共查询到20条相似文献,搜索用时 31 毫秒
1.
Fan Yang Hong-Ping Chen Xiao-Fei Shen Hu-Lan Chen Yin Chen Li-Xia Wang 《Natural product research》2019,33(19):2856-2859
A new abietane diterpenoid glycoside, ajugaside B (1), along with three known compounds (2–4), were isolated from the whole plants of Ajuga ovalifolia var. calantha. The structure of the new compound (1) was elucidated by means of spectroscopic analyses (HRESIMS, IR, NMR and ECD). All of the isolated compounds were evaluated for their antitumor activities against MGC803, MCF-7, A549, HT29 and HepG2 cell lines. Compounds 3–4 showed moderate cytotoxicity against all tested cell lines with IC50 values of 1.8–7.3?μM. 相似文献
2.
AbstractChemical investigation of the aerial parts of Mikania micrantha led to the isolation of eight sesquiterpenoids and ten diterpenoids, including five cadinane sesquiterpenoids (1?5), three bisabolene sesquiterpenoids (6???8), nine ent-kaurane diterpenoids (9–17), and an abietane diterpenoid (18). Among them, 1???3 are new and feature a rare lactone or furan ring derived from C-6 isopropyl group side chain. Compound 18 was isolated from genus Mikania for the first time, and was also the first example of abietane-type diterpenoids from this plant. Their structures were elucidated on the basis of extensive spectroscopic analyses (1D and 2D NMR, HRESIMS, and ECD). All compounds were examined for their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophage cells, and compound 18 exhibited pronounced inhibition on NO production (IC50 = 11.04?µM), being comparable to the positive control, quercetin (IC50 = 11.15?µM). 相似文献
3.
Abrar Ahmed Wei Li Jun-Sheng Zhang Pek-Ha Sam Yi-Hong Zou 《Natural product research》2018,32(2):175-181
Phytochemical investigation of Cephalotaxus sinensis has led to the isolation of a new bisabolane sesquiterpenoid (1), a new abietane diterpenoid (2), and 13 known compounds (3–15). Their structures were elucidated by extensive spectroscopic analysis (MS, UV, IR, and NMR). 相似文献
4.
Yin-Di Zhu Jing-Yi Zhang Peng-Fei Li Hai-Feng Wu Nai-Liang Zhu Hai Jiang 《Natural product research》2016,30(9):1075-1080
Two new abietane diterpenoid glycosides, named clinopoditerpenes B (1) and C (2), were isolated from Clinopodium chinese. The structures of the new compounds were determined on the basis of extensive spectral analysis. Compound 1 exhibited cardioprotective effect against H2O2-induced apoptosis in H9c2 cells. 相似文献
5.
Two novel abietane diterpenoids, wardinols A and B ( 1 and 2 , resp.), together with five known diterpenoids, 3 – 7 , were isolated from the fruits of Illicium wardii A.C.Sm . Their structures were elucidated on the basis of intensive spectroscopic analysis, including 1D‐ and 2D‐NMR spectroscopy. Wardinol A ( 1 ) is a rare 9,10‐epoxy‐9,10‐secoabietane diterpenoid. All of the isolated compounds were evaluated for their cytotoxicities against three human tumor cell lines, A549, HCT116, and CCRF‐CEM. 相似文献
6.
Zhi-Hua Jiang Yan-Ping Liu Miao He Jin-Hua Zhao Ting-Ting Wang Xing-Yang Feng 《Natural product research》2018,32(20):2418-2423
A new abietane diterpenoid, tripterregeline A (1), together with six known diterpenoids (2–7), were isolated from the roots of Tripterygium regelii. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparison with data reported in the literature. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1–7 showed significant inhibitory effects against various human cancer cell lines with IC50 values ranging from 0.58 to 21.06 μM. 相似文献
7.
Yan-Ping Liu Qing Wen Shi Hu Yan-Lei Ma Zhi-Hua Jiang Jin-Ying Tang 《Natural product research》2019,33(8):1169-1174
Phytochemical investigation on the stems and leaves of Trigonostemon howii resulted in the isolation of a new abietane diterpenoid, trigohowimine A (1), along with seven known structurally diverse diterpenoids (2–8). The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparison with data reported in the literature. New compound 1 was evaluated for its cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480. Compound 1 showed significant inhibitory effects against various human cancer cell lines with IC50 values ranging from 0.82 to 8.53 μM. 相似文献
8.
Ai‐Hua Zhao Sheng‐Hong Li Qin‐Shi Zhao Zhong‐Wen Lin Han‐Dong Sun Yang Lu Li‐Li Zhang Qi‐Tai Zheng 《Helvetica chimica acta》2003,86(10):3470-3475
A novel 13(12→11)abeo‐abietane skeletal diterpenoid, micranthin C ( 1 ), was isolated from Isodon lophanthoids var. micranthus. Its structure was determined by various spectroscopic techniques and finally confirmed by single‐crystal X‐ray diffraction. 相似文献
9.
Agallochaexcoerin A (1), a seco-manoyl oxide diterpenoid was metabolised by pathogenic fungus, Aspergillus flavus, in growth media to yield a new metabolite, termed agallochaexcoerin G (2). It was confirmed by using IR, UV, 1H NMR and HR-ESI-MS techniques. This microbial bioconversion was achieved by unusual dehydration at C-4 position. 相似文献
10.
Jian‐You Li Ying Peng Ling‐Zhi Li Pin‐Yi Gao Chang Gao Su‐Xia Xia Shao‐Jiang Song 《Helvetica chimica acta》2013,96(2):313-319
Two new abietane‐type diterpenoids, named triptobenzene R ( 1 ) and triptobenzene S ( 2 ), together with three known abietane‐type diterpenoids, triptophenolide ( 3 ), triptonodiol ( 4 ), and triptonoterpene methyl ether ( 5 ), were isolated from the roots of Tripterygium wilfordii Hook . f. Their structures and relative configurations were established by detailed spectral studies, including 1D‐ and 2D‐NMR (HSQC, HMBC, and NOESY), and HR‐ESI‐TOF‐MS, and by comparison with published data. Their absolute configurations were assigned by the CD technique, applied for the first time to abietane diterpenes from Tripterygium wilfordii. Compound 2 is the first abietane‐type norditerpenoid isolated from the genus Tripterygium. 相似文献
11.
Xuemei Niu Shenghong Li Qinshi Zhao Shuangxi Mei Zhongwen Lin Handong Sun Yang Lu Cheng Wang Qitai Zheng 《Helvetica chimica acta》2003,86(2):299-306
Two novel ent‐abietane diterpenoids, 3α,20‐epoxy‐6β‐hydroxy‐1,7‐dioxo‐ent‐abiet‐15(17)‐en‐16‐oic acid ( 1 ) and ent‐abieta‐7,15(17)‐diene‐3β,16,18‐triol ( 2 ) were isolated from Isodon eriocalyx var. laxiflora. Their structures were determined by extensive spectroscopic analysis and confirmed by X‐ray crystallography. Compound 1 is an unprecedented example that establishes that a naturally occurring ent‐abietane diterpenoid can have an oxygenation pattern almost identical to those of 3α,20‐epoxy‐ent‐kaurane diterpenoids. 相似文献
12.
Kang He Juan Zou Yu-Xue Wang Chen-Liang Zhao Jiang-Hai Ye Jing-Jie Zhang Lu-Tai Pan Hong-Jie Zhang 《Molecules (Basel, Switzerland)》2021,26(13)
A phytochemical investigation of the leaves of the medicinal plant Isodon rubescens led to the isolation of the two new degraded abietane lactone diterpenoids rubesanolides F (1) and G (2). Their structures were elucidated based on the analyses of the HRESIMS and 1D/2D NMR spectral data, and their absolute configurations were determined by ECD spectrum calculations and X-ray single crystal diffraction methods. Compounds 1 and 2, with a unique γ-lactone subgroup between C-8 and C-20, were found to form a carbonyl carbon at C-13 by removal of the isopropyl group in an abietane diterpene skeleton. Rubesanolide G (2) is a rare case of abietane that possesses a cis-fused configuration between rings B and C. The two isolates were evaluated for their biological activities against two cancer cell lines (A549 and HL60), three fungal strains (Candida alba, Aspergillus niger and Rhizopus nigricans) and three bacterial strains (Escherichia coli, Staphylococcus aureus and Bacillus subtilis). 相似文献
13.
Yoshikawa K Kokudo N Tanaka M Nakano T Shibata H Aragaki N Higuchi T Hashimoto T 《Chemical & pharmaceutical bulletin》2008,56(1):89-92
From Cladonia rangiferina were isolated two novel abietane diterpenoids, hanagokenols A (1) and B (2). Also in this investigation, four known abitetane diterpenoids (3-6), four known labdane diterpenoids (7-10), one known isopimarane diterpenoid (11), and six known aromatic compounds were isolated. These structures were elucidated primarily through extensive NMR experiments. Hanagokenol A (1) was a unique abietane diterpene having an ether linkage between C-6 and C-18 of sugiol. Hanagokenol B (2) is also a unique secoabietane diterpene, having gamma-lactone which occurred by cleavage and subsequently oxidation between C-6/C-7 of 12-hydroxydehydroabietinol. Furthermore, all the isolated compounds (1-17) were tested for the antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE). 相似文献
14.
A new denudatine-type C20-diterpenoid alkaloid, designated as sinchianine (1), together with eight known diterpenoid alkaloids, 12-acetyl-12-epi-napelline (2), 12-epi-napelline (3), neoline (4), talatisamine (5), 14-O-acetylsenbusine A (6) and benzoylaconine (7), songorine (8) and aconitine (9), were isolated from the whole herb of Aconitum sinchiangense W. T. Wang. Their structures were elucidated on the basis of extensive spectroscopic analyses (NMR and HR-ESI-MS) and comparison with data reported in the literature. 相似文献
15.
Raushanara Akter Shaikh J. Uddin Joe Tiralongo I. Darren Grice 《Natural product research》2016,30(23):2688-2693
A new diterpenoid glycoside, 6E,10E,14Z-(3S)-17-hydroxygeranyllinalool-17-O-β-d-glucopyranosyl-(1?→?2)-[α-l-rhamnopyranosyl-(1?→?6)]-β-d-glucopyranoside (1) together with the known diterpenoid glycoside (2) and two known flavonoid glycosides (3, 4) were isolated from the methanol extract of Blumea lacera leaves. The structures were determined by the interpretation of their spectroscopic data and comparison with the literature. All compounds were isolated for the first time from B. lacera and evaluated for their cytotoxic activity. Only the new compound (1) showed strong cytotoxic activity with the lowest IC50 value (8.3 μM) being displayed against MCF-7 breast cancer cells. In apoptosis and cell cycle analysis, 1 revealed strong apoptotic activity against MCF-7 cells (45.5% AV+/PI?) after 24 h, but showed no arresting of any of the cell cycle phases in MCF-7. 相似文献
16.
《Journal of carbohydrate chemistry》2013,32(7-8):733-746
Radical C-glycosidation of racemic 5-exo-benzeneselenyl-6-endo-chloro-3-methylidene-7-oxabicyclo[2.2.1]heptan-2-one ((±)-2) with α-acetobromofucose (3) provided a mixture of α-C-fucosides that were reduced with NaBH4 to give two diastereomeric alcohols that were separated readily. One of them ((?)-6) was converted into (?)-methyl 2-acetamido-4-O-acetyl-2,3-dideoxy-3-C-(3′,4′,5′-tri-O-acetyl-2′,6′-anhydro-1′,7′-dideoxy-α-L-glycero-D-galacto-heptitol-1′-C-yl)-α -D-galactopyranuronate ((?)-11) and then into (?)-methyl 2-acetamido-2,3-dideoxy-3-C-(2′,6′-anhydro-1′,7′-dideoxy-α-L-glycero-D-galacto-heptitol-1′-C-yl)-β -D-galactopyranoside ((?)-1), a new α-C(1→3)-L-fucopyranoside of N-acetylgalactosamine. Its 1H NMR data shows that this C-disaccharide (α-L-Fucp-(1→3)CH2-β-D-GalNAc-OMe) adopts a major conformation in solution similar to that expected for the corresponding O-linked disaccharide, i.e., with antiperiplanar σ(C-3′,C-2′) and σ(C-1′,C-3) bonds. 相似文献
17.
Li-Mei Li Guo-You Li Wei-Lie Xiao Sheng-Hong Li Quan-Bin Han Li-Guang Lou 《Tetrahedron letters》2006,47(29):5187-5190
Parvifoline X (1), a new rearranged ent-kaurane diterpenoid, and parvifoline Y (2), a new 8,15-seco-ent-kaurane diterpenoid, were isolated from the leaves of Isodon parvifolius. Their structures were elucidated by spectroscopic methods including 2D NMR analysis, and supported by a biogenetic pathway. Parvifoline X (1), possessing a new 15(8→11)-abeo-7α,20-epoxy-ent-kaurane skeleton, was found from the genus Isodon for the first time. Compounds 1 and 2 were evaluated for their inhibitory activity against A549, HT-29, and K562 cell lines. Parvifoline Y (2) was the most cytotoxic against A549 cells with an IC50 value of 4.97 μM. 相似文献
18.
Abolfazl Shakeri Milena Masullo Alfredo Bottone Javad Asili Seyed Ahmad Emami Sonia Piacente 《Natural product research》2019,33(14):2016-2023
Two new sesquiterpene lactones, rhizantholide A (1) and rhizantholide B (2), together with five known compounds (3-7) have been isolated from the aerial parts of Centaurea rhizantha (Asteraceae). Sesquiterpene lactones belong to guaianolide class, and rhizantholide B is a rare guaianolide characterized by a free primary alcoholic function at C-10 along with a 3β,10β-epoxy function. Their structures have been established on the basis of 1D and 2D NMR experiments, as well as HR-ESIMS. The antimicrobial activity of compounds 1-7 has been evaluated against Gram-positive and Gram-negative strains. Only deacylcynaropicrin 8-O-[3′-hydroxy-2′-methylpropionate] (5) showed moderate antibacterial activity against Staphylococcus aureus with a MIC/MBC value of 500 μg/mL. All isolated compounds have been also evaluated for their cytotoxic activities against cancer cells. Among them, compound 5 showed the highest cytotoxic activity with IC50 values in the range 5.02–16.76 μg/mL. 相似文献
19.
Mohammad Helal Uddin Mohammed Kamrul Hossain Meher Nigar Michael Chandro Roy Junichi Tanaka 《Chemistry of Natural Compounds》2012,48(3):412-415
Chemical investigation of an Okinawan marine sponge resulted in the isolation of two new spongian-class diterpenes 1 and 2 together with two known compounds, chromodorolide B (3) and chromodorolide C (4). Compound 1, named chromodorolide D, is an example of a diterpenoid with a highly rearranged chromodorane carbon skeleton, while compound 2 retains the open side chains. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis and chemical conversion. Compounds 1–4 exhibited significant cytotoxicity against NBT-T2 rat bladder epithelial cells. 相似文献
20.
Chengcheng Zhao Zheming Ying Xiaojun Tao Mingyue Jiang 《Natural product research》2018,32(13):1548-1553
A new lactam alkaloid named oleraciamide D (1), indentified as (5R)-4-(3-methoxy-4-hydroxyphenyl)-5-(4-hydroxyphenyl)-5,6-dihydropyridin-2(1H)-one, together with five known compounds, indole-3-aldehyde (2), portulacatone (3), N-trans-feruloyloctopamine (4), N-trans-feruloyl-3′-O-methyldopamine (5) and N-trans-feruloyltyramine (6) were isolated from Potulaca oleracea L. Among them, indole-3-aldehyde (2) was isolated from the medicine for the first time. The structure of the new alkaloid was elucidated via UHPLC-ESI-Q-TOF/MS, 1D NMR and 2D NMR. The five known compounds were established by comparing the 1H-NMR and 13C NMR with the reported literature. Oleraciamide D (1) showed cytotoxicity against SH-SY5Y cells when concentration at 50 uM by CCK-8 method. 相似文献