, including those containing an internal or terminal triple bond. This led to the formation of a carbamoylpalladium species, the fate of which, as predicted by theoretical calculations, strongly depended on the nature of the substituent on the triple bond. In particular, 8‐endo‐dig cyclization preferentially occurred when the triple bond was terminal, leading to the formation of carbonylated ζ‐lactam derivatives, the structures of which have been confirmed by XRD analysis. These novel medium‐sized heterocyclic compounds showed antitumor activity against both estrogen receptor‐positive (MCF‐7) and triple negative (MDA‐MB‐231) breast cancer cell lines. In particular, ζ‐lactam 3 j′ may represent a novel and promising antitumor agent because biological tests clearly demonstrate that this compound significantly reduces cell viability and motility in both MCF‐7 and MDA‐MB‐231 breast cancer cell lines, without affecting normal breast epithelial cell viability. 相似文献
7.
Ahmed A. Fadda Ehab Abdel‐Latif Ahmed Fekri Amal R. Mostafa 《Journal of heterocyclic chemistry》2019,56(3):804-814
Newly synthesized 1,2,3‐benzotriazine‐4‐one derivatives substituted at position‐3 were characterized by various analytical and spectral techniques. The in vitro antitumor activity was evaluated against three different cell lines (liver cells cancer, colorectal cancer, and breast cancer), where compounds 7b , 15 , and 25 showed strong antitumor activity with IC50 ranging from 5.54 to 16.26 μM. In addition, molecular modeling studies using MOE were performed to investigate their binding modes to the C‐Met kinase active site. Docking results demonstrated that all new compounds recognized the active sites of C‐Met kinase and form different types of bonding interactions with key active site amino acid residues. 相似文献
8.
Tetsuo Suami Tsuguhiro Kato Kazuaki Kanai Shuichi Ohki Hideyo Yamashita 《Journal of carbohydrate chemistry》2013,32(3):417-427
Abstract 2-Chloroethylnitrosourea derivatives of sucrose have been synthesized as potential antineoplastic agents. Two compounds: 6-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-6-deoxysucrose and 6′-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-6′-deoxysucrose exhibited significant antitumor activity against experimental leukemia L1210 in mice. Their chemical decomposition rates (T0.5) have been determined. 相似文献
9.
Dongmei Chen Yumei Chen Di Yang Zhaopeng Zheng Zhixu Zhou 《Journal of heterocyclic chemistry》2021,58(8):1628-1636
A series of novel N-(3-((6-bromopyrido[2,3-d]pyrimidin-4-yl)oxy)phenyl)pyrrolidine-1-carboxamide and 1-(3-((6-bromopyrido[2,3-d]pyrimidin-4-yl)oxy)phenyl)-3-propylurea derivatives were synthesized. Their antitumor activities against human breast carcinoma cells (MCF-7) and human colon cancer cells (HCT-116) in vitro were evaluated, using sorafenib as a positive control drug. Anticancer bioassays indicated that several compounds exhibited appreciable anticancer activity against MCF-7 and HCT-116 cells. Particularly, compounds 9g and 8b demonstrated the most significant inhibitory effect against HCT-116 and MCF-7 cells, with inhibition ratios of 25.56% and 26.46%, respectively. Additionally, the synthesized pyridine[2,3-d]pyrimidine derivatives containing a urea group moieties exhibited antitumor activities against MCF-7 and HCT-116 cells in vitro. 相似文献
10.
《Journal of Coordination Chemistry》2012,65(13):2342-2352
Five complexes have been synthesized by the reaction of lanthanide(III) nitrate with 2-thenoyltrifluoroacetone (HTTA) and p-hydroxybenzoic acid (L). The complexes have been characterized by elemental analysis, molar conductivity, FT-IR, UV-Vis, 1H NMR, TG-DTA, XPS, and transmission electron microscope. The general formula of the complexes is Na[Ln(TTA)3L] (Ln?=?La3+,?Ce3+,?Nd3+,?Eu3+,?Er3+). The antibacterial activities indicate that all five complexes exhibit antibacterial ability against Escherichia coli and Staphylococcus aureus with broad antimicrobial spectrums. The antitumor activity of the five complexes against K562 tumor cell in vitro is measured using methyl thiazolyl tetrazolium (MTT) colorimetry. The results show that the complexes induce K562 tumor cell apoptosis, and the complexes exhibit inhibitory effect on leukemia K562 cells. 相似文献
11.
Le Moyec L Mille-Hamard L Triba MN Breuneval C Petot H Billat VL 《Analytical and bioanalytical chemistry》2012,404(2):593-602
Exercise modulates the metabolome in urine or blood as demonstrated previously for humans and animal models. Using nuclear magnetic resonance (NMR) metabolomics, the present study compares the metabolic consequences of an exhaustive exercise at peak velocity (Vp) and at critical velocity (Vc) on mice. Since small-volume samples (blood and urine) were collected, dilution was necessary to acquire NMR spectra. Consequently, specific processing methods were applied before statistical analysis. According to the type of exercise (control group, Vp group and Vc group), 26 male mice were divided into three groups. Mice were sacrificed 2 h after the end of exercise, and urine and blood samples were drawn from each mouse. Proton NMR spectra were acquired with urine and deproteinized blood. The NMR data were aligned with the icoshift method and normalised using the probabilistic quotient method. Finally, data were analysed with the orthogonal projection of latent-structure analysis. The spectra obtained with deproteinized blood can neither discriminate the control mice from exercised mice nor discriminate according to the duration of the exercise. With urine samples, a significant statistical model can be estimated when comparing the control mice to both groups, Vc and Vp. The best model is obtained according to the exercise duration with all mice. Taking into account the spectral regions having the highest correlations, the discriminant metabolites are allantoin, inosine and branched-chain amino acids. In conclusion, metabolomic profiles assessed with NMR are highly dependent on the exercise. These results show that urine samples are more informative than blood samples and that the duration of the exercise is a more important parameter to influence the metabolomic status than the exercise velocity. 相似文献
12.
Aisha Y. Hassan Marwa T. Sarg Samiha A. El-Sebaey 《Journal of heterocyclic chemistry》2020,57(2):694-715
As a continuation of our research on developing anticancer agents and based on the proven proprieties of thieno[2,3-b]pyridines as anticancer, we have designed to synthesize novel thieno[2,3-b]pyridine derivatives that incorporate different biologically active heterocycles through various chemical reactions. All of the newly obtained compounds, compared with the standard anticancer drug (doxorubicin), were screened in vitro for their antitumor activity against hepatocellular carcinoma (HepG-2) and human breast cancer (MCF-7) cell lines. The results revealed that compounds 3 , 7 , 12 , and 19 were found to be the most potent against both HepG-2 and MCF-7 cell lines exhibiting IC50 values ranging from 3.67 to 11.50 and 5.13 to 11.80 μg/mL, respectively, among which compound 7 has a more potent activity than the reference drug doxorubicin against HepG-2 cell line, showing IC50 value of 3.67 μg/mL (doxorubicin 4.65 μg/mL). 相似文献
13.
Nour H. Aboalhaija Heba Syaj Fatma Afifi Suhair Sunoqrot Eveen Al-Shalabi Wamidh Talib 《Molecules (Basel, Switzerland)》2022,27(18)
Lavandula angustifolia is the most widely cultivated Lavandula species for medicinal use. In this study, chemical and biological evaluation of L. angustifolia aqueous, methanol (MeOH), ethanol (EtOH), ethyl acetate (EtOAc), and chloroform (CHCl3) extracts were conducted. Phytochemically, the extracts’ total phenol and flavonoid contents and their antioxidant potential were evaluated. Ethanol extract was analyzed by LC-MS. All extracts were screened in vitro for their antitumor potential using human breast cancer cell lines MCF-7 and MDA-MB-23. For the first time, the antiproliferative potential of the EtOH extract was tested in vivo using mice with induced breast cancer. Ethanol extract exhibited the best cytotoxicity and safety profile of the tested extracts, with IC50 values of 104.1 µg/mL on MCF-7 and 214.5 µg/mL on MDA-MB-231 cell lines, respectively. In vivo, this extract revealed a reduction in tumor size by 43.29% in the treated group, compared to an increase in the tumor growth by 58.9% in the control group. Moreover, undetected tumor was found in 12.5% of the sample size. In conclusion, this study provides novel insight and evidence on the antiproliferative efficacy of L. angustifolia ethanol extract against breast cancer with potent anti-oxidant potential. 相似文献
14.
《Journal of Coordination Chemistry》2012,65(24):4332-4346
In the search for antitumor active metal complexes several ruthenium complexes have been reported to be promising. A series of mononuclear Ru(II) complexes, [Ru(T)2(S)]2+, where T?=?2,2′-bipyridine/1,10-phenanthroline and S?=?CH3-bitsz, Cl-bitsz, Br-bitsz, tmtsz, dmtsz, have been prepared and characterized by UV-Vis, IR, 1H-NMR, FAB-mass spectroscopy, and elemental analysis. The complexes were subjected to in vivo anticancer activity against a transplantable murine tumor cell line Ehrlich's ascitic carcinoma (EAC) and in vitro cytotoxic activity against human cancer cell line Molt 4/C8, CEM, and murine tumor cell line L1210. Ruthenium complexes showed promising biological activity especially in decreasing tumor volume and viable ascitic cell counts. Treatment with these complexes prolonged the life span of EAC-tumor-bearing mice by 10–48%. In vitro evaluation of these ruthenium complexes revealed cytotoxic activity from 0.21 to 24?µmol?L?1 against Molt 4/C8, 0.16–19?µmol?L?1 against CEM, and 0.75–32?µmol?L?1 against L1210 cell proliferation, depending on the nature of the compound. 相似文献
15.
Dr. Jaroslav Malina Prof. Dr. Nicholas P. Farrell Prof. Dr. Viktor Brabec 《化学:亚洲杂志》2011,6(6):1566-1574
The trinuclear platinum compound [{trans‐PtCl(NH3)2}2(μ‐trans‐Pt(NH3)2{NH2(CH2)6NH2}2)]4+ (BBR3464) belongs to the polynuclear class of platinum‐based anticancer agents. These agents form in DNA long‐range (Pt,Pt) interstrand cross‐links, whose role in the antitumor effects of BBR3464 predominates. Our results show for the first time that the interstrand cross‐links formed by BBR3464 between two guanine bases in opposite strands separated by two base pairs (1,4‐interstrand cross‐links) exist as two distinct conformers, which are not interconvertible, not only if these cross‐links are formed in the 5′‐5′, but also in the less‐usual 3′‐3’ direction. Analysis of the conformers by differential scanning calorimetry, chemical probes of DNA conformation, and minor groove binder Hoechst 33258 demonstrate that each of the four conformers affects DNA in a distinctly different way and adopts a different conformation. The results also support the thesis that the molecule of antitumor BBR3464 when forming DNA interstrand cross‐links may adopt different global structures, including different configurations of the linker chain of BBR3464 in the minor groove of DNA. Our findings suggest that the multiple DNA interstrand cross‐links available to BBR3464 may all contribute substantially to its cytotoxicity. 相似文献
16.
Dr. Dongdong Sun Dr. Yanan Liu Du Liu Rong Zhang Xicheng Yang Prof. Jie Liu 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(14):4285-4295
Telomerase inhibition is an attractive strategy for cancer chemotherapy. In the current study, we have synthesized and characterized two chiral ruthenium(II) complexes, namely, Λ‐[Ru(phen)2(p‐MOPIP)]2+ and Δ‐[Ru(phen)2(p‐MOPIP)]2+, where phen is 1,10‐phenanthroline and p‐MOPIP is 2‐(4‐methoxyphenyl)‐imidazo[4,5f][1,10]phenanthroline. The chiral selectivity of the compounds and their ability to discriminate quadruplex DNA were investigated by using UV/Vis, fluorescence spectroscopy, circular dichroism spectroscopy, fluorescence resonance energy transfer melting assay, polymerase chain reaction stop assay and telomerase repeat amplification protocol. The results indicate that the two chiral compounds could induce and stabilize the formation of antiparallel G‐quadruplexes of telomeric DNA in the presence or absence of metal cations. We report the remarkable ability of the two complexes Λ‐[Ru(phen)2(p‐MOPIP)]2+ and Δ‐[Ru(phen)2(p‐MOPIP)]2+ to stabilize selectively G‐quadruplex DNA; the former is a better G‐quadruplex binder than the latter. The anticancer activities of these complexes were evaluated by using the MTT assay. Interestingly, the antiproliferative activity of Λ‐[Ru(phen)2(p‐MOPIP)]2+ was higher than that of Δ‐[Ru(phen)2(p‐MOPIP)]2+, and Λ‐[Ru(phen)2(p‐MOPIP)]2+ showed a significant antitumor activity in HepG2 cells. The status of the nuclei in Λ/Δ‐[Ru(phen)2(p‐MOPIP)]2+‐treated HepG2 cells was investigated by using real‐time living cell microscopy to determine the effects of Λ/Δ‐[Ru(phen)2(p‐MOPIP)]2+ on intracellular accumulation. The results show that Λ/Δ‐[Ru(phen)2(p‐MOPIP)]2+ can be taken up by HepG2 cells and can enter into the cytoplasm as well as accumulate in the nuclei; this suggests that the nuclei were the cellular targets of Λ/Δ‐[Ru(phen)2(p‐MOPIP)]2+. 相似文献
17.
Chen Zhao Xinyao Wang Dr. Yanfeng Yin Prof. Wenming Tian Dr. Guang Zeng Dr. Haitao Li Prof. Sheng Ye Prof. Limin Wu Prof. Jian Liu 《Angewandte Chemie (International ed. in English)》2023,62(12):e202218318
Designing polymeric photocatalysts at the molecular level to modulate the photogenerated charge behavior is a promising and challenging strategy for efficient hydrogen peroxide (H2O2) photosynthesis. Here, we introduce electron-deficient 1,4-dihydroxyanthraquinone (DHAQ) into the framework of resorcinol-formaldehyde (RF) resin, which modulates the donor/acceptor ratio from the perspective of molecular design for promoting the charge separation. Interestingly, H2O2 can be produced via oxygen reduction and water oxidation pathways, verified by isotopic labeling and in situ characterization techniques. Density functional theory (DFT) calculations elucidate that DHAQ can reduce the energy barrier for H2O2 production. RF-DHAQ exhibits excellent overall photosynthesis of H2O2 with a solar-to-chemical conversion (SCC) efficiency exceeding 1.2 %. This work opens a new avenue to design polymeric photocatalysts at the molecular level for high-efficiency artificial photosynthesis. 相似文献
18.
《Journal of Coordination Chemistry》2012,65(21):3839-3847
By introducing antibacterial drug pipemidic acid into octamolybdates, two new compounds, (HPPA)4[Mo8O26] 2H2O (1) and [Ni2(PPA)2(H2O)4] [Mo8O26] 3H2O (2) (PPA?=?8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)pyrido(2,3-d)pyrimidine-6-carboxylic acid), have been synthesized and characterized by physical methods. Single-crystal X-ray analysis reveal that 1 and 2 crystallize in the triclinic system, space group P-1, in which supramolecular interactions play vital roles in stabilizing the structure of 1 and 2. The results of their antitumor activities in vitro show that the compounds exhibit good anti-SGC7901 and anti-SMMC7721 activities, which indicates that the antitumor activities of Polyoxometalates can be modulated by the surface modification with drugs. 相似文献
19.
Yafei Guo Yushun Zhang Jiuling Li Fen Zhao Yang Liu Min Su Yubo Jiang Yuqi Liu Jihong Zhang Bo Yang Rui Yang 《中国化学》2016,34(4):425-431
An inclusion complex of podophyllotoxin (PPT) with γ‐cyclodextrin (γ‐CD) was prepared. The behavior, characterization, and water solubility of the inclusion complex were carefully investigated via fluorescence spectroscopy, thermogravimetry, differential scanning calorimetry, X‐ray diffraction analysis, and 1H and 2D nuclear magnetic resonance spectroscopy. Furthermore, antitumor activity to human cancer lines and toxicity in mice were studied. Results showed that the inclusion complex formed in a 1:1 ratio with a considerable apparent stability constant Ks (4245.5 L·mol?1). Water solubility was considerably improved. In addition, the anticancer activity of the inclusion complex was better than that of cis‐platinum (DDP, positive control). Most importantly, the toxicity of podophyllotoxin inclusion complex reduced and became more safety to mice which will be great valuable to research its applications as a kind of antitumor drug to human in the further. 相似文献
20.
Control of Luminescence by Tuning of Crystal Symmetry and Local Structure in Mn4+‐Activated Narrow Band Fluoride Phosphors
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Mu‐Huai Fang Wei‐Lun Wu Prof. Dr. Ye Jin Tadeusz Lesniewski Dr. Sebastian Mahlik Prof. Dr. Marek Grinberg Prof. Dr. Mikhail G. Brik Dr. Alok M. Srivastava Dr. Chang‐Yang Chiang Prof. Dr. Wuzong Zhou Dr. Donghyuk Jeong Prof. Dr. Sun Hee Kim Dr. Grzegorz Leniec Prof. Dr. Slawomir M. Kaczmarek Dr. Hwo‐Shuenn Sheu Prof. Dr. Ru‐Shi Liu 《Angewandte Chemie (International ed. in English)》2018,57(7):1797-1801
Mn4+‐doped fluoride phosphors have been widely used in wide‐gamut backlighting devices because of their extremely narrow emission band. Solid solutions of Na2(SixGe1?x)F6:Mn4+ and Na2(GeyTi1?y)F6:Mn4+ were successfully synthesized to elucidate the behavior of the zero‐phonon line (ZPL) in different structures. The ratio between ZPL and the highest emission intensity υ6 phonon sideband exhibits a strong relationship with luminescent decay rate. First‐principles calculations are conducted to model the variation in the structural and electronic properties of the prepared solid solutions as a function of the composition. To compensate for the limitations of the Rietveld refinement, electron paramagnetic resonance and high‐resolution steady‐state emission spectra are used to confirm the diverse local environment for Mn4+ in the structure. Finally, the spectral luminous efficacy of radiation (LER) is used to reveal the important role of ZPL in practical applications. 相似文献