共查询到20条相似文献,搜索用时 15 毫秒
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M. Sc. Marc P. Baggelaar M. Sc. Freek J. Janssen Annelot C. M. van Esbroeck Ing. Hans den Dulk M. Sc. Marco Allarà M. Sc. Sascha Hoogendoorn Dr. Ross McGuire Dr. Bogdan I. Florea Ing. Nico Meeuwenoord Ing. Hans van den Elst Prof. Dr. Gijsbert A. van der Marel Prof. Dr. Jaap Brouwer Prof. Dr. Vincenzo Di Marzo Prof. Dr. Herman S. Overkleeft Dr. Mario van der Stelt 《Angewandte Chemie (International ed. in English)》2013,52(46):12193-12193
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Cover Picture: Deactivation of Mcl‐1 by Dual‐Function Small‐Molecule Inhibitors Targeting the Bcl‐2 Homology 3 Domain and Facilitating Mcl‐1 Ubiquitination (Angew. Chem. Int. Ed. 46/2016) 下载免费PDF全文
Dr. Ting Song Ziqian Wang Dr. Fangling Ji Dr. Yingang Feng Yudan Fan Gaobo Chai Dr. Xiangqian Li Zhiqiang Li Dr. Zhichao Zhang 《Angewandte Chemie (International ed. in English)》2016,55(46):14179-14179
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Markus Leimbacher Dr. Yixin Zhang Dr. Luca Mannocci Michael Stravs Dr. Tim Geppert Dr. Jörg Scheuermann Prof. Gisbert Schneider Prof. Dario Neri 《Chemistry (Weinheim an der Bergstrasse, Germany)》2012,18(25):7729-7737
Libraries of chemical compounds individually coupled to encoding DNA tags (DNA‐encoded chemical libraries) hold promise to facilitate exceptionally efficient ligand discovery. We constructed a high‐quality DNA‐encoded chemical library comprising 30 000 drug‐like compounds; this was screened in 170 different affinity capture experiments. High‐throughput sequencing allowed the evaluation of 120 million DNA codes for a systematic analysis of selection strategies and statistically robust identification of binding molecules. Selections performed against the tumor‐associated antigen carbonic anhydrase IX (CA IX) and the pro‐inflammatory cytokine interleukin‐2 (IL‐2) yielded potent inhibitors with exquisite target specificity. The binding mode of the revealed pharmacophore against IL‐2 was confirmed by molecular docking. Our findings suggest that DNA‐encoded chemical libraries allow the facile identification of drug‐like ligands principally to any protein of choice, including molecules capable of disrupting high‐affinity protein–protein interactions. 相似文献
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Inside Back Cover: Single‐Molecule Mechanochemical Sensing Using DNA Origami Nanostructures (Angew. Chem. Int. Ed. 31/2014) 下载免费PDF全文
Dr. Deepak Koirala Prakash Shrestha Tomoko Emura Kumi Hidaka Shankar Mandal Prof. Dr. Masayuki Endo Prof. Dr. Hiroshi Sugiyama Prof. Dr. Hanbin Mao 《Angewandte Chemie (International ed. in English)》2014,53(31):8251-8251
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Bharat Kumar Ruth L. Viboh Margel C. Bonifacio William B. Thompson Jonathan C. Buttrick Babe C. Westlake Min‐Soo Kim Prof. Robert W. Zoellner Prof. Sergey A. Varganov Philipp Mörschel Jaroslav Teteruk Prof. Dr. Martin U. Schmidt Prof. Benjamin T. King 《Angewandte Chemie (International ed. in English)》2012,51(51):12897-12897
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Back Cover: Phenotypic Screening to Identify Small‐Molecule Enhancers for Glucose Uptake: Target Identification and Rational Optimization of Their Efficacy (Angew. Chem. Int. Ed. 20/2014) 下载免费PDF全文
Dr. Minseob Koh Dr. Jongmin Park Ja Young Koo Donghyun Lim Dr. Mi Young Cha Ala Jo Prof. Dr. Jang Hyun Choi Prof. Dr. Seung Bum Park 《Angewandte Chemie (International ed. in English)》2014,53(20):5216-5216
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Cover Picture: Selection of DNA‐Encoded Small Molecule Libraries Against Unmodified and Non‐Immobilized Protein Targets (Angew. Chem. Int. Ed. 38/2014) 下载免费PDF全文
Peng Zhao Zitian Chen Yizhou Li Dawei Sun Yuan Gao Prof. Yanyi Huang Prof. Xiaoyu Li 《Angewandte Chemie (International ed. in English)》2014,53(38):9963-9963
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Inside Back Cover: Self‐Assembly of a 3d–5f Trinuclear Single‐Molecule Magnet from a Pentavalent Uranyl Complex (Angew. Chem. Int. Ed. 49/2014) 下载免费PDF全文
Lucile Chatelain James P. S. Walsh Dr. Jacques Pécaut Dr. Floriana Tuna Dr. Marinella Mazzanti 《Angewandte Chemie (International ed. in English)》2014,53(49):13621-13621
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Inside Back Cover: Lability‐Controlled Syntheses of Heterometallic Clusters (Angew. Chem. Int. Ed. 11/2014) 下载免费PDF全文
Dr. Graham N. Newton Dr. Kiyotaka Mitsumoto Rong‐Jia Wei Fumichika Iijima Dr. Takuya Shiga Prof. Dr. Hiroyuki Nishikawa Prof. Dr. Hiroki Oshio 《Angewandte Chemie (International ed. in English)》2014,53(11):3033-3033
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Inside Back Cover: Fragment‐Based Discovery of a Dual pan‐RET/VEGFR2 Kinase Inhibitor Optimized for Single‐Agent Polypharmacology (Angew. Chem. Int. Ed. 30/2015) 下载免费PDF全文
Brendan Frett Francesca Carlomagno Maria Luisa Moccia Annalisa Brescia Giorgia Federico Valentina De Falco Brittany Admire Zhongzhu Chen Wenqing Qi Massimo Santoro Hong‐yu Li 《Angewandte Chemie (International ed. in English)》2015,54(30):8847-8847