Marginal quantile regression for varying coefficient models with longitudinal data

In this paper, we investigate the quantile varying coefficient model for longitudinal data, where the unknown nonparametric functions are approximated by polynomial splines and the estimators are obtained by minimizing the quadratic inference function. The theoretical properties of the resulting estimators are established, and they achieve the optimal convergence rate for the nonparametric functions. Since the objective function is non-smooth, an estimation procedure is proposed that uses induced smoothing and we prove that the smoothed estimator is asymptotically equivalent to the original estimator. Moreover, we propose a variable selection procedure based on the regularization method, which can simultaneously estimate and select important nonparametric components and has the asymptotic oracle property. Extensive simulations and a real data analysis show the usefulness of the proposed method.

     

Adaptive penalized M-estimation with current status data

Current status data arises when a continuous response is reduced to an indicator of whether the response is greater or less than a random threshold value. In this article we consider adaptive penalized M-estimators (including the penalized least squares estimators and the penalized maximum likelihood estimators) for nonparametric and semiparametric models with current status data, under the assumption that the unknown nonparametric parameters belong to unknown Sobolev spaces. The Cox model is used as a representative of the semiparametric models. It is shown that the modified penalized M-estimators of the nonparametric parameters can achieve adaptive convergence rates, even when the degrees of smoothing are not known in advance. consistency, asymptotic normality and inference based on the weighted bootstrap for the estimators of the regression parameter in the Cox model are also established. A simulation study is conducted for the Cox model to evaluate the finite sample efficacy of the proposed approach and to compare it with the ordinary maximum likelihood estimator. It is demonstrated that the proposed method is computationally superior.We apply the proposed approach to the California Partner Study analysis.     

Randomly censored partially linear single-index models

This paper proposes a method for estimation of a class of partially linear single-index models with randomly censored samples. The method provides a flexible way for modelling the association between a response and a set of predictor variables when the response variable is randomly censored. It presents a technique for “dimension reduction” in semiparametric censored regression models and generalizes the existing accelerated failure-time models for survival analysis. The estimation procedure involves three stages: first, transform the censored data into synthetic data or pseudo-responses unbiasedly; second, obtain quasi-likelihood estimates of the regression coefficients in both linear and single-index components by an iteratively algorithm; finally, estimate the unknown nonparametric regression function using techniques for univariate censored nonparametric regression. The estimators for the regression coefficients are shown to be jointly root-n consistent and asymptotically normal. In addition, the estimator for the unknown regression function is a local linear kernel regression estimator and can be estimated with the same efficiency as all the parameters are known. Monte Carlo simulations are conducted to illustrate the proposed methodology.     

RCV-based error density estimation in the ultrahigh dimensional additive model

In this paper, we mainly study how to estimate the error density in the ultrahigh dimensional sparse additive model, where the number of variables is larger than the sample size. First, a smoothing method based on B-splines is applied to the estimation of regression functions. Second, an improved two-stage refitted cross-validation (RCV) procedure by random splitting technique is used to obtain the residuals of the model, and then the residual-based kernel method is applied to estimate the error density function. Under suitable sparse conditions, the large sample properties of the estimator including the weak and strong consistency, as well as normality and the law of the iterated logarithm are obtained. Especially, the relationship between the sparsity and the convergence rate of the kernel density estimator is given. The methodology is illustrated by simulations and a real data example, which suggests that the proposed method performs well.

     

A Note on the Nonparametric Least-squares Test for Checking a Polynomial Relationship

Recently, Gijbels and Rousson[6] suggested a new approach, called nonparametric least-squares test, to check polynomial regression relationships. Although this test procedure is not only simple but also powerful in most cases, there are several other parameters to be chosen in addition to the kernel and bandwidth.As shown in their paper, choice of these parameters is crucial but sometimes intractable. We propose in this paper a new statistic which is based on sample variance of the locally estimated pth derivative of the regression function at each design point. The resulting test is still simple but includes no extra parameters to be determined besides the kernel and bandwidth that are necessary for nonparametric smoothing techniques. Comparison by simulations demonstrates that our test performs as well as or even better than Gijbels and Rousson‘s approach.Furthermore, a real-life data set is analyzed by our method and the results obtained are satisfactory.     

纵向数据非参数混合效应模型的一个局部不变估计

非参数核回归方法近年来已被用于纵向数据的分析(Lin和Carroll,2000)．一个颇具争议性的问题是在非参数核回归中是否需要考虑纵向数据间的相关性．Lin和Carroll (2000)证明了基于独立性(即忽略相关性)的核估计在一类核GEE估计量中是(渐近)最有效的．基于混合效应模型方法作者提出了一个不同的核估计类,它自然而有效地结合了纵向数据的相关结构．估计量达到了与Lin和Carroll的估计量相同的渐近有效性,且在有限样本情形下表现更好．由此方法可以很容易地获得对于总体和个体的非参数曲线估计．所提出的估计量具有较好的统计性质,且实施方便,从而对实际工作者具有较大的吸引力．     

Data-Adaptive Estimation of Time-Varying Spectral Densities

This article introduces a data-adaptive nonparametric approach for the estimation of time-varying spectral densities from nonstationary time series. Time-varying spectral densities are commonly estimated by local kernel smoothing. The performance of these nonparametric estimators, however, depends crucially on the smoothing bandwidths that need to be specified in both time and frequency direction. As an alternative and extension to traditional bandwidth selection methods, we propose an iterative algorithm for constructing localized smoothing kernels data-adaptively. The main idea, inspired by the concept of propagation-separation, is to determine for a point in the time-frequency plane the largest local vicinity over which smoothing is justified by the data. By shaping the smoothing kernels nonparametrically, our method not only avoids the problem of bandwidth selection in the strict sense but also becomes more flexible. It not only adapts to changing curvature in smoothly varying spectra but also adjusts for structural breaks in the time-varying spectrum. Supplementary materials, including the R package tvspecAdapt containing an implementation of the routine, are available online.     

Numerical discretization-based kernel type estimation methods for ordinary differential equation models

We consider the problem of parameter estimation in both linear and nonlinear ordinary differential equation(ODE) models. Nonlinear ODE models are widely used in applications. But their analytic solutions are usually not available. Thus regular methods usually depend on repetitive use of numerical solutions which bring huge computational cost. We proposed a new two-stage approach which includes a smoothing method(kernel smoothing or local polynomial fitting) in the first stage, and a numerical discretization method(Eulers discretization method, the trapezoidal discretization method,or the Runge–Kutta discretization method) in the second stage. Through numerical simulations, we find the proposed method gains a proper balance between estimation accuracy and computational cost.Asymptotic properties are also presented, which show the consistency and asymptotic normality of estimators under some mild conditions. The proposed method is compared to existing methods in term of accuracy and computational cost. The simulation results show that the estimators with local linear smoothing in the first stage and trapezoidal discretization in the second stage have the lowest average relative errors. We apply the proposed method to HIV dynamics data to illustrate the practicability of the estimator.     

Asymptotically optimal choice of the smoothing parameter in a nonparametric kernel estimator for a probability density

This paper presents a method of estimation of an “optimal” smoothing parameter (window width) in kernel estimators for a probability density. The obtained estimator is calculated directly from observations. By “optimal” smoothing parameters we mean those parameters which minimize the mean integral square error (MISE) or the integral square error (ISE) of approximation of an unknown density by the kernel estimator. It is shown that the asymptotic “optimality” properties of the proposed estimator correspond (with respect to the order) to those of the well-known cross-validation procedure [1, 2]. Translated fromStatisticheskie Metody Otsenivaniya i Proverki Gipotez, pp. 67–80, Perm, 1990.     

Stahel-Donoho kernel estimation for fixed design nonparametric regression models

This paper reports a robust kernel estimation for fixed design nonparametric regression models. A Stahel-Donoho kernel estimation is introduced, in which the weight functions depend on both the depths of data and the distances between the design points and the estimation points. Based on a local approximation, a computational technique is given to approximate to the incomputable depths of the errors. As a result the new estimator is computationally efficient. The proposed estimator attains a high breakdown point and has perfect asymptotic behaviors such as the asymptotic normality and convergence in the mean squared error. Unlike the depth-weighted estimator for parametric regression models, this depth-weighted nonparametric estimator has a simple variance structure and then we can compare its efficiency with the original one. Some simulations show that the new method can smooth the regression estimation and achieve some desirable balances between robustness and efficiency.     

基于局部多项式展开的多元非参数模型贝叶斯带宽选择

在多元非参数模型中带宽和阶的选择对局部多项式估计量的表现十分重要。本文基于交叉验证准则提出一个自适应贝叶斯带宽选择方法。在给定的误差密度函数下,该方法可推导出对应的似然函数,并构造带宽参数的后验密度函数。随后,通过带宽的后验期望可同时获得阶和带宽的估计。数值模拟的结果表明,该方法不仅比大拇指准则方法精确,且比交叉验证方法耗时更少。与此同时,与Nadaraya-Watson估计相比,所提带宽选择方法对多元非参数模型的适应性要更好。最后,本文通过一组实际数据说明有限样本下所提贝叶斯带宽选择的表现很好。     

One-stage and two-stage DEA estimation of the effects of contextual variables

Two-stage data envelopment analysis (2-DEA) is commonly used in productive efficiency analysis to estimate the effects of operational conditions and practices on performance. In this method the DEA efficiency estimates are regressed on contextual variables representing the operational conditions. We re-examine the statistical properties of the 2-DEA estimator, and find that it is statistically consistent under more general conditions than earlier studies assume. We further show that the finite sample bias of DEA in the first stage carries over to the second stage regression, causing bias in the estimated coefficients of the contextual variables. This bias is particularly severe when the contextual variables are correlated with inputs. To address this shortcoming, we apply the result that DEA can be formulated as a constrained special case of the convex nonparametric least squares (CNLS) regression. Applying the CNLS formulation, we develop a new semi-nonparametric one-stage estimator for the coefficients of the contextual variables that directly incorporates contextual variables to the standard DEA problem. The proposed method is hence referred to as one-stage DEA (1-DEA). Evidence from Monte Carlo simulations suggests that the new 1-DEA estimator performs systematically better than the conventional 2-DEA estimator both in deterministic and noisy scenarios.     

Semiparametric estimation of average treatment effect through a random coefficient dummy endogenous variable model

This paper provides an estimation procedure for average treatment effect through a random coefficient dummy endogenous variable model. A leading example of the model is estimating the effect of a training program on earnings. The model is composed of two equations: an outcome equation and a decision equation. Given the linear restriction in outcome and decision equations, Chen (1999) provided a distribution-free estimation procedure under conditional symmetric error distributions. In this paper we extend Chen’s estimator by relaxing the linear index into a nonparametric function, which greatly reduces the risk of model misspecification. A two-step approach is proposed: the first step uses a nonparametric regression estimator for the decision variable, and the second step uses an instrumental variables approach to estimate average treatment effect in the outcome equation. The proposed estimator is shown to be consistent and asymptotically normally distributed. Furthermore, we investigate the finite performance of our estimator by a Monte Carlo study and also use our estimator to study the return of college education in different periods of China. The estimates seem more reasonable than those of other commonly used estimators.     

A bias corrected nonparametric regression estimator

In this article, we propose a new method of bias reduction in nonparametric regression estimation. The proposed new estimator has asymptotic bias order h⁴, where h is a smoothing parameter, in contrast to the usual bias order h² for the local linear regression. In addition, the proposed estimator has the same order of the asymptotic variance as the local linear regression. Our proposed method is closely related to the bias reduction method for kernel density estimation proposed by Chung and Lindsay (2011). However, our method is not a direct extension of their density estimate, but a totally new one based on the bias cancelation result of their proof.     

Asymptotic Analysis of the Jittering Kernel Density Estimator

Jittering estimators are nonparametric function estimators for mixed data. They extend arbitrary estimators from the continuous setting by adding random noise to discrete variables. We give an in-depth analysis of the jittering kernel density estimator, which reveals several appealing properties. The estimator is strongly consistent, asymptotically normal, and unbiased for discrete variables. It converges at minimax-optimal rates, which are established as a by-product of our analysis. To understand the effect of adding noise, we further study its asymptotic efficiency and finite sample bias in the univariate discrete case. Simulations show that the estimator is competitive on finite samples. The analysis suggests that similar properties can be expected for other jittering estimators.     

Asymptotic distributions of two “synthetic data” estimators for censored single-index models

The censored single-index model provides a flexible way for modelling the association between a response and a set of predictor variables when the response variable is randomly censored and the link function is unknown. It presents a technique for “dimension reduction” in semiparametric censored regression models and generalizes the existing accelerated failure time models for survival analysis. This paper proposes two methods for estimation of single-index models with randomly censored samples. We first transform the censored data into synthetic data or pseudo-responses unbiasedly, then obtain estimates of the index coefficients by the rOPG or rMAVE procedures of Xia (2006) [1]. Finally, we estimate the unknown nonparametric link function using techniques for univariate censored nonparametric regression. The estimators for the index coefficients are shown to be root-n consistent and asymptotically normal. In addition, the estimator for the unknown regression function is a local linear kernel regression estimator and can be estimated with the same efficiency as the parameters are known. Monte Carlo simulations are conducted to illustrate the proposed methodologies.     

Multivariate Failure Times Regression with a Continuous Auxiliary Covariate

How to take advantage of the available auxiliary covariate information when the primary covariate of interest is not measured is a frequently encountered question in biomedical study. In this paper, we consider the multivariate failure times regression analysis in which the primary covariate is assessed only in a validation set, but a continuous auxiliary covariate for it is available for all subjects in the study cohort. Under the frame of marginal hazard model, we propose to estimate the induced relative risk function in the non-validation set through kernel smoothing method and then obtain an estimated pseudo-partial likelihood function. The proposed estimator which maximizes the estimated pseudo-partial likelihood is shown to be consistent and asymptotically normal. We also give an estimator of the marginal cumulative baseline hazard function. Simulation studies are conducted to evaluate the finite sample performance of our proposed estimator. The proposed method is illustrated by analyzing a heart disease data from the Study of Left Ventricular Dysfunction (SOLVD).     

Adaptive Fourier tester for statistical estimation

Based on Takenaka–Malmquist (TM) system, a new nonparametric estimator for probability density function is proposed. The TM estimation method is completely different from the existent density estimation methods in that the estimator depends on an approximate system with poles in a complex plane. Compared with the classic Fourier estimator, the TM estimator will offer more flexibility and adaptivity for real data due to the poles and nonlinearity of the phase of TM system. We compare the TM estimator with kernel, wavelet, and spline estimators by simulations. It shows that the introduced TM estimator is a more promising method than the existing and commonly used methods. Copyright © 2016 John Wiley & Sons, Ltd.     

纵向数据边际模型非参数光滑方法的比较

对于纵向数据边际模型的均值函数, 有很多非参数估计方法, 其中回归样条, 光滑样条, 似乎不相关(SUR)核估计等方法在工作协方差阵正确指定时具有最小的渐近方差. 回归样条的渐近偏差与工作协方差阵无关, 而SUR核估计和光滑样条估计的渐近偏差却依赖于工作协方差阵. 本文主要研究了回归样条, 光滑样条和SUR核估计的效率问题. 通过模拟比较发现回归样条估计的表现比较稳定, 在大多数情况下比光滑样条估计和SUR核估计的效率高.     

Two-sample homogeneity tests based on divergence measures

The concept of f-divergences introduced by Ali and Silvey (J R Stat Soc (B) 28:131–142, 1996) provides a rich set of distance like measures between pairs of distributions. Divergences do not focus on certain moments of random variables, but rather consider discrepancies between the corresponding probability density functions. Thus, two-sample tests based on these measures can detect arbitrary alternatives when testing the equality of the distributions. We treat the problem of divergence estimation as well as the subsequent testing for the homogeneity of two-samples. In particular, we propose a nonparametric estimator for f-divergences in the case of continuous distributions, which is based on kernel density estimation and spline smoothing. As we show in extensive simulations, the new method performs stable and quite well in comparison to several existing non- and semiparametric divergence estimators. Furthermore, we tackle the two-sample homogeneity problem using permutation tests based on various divergence estimators. The methods are compared to an asymptotic divergence test as well as to several traditional parametric and nonparametric procedures under different distributional assumptions and alternatives in simulations. It turns out that divergence based methods detect discrepancies between distributions more often than traditional methods if the distributions do not differ in location only. The findings are illustrated on ion mobility spectrometry data.