共查询到20条相似文献,搜索用时 31 毫秒
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在过去50年中,对羟基苯甲酸酯类防腐剂(parabens)被广泛用于食品、药品和化妆品的生产中.常用的parabens包括对羟基苯甲酸甲酯、乙酯、丙酯、丁酯、异丙酯和异丁酯.此类防腐剂已在人体血液和尿液中广泛检出,在人体内主要以代谢物对羟基苯甲酸的形式存在.研究表明,该类防腐剂可能与乳腺癌的发病有关,动物实验表明该类防腐剂可能具有雌激素活性,因此其在环境介质和人体组织中的残留、污染和毒性受到广泛关注.本文综述了parabens在体外暴露(食品、药品、化妆品、空气、灰尘、水和土壤)和体内暴露(血液、尿液、脂肪组织)方面的最新研究进展,总结了不同环境介质和人体组织中parabens的含量水平以及暴露量,对体外暴露和体内暴露进行了比较,探讨了parabens人体暴露的主要途径.最后对parabens研究的发展趋势进行了展望. 相似文献
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铬与人体健康 总被引:20,自引:1,他引:20
梁奇峰 《广东微量元素科学》2006,13(2):67-69
介绍了铬的生理功能,指出三价铬是人体必需的微量元素,六价铬则是严重危害人体健康的有害元素,必须适量补铬和严防六价铬的中毒,才能维持人体健康。 相似文献
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氟元素与人体健康 总被引:5,自引:0,他引:5
罗媛 《广东微量元素科学》2002,9(11):21-23
氟元素是人体必需微量元素,在人体内主要分布于骨骼和牙齿中。氟通过各种途径对人体发生作用。人体内少量的氟对于生长发育,骨骼代谢等有一定的影响,而含氟量过量或过少会引起某些疾病,并且氟的特性对于人体健康也有影响。 相似文献
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Cerebrospinal fluid (CSF) has frequently been extensively studied to explore several different central nervous system (CNS) disorders because it contains proteins, enzymes, hormones, neuropeptides and neurotransmitters that play critical regulatory roles in many different physiological processes. Individual neuropeptidergic systems in CSF have been studied. In theory, peptidomics offers a bird's-eye, comprehensive and systems-level approach to analyze all of the peptidergic systems that have been expressed in CSF at any given time. In this study, low molecular mass (M(r) < 5 kDa) peptides were isolated by ultrafiltration. The isolated peptides, with or without trypsin digestion, were preferentially enriched with a solid-phase extraction cartridge, and the peptides were separated with capillary liquid chromatography and analyzed with on-line quadrupole time-of-flight mass spectrometry (MS). In this proof-of-principle study, the 20 representative MS-characterized peptides were shown to be derived from 12 proteins, among which four proteins, amyloid-like protein 1, secretogranin I, granin-like neuroendocrine peptide precursor and neurosecretory protein VGF, have been shown elsewhere to be either associated with CNS disorders or to play a central role in the CNS. The long-term goals of this peptidomics study are to monitor the changes (amount; modifications) of CSF peptides, clarify the aberrant processing of large intact protein precursors, elucidate the molecular mechanisms of CNS disorders and find biomarkers. This analytical method is effective for the analysis of the human lumbar CSF peptidome. 相似文献
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人纤维蛋白溶酶原的化学修饰 总被引:2,自引:0,他引:2
分别以乙基咪唑 (NAI)、 1 ,2 -环己二酮 (CHD)、碳二亚胺 (EDC)和氯氨 -T(Ch-T)作修饰剂 ,研究人纤维蛋白溶酶原 (HPg)中的酪氨酸、精氨酸、羧基和蛋氨酸残基对 HPg活性的影响 ,发现 HPg中的酪氨酸和精氨酸残基的修饰对 HPg活性影响不大 ,而羧基和蛋氨酸残基的修饰导致 HPg酶活性丧失 .按 Keech和Farrant动力学方法分析 ,得出有以两个羧基和一个蛋氨酸残基为 HPg活性的必需基团 ,其中一个羧基为活性中心外的必需基团 相似文献
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Dr. Margit Winkler Dr. Martina Geier Dr. Steven P. Hanlon Prof. Dr. Bernd Nidetzky Prof. Dr. Anton Glieder 《Angewandte Chemie (International ed. in English)》2018,57(41):13406-13423
Human enzymes have been widely studied in various disciplines. The number of reactions taking place in the human body is vast, and so is the number of potential catalysts for synthesis. Herein, we focus on the application of human enzymes that catalyze chemical reactions in course of the metabolism of drugs and xenobiotics. Some of these reactions have been explored on the preparative scale. The major field of application of human enzymes is currently drug development, where they are applied for the synthesis of drug metabolites. 相似文献
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大豆异黄酮与人体健康 总被引:2,自引:0,他引:2
大豆异黄酮是一种近年来引起营养与医学界广泛关注的物质,它对于人体健康有着重要的作用,可以有效地防治癌症、心血管疾病,抵抗骨质疏松症、妇女更年期综合症等疾病,因而越来越受到人们的重视。本文介绍了大豆异黄酮的结构、对人体健康的影响以及它的利用前景。 相似文献
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饮用水与人体健康 总被引:1,自引:0,他引:1
张文渊 《广东微量元素科学》2002,9(10):68-70
随着人类社会的进步,经济的发展,生活水平的提高,喝什么样的水有益健康逐步成为人们越来越关心的问题。将我国《生活饮用水卫生标准》与世界卫生组织的《饮用水水质准则》比较,卫生学指标的要求大体相同。有毒有害物质的指标要求大体相同。矿泉水和城市自来水是首选的健康饮水。 相似文献