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Yong‐Jun Bian Chao‐Yue Chen Prof. Zhi‐Zhen Huang 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(3):1129-1133
An efficient palladium‐catalyzed C? H functionalization of aldehydes with various N‐substituted N‐heteroarene‐2‐carboxamides has been developed for the synthesis of secondary imides. The reaction tolerates various functionalities, such as methoxy, fluoro, chloro, and bromo groups. A tentative radical mechanism for a PdII/PdIV catalytic cycle is proposed. 相似文献
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Dr. Natarajan Senthilkumar Dr. Kanniyappan Parthasarathy Dr. Parthasarathy Gandeepan Prof. Dr. Chien‐Hong Cheng 《化学:亚洲杂志》2013,8(9):2175-2181
An efficient method for the one‐pot synthesis of substituted phenanthridinone derivatives from N‐methoxybenzamides and aryltriethoxysilanes through rhodium‐catalyzed dual C? H bond activation and annulation reactions is described. A double‐cycle mechanism is proposed to account for this catalytic reaction. In addition, isotope‐labeling studies were performed to understand the intimate mechanism of the reaction. 相似文献
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Christophe Aïssa Kelvin Y. T. Ho Daniel J. Tetlow María Pin‐N 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2014,126(16):4293-4296
The use of α,ω‐dienes as functionalization reagents for olefinic carbon–hydrogen bonds has been rarely studied. Reported herein is the rhodium(I)‐catalyzed rearrangement of prochiral 1,6‐heptadienes into [2,2,1]‐cycloheptane derivatives with concomitant creation of at least three stereogenic centers and complete diastereocontrol. Deuterium‐labeling studies and the isolation of a key intermediate are consistent with a group‐directed C H bond activation, followed by two consecutive migratory insertions, with only the latter step being diastereoselective. 相似文献
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Toshiki Kurokawa Mihyong Kim J. DuBois 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2009,121(15):2815-2817
Schließen und öffnen : N‐Boc‐N‐alkylsulfamide sind geeignete Substrate für die Titelreaktion. Die oxidative Cyclisierung im ersten Schritt ist hoch chemoselektiv sowie stereospezifisch und diastereoselektiv. Mit neuen Verfahren zur Öffnung der dabei erhaltenen Sechsringheterocyclen werden unterschiedlich geschützte 1,3‐Diamine zugänglich (siehe Schema).
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Hui Yu Guoying Zhang Hanmin Huang 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2015,127(37):11062-11066
A fundamentally novel approach to bioactive quinolizinones is based on the palladium‐catalyzed intramolecular cyclocarbonylation of allylamines. [Pd(Xantphos)I2], which features a very large bite angle, has been found to facilitate the rapid carbonylation of azaarene‐substituted allylamines into bioactive quinolizinones in good to excellent yields. This transformation represents the first dearomative carbonylation and is proposed to proceed by palladium‐catalyzed C N bond activation, dearomatization, CO insertion, and a Heck reaction. 相似文献
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Toshiki Kurokawa Dr. Mihyong Kim Dr. J. Du Bois Prof. 《Angewandte Chemie (International ed. in English)》2009,48(15):2777-2779
A grand opening : N‐Boc‐N‐alkylsulfamides are effective substrates for the title transformation. Oxidative cyclization is highly chemoselective as well as being both stereospecific and diastereoselective. With the advent of new protocols that facilitate ring opening of the six‐membered‐ring heterocyclic products, access to differentially protected 1,3‐diamines has been made possible (see scheme).
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Rongguo Ren Huijun Zhao Leitao Huan Chen Zhu 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2015,127(43):12883-12887
A novel, manganese‐catalyzed oxidative azidation of cyclobutanols is described. A wide range of primary, secondary, and tertiary alkyl azides were generated in synthetically useful yields and exclusive regioselectivity. Aside from linear alkyl azides, otherwise elusive medium‐sized cyclic azides were also readily prepared. Preliminary mechanistic studies reveal that the reaction likely proceeds by a radical‐mediated C C bond cleavage/C N3 bond formation pathway. 相似文献