Ascorbic acid as an eluent for99mTc in99Mo−99mTc generator system

A simple chromatographic procedure for clean separation of the important radionuclide,^99m Tc, in the equilibrium mixture,⁹⁹Mo−^99mTc, has been demonstrated. Separation of pure^99mTc has been achieved by preferential extraction of the radioisotope through an anion exchange resin column of Amberlite IRA-410 using Na-ascorbate solution at pH 7 as an eluent. The radiochemical purity of the separated radiotracer has been verified by taking recourse to γ-ray spectrometry. The potentiality of the developed procedure lies in the facts that the eluting agent, ascorbic acid, itself h got its own biomedical importance as Vitamin C and the concerned radioisotope can be obtained in both Tc(IV) and Tc(VII) states as per requirement for diagnostic purposes.     

Long-lived γ-radionuclidic impurities in spent99Mo/99mTc generators

The long-lived -radionuclidic impurities in the columns of spent⁹⁹Mo/^99mTc generators one year after the calibration date have been determined by -spectrometry. Three radionuclidic impuritiesfission products (¹⁰³Ru,¹⁰⁶Ru and¹²⁵Sb) were detected. Also in the majority of samples three radioisotopes of tungsten (¹⁸¹W,¹⁸⁵W and¹⁸⁸W) were also present. The contents of the impurities were found to vary greatly. According to the activity, energy and half-life, the main contribution to the residual activity in the spent generators is due to the presence of¹²⁵Sb.     

An Alumina Based 99Mo–99mTc Generator to Produce 99mTc in Organic Medium Suitable for Industrial Radiotracer Applications

An industrial chromatographic ⁹⁹Mo–^99mTc generator has been developed with the aid of chromatographic alumina to obtain ^99mTc in a non-aqueous medium. This generator system takes advantage of tributyl phosphate to extract ^99mTc selectively with appreciable yield and in high radiochemical and radionuclidic purity. This facile, versatile and efficient approach provides ^99mTc at industrial sites in a medium soluble in hydrocarbon solvents, for radiotracer applications.     

99mTc放射性药物化学

^99mTc放射性药物在科学研究和临床上已经得到了广泛的应用,但如何发展药效更好的药物以适应临床诊断的需求,依然是亟待解决的问题。新药物配体和金属核的引入以及新的标记方法的发展是目前^99mTc的放射性药物的热点。本文介绍^99mTc放射性药物化学的几种新标记方法,包括羰基锝标记的新型配体和新方法、^99mTc高价配合物的制备和应用等,旨在对有关研究者提供参考。     

Technetium-99m generator based on 12-molybdocerate —99Mo precipitate as column matrix

The preparation of insoluble 12-molybdocerate(IV) from⁹⁹Mo of low specific activity, produced by thermal neutron irradiation of MoO₃, is described. Samples of the material are dried at 50, 100 and 200°C and used as column matrices from which the generated^99mTc activity is periodically eluted with saline solution or saline solution containing 5·10^–5M K₂CrO₄ as an oxidant. The elution yields of^99mTc are high and reproducible (95–81%) with radionuclidic purity 99.98%. Both chemical and radiochemical purity (as TcO ₄ ^– ) of the eluates decrease with increasing drying temperature of the column matrix. Using chromated saline solution as eluent improves the radiochemical purity of the^99mTc eluate.     

99mTcN-MIBI在体外肿瘤细胞内的摄取及其与99mTc-MIBI的比较研究

研究了结肠癌细胞CL-187、肺腺癌细胞L-973以及乳腺癌细胞MCF-7分别对^99mTcN-MIBI和^99mTc-MIBI配合物的摄取情况.结果表明,^99mTcN-MIBI在3种肿瘤细胞内培养20～40min时的摄取达到极大值,并且摄取量明显高于^99mTc-MIBI,特别是在结肠癌细胞CL-187中.^99mTcN-MIBI在乳腺癌细胞MCF-7内的摄取量最高,培养40min时的单位细胞摄取百分率约为30%/105个细胞;在结肠癌细胞CL-187内的摄取量次之;在肺腺癌细胞L-973内的摄取量最低.细胞摄取条件实验结果表明:细胞浓度和培养温度的变化均会对细胞摄取产生影响.     

四川大学化学学院99周年院庆

今年是四川大学110周年校庆，化学学院也迎来了她99周年的华诞。百年办学历史所积淀的深厚文化底蕴和培养的近万名莘莘学子，是学院最宝贵的财富和最大的自豪。目前，学院拥有博士学位授予权化学一级学科点和化学博士后科研流动站，具备完整的化学人才培养体系；有一支素质好，结构合理的教学科研队伍；承担的科研项目数、SCI论文发表数、科研经费等多项核心指标均在全校名列前茅。作为国家“211”工程和“985”工程重点建设的学科之一，学院正努力朝着建设在国际上具有较大影响、国内一流的创新性、研究型学院的目标奋进。     

Separation of 99mTc from 99Mo by Using TOPO — Kerosene Supported Liquid Membrane

Transport of ^99mTcO₄ ^– ions across TOPO-kerosene based supported liquid membrane was investigated at different concentrations of phosphoric acid as a feed solution and different concentrations of TOPO in the membrane, where 0.9% NaCl aqueous solution was used as a stripping solution. The flux of TcO₄ ^– ions across this liquid membrane varied with the concentration of both H₃PO₄ and TOPO. The best permeability coefficient was obtained at concentrations, [H₃PO₄] = 3 mole·l^–1 and [TOPO] = 0.5 mole·l^–1 (P = 2.08·10^–9 m²·s^–1). The results were utilized for the separation of ^99mTc from ⁹⁹Mo, where a selective and effective separation was obtained since no ⁹⁹Mo transport across this liquid membrane was noticed while a high rate of ^99mTc transport took place.     

99mTc放射性药物中的配位化学

在99mTc间接标记放射性药物中双功能螯合剂起到重要的连接作用,其在很大程度上决定了放射性药物的理化性质。99mTc标记放射性药物中常用的双功能螯合剂大都含有N、S、P等杂原子,本文以与锝核配位杂原子的不同对双功能螯合剂进行分类,分别对NxS(4-x)型配体、“3＋1”混合配体、含膦配体以及以[99mTc(CO)3]+为配位中心的99mTc放射性药物逐一进行介绍。     

Integral cross section of the99Tc(γ,γ′)99mTc reaction at 4 MeV

^99mTc production was studied with the aid of photoexcitation by a 4 MeV endpoint energy bremsstrahlung from the LINAC of the Institute of Isotopes, Budapest. The intensity of the -flux was monitored by disc-shaped natural indium plates, placed in front of and behind the small cylindrical aluminium holders containing TcO₂ samples in a powder form. Isomeric activities were measured through the 140 keV -line by a Ge spectrometer. The integral cross section at 4 MeV was found to be 63.3±7.1 bMeV, which can be considered reasonable compared to the corresponding value of 55.3 bMeV established for the¹¹⁵In (,)^115mIn reaction. We also attempted the photoexcitation of^99mTc by irradiation with -rays from a 1.5×10¹⁵ Bq⁶⁰Co source, but no isomeric activity could be observed. This places the first activation level between 1.33 and 4 MeV.     

TEG-99环氧树脂的合成与性能研究

以松节油为原料合成出新型TEG - 99环氧树脂 ,研究了它分别与典型胺类、聚酰胺类及酸酐类固化剂的固化反应和固化产物的性能。结果表明 ,以松节油为原料合成TEG - 99环氧树脂的过程简单、稳定 ,产物具有与双酚A型环氧树脂相似的外观、理化性能、固化特征等 ,是松节油综合利用的一个有前景的途径     

新型红外光谱仪问世验中药准确度99％

据香港文汇报报道,香港浸会大学计算器科学系副教授张晓明博士领导的科研小组成功开发一项基于红外光谱特征的检测系统,只需数分钟便可测定药材真伪,准确度高达99％,更可验出药材品种和产地,准确度亦达94％,而且成本更低。目前,其核心红外光谱特征提取技术获得中国国家知识产权局授予发明专利权。     

Separation of no-carrier-added 99mTcO4 − from 99Mo–99mTc equilibrium mixture by PEG based aqueous biphasic separation technique using sodium/potassium salts of citric and tartaric acid

Extraction and separation of no-carrier-added (nca) ^99mTcO₄ ^? from ⁹⁹Mo–^99mTc equilibrium mixture was carried out by environmentally benign polyethylene glycol based liquid–liquid aqueous biphasic systems (ABS) consisting various inorganic salts. Among the various inorganic salt trisodium citrate and potassium sodium tartrate showed the suitable salt rich phase for the best separation in this report. The concentration variation of salt rich phase, temperature and PEG phase also exhaustively studied in paper for the achievement of high separation factor. At 40 °C temperature in 50 % (w/v) PEG-4000-2M Na₃citrate showed the highest separation factor (S _Tc/Mo) 1.2 × 10⁷.     

99号元素釾和100号元素钲

元素周期系究竟终止于多少号元素的问题虽然在目前还没有解决,但是99号和100号元素的存在已经是没有问题的了。不过由于现在原子核研究工作的公开发表往往较慢,所以关于99号元素和100号元素的制法和性质,还没有详细的报导,目前仅仅知道有几篇文献记述这两种元素的发现。 C.Martin一文是一个报导消息的文章,并不是作者本人的工作报告。文中说:用碳核轰击94     

Technetium-99 in the Rhône river water

⁹⁹Tc a pure -particle emitter with long half-life (T=2.13×10⁵ y) was measured in Rhône river water and in Mediterranean sea water near the river mouth. The values obtained in the Rhône river allowed us to show the downstream distribution of the effluents from the nuclear fuel reprocessing plant of Marcoule: the⁹⁹Tc activity which is low above the plant, 0.016 mBq 1^–1, is 0.4 mBq 1^–1 at Roquemaure, located 14 km below the plant, and then decreases as a function of distance from the plant.     

新型净化器对PM2.5去除率逾99%

<正>上海理工大学环境与建筑学院陈剑波教授科研团队,经过多年潜心研究,自主研发出一款高性能的空气净化器,能够有效去除0.3μm以下微粒。根据上海市环境保护产品质量监督检验总站检测,此款新型净化器对PM2.5去除率超过99%、甲醛的净化效率达到96%;经瑞士公证行SGS检测,对总挥发性有机化合物净化效率达到96.5%。陈剑波说,与传统空气吸附剂(活性炭等)相比最大的不同是该款净化器中研发的空气净化媒介不仅能够物理吸附,还能不断地将污染物分子进行催化氧化分解,瓦解污染     

脑显像剂^99mTc—ECD的制备研究

＾９９ｍＴｃ－ＥＣＤ是目前脑显像剂中一种较为理想的放射性诊断药物。本文介绍了从基本原料（Ｌ）半胱氨酸开始合成配体ＥＣＤ（Ｎ，Ｎ”－乙撑－双－Ｌ－半胱氨酸乙酯），采用锡作还原剂实现了一步法＾９９ｍＴｃ标记ＥＣＤ，并对制备的＾９９ｍＴｃ－ＥＣＤ进行了初步动物实验以评价其生物学性能。     

ICP-MS法测定食品中微量~(99)Tc

针对食品样品中微量锝的检测,建立了一种高效、定量分离99Tc,并能有效除去钼、钌的方法。方法采用聚乙二醇-4000涂覆的C18-U柱分离锝、钼和钌,用2 mol/L碳酸钠溶液体系上柱后,去离子水洗脱吸附在柱上的锝。该方法对99Tc的平均回收率为100%,钼的去污因子为1.3×104,钌的去污因子为6.2×103。99Tc采用质谱法测量。方法用于食品中99Tc的检测,99Tc含量在1~20 ng/kg干样之间。