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1.
Simona Cerritelli Diana Velluto Jeffrey A. Hubbell Antonella Fontana 《Journal of polymer science. Part A, Polymer chemistry》2008,46(7):2477-2487
We explored the effects of addition of the nonionic surfactant Triton X‐100 on the stability of aggregates of poly(ethylene glycol‐bl‐propylene sulfide) di‐ and triblock copolymers. Fluorescence spectra of pyrene, used as a probe molecule, elucidated the various stages of transformation from pure copolymeric micelles to surfactant‐rich micelles. Turbidity measurements yielded insight into the mechanism of the interaction, the hydrophobicity of the copolymer driving the process. Triton X‐100 tends to strongly interact with highly hydrophobic copolymers by inserting into the core of the micellar aggregates. On the other hand, Triton X‐100 tends to interact with the corona of micelles formed by less hydrophobic copolymers which, for this reason, are more stable upon addition of this destabilizing agent. Kinetic data give evidence that only monomers, not micelles of surfactant, interact with the copolymer micelles. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 2477–2487, 2008 相似文献
2.
We report an anionic surfactant approach for size and shape control in polyaniline, polypyrrole, and their polyaniline‐co‐polypyrrole random copolymer nanomaterials. A renewable resource azobenzenesulfonic acid anionic surfactant was developed for template‐assisted synthesis of these classes of nanomaterials. The surfactant exists as 4.3 nm micelle in water and self‐organizes with pyrrole to produce spherical aggregates. The sizes of the spherical aggregates were controlled by water dilution and subsequent oxidation of these templates, produced polypyrrole nanospheres of 0.5 μM to 50 nm dimensions. The anionic surfactant interacts differently with aniline and forms cylindrical aggregates, which exclusively produce nanofibers of ∼180 nm in diameter with length up to 3–5 μM. The template selectivity of surfactant toward aniline and pyrrole was used to tune the nanostructure of the aniline‐pyrrole random copolymers from nanofiber‐to‐nanorod‐to‐nanospheres. Dynamic light scattering technique and electron microscopes were used to study the mechanistic aspects of the template‐assisted polymerization. The four probe conductivity of the copolymers showed a nonlinear trend and the conductivity passes through minimum at 60–80% of pyrrole in the feed. The amphiphilic dopant effectively penetrates into the crystal lattices of the polymer chain and induces high solid state ordering in the homopolymer nanomaterials. © 2009 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 47: 830–846, 2009 相似文献
3.
Xia Li Qi Wu Min Lu Fu Zhang Xianfu Lin 《Journal of polymer science. Part A, Polymer chemistry》2008,46(8):2734-2744
Hepatoma‐targeting micelles were successfully prepared by self‐assembly of galactose‐functionalized ribavirin‐containing amphiphilic random copolymer as novel drug delivery vehicles. The ribavirin‐containing random copolymer with galactose as the targeting ligand was facilely synthesized by combining enzymatic transesterification with radical polymerization and fully characterized by FTIR, NMR, and GPC. The formation of micelle‐type aggregates from the random copolymer was verified by UV–vis and fluorescence spectroscopy using pyrene as the guest molecule. Transmission electron microscopy (TEM) and dynamic light scattering (DLS) experiments revealed that the micelles were well dispersed as spherical nanoparticles in water, whose hydrodynamic diameter was 217 ± 19 nm. Their biological recognition to fluorescein‐labeled peanut agglutinin investigated by confocal laser scanning microscopy (CLSM) proved the existence of hydrophilic galactose targeting moieties on the surface of micelles. Cell cytotoxicity tests and the inhibition experiment of galactose performed by MTT assay showed that the micelles had evident targeting function to hepG2 cells and the galactose moieties on the surface of micelles mediated cellar uptake of micelles. In vitro release studies indicated that ribavirin could be slowly released from the copolymer with pseudo zero‐order kinetics. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 2734–2744, 2008 相似文献
4.
M. Marini M. Toselli S. Borsacchi G. Mollica M. Geppi F. Pilati 《Journal of polymer science. Part A, Polymer chemistry》2008,46(5):1699-1709
Organic–inorganic hybrid core‐shell nanoparticles with diameters ranging from 100 to 1000 nm were prepared by a one‐pot synthesis based on base catalyzed sol–gel reactions using tetraethoxysilane and a triethoxysilane‐terminated polyethylene‐b‐poly(ethylene glycol) as reactants. Data from TEM, TGA, and solid‐state NMR analysis are in agreement with the formation of core‐shell nanoparticles with an inorganic‐rich core and an external shell consisting of an amphiphilic block copolymer monolayer. The influence of the organic–inorganic ratio, solution concentration, and postcuring temperature on core and shell dimensions of the nanospheres were investigated by TEM microscopy. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 1699–1709, 2008 相似文献
5.
Poly(ethylene glycol) (PEG) was modified with aniline groups at both the end, and then PEG‐PANI rod‐coil block polymers have been synthesized by polymerization of the aniline with the aniline‐modified PEG. FTIR, NMR, and elemental analysis provided the chemical strucutre of the as‐prepared polymers. The achiral rod‐coil copolymer could form different superstructures by means of self‐assembly when adding diethyl ether into its THF solution and the length of PANI segments is a key factor to the superstructures. AFM measurements revealed that they form spring‐like helical superstructures from the short PANI‐containing copolymers while these form fibrous helical superstructures from the longer PANI‐containing copolymer. A possible mechanism of the helical superstructures is suggested in this article and the driving force is believed the π–π stacking of the rigid segment of the copolymers. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 12–20, 2008 相似文献
6.
Meihan Dan Fei Huo Xu Zhang Xiaohui Wang Wangqing Zhang 《Journal of polymer science. Part A, Polymer chemistry》2013,51(7):1573-1584
The dispersion reversible addition‐fragmentation chain transfer (RAFT) polymerization of 4‐vinylpyridine in toluene in the presence of the polystyrene dithiobenzoate (PS‐CTA) macro‐RAFT agent with different chain length is discussed. The RAFT polymerization undergoes an initial slow homogeneous polymerization and a subsequent fast heterogeneous one. The RAFT polymerization rate is dependent on the PS‐CTA chain length, and short PS‐CTA generally leads to fast RAFT polymerization. The dispersion RAFT polymerization induces the self‐assembly of the in situ synthesized polystyrene‐b‐poly(4‐vinylpyridine) block copolymer into highly concentrated block copolymer nano‐objects. The PS‐CTA chain length exerts great influence on the particle nucleation and the size and morphology of the block copolymer nano‐objects. It is found, short PS‐CTA leads to fast particle nucleation and tends to produce large‐sized vesicles or large‐compound micelles, and long PS‐CTA leads to formation of small‐sized nanospheres. Comparison between the polymerization‐induced self‐assembly and self‐assembly of block copolymer in the block‐selective solvent is made, and the great difference between the two methods is demonstrated. The present study is anticipated to be useful to reveal the chain extension and the particle growth of block copolymer during the RAFT polymerization under dispersion condition. © 2013 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013 相似文献
7.
Peng Xu Xin Ji Volker Abetz Shimei Jiang Jiacong Shen 《Journal of Polymer Science.Polymer Physics》2008,46(19):2047-2053
Polystyrene‐block‐poly(2‐vinylpyridine) (PS‐b‐P2VP) diblock copolymer was functionalized with luminescent chlorotricarbonyl rhenium (I) phenanthroline complex in the presence of silver perchlorate. The copolymer‐metal complex showed high sensitivity to the solvent system. Different morphologies and dimensions of the rhenium complex within nanosized micelles were controlled by changing the solvent systems. Core‐embedded rhenium complex within micelles appear by adding methanol, a poor solvent for the copolymer‐metal complex, to the solution of common solvent tetrahydrofuran (THF); the number of the core‐embedded rhenium complex and the scale of the micelles are strongly related to the addition of methanol. Moreover, a novel morphology of corona‐embedded rhenium complex micelles was prepared by dropping the original THF solution of copolymer‐metal complex into water at a low pH value. © 2008 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 46: 2047–2053, 2008 相似文献
8.
Mohammad Rezaul Karim Jeong Hyun Yeum Min‐Young Lee Mu Sang Lee Kwon Taek Lim 《先进技术聚合物》2009,20(7):639-644
Sulfonated polyaniline‐silver (SPAni‐Ag) hybrid nanocomposites have been synthesized by the in situ reduction using a UV‐curing polymerization method without using any reducing or binding agent. An aqueous solution of aniline and orthoanilinic acid (OA) comonomers, a free‐radical oxidant and silver metal salts were irradiated by UV rays. Reduction of the silver salt in aqueous aniline and OA leads to the formation of silver particles which in turn catalyze the oxidation of comonomers to sulfonated polyaniline (SPAni). The resultant SPAni‐Ag nanocomposites were characterized by using different spectroscopy analyses like UV–visible (UV–Vis), X‐ray diffraction (XRD) and infrared spectroscopy. The absorption bands were revealed to be optically active and the peaks blue‐shifted due to the presence of metallic silver within the SPAni matrix. The XRD patterns displayed both the broad amorphous polymeric and sharp metallic peaks. Scanning electron microscopy and transmission electron microscopy of the nanocomposites showed a uniform size distribution with spherical and granular morphology. Thermogravimetric analysis revealed that the nanocomposites had a better thermal stability than the bulk SPAni. Copyright © 2008 John Wiley & Sons, Ltd. 相似文献
9.
Stéphane Jéol Françoise Fenouillot Alain Rousseau Christiane Monnet Karine Masenelli‐Varlot Jean‐François Briois 《Journal of polymer science. Part A, Polymer chemistry》2008,46(12):3985-3991
The preparation of poly(2,6‐dimethyl‐1,4‐phenylene ether)‐b‐poly(ethylene terephthalate) block copolymer was performed by the reaction of the 2‐hydroxyethyl modified poly(2,6‐dimethyl‐1,4‐phenylene ether) (PPE‐EtOH) with poly(ethylene terephthalate) (PET) by an in situ process, during the synthesis of the polyester. The yield of the reaction of the 2‐hydroxyethyl functionalized PPE‐EtOH with PET was close to 100%. A significant proportion of the PET‐b‐PPE‐EtOH block copolymer was found to have short PET block. Nevertheless, the copolymer structured in the shape of micelles (20 nm diameter) and very small domains with 50–200 nm diameter, whereas unmodified PPE formed much larger domains (1.5 μm) containing copolymer. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 3985–3991, 2008 相似文献
10.
Hisatoyo Morinaga Bungo Ochiai Hideharu Mori Takeshi Endo 《Journal of polymer science. Part A, Polymer chemistry》2006,44(6):1985-1996
Ring‐opening polymerizations of trimethylene carbonate (TC) and 2,2‐dimethyltrimethylene carbonate (DTC) are initiated from hydroxyl‐terminated polyethylene glycol (PEG) and PEG‐based surfactants (Triton X‐100 or Triton X‐405) in the absence of any catalysts. The metal‐ and solvent‐free polymerizations proceed under melt at 150 °C, affording Triton X‐100‐block‐poly(TC) with Mn of 1400–5200 and Triton X‐100‐block‐poly(DTC) with Mn of 1800–7100 in excellent yields. The molecular weights and the comonomer composition of the resulting copolymers are controlled by the feed ratios of the monomers to the initiators, confirmed by gel permeation chromatography and 1H NMR spectroscopy. The solubilities of the block copolymers composed of hydrophilic PEG segment and hydrophobic poly(TC) or poly(DTC) segment depend on both the compositions and the components. For example, Triton X‐100‐block‐poly (TC) (TC/EG = 9.5/9.5) and Triton X‐405‐block‐poly(TC) (TC/EG = 28/40, 46/40) milky suspend in water, while Triton X‐405‐block‐poly(TC) (TC/EG = 9.7/40) dissolves in water. A dynamic light scattering study reveals that the particle distribution of a copolymer, Triton X‐405‐block‐poly(TC) (TC/EG = 9.7/40) in water, has a monodisperse unimodal pattern ranging from 92 to 368 nm. © 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 1985–1996, 2006 相似文献
11.
Jie Han Genping Song Rong Guo 《Journal of polymer science. Part A, Polymer chemistry》2007,45(13):2638-2645
A general route, involving swelling–evaporation processes, is proposed for the generation of polymer hollow nanospheres derived from polymer nanoparticles for the first time. Different swelling reagents, such as ethanol, o‐toluidine, toluene, and carbon tetrachloride, have been used to study their effect on the morphology of the resultant polymer hollow structures. The evaporation conditions, such as the temperature and pressure, can be used to tune the size and shell thickness of the polymer hollow structures. The chemical structures of the polymer have been characterized with X‐ray diffraction, Fourier transform infrared, and ultraviolet–visible spectroscopy. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 2638–2645, 2007 相似文献
12.
Takakazu Yamamoto Abla Mahmut Masahiro Abe Shin‐Ichi Kuroda Tatsuya Imase Shintaro Sasaki 《Journal of Polymer Science.Polymer Physics》2005,43(16):2219-2224
An alternating copolymer, Copoly‐1 , of thiophene and N‐(phenylethynyl)pyrrole was prepared by palladium‐catalyzed polycondensation. Powder X‐ray diffraction (XRD) analysis indicated that Copoly‐1 formed a stacked packing structure with doubly‐running polymer main chains. Optical data support the molecular and packing structures of Copoly‐1 . © 2005 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 43: 2219–2224, 2005 相似文献
13.
Shurun Li Jianping Deng Wantai Yang 《Journal of polymer science. Part A, Polymer chemistry》2010,48(4):936-942
The amphiphilic poly(AM‐co‐SA)‐ITXH macrophotoinitiator was synthesized by precipitation photopolymerization under UV irradiation with isopropylthioxanthone (ITX) as free radical photoinitiator. A novel method has been developed to prepare amphiphilic core‐shell polymer nanospheres via photopolymerization of methyl methacrylate (MMA) in aqueous media, with amphiphilic copolymer macrophotoinitiator poly(AM‐co‐SA)‐ITXH. During polymerization, the amphiphilic macroradicals underwent in situ self‐assembly to form polymeric micelles, which promoted the emulsion polymerization of the monomer. Thus, amphiphilic core‐shell nanospheres ranging from 70 to 140 nm in diameter were produced in the absence of surfactant. The conversion of the monomer, number average molecular weights (Mn), and particle size were found to be highly dependent on the macrophotoinitiator and monomer concentration. The macrophotoinitiator and amphiphilic particles were characterized by FTIR, UV‐vis, 1H NMR, TEM, DSC, and contact angle measurements. The results showed the particles had well‐defined amphiphilic core‐shell structure. This new method is scientifically and technologically significant because it provides a commercially viable route to a wide variety of novel amphiphilic core‐shell nanospheres. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 936–942, 2010 相似文献
14.
Jinyao Liu Zhihua Nie Yong Gao Alex Adronov Huaming Li 《Journal of polymer science. Part A, Polymer chemistry》2008,46(21):7187-7199
Covalent functionalization of alkyne‐decorated multiwalled carbon nanotubes (MWNTs) with a well‐defined, azide‐derivatized, thermoresponsive diblock copolymer, poly(N,N‐dimethylacrylamide)‐poly(N‐isopropylacrylamide) (PDMA‐PNIPAM) was accomplished by the Cu(I)‐catalyzed [3 + 2] Huisgen cycloaddition. It was found that this reaction could simultaneously increase the molecular size and bonding density of grafted polymers when PDMA‐PNIPAM micelles were employed in the coupling system. On the other hand, attachment of molecularly dissolved unimers of high‐molecular weight onto the nanotube resulted in low‐graft density. The block copolymer bearing azide groups at the PDMA end was prepared by reversible addition–fragmentation transfer polymerization, which formed micelles with a diameter of ~40 nm at temperatures above its critical micelle temperature. Scanning electron microscopy was utilized to demonstrate that the coupling reaction was successfully carried out between copolymer micelles and alkyne‐bearing MWNTs. FTIR spectroscopy was utilized to follow the introduction and consumption of alkyne groups on the MWNTs. Thermogravimetric analysis indicated that the functionalized MWNTs consisted of about 45% polymer. Transmission electron microscopy was utilized to image polymer‐functionalized MWNTs, showing relatively uniform polymer coatings present on the surface of nanotubes. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 7187–7199, 2008 相似文献
15.
Xiao‐Li Sun Wei‐Dong He Jian Li Ning He Shou‐Chen Han Li‐Ying Li 《Journal of polymer science. Part A, Polymer chemistry》2008,46(20):6950-6960
Pyrrolyl‐capped poly(N‐isopropylacrylamide) macromonomers (Py‐PNIPAM) were prepared through reversible addition‐fragmentation‐transfer polymerization with benzyl 1‐pyrrolylcarbodithioate as chain‐transfer agent. Polymerizations of Py‐PNIPAM with/without pyrrole using AgNO3 as oxidizing agent and dimethylforamide as solvent resulted in graft copolymers of polypyrrole‐graft‐poly(N‐isopropylacrylamide) (PPy‐g‐PNIPAM) as well as silver nanoparticles, leading to the formation of PPy‐g‐PNIPAM/silver nanocomposites. The resulting nanocomposites were soluble in water when the content of PPy was low, and when the molar ratio of Py/Py‐PNIPAM increased to 30, the resulting products became insoluble in water. The resulting nanocomposites had special optical properties because of PPy as well as the temperature‐responsible PNIPAM. The chemical structure and composition of nanocomposite were characterized by 1H nuclear magnetic resonance spectroscopy, gel permeation chromatograms, fourier transform infrared spectroscopy, and X‐ray diffraction. Their optical properties were characterized by UV–vis and fluorescence spectroscopy. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 6950–6960, 2008 相似文献
16.
Ke Sha Dongshuang Li Yapeng Li Xiaotian Liu Shuwei Wang Jingqi Guan Jingyuan Wang 《Journal of polymer science. Part A, Polymer chemistry》2007,45(22):5037-5049
Amphiphilic diblock copolymer polycaprolactone‐block‐poly(glycidyl methacrylate) (PCL‐b‐PGMA) was synthesized via enzymatic ring‐opening polymerization (eROP) and atom transfer radical polymerization (ATRP). Methanol first initiated eROP of ?‐caprolactone (?‐CL) in the presence of biocatalyst Novozyme‐435 under anhydrous conditions. The resulting monohydroxyl‐terminated polycaprolactone (PCL–OH) was subsequently converted to a bromine‐ended macroinitiator (PCL–Br) for ATRP by esterification with α‐bromopropionyl bromide. PCL‐b‐PGMA diblock copolymers were synthesized in a subsequent ATRP of glycidyl methacrylate (GMA). A kinetic analysis of ATRP indicated a living/controlled radical process. The macromolecular structures were characterized for PCL–OH, PCL–Br, and the block copolymers by means of nuclear magnetic resonance, gel permeation chromatography, and infrared spectroscopy. Differential scanning calorimetry and wide‐angle X‐ray diffraction analyses indicated that the copolymer composition (?‐CL/GMA) had a great influence on the thermal properties. The well‐defined, amphiphilic diblock copolymer PCL‐b‐PGMA self‐assembled into nanoscale micelles in aqueous solutions, as investigated by dynamic light scattering and transmission electron microscopy. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 5037–5049, 2007 相似文献
17.
Chao Deng Xuesi Chen Jing Sun Tiancheng Lu Wenshou Wang Xiabin Jing 《Journal of polymer science. Part A, Polymer chemistry》2007,45(15):3218-3230
A novel amphiphilic biodegradable triblock copolymer (PGL‐PLA‐PGL) with polylactide (PLA) as hydrophobic middle block and poly(glutamic acid) (PGL) as hydrophilic lateral blocks was successfully synthesized by ring‐opening polymerization (ROP) of L ‐lactide (LA) and N‐carboxy anhydride (NCA) consecutively and by subsequent catalytic hydrogenation. The results of cell experiment of PGL‐PLA‐PGL suggested that PGL could improve biocompatibility of polyester obviously. The copolymer could form micelles of spindly shape easily in aqueous solution. The pendant carboxyl groups of the triblock copolymer were further activated with N‐hydroxysuccinimide and combined with a cell‐adhesive peptide GRGDSY. Incorporation of the oligopeptide further enhanced the hydrophilicity and led to formation of spherical micelles. PGL‐PLA‐PGL showed better cell adhesion and spreading ability than pure PLA and the GRGDSY‐containing copolymer exhibited even further improvement in cell adhesion and spreading ability, indicating that the copolymer could find a promising application in drug delivery or tissue engineering. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 45: 3218–3230, 2007 相似文献
18.
《Journal of Polymer Science.Polymer Physics》2018,56(10):769-777
Polymeric nanospheres with uniform sizes, functional surfaces, and high mechanical strength and thermostability are attracting wide interest in different applications. Here, a new kind of polysulfone micellar spheres with PEGylated surfaces is prepared via directly heating the solution of an amphiphilic block copolymer, polysulfone‐b‐polyethylene glycol (PSF‐b‐PEG). The sizes of the micelles are uniform and tunable between ∼42 and ∼443 nm. TEM characterizations show that the micelles are core‐shell structures with PEG as the corona and PSF as the core. PEG endows the micelles with dispersibility in water and good biocompatibility, while PSF provides the mechanical strength and thermostability. The effects of PEG contents, polymer solution concentrations, solvent types, and heating temperatures are systematically investigated. Furthermore, heat resistance tests show that the micelles are stable at 150–180 °C. These PSF‐b‐PEG micellar spheres are expected to be applied in demanding environmental conditions such as heating involved surface modification process. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2018 , 56, 769–777 相似文献
19.
Xin Xiao Shangjin He Meihan Dan Yang Su Fei Huo Wangqing Zhang 《Journal of polymer science. Part A, Polymer chemistry》2013,51(15):3177-3190
Dispersion RAFT polymerization of styrene in the alcohol/water mixture mediated with the brush macro‐RAFT agent of poly[poly(ethylene oxide) methyl ether vinylphenyl‐co‐styrene] trithiocarbonate [P(mPEGV‐co‐St)‐TTC] with similar molecular weight but different chemical composition is investigated. Well‐controlled RAFT polymerization including an initial slow homogeneous polymerization and a subsequent fast heterogeneous polymerization at almost complete monomer conversion is achieved. The molecular weight of the synthesized block copolymer increases linearly with the monomer conversion, and the polydispersity is relatively narrow (PDI < 1.3). The RAFT polymerization kinetics is dependent on the chemical composition in the brush macro‐RAFT agents, and those with high content of hydrophobic segment lead to fast RAFT polymerization. The growth of the block copolymer nano‐objects during the RAFT polymerization is explored, and various block copolymer nano‐objects such as nanospheres, worms, vesicles and large‐compound‐micelle‐like particles are prepared. The parameters such as the chemical composition in the brush macro‐RAFT agent, the chain length of the solvatophobic block, the concentration of the feeding monomer and the solvent character affecting the size and morphology of the block copolymer nano‐objects are investigated. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 3177–3190 相似文献
20.
Peptide‐poly(tert‐butyl methacrylate) conjugate into composite micelles in organic solvents versus peptide‐poly(methacrylic acid) conjugate into spherical and worm‐like micelles in water: Synthesis and self‐assembly
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Anupam Saha Somdeb Jana Tarun K. Mandal 《Journal of polymer science. Part A, Polymer chemistry》2016,54(18):3019-3031
Peptide–polymer conjugates are versatile class of biomaterials composed of a peptide block covalently linked with a synthetic polymer block. This report demonstrates the synthesis of peptide‐poly(tert‐butyl methacrylate) (Peptide‐PtBMA) conjugates of varying molecular weights via a “grafting from” atom transfer radical polymerization (ATRP) technique using as‐synthesized peptide‐based initiator in toluene. Peptide‐PtBMA conjugate is soluble in many organic solvents and undergoes self‐assembly into micro/nanospheres in DMF/THF as observed from both FESEM and DLS results. The conjugate micro/nanospheres are nothing but the composite micelles formed by the secondary aggregation of primary micelles generated initially in these organic solvents. The hydrolysis of tert‐butyl groups of Peptide‐PtBMA conjugate leads to the formation of peptide‐poly(methacrylic acid) (Peptide‐PMA) conjugate. The circular dichroism (CD) analysis exhibits the presence of β‐sheet conformation of peptide moiety in synthesized conjugates. The formed Peptide‐PMA conjugate is soluble in water and owing to its amphiphilic character, the conjugate molecules self‐assemble into spherical micelles as well as worm‐like micelles upon increasing the concentration of conjugate in water. However, the sodium salt of Peptide‐PMA conjugates (Peptide‐PMAS) self‐assembles into only spherical swollen micelles in water at higher (pH ~10). The critical aggregation concentrations (CACs) of both Peptide‐PMA and Peptide‐PMAS micelles are measured by fluorescence spectroscopy. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016 , 54, 3019–3031 相似文献