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1.
De Qing LONG De Jiang LI Wei Quan CAI Sheng Sheng CHEN Department of Chemistry Yunyang Teachers College Hubei College of Chemical Engineering Wuhan University of Technology Wuhan 《中国化学快报》2006,(11)
Ten novel 2-alkylthio-5-(3, 4, 5-tribenzyloxyphenyl)-1, 3, 4-oxadiazole derivatives (5a-j) were synthesized from methyl 3, 4, 5-trihydroxybenzoate by etherification, hydrazidation, cyclization and thioetherification reactions. The structures of 5a-j were confirmed by 1HNMR, MS spectra and elemental analysis. The results indicated that most of the compounds 5 exhibited good fungicidal activities. The activity of 5h is higher than 90% against Fusarium oxysporum and Botrytis cinereapers in 50 mg/L. 相似文献
2.
Synthesis of novel 4-(4-methylsulfonylphenyl)-3-phenyl-2(3H)-thiazole thione derivatives with functionalized diarylheterocycle pharmacophore as potential COX-2 inhibitors was described. The title compounds were synthesized by cyclocondensation of corresponding dithiocarbamate and 2-bromo-1-(4-methylsulfonylphenyl)ethanone, followed by dehydration with H2SO4. All of the target compounds were characterized by ^1H NMR, IR and mass spectral data. 相似文献
3.
A novel benzisothiazolin-3-one derivative, 2-(benzo[d]isothiazol-3-yloxy)-N-(3- cyano-l-(4-fluorophenyl)-lH-pyrazol-5-yl) acetamide (8), was synthesized from the initial compound benzo[d]isothiazol-3(2H)-one (BIT) 1 and 4-fluoroaniline 3. The structure of the target compound 8 was determined by elemental analyses, IR and 1H NMR. The single crystals of intermediate compound 6 and the target compound 8 were obtained and determined by X-ray diffraction analysis. The preliminary biological activity was also evaluated and the results showed tile target compound exhibited a good anti-microbial activity. 相似文献
4.
Li Gang REN Xiang Yang LIU Yi GU 《中国化学快报》2006,17(11):1511-1514
A novel diamine 4-[(4'-butoxyphenoxy)carbonyl]phenyl-3",5"-diaminobenzoate (BCDA) was synthesized from 4-butoxyphenol, 4-hydroxybenzoic acid and 3,5-dinitrobenzoic acid through four main intermediates, and a series of polyimides were also synthesized. All the intermediates and the final product were characterized by FTIR and 1H-NMR. The key step in synthesis route is selective hydrolyzation of two ester groups in 4-butoxyphenyl-4'-acetoxybenzoate, by adjusting the reaction temperature and the concentration of ammonia, shorteding the reaction time. The properties of the novel polyimides, such as the aggregation structures, glass transition temperature, solubility and the pretilt angles, were carded out. 相似文献
5.
Yah Chao WU Xiao Mao ZOU Fang Zhong HU Hua Zheng YANG 《中国化学快报》2005,16(9):1143-1146
A series of novel 5-sulfoxide-substituted pyrazolo[5,1-d] [1,2,3,5]tetrazin-4(3H)ones 4a-j were designed and efficiently synthesized via a diazotization of 5-amine-3-methylsulfinyl- 1H-pyrazole, followed by cycloaddition with aryl isocyanate. A possible reaction mechanism is outlined and discussed. These new compounds exhibit some biological activity as preliminary bioassay indicated. Their structures were confirmed with ^1H NMR, IR and elemental analysis. 相似文献
6.
Jin YANG Li Gang REN Xiang Yang LIU Yi GU 《中国化学快报》2005,16(9):1151-1154
This is a part of our systematic research work on polyimides with mesogenic unit side chain. In this study, a new 4'-phenylpbenyl 4-(3",5"-diaminobenzoyloxy)benzoate and polyimide were synthesized, and characterized by FTIR, ^1H-NMR, inherent viscosity, mechanical properties, and solubility measurements. The diamine composed with mesogenic unit aryl ester groups and bipbenyl group with longer L/D ratio, was synthesized by two key steps. Firstly, the hydroxy group of 4-hydroxybenzoic acid was protected by acetoxy group for avoiding self- polymerization of 4-hydroxybenzoic acid, and then selectively hydrolyzed after esterification of carboxyl. Secondly, a selective catalysis hydrogenation was adopted to prevent the aryl ester from deoxidation. Based on this diamine, a novel polyimide was prepared by polycondensation of 4'-phenylphenyl 4-(3", 5"-diaminobenzoyloxy)benzoate and 4-aminophenyl ether(ODA) with 4, 4'-oxydiphthalic anhydride(ODPA) in N-methyl-2-pyrrolidone (NMP). The resulting polyimide with longer side chain showed better solubility and more regular structure. Its inherent viscosity is lower than that without side chains, but its modulus and strength not only maintained, even improved. 相似文献
7.
ZHANG Shuo WANG Wenjin LI Chuan LIU Peng XU Weiren TANG Lida WANG Jianwu ZHAO Guilong 《高等学校化学研究》2014,30(2):250-256
A facile 7-step procedure for the synthesis of enantiomerically pure 1-(5-bromo-2-chlorophenyl)-1-(4-ethoxyphenyl)ethanes[(R)-2 and(S)-2] that started from (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone 3 was developed.The key step was the resolution of 2-(5-bromo-2-chlorophenyl)-2-(4-ethoxyphenyl)acetic acid 6 by crystallizations of its L-and D-menthyl esters 7 and 8 from petroleum ether to give optically pure enantiomers 9 and 10,respectively.The absolute configurations of the products were unambiguously determined by single-crystal X-ray diffractions of four key intermediates,9,10,13 and 14.This procedure is characterized by inexpensiveness,scalability and ability to produce two individual enantiomers of a diarylethane with unambiguously determined absolute configurations and high enantiomeric purities. 相似文献
8.
A convenient approach for the preparation of (2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-chlorophenyl)-6-(hydroxymethyl)- tetrahydro-2H-pyran-3,4,5-triol I is developed. The target compound via four steps is synthesized from 4-bromo-2-(bromomethyl)- 1-chlorobenzene and the isomers of undesired ortho-products were avoided during the preparation. 相似文献
9.
WANG Xi-Cun WANG Fang QUAN Zheng-Jun ZHANG Zhang 《结构化学》2009,28(8):957-962
The synthesis for acyliminothiazolines by treatment of N, N□-substituted thioureas with α-bromoacetophenone under aqueous media was described. 2-(2-Benzofuroylimino)-3-aryl- 4-phenyl-1,3- thiazolines were characterized by infrared, NMR spectroscopy and elemental analysis. The single crystals of compounds 4a and 4b were grown by slow evaporation of 80% ethanol solution at room temperature. Compounds 4a and 4b crystallize in triclinic space group P1 and monoclinic space group P21/c, respectively. 相似文献
10.
Xin Bo ZHOU Cui Fang LIN Song LI 《中国化学快报》2005,16(10):1301-1304
The synthesis of (S)-2-(3-arylacrylamido)-3-{4-[2-(5-methyl-2-phenyloxazol-4-yl)etho- xy]phenyl}propanoic acids is described. Their structures were confirmed by ^1H-NMR. 相似文献
11.
ZHU Hongwei WANG Baolei ZHANG Xiulan XIONG Lixia YU Shujing LI Zhengming 《高等学校化学研究》2014,30(3):409-414
A series of novel 3-bromo-1-(3-chloropyridin-2-yl)-N-hydroxy-N-aryl-lH-pyrazole-5-carboxamides was synthesized by the reaction of pyrazole carbonyl chloride with each of substituted phenylhydroxyamines. The latter ones were prepared in good yields by reducing substituted nitrobenzene compounds with Zn/NH4CI reductant system in alcohol. Structures of the title compounds were determined by IR, 1H NMR, and HRMS. Their insecticidal and fungicidal activities were evaluated by larvicidal test against oriental armyworm and the mycelium growth rate method, respectively. 相似文献
12.
Jian XU Zhi Lan LIU Ren Xi ZHUO 《中国化学快报》2006,17(10):1365-1368
Novel biodegradable copolymer poly(CC-co-EEP) was synthesized by ring-opening copolymerization of cyclic carbonate 9-phenyl-2, 4, 8, 10-tetraoxaspiro-[5, 5]undcane-3-one (CC) and ethylene ethyl phosphate (EEP). The obtained poly (CC-co-EEP)s were characterized by FTIR, ^1H NMR, ^13C NMR and gel permeation chromatography (GPC). In vitro hydrolytic degradation of the copolymers were investigated in phosphate buffer solution (pH=7.4). Hydrophilic phosphate units apparently improved the degradability of poly(carbonate-phosphate). 相似文献
13.
The copolymer poly(3-(4-fluorophenyl)thiophene-co-3-methylthiophene) was successfully prepared from mixtures of 3-(4-fluorophenyl)thiophene (FPT) and 3-methylthiophene (MET) via electrochemical oxidation in boron trifluoride diethyl etherate (BFEE) and its mixed electrolytes with acetonitrile (ACN). The influence of monomer concentration ratios on the copolymerization was investigated by using linear sweep voltammetry and cyclic voltammetry. The structure and morphology of these copolymer films were elucidated by UV-Vis, infrared spectroscopy, elemental analysis, thermal analysis and scanning electron microscopy (SEM), respectively. The results showed that the molar ratio of FPT and MeT units, when copolymer was electrodeposited from feed ratio of FPT:MeT = 1:2, was about 1.08:1. In addition, the introduction of ACN into BFEE has little effect on the properties of as-formed copolymers. 相似文献
14.
Jian Ge ZHANG Chang Sheng JIANG Guo Qiang LIN Ren WEN 《中国化学快报》2005,16(9):1205-1208
A new method for the synthesis of 4, 4-diaryl/diheteroaryl-3-butenyl derivatives of nipecotic acid as GABA transporter inhibitors is described. The key intermediates 4-tosyl-1, 1-diaryl/diheteroaryl-1-butene 10a-d were synthesized by Wittig reaction, and followed by alkylation with (R)-3-piperidinecarboxylate. The resulting N-cycloalkylated amino acid esters 11a-d were saponified and then acidified to get the target compounds 1a-d. The preliminary bioassays showed that la-d exhibited excellent inhibition of [3H]-GABA uptake in vitro of culture cells. 相似文献
15.
The title compound 3-methyl-l-(4-methylphenyl)-4-(N-4-trifluoromethylphenyl) aminomethyl-5-(4-methoxyphenylthio)-lH-pyrazole has been synthesized via a four-step reaction and characterized by IR, 1H NMR, elemental analysis and X-ray crystallography. The compound crystallizes in monoclinic, space group P21/c with a = 8.7170(15), b = 18.355(3), c = 15.292(3) A, fl = 103.445(3)°, V= 2379.7(7) A3, Dc = 1.350 g/cm3, Z = 4, p = 0.184, F(000) = 1008, and the final R = 0.0491 and wR = 0.1339 for 4160 observed reflections (I 〉 2a(/)). The results demonstrate that there is a face-to-face π-π stacking interaction between one benzene ring (C(19)-C(24)) and another (C(I 3)-C(! 8)) at a plane-plane distance of 3.3539 A. The ring normal and vector between the ring centroids form an angle of 18.2° up to the centroid-to-centroid distance of 3.5273 A. The crystal structure is stabilized by the intermolecular hydrogen bond of N(3)-H(3A)...N(2) (symmetry code: A -x+l, -y+l, -z). The preliminary biological test shows that the title compound has a moderate antifungal activity. 相似文献
16.
The syntheses of 5-substituted-3-[( 2' R, 4' R)-4 ' -hydroxy-2 ' -hydroxymethyltetra-hydrofuran-4' -yl]D-1 ,2, 4-oxadiazoles and their epimers were accomplished with the aid of th construction of 1,2, 4-oxadiazoles by condensation of O-acylated cyanohydrins with hydroxylamine via intramolecular transacylation and subsequent cyclization. 相似文献
17.
The title compound 1-(β-D-glucopyranosyl)-3-amino-5-methyl- 1H- 1,2,4-triazole was synthesized and characterized by IR, 1H-NMR and elemental analysis. Its single crystals of 2H2O adduct suitable for X-ray analysis were obtained by the slow evaporation of a H2O solution and its structure was determined by single-crystal X-ray diffraction. The crystal belongs to orthorhombic, space group P212121 with a = 7.7490(15), b = 10.424(2), c = 17.447(4) A^°, V = 1409.3(5) A^°^3, Z= 4, C9H20N4O7, Mr = 296.29, Dc = 1.396 g/cm^3,μ = 0.120 mm^-1, S = 1.007, F(000) = 632, R = 0.0686 and wR = 0.1560 for 1217 observed reflections with I 〉 20(I). The title molecules are linked through intermolecular hydrogen bonds to form two 1-D chain structures, and such adjacent chains are further linked by intermolecular hydrogen bonds and H2O bridges to form a 3-D supramolecular network structure. The preliminary bioassay results showed that the title compound exhibits fungicidal activities against Gibberella zeae and Colletotrichum orbiculare. 相似文献
18.
Lihe Zheng Dong Xuan Jianjun Guo Hui Lou Xiaoming Zheng 《天然气化学杂志》2006,15(1):52-57
The non-oxidative aromatization of mixed CH4 with C3H8 over La-promoted Zn/HZSM-5 catalysts was studied in a fixed-bed reactor at 823 K with space velocity 600 h^-1 and CH4/C3H8 (mol ratio)=5:l. The propane conversion and the aromatic selectivities were up to 99% and 60% over the catalyst respectively, while methane conversion had an induction period with the highest conversion of 30%. The structure and surface acidity of the catalysts were characterized by XRD, NH3-TPD and TG-DTA. The influences of reaction and regenerative conditions on the activity and selectivity were also investigated. 相似文献
19.
4-(4,6-Dimethylpyrimidin-2-yl)-3-thio-allophanic acid methyl ester was synthesized with mixing 2-amino-4,6- dimethylpyrimidine, potassium thiocyanate and methyl chloroformate in ethyl acetate. Single crystals suitable for X-ray diffraction measurement were obtained by recrystallization from dimethylformamide at room temperature. The crystal belongs to monoclinic symmetry with space group C2/m, and crystal parameters of a= 1.7537(5) nm, b= 0.6759(2) nm, c=1.1148(3) nm, β=118.557(4)°, V=1.1605(6) nm^3, Z=4, De= 1.375 g/cm^3,μ=0.271 mm^-1, F(000)=504, and 1519 [1〉2σ(I)] observable independent reflections were used for the determination and refmement of the crystal structures with final R1 of 0.0372 and wR2 of 0.0992. The theoretical investigation of the title compound was carried out with DRT-B3LYP/6-311G, HF/6-311G and MP2/6-311G methods, and the atomic net charges and the population were discussed. 相似文献
20.
The title molecule, 3-(4-(dimethylamino)benzylidene)-l,5-dioxaspiro[5.5] unde- cane-2,4-dione (I), was synthesized and characterized by elemental analysis, IR, UV-vis spectra and X-ray diffraction analysis. The compound belongs to the triclinic system, space group Pi with a = 6.3640(6), b = 7.7404(8), c = 16.2890(18) A, α = 86.860(2), β = 85.837(2), γ = 79.6720(10)°, V = 786.60(14) A3, D, = 1.331 g/cm3, and F(000) = 336. Geometrical structure of the title compound was optimized by density functional theory (DFT) using B3LYP method with 6-31G** as the basis set. The vibrational frequencies were calculated by the DFT method and the results are consistent with the observed frequencies. The electronic absorption spectra were studied with the time- dependent density functional theory (TD-DFT), showing the calculation results in good agreement with the corresponding experimental data. 相似文献