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1.
Ali K.Khalafallah Suleiman A.Suleiman Afifi H.Yousef Nadia A.A.El-kanzi Abou El-Hamd H.Mohamed 《中国化学快报》2009,20(12):1465-1468
In continuation of our chemical investigation on some medicinal plants of the genus Tephrosia,re-investigation of the methylenechloride/methanol(1:1) extract of the air-dried aerial part of Tephrosia apollinea afforded a new prenylated flavonoid 1, in addition to an aromatic ester,a sesquiterpene,a lignan and several known prenylated flavonoids.The structures were established by(~1H NMR,~(13)C NMR,DEPT,~1H-~1H COSY,HMQC,HMBC,NOESY and HRMS).Relative configurations of 9 and 10 were confirmed by X-ray anal... 相似文献
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Jean Claude Didelot Tomani Olivier Bonnet Alain Nyirimigabo William Deschamps Alembert Tiabou Tchinda Olivia Jansen Allison Ledoux Marie Jeanne Mukazayire Luc Vanhamme Michel Frdrich Raymond Muganga Jacob Souopgui 《Molecules (Basel, Switzerland)》2021,26(9)
Malaria remains one of the leading causes of death in sub-Saharan Africa, ranked in the top three infectious diseases in the world. Plants of the Eriosema genus have been reported to be used for the treatment of this disease, but scientific evidence is still missing for some of them. In the present study, the in vitro antiplasmodial activity of the crude extract and compounds from Eriosema montanum Baker f. roots were tested against the 3D7 strain of Plasmodium falciparum and revealed using the SYBR Green, a DNA intercalating compound. The cytotoxicity effect of the compounds on a human cancer cell line (THP-1) was assessed to determine their selectivity index. It was found that the crude extract of the plant displayed a significant antiplasmodial activity with an IC50 (µg/mL) = 17.68 ± 4.030 and a cytotoxic activity with a CC50 (µg/mL) = 101.5 ± 12.6, corresponding to a selective antiplasmodial activity of 5.7. Bioactivity-guided isolation of the major compounds of the roots’ crude extract afforded seven compounds, including genistein, genistin and eucomic acid. Under our experimental conditions, using Artemisinin as a positive control, eucomic acid showed the best inhibitory activity against the P. falciparum 3D7, a well-known chloroquine-sensitive strain. The present results provide a referential basis to support the traditional use of Eriosema species in the treatment of malaria. 相似文献
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Isolation and identification of new prenylated acetophenone derivatives from Acronychia oligophlebia
Qian-Wen Niu Neng-Hua Chen Zhong-Nan Wu Ding Luo Ying-Ying Li Yu-Bo Zhang 《Natural product research》2019,33(15):2230-2235
Three new prenylated acetophenone derivatives, acronyculatin P (1), acronyculatin Q (2), and acronyculatin R (3) were isolated from the leaves of Acronychia oligophlebia. Their structures were identified by extensive analyses of spectroscopic data (IR, UV, ESI-HRMS, 1D and 2D NMR) and comparison with the literatures. In addition, the cytotoxic activity against MCF-7 cells of the compounds were evaluated by the MTT assay and the IC50 values were 56.8, 40.4 and 69.1?μM, respectively. 相似文献
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Yina Xiao 《Natural product research》2018,32(8):902-908
The microbial transformation studies of 7-O-prenylquercetin (1), 4′-O-prenylquercetin (2) and quercetin (3) were investigated with 20 different microbial strains to discover new metabolites. It was revealed that the fungus Mucor hiemalis was the most appropriate micro-organism which was capable of transforming these flavonoids. Structures of the three new (4–6) and one known (7) metabolites were elucidated as 7-O-prenylquercetin 3-O-β-D-glucopyranoside (4), 4′-O-prenylquercetin 3-O-β-D-glucopyranoside (5), 4′-O-prenylquercetin 3′-O-β-D-glucopyranoside (6) and quercetin 5-O-β-D-glucopyranoside (7) by the spectroscopic methods. 相似文献
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Indole alkaloids from the African Strychnos species, their antiplasmodial and cytotoxic action, and structure -activity relationships are discussed in the review 相似文献
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西非灰毛豆中鱼藤素的分析 总被引:1,自引:0,他引:1
改进了植物中鱼藤素的HPLC检测方法;比较UV吸收光谱发现,检测波长设为260nm可以有选择地检测鱼藤素,减少鱼藤酮的干扰;CHCl3-MeOH(体积比91)溶剂适于提取植物中鱼藤素,经C-18柱层析,用MeOH-H2O(体积比2080)洗脱能有效去除大部分杂质,而用MeOH-H2O(体积比8515~1000)洗脱可收集鱼藤素;对西非灰毛豆植株中鱼藤素的含量分析试验结果表明,该植物中的鱼藤素主要存在于叶中,平均含量为200×10-3(w),其中又以上部叶和新叶含量最多,分别为25.2×10-3和22.0×10-3(w);根和枝条中含量很低,尤其是枝条仅含0.65×10-3(w),基本上没有实用价值;鱼藤素的杀虫活性不如鱼藤酮,但由于其含量高,在制作杀虫剂时也不能忽视其作用. 相似文献
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Liuyuan Chen Yinghui Duan Chang Li Yu Wang Xupeng Tong Yi Dai Xinsheng Yao 《Magnetic resonance in chemistry : MRC》2013,51(12):842-846
Four new prenylated flavonoids, cudraflavanones E‐F (1–2) and cudraflavones F‐G (6–7), together with eight known compounds were isolated from the roots of Cudrania tricuspidata. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses, including 1D and 2D NMR, HRESIMS and CD. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
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Nasir Tajuddeen Tarryn Swart Heinrich C. Hoppe Fanie R. van Heerden 《Molecules (Basel, Switzerland)》2021,26(13)
Ethnobotanical surveys indicate that the Masai and Kikuyu in Kenya, the Venda in South Africa, and the Gumuz people of Ethiopia use Pappea capensis for the treatment of malaria. The present study aimed to investigate the phytochemical and antiplasmodial properties of the plant leaves. The bioactive compounds were isolated using chromatographic techniques. The structures were established using NMR, HRMS, and UV spectroscopy. Antiplasmodial activity of P. capensis leaf extract and isolated compounds against chloroquine-sensitive 3D7 P. falciparum was evaluated using the parasite lactate dehydrogenase assay. Cytotoxicity against HeLa (human cervix adenocarcinoma) cells was determined using the resazurin assay. The extract inhibited the viability of Plasmodium falciparum by more than 80% at 50 µg/mL, but it was also cytotoxic against HeLa cells at the same concentration. Chromatographic purification of the extract led to the isolation of four flavonoid glycosides and epicatechin. The compounds displayed a similar activity pattern with the extract against P. falciparum and HeLa cells. The results from this study suggest that the widespread use of P. capensis in traditional medicine for the treatment of malaria might have some merits. However, more selectivity studies are needed to determine whether the leaf extract is cytotoxic against noncancerous cells. 相似文献
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A. M. C. Arriaga J. Q. Lima J. N. Vasconcelos M. C. F. de Oliveira M. Andrade‐Neto G. M. P. Santiago D. E. A. Uchoa G. T. Malcher J. Mafezoli R. Braz‐Filho 《Magnetic resonance in chemistry : MRC》2009,47(6):537-540
1H and 13C NMR chemical shifts of praecansone B, pongaflavone and dehydrorotenone isolated from Tephrosia egregia Sandw and obovatin from T. toxicaria Pers. were unambiguously assigned by 1D and 2D NMR experiments including 1H, 1H COSY, gHMQC and gHMBC, allowing the correction of literature assignments.Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
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Yancho Zarev Kenn Foubert Paul Cos Louis Maes Esameldin Elgorashi Sandra Apers 《Natural product research》2020,34(7):1037-1040
AbstractSeven tetracyclic spiro-alkaloids, i.e. glucoerysodine (1), erysodine (2), epi-erythratidine (3), erysovine (4), erythratidine (5), erysotrine (6) and erythraline (7) were isolated from the seeds of Erythrina latissima by means of conventional separation methods and HPLC-DAD-SPE-NMR. Their structures were elucidated by spectroscopic means. This is the first report on the isolation of compounds 3, 5 and 6 from this plant. Antiplasmodial activity against the chloroquine-resistant strain Plasmodium falciparum K1 and cytotoxicity against MRC-5 cells (human fetal lung fibroblast cells) was assessed in vitro. Erysodine (2) and erysovine (4) showed moderate activity (IC50 6.53?µM and 4.05?µM, respectively), compared with the standard chloroquine (IC50 = 0.14?µM). No cytotoxicity was observed in a concentration up to 64.0?µM. 相似文献
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Xu Pang Shuang-Shuang Yin Hai-Yang Yu Yi Zhang Tao Wang Li-Min Hu 《Natural product research》2018,32(19):2253-2259
Phytochemical study on the leaves of Epimedium brevicornu finally led to the isolation of four prenylated flavonoids (1–4) and three dihydrophenanthrenes (5–7), of which 1, 2, 5 and 7 were new compounds. The structures of these compounds were established mainly by spectroscopic techniques, including NMR spectroscopy and mass spectrometry. These isolates exhibited the cytotoxic activities against HepG2 cells with the IC50 values of 32.8–87.3 μM. 相似文献
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Chemical investigation of the root bark of Morus alba led to the isolation of a new flavone, dioxycudraflavone A (1) and a new 2-arylbenzofuran, 5-hydroxyethyl moracin M (2), together with seven known compounds namely sanggenon V (3), morusin (4), morusignin L (5), licoflavone C (6), moracin C (7), alfafuran (8) and mulberrofuran G (9). The structure elucidation of these compounds was based on analyses of spectroscopic data including 1D, 2D NMR and HR-ESI-MS. All compounds were evaluated for the α-glucosidase inhibitory and cytotoxic activities. Compounds 2–4, 8 and 9 exhibited strong α-glucosidase inhibitory activities with IC50 less than 10 μM, while only 4 and 9 showed moderate cytotoxic effects against lung cancer cells. 相似文献
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Tran Van Chien Nguyen The Anh Nguyen Tuan Thanh Tran Thi Phuong Thao Tran Van Loc Tran Van Sung 《Natural product research》2019,33(2):212-218
Two new prenylisoflavones, 3′,4′,5-trihydroxy-8-prenyl-dihydrofuran[2″,3″:7,6]isoflavone (1) and 4′,5-dihydroxy-8-prenyl-dihydrofuran[2″,3″:7,6]isoflavone (2), along with five known prenylisoflavones (3–7), benzylalcohol-4-O-β-d-glucoside (8) and two cinnamic acid esters (9, 10) were isolated from the leaves of Maclura cochinchinensis (Cudrania cochinchinensis). Their structures were elucidated by analysis of NMR (1H-, 13C-NMR, HSQC, HMBC), MS spectra and comparison with the published data. Compounds 4–10 were the first time isolated from this species. Prenylisoflavones 1–4 and 6–7 were evaluated for their in vitro cytotoxic activity on KB and HepG2 cancer cell lines. Compound 4 showed cytotoxic activity against both cancer cell lines with IC50 values of 26.99 and 19.95 μM, respectively. The other compounds were considered as inactive. 相似文献
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Faisal Nadeem Fozia Fozia Madeeha Aslam Ijaz Ahmad Shakeel Ahmad Riaz Ullah Mikhlid H. Almutairi Lotfi Aleya Mohamed M. Abdel-Daim 《Molecules (Basel, Switzerland)》2022,27(15)
The use of non-toxic synthesis of iron oxide nanoparticles (FeO NPs) by an aqueous plant extract has proven to be a viable and environmentally friendly method. Therefore, the present investigation is based on the FeO NPs synthesis by means of FeCl3·6H2O as a precursor, and the plant extract of Nephrolepis exaltata (N. exaltata) serves as a capping and reducing agent. Various techniques were used to examine the synthesized FeO NPs, such as UV-Visible Spectroscopy (UV-Vis), Fourier Transform Infrared Spectroscopy (FT-IR), X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and Energy Dispersive X-ray (EDX). The FT-IR studies were used to identify different photoactive biomolecules at 3285, 2928, 1415, 1170, and 600 cm−1 in the wavenumber range from 4000 to 400 cm−1, indicating the -OH, C-H, C-O, C-C, and M-O groups, respectively. The XRD examination exhibited crystallinity, and the average diameter of the particle was 16 nm. The spherical nature of synthesized FeO NPs was recognized by SEM images, while the elemental composition of nanoparticles was identified by an EDX spectrophotometer. The antiplasmodial activity of synthesized FeO NPs was investigated against Plasmodium parasites. The antiplasmodial property of FeO NPs was evaluated by means of parasite inhibitory concentration, which showed higher efficiency (62 ± 1.3 at 25 μg/mL) against Plasmodium parasite if compared to plant extracts and precursor. The cytotoxicity of FeO NPs was also assessed in human peripheral blood mononuclear cells (PBMCs) under in vitro conditions. The lack of toxic effects through FeO NPs keeps them more effective for use in pharmaceutical and medical applications. 相似文献
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Fozia A. Adem Victor Kuete Armelle T. Mbaveng Matthias Heydenreich Andreas Koch Albert Ndakala 《Natural product research》2019,33(18):2609-2617
A new isoflavone, 4′-prenyloxyvigvexin A (1) and a new pterocarpan, (6aR,11aR)-3,8-dimethoxybitucarpin B (2) were isolated from the leaves of Lonchocarpus bussei and the stem bark of Lonchocarpus eriocalyx, respectively. The extract of L. bussei also gave four known isoflavones, maximaisoflavone H, 7,2′-dimethoxy-3′,4′-methylenedioxyisoflavone, 6,7,3′-trimethoxy-4′,5′-methylenedioxyisoflavone, durmillone; a chalcone, 4-hydroxylonchocarpin; a geranylated phenylpropanol, colenemol; and two known pterocarpans, (6aR,11aR)-maackiain and (6aR,11aR)-edunol. (6aR,11aR)-Edunol was also isolated from the stem bark of L. eriocalyx. The structures of the isolated compounds were elucidated by spectroscopy. The cytotoxicity of the compounds was tested by resazurin assay using drug-sensitive and multidrug-resistant cancer cell lines. Significant antiproliferative effects with IC50 values below 10 μM were observed for the isoflavones 6,7,3′-trimethoxy-4′,5′-methylenedioxyisoflavone and durmillone against leukemia CCRF-CEM cells; for the chalcone, 4-hydroxylonchocarpin and durmillone against its resistant counterpart CEM/ADR5000 cells; as well as for durmillone against the resistant breast adenocarcinoma MDA-MB231/BCRP cells and resistant gliobastoma U87MG.ΔEGFR cells. 相似文献
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Bhuvaneswari Thirumangalam Karunanithi 《Journal of Dispersion Science and Technology》2013,34(10):1441-1450
AbstractThe present study investigated the adsorption and inhibition behavior of leaf extract of Tephrosia Purpurea (T. purpurea) on mild steel corrosion in 1?N H2SO4 solution using electrochemical and surface morphological methods. Techniques adopted for electrochemical studies were Potentiodynamic Polarization and Electrochemical Impedance Spectroscopy (EIS) technique; and surface morphological studies were carried out using Scanning Electron Microscopy (SEM), and Atomic Force Microscopy (AFM). The leaf extract of T. purpurea was characterized using UV-Visible spectroscopy (UV-Vis), Fourier-Transform Infrared Spectroscopy (FT-IR), Nuclear Magnetic Resonance Spectroscopy (NMR) and Gas Chromatography – Mass Spectrometry (GCMS). The results obtained from electrochemical studies exhibited the potential of T. purpurea as good corrosion inhibitor. And, it was found that, the inhibition efficiency (I.E in %) increases with increase in concentration of the inhibitor molecules, the optimum inhibitor concentration observed was 300?ppm and the inhibition efficiency of 93% was observed at this inhibitor concentration. Above 300?ppm, there was not much changes in inhibition efficiency. Polarization studies provided the information that the inhibition is of mixed type and EIS confirmed that the corrosion process is controlled by single charge transfer mechanism. And, it was obtained that, the adsorption of inhibitor molecules obeys Langmuir adsorption isotherm. The inhibition is mainly by the adsorption of inhibitor molecules on the mild steel electrode surface, which was confirmed by FT-IR, SEM and AFM studies. Through all the experimental results, it can be arrived that, the leaf extract of T. purpurea performed as a good corrosion inhibitor for mild steel in 1?N sulfuric acid medium. 相似文献
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Jin Yong PENG Guo Rong FAN Yu Tian WU 《中国化学快报》2006,17(2):218-220
Patrinia villosa Juss is a famous traditional Chinese medicine and often used in folkmedicine as anti-virus and anti-bacteria agent1,2. However, there is little research aboutits chemical study through a literature search. In order to find bioactive princ… 相似文献
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The structure of elongatin, an isoflavone isolated from Tephrosia elongata E. Mey., has been established as 4′,5-dihydroxy-2′,5′-dimethoxy-2″,2″-dimethylpyrano[5″,6″-g]isoflavone. 相似文献
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Wilawan Mahabusarakam Pattama Mecawun Souwalak Phongpaichit 《Natural product research》2016,30(20):2323-2328
Two new prenylated xanthones, namely dulcisxanthone H and dulcisxanthone I along with garciniaxanthone C, were isolated from the dichloromethane extract of the green branch of Garcinia dulcis. Their structures were elucidated by the analysis of 1-D and 2-D NMR spectral data. Their antibacterial activities were also examined. 相似文献