共查询到20条相似文献,搜索用时 11 毫秒
1.
V. V. Burmistrov D. A. Pitushkin V. V. Vasipov G. M. Butov 《Russian Journal of Organic Chemistry》2017,53(8):1176-1179
Reactions of adamantan-1(2)-amines and adamantan-1(2)-ylalkanamines with ethyl isothiocyanatoacetate afforded ethyl ({[adamantan-1(2)-ylalkyl]carbamothioyl}amino)acetates in 85–95% yields. The hydrolysis of ethyl {[(adamantan-2-yl)carbamothioyl]amino}acetate in alkaline medium resulted in the formation of {[(adamantan-2-yl)carbamothioyl]amino}acetic acid in a virtually quantitative yield. 相似文献
2.
微波辐射下2-[4-二-(4-氟苯)甲基]哌嗪乙酰腙化合物的合成 总被引:3,自引:0,他引:3
微波辐射条件下, 以丙酮作溶剂, 1-[二-(4-氟苯)甲基]哌嗪与氯乙酸乙酯反应得到2-[二-(4-氟苯)甲基]哌嗪乙酸乙酯(1), 1与水合肼在微波辐射条件下反应得到2-[二-(4-氟苯)甲基]哌嗪乙酰肼(2), 进一步在微波辐射条件下由2-[二- (4-氟苯)甲基]哌嗪乙酰肼(2)与取代芳香醛反应制得目标化合物3a~3f. 合成的6个目标化合物通过熔点测定和质谱、红外光谱、核磁共振氢谱分析、元素分析对其结构进行确证. 相似文献
3.
Man’kova P. A. Reznikov A. N. Shiryaev V. A. Baimuratov M. R. Rybakov V. B. Klimochkin Yu. N. 《Russian Journal of Organic Chemistry》2021,57(2):226-236
Russian Journal of Organic Chemistry - The reduction of 1-(adamantan-1-yl)-2-azidoethan-1-one oxime with LiAlH4 gave racemic 1-(adamantan-1-yl)ethane-1,2-diamine, which was resolved with l-tartaric... 相似文献
4.
D’yachenko V. S. Burmistrov V. V. Butov G. M. 《Russian Journal of Organic Chemistry》2019,55(11):1679-1685
Russian Journal of Organic Chemistry - Ethyl [(adamantan-1-yl)alkylene(phenylene)amino]oxoacetates and N1,N2-bis[(adamantan-1-yl)-alkylene(phenylene)oxamides were prepared in yields of 72–87... 相似文献
5.
Two series of new adamantyl derivatives of polynitrogen heterocycles, 2-(adamantan-1-yl)-5-aryl- 1,3,4-oxadiazoles and 2-(adamantan-1-yl)-5-aryl-2H-tetrazoles, have been synthesized, and their structure has been determined by NMR spectroscopy, mass spectrometry, and X-ray analysis. Biological studies in vitro have revealed high inhibitory activity of some of the synthesized 2-(adamantan-1-yl)-5-aryl-2H-tetrazoles against H1N1 influenza A viruses in combination with a relatively low selectivity. 相似文献
6.
Yu. L. Zborovskii V. V. Orysyk V. I. Staninets V. V. Bon’ 《Russian Journal of Organic Chemistry》2011,47(6):881-885
Cyclization of 2-(2-{4-[allylamino(thioxo)methyl]piperazin-1-yl}ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione by the action of iodine, bromine, or sulfuryl chloride gave 2-(2-{4-[4,5-dihydro-5-(halomethyl)-thiazol-2-yl]piperazin-1-yl}ethyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione hydrohalides which were converted into 2-{2-[4-(5-methylthiazol-2-yl)piperazin-1-yl]ethyl}-1H-benzo[de]isoquinoline-1,3(2H)-dione. 相似文献
7.
In the reaction of N-[2-(5-bromouracil-1-yl)ethyl]alkylamines with alkylamines at 40 °C kine-substitution takes place with the formation of N-[2-(6-alkylamino-uracil-1-yl)ethyl]alkylamines.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1260–1261, September, 1984. 相似文献
8.
A. Heshmat Moustafa Samia A. El-Abbady R. Alan Jones 《Journal of heterocyclic chemistry》1981,18(7):1461-1463
Cycloaddition to 1-(4,6-dimethylpyrimidin-2-yl)- and 1-(4,6-dimethoxy-s-triazin-2-yl)-3-oxidopyridinium betaines across the 2,6-positions of the pyridine rings with indene, acenaphthylene and ethyl cinnamate gave substituted 8-aza[3.2.1]bicycIooct-3-en-2-ones, whereas the [6π + 4π] cycloaddition reaction with 6,6-dimethylfulvene gave a tricyclo[6.3.1.02.6]dodeca-2,(6),4,9-trien-11-one. Structural and configurational assignments of the cycloadducts were deduced from 1H nmr and ir spectral data. 相似文献
9.
Burlov A. S. Divaeva L. N. Vlasenko V. G. Koshchienko Yu. V. V. Chaltsev B. V. Mashchenko S. A. Kiskin M. A. 《Journal of Structural Chemistry》2022,63(8):1284-1290
Journal of Structural Chemistry - A Co(II) complex with 1-{1-[2-(o-tolyloxy)ethyl]-1H-benzimidazol-2-yl}ethan-1-ol is prepared. It is established by elemental analysis and IR spectroscopy that the... 相似文献
10.
以对氨基苯腈为起始原料,经胺化反应制得N-(4-氰基苯基)甘氨酸(4);4与N-[3-氨基-4-(甲基氨基)苯甲酰基]-N-2-吡啶-β-丙氨酸乙酯(5)经酰胺化后经闭环反应,合成了达比加群酯的关键中间体——3-【【【2-{[(4-氰基苯基)氨基]甲基}-1-甲基-1H-苯并咪唑-5-基】羰基】(吡啶-2-基)氨基】丙酸乙酯,总收率79.6%,其结构经~1H NMR和ESI-MS确证。 相似文献
11.
Burmistrov V. V. Mokhov V. M. Danilov D. V. Fayzullin R. R. Butov G. M. 《Russian Journal of Organic Chemistry》2022,58(3):259-267
Russian Journal of Organic Chemistry - A procedure has been developed for the synthesis of rac-1-[isocyanato(phenyl)methyl]adamantane from rac-2-(adamantan-1-yl)-2-phenylacetic acid in 95% yield.... 相似文献
12.
Stereospecifity of the neuroleptic activity and chirality of (+)-3-{2-[4-(8-fluoro-2-methyl-10, 11-dihydrodibenzo[b,f]thiepin-10-yl)-1-piperazinyl]ethyl}-2-oxazolidinone (16). The synthesis and stereospecific neuroleptic action in animals of the (+)-enantiomer of 3-{2-[4-(8-fluoro-2-methyl-10,11-dihydrodibenzo [b,f]thiepin-10-yl)-1-piperazinyl]ethyl}-2-oxazolidinone ( 16 ) are briefly described. The (10S)-configuration of this compound was determined by X-ray diffraction. 相似文献
13.
Kristina Mickevičienė Aušra Voskienė Vytautas Mickevičius 《Research on Chemical Intermediates》2014,40(4):1619-1631
Mono- and disubstituted benzimidazoles were synthesized during alkaline hydrolysis or reactions with ethyl chloroacetate of 1-phenyl substituted 4-(1H-benzimidazol-2-yl)-2-pyrrolidinones. The properties of the synthesized ethyl-[2-(1-(substituted phenyl)-5-oxopyrrolidinyl-3-yl)-1H-benzimidazolyl]ethanoates have been investigated and their benzimidazolium chlorides, 1-carboxymethylbenzimidazoles, condensation products of 2-{2-[1-(3-methylphenyl)-5-oxo-3-pyrrolidinyl]-1H-benzimidazol-1-yl}acetohydrazide with various aromatic aldehydes and aliphatic ketones have been obtained. 相似文献
14.
Nasakin O. E. Kazantseva M. I. Varkentin L. I. Gein V. L. 《Russian Journal of General Chemistry》2018,88(6):1270-1272
Russian Journal of General Chemistry - 1-[2-(1H-indol-3-yl)ethyl]-4-acetyl-3-hydroxy-5-phenyl-1H-pyrrole-2(5H)-ones were synthesized by the short heating of a mixture of tryptamine, aromatic... 相似文献
15.
Yoshihisa Kurasawa Ritsuko Katoh Fumiko Mori Minori Fukuchi Megumi Okamoto Atsushi Takada Ho Sik Kim Yoshihisa Okamoto 《Journal of heterocyclic chemistry》1992,29(4):1009-1011
The reaction of 6-chloro-2-hydrazinoquinoxaline 4-oxide 6 with ethyl 2-(ethoxymethylene)-2-cyanoacetate or (1-ethoxyethylidene)malononitrile gave 2-(5-amino-4-ethoxycarbonylpyrazol-1-yl)-6-chloroquinoxaline 4-oxide 7a or 2-(5-amino-4-cyano-3-methylpyrazol-1-yl)-6-chloroquinoxaline 4-oxide 7b , respectively. The reaction of compound 7a or 7b with dimethyl acetylenedicarboxylate resulted in the 1,3-dipolar cycloaddition reaction and then ring transformation to afford 4-(5-amino-4-ethoxycarbonylpyrazol-1-yl)-8-chloro-1,2,3-trismethoxycarbonylpyrrolo[1,2-α]quinoxaline 8a or 4-(5-amino-4-cyano-3-methylpyrazol-1-yl)-8-chloro-1,2,3-trismethoxycarbonylpyrrolo[1,2-α]quinoxaline 8b , respectively. 相似文献
16.
N. F. Kirillov E. A. Nikiforova P. A. Slepukhin M. I. Vakhrin 《Russian Journal of General Chemistry》2012,82(5):891-894
Methyl 1-bromoalkanecarboxylates react with zinc and ethyl 5-aryl-3-oxo-2,2-diethylpent-4-enoates to form ethyl 2-(10-aryl-6-oxo-7-oxaspiro[4.5]dec-8-en-8-yl)-2-ethylbutanoates and ethyl 2-(5-aryl-1-oxo-2-oxaspiro[5.5]undec-3-en-3-yl)-2-ethylbutanoates. 相似文献
17.
A reaction of methyl 2-(4-allyl-2-methoxyphenoxy)acetate with adamantan-2-amine and (adamantan-1-yl)methylamine in butanol leads, together with the target amides, to the formation of butyl ester of the corresponding acid, which is resistant to aminolysis. 相似文献
18.
Christophe Jacopin Mathieu Laurent Marc Belmans Luc Kemps Marcel Crsiat Jacqueline Marchand-Brynaert 《Tetrahedron》2001,57(52):10383-10389
5-{3-[1-(tert-Butyldimethylsilyloxy)ethyl]-4-oxo-azetidin-2-yl}-2,2,5-trimethyl-[1,3]dioxane-4,6-dione (3) has been submitted to nucleophilic attack with various nucleophiles. Meldrum's moiety transesterification, C4-substitution, β-lactam ring opening and Meldrum's moiety decarboxylation were observed. Reaction of 3 with ethanethiol and dimethylaminopyridine in ethanol quantitatively furnished ethyl 2-{3-[1-(tert-butyldimethylsilyloxy)ethyl]-4-oxo-azetidin-2-yl}-thiopropionate as the 1:1 mixture of β (7a) and (8a) diastereoisomers. 相似文献
19.
V. Yu. Petukhova Yu. A. Strelenko K. A. Lyssenko N. N. Makhova 《Russian Chemical Bulletin》2007,56(8):1550-1554
A method for the synthesis of 1-[ω-(3,3-dialkyldiaziridin-1-yl)alkyl]-3,3-dialkyldiaziridines based on the reaction of ketoxime
O-arenesulfonates with alkylenediamines was developed. Diastrereomers (the racemic and meso forms) of 1-[2-(3,3-dimethyldiaziridin-1-yl)ethyl]-3,3-dimethyldiaziridine were isolated. The structure of the meso form was confirmed by X-ray diffraction analysis.
Dedicated to Academician V. A. Tartakovsky on his 75th birthday.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1491–1495, August, 2007. 相似文献
20.
The azidation of 2,2-bis(2-cyanoethyl)-20-hydroxydammar-24-en-3-one afforded new tetrazole derivatives of natural dipterocarpol, 2-(2-cyanoethyl)-2-[2-(1H-tetrazol-5-yl)ethyl]-20-hydroxydammar-24-en- 3-ones, 2,2-bis[2-(1H-tetrazol-5-yl)ethyl]-20-hydroxydammar-24-en-3-one, and 2,2-bis[2-(1H-tetrazol-5-yl)- ethyl]-3-oxo-25,26,27-trinordammaran-(20S),24-olide. The structure of the final and intermediate products was determined by NMR spectroscopy and X-ray analysis. 相似文献