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1.
A series of N‐aryl 2‐alkenamides were produced efficiently by treating N‐aryl 3‐(phenylsulfonyl)‐propanamides with potassium tert‐butoxide in THF at 0°C. With out isolation, it was further treated with an additional equivalent of potassium tert‐butoxide and allyl bromide to give N‐allyl N‐aryl 2‐alkenamides in one pot in good yields. Followed by a ring‐closing metathesis reaction, these N‐allyl N‐aryl 2‐alkenamides were respectively converted into corresponding N‐aryl α,β‐unsaturated γ‐lactams in moderate yields. 相似文献
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Agata Biaoska Zbigniew Ciunik 《Acta Crystallographica. Section C, Structural Chemistry》2006,62(4):o182-o185
Comparison of the structures of strychninium N‐phthaloyl‐β‐alaninate N‐phthaloyl‐β‐alanine, C21H23N2O2+·C11H8NO4−·C11H9NO4, and brucinium N‐phthaloyl‐β‐alaninate 5.67‐hydrate, C23H27N2O4+·C11H8NO4−·5.67H2O, reveals that, unlike strychninium cations, brucinium cations display a tendency to produce stacking interactions with cocrystallizing guests. 相似文献
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Kun‐Heng Chiang Shi‐Han Lu Wan‐Ping Yen Naoto Uramaru Wei‐Siou Tseng Te‐Wei Chang Fung Fuh Wong 《Heteroatom Chemistry》2016,27(4):235-242
A convenient synthetic method for N‐arylformamide derivatives was successfully developed by reacting α‐iodo‐N‐arylacetamides with formamide. This method was applicable to α‐iodo‐N‐arylacetamide substrates bearing electron‐donating or electron‐withdrawing groups, N‐(benzo[d][1,3]dioxol‐5‐yl)‐2‐iodoacetamide, 2‐iodo‐N‐(pyridin‐2‐yl)acetamide, and 2‐iodo‐N‐(naphthalen‐4‐yl)acetamide to give the corresponding N‐arylformamides in moderate to excellent yields (65–94%). A plausible mechanism was proposed to account for the new transformation. 相似文献
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Dr. Tetsuo Sato Yoichi Hirose Daisuke Yoshioka Tsubasa Shimojo Prof. Dr. Shuichi Oi 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(46):15710-15718
The synthesis and characterisation of a series of new Rh and Au complexes bearing 1,2,4‐triazol‐3‐ylidenes with a N‐2,4‐dinitrophenyl (N‐DNP) substituent are described. IR, NMR, single‐crystal X‐ray diffraction and computational analyses of the Rh complexes revealed that the N‐heterocyclic carbenes (NHCs) behaved as strong π acceptors and weak σ donors. In particular, a natural bond orbital (NBO) analysis revealed that the contributions of the Rh→Ccarbene π backbonding interaction energies (ΔEbb) to the bond dissociation energies (BDE) of the Rh? Ccarbene bond for [RhCl(NHC)(cod)] (cod=1,5‐cyclooctadiene) reached up to 63 %. The Au complex exhibited superior catalytic activity in the intermolecular hydroalkoxylation of cyclohexene with 2‐methoxyethanol. The NBO analysis suggested that the high catalytic activity of the AuI complex resulted from the enhanced π acidity of the Au atom. 相似文献
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Kirill N. Zelenin Igor V. Lagoda Valeriy V. Alekseyev Jari Sinkkonen Kalevi Pihlaja Roustem A. Shaikhutdinov 《Journal of heterocyclic chemistry》2002,39(4):805-810
A universal scheme is proposed for the molecular design of heterocyclic recyclizations by replacing the exocyclic hydroxyl groups in exo‐trig‐ ring‐chain tautomeric molecules with substituted amines or hydrazines. The practical applicability of this approach is demonstrated by the condensations of 5‐hydroxy‐5‐methyl‐3‐isoxazolidinones with thioaroyl‐hydrazines and 2‐aminomethylaniline. The condensation products were studied by modern 1H, 13C and 15N NMR spectroscopic methods using three solvents: CDC13, DMSO[D6] and CD3CN. The solvent was found to have a strong effect to the relative amounts of the tautomers. 相似文献
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Lourdes Urpí Katia Jimnez Xavier Solans Alfonso Rodríguez‐Galn Jordi Puiggalí 《Acta Crystallographica. Section C, Structural Chemistry》2003,59(1):o24-o26
The β‐alanine residue of the title compound, C5H8ClNO3, has a ggt folded conformation, which is mainly stabilized through intermolecular N—H⋯O=C (amide–acid) and O—H⋯O=C (acid–amide) hydrogen bonds. In addition, a cis conformation is found for the Cl—CH2—C(=O)—NH torsion angle, which is associated with the presence of an intramolecular hydrogen bond. 相似文献
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A series of new N‐benzoyl‐N‐tert‐butyl‐N′‐(β‐triphenylgermyl)propionylhydrazines were synthesized by the condensation reaction of β‐triphenylgermyl propanoic acid with N‐benzoyl‐N‐tert‐butylhydrazines in good yields by using N,N′‐dicyclohexylcorbodiimide as dehydrating agent. These title compounds were evaluated for molting hormone mimicking activity. The results of bioassay showed that the compounds exhibit moderate larvicidal activity, and toxicity assays indicated that the title compounds can induce a premature, abnormal and lethal larval molt. We found that the title compounds possess potential anticancer activities in vitro. Copyright © 2002 John Wiley & Sons, Ltd. 相似文献
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Fathy M. Abdelrazek Nehal A. Sobhy Peter Metz Akram A. Bazbouz 《Journal of heterocyclic chemistry》2012,49(2):381-387
3‐Oxo‐N‐[4‐(3‐oxo‐3‐phenylpropionylamino)‐phenyl]‐3‐phenylpropionamide 1 and its derivative 2‐benzoyl‐N‐[4‐(2‐benzoyl‐3‐(dimethylamino‐acryloylamino)‐phenyl]‐3‐dimethylaminoacrylamide 12 are used for the synthesis of the hitherto not known bis‐heterocyclic amine and bis‐heterocyclic carboxamide derivatives. Plausible mechanisms are discussed for the formation of the new compounds. J. Heterocyclic Chem., (2012). 相似文献
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Hanife Saraçoǧlu Alaaddin Cukurovali 《International journal of quantum chemistry》2012,112(16):2775-2781
The title molecule, N‐[4‐(3‐Methyl‐3‐phenyl‐cyclobutyl)‐thiazol‐2‐yl]‐N′‐pyridin‐3ylmethylene‐ hydrazine (C20 H20 N4 S1), was characterized by 1H‐NMR, 13C‐NMR, IR, UV‐visible, and X‐ray determination. In addition to the molecular geometry from X‐ray experiment, the molecular geometry, vibrational frequencies and gauge including atomic orbital 1H‐ and 13C‐NMR chemical shift values of the title compound in the ground state have been calculated using the Hartree‐Fock and density functional method (B3LYP) with 6‐31G(d, p) basis set. The calculated results show that optimized geometries can well reproduce the crystal structural parameters. By using time‐dependent density functional theory method, electronic absorption spectrum of the title compound has been predicted. © 2011 Wiley Periodicals, Inc. 相似文献
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Catherine Michaux Caroline Charlier Fabien Julmont Jean‐Michel Dogn Xavier De Leval Bernadette Norberg Bernard Pirotte Franois Durant 《Acta Crystallographica. Section C, Structural Chemistry》2002,58(2):o88-o89
The title compound, C12H12N2O3S, is a strict pyridine analogue of nimesulide, a selective inhibitor of cyclooxygenase‐2. The structure is characterized by a pyridinium ring with a deprotonated sulfonamide group. An intermolecular charge‐assisted hydrogen bond between these two groups is observed within the crystal packing, linking the molecules into an infinite chain running along the b‐axis direction. 相似文献
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Surendra Kumar Nayak Vikramdeep Monga Navneet Kaur Rahul Jain 《Journal of heterocyclic chemistry》2007,44(6):1265-1269
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Christopher Glidewell John N. Low Janet M. S. Skakle Solange M. S. V. Wardell James L. Wardell 《Acta Crystallographica. Section C, Structural Chemistry》2002,58(8):o487-o490
In 2‐iodo‐N‐(3‐nitrobenzyl)aniline, C13H11IN2O2, the molecules are linked into a three‐dimensional structure by a combination of C—H?O hydrogen bonds, iodo–nitro interactions and aromatic π–π‐stacking interactions, but N—H?O and C—H?π(arene) hydrogen bonds are absent. In the isomeric 3‐iodo‐N‐(3‐nitrobenzyl)aniline, a two‐dimensional array is generated by a combination of N—H?O, C—H?O and C—H?π(arene) hydrogen bonds, but iodo–nitro interactions and aromatic π–π‐stacking interactions are both absent. 相似文献
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N‐(2‐Bromoethyl)‐4‐piperidino‐1,8‐naphthalimide and N‐(3‐bromopropyl)‐4‐piperidino‐1,8‐naphthalimide
Tei Tagg C. John McAdam Brian H. Robinson Jim Simpson 《Acta Crystallographica. Section C, Structural Chemistry》2008,64(7):o388-o391
N‐(2‐Bromoethyl)‐4‐piperidino‐1,8‐naphthalimide, C19H19BrN2O2, (I), and N‐(3‐bromopropyl)‐4‐piperidino‐1,8‐naphthalimide, C20H21BrN2O2, (II), are an homologous pair of 1,8‐naphthalimide derivatives. The naphthalimide units are planar and each piperidine substituent adopts a chair conformation. This study emphasizes the importance of π‐stacking interactions, often augmented by other contacts, in determining the crystal structures of 1,8‐naphthalimide derivatives. 相似文献
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Rafael Germano Santana Derisvaldo Rosa Paiva Roberto da Silva Gomes Adriana Karla C. A. Reis 《Magnetic resonance in chemistry : MRC》2013,51(5):316-319
The complete assignment of the 1H and 13C NMR spectra of various 2‐acetamido‐3‐mercapto‐3‐methyl‐N‐aryl‐butanamides and 2‐acetamide‐3‐methyl‐3‐nitrososulfanyl‐N‐aryl‐butanamides with p‐methoxy, o‐chloro and m‐chloro substituents is reported. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
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Novel N‐aryl (and N‐alkyl) γ‐ and δ‐imino esters 2a–g ( 3a–g ) and N‐aryl (and N‐alkyl) ketimines 2h–j ( 3h–j ) were synthesized in high yields (80–99%) from their corresponding γ‐ and δ‐keto esters and ketones in this study. The structures of the synthesized compounds were clarified by Fourier transform infrared (FT‐IR), NMR (1H and 13C), mass spectrometry, and elemental analyses. Isomerizations [E/Z] were also determined by their 1H NMR spectra. The free‐radical scavenging activity of imines was evaluated using the 1,1‐diphenyl‐2‐picryl‐hydrazyl (DPPH) method. The relationships between the structure and antioxidant activity of these compounds are discussed. Among these compounds, 2a–c (at the concentration 1000 μg/mL) exhibit high antioxidant activity similar to those of the standards (butylated hydroxyanisole [ BHA], butylated hydroxytoluene [ BHT], and ascorbic acid). 相似文献
20.
Antonija Hergold‐Brundi Gordana Pavlovi Ana Dunja Mance Kreimir Jakop
i 《Acta Crystallographica. Section C, Structural Chemistry》2000,56(11):e520-e521
The title compound, C15H14N2O3, is the first example of a structurally determined tertiary amine with both N‐5‐nitrofurfuryl and N‐prop‐2‐ynyl moieties. The molecule is not planar, i.e. the furan ring is inclined at an angle of 84.35 (4)° to the phenyl ring. The crystal structure is dominated by van der Waals forces. The terminal alkynyl group as the strongest C—H hydrogen‐bond donor is not involved in hydrogen‐bond formation. 相似文献