共查询到20条相似文献,搜索用时 15 毫秒
1.
2.
An efficient triethylamine-catalyzed synthesis of 4-amino-3,5-dicyano-6-arylphthalates is described.A one-pot,simple pseudo four-component reaction between arylaldehydes,dialkyl acetylenedicarboxylates, and twice as much malononitrile gave 4-amino-3,5-dicyano-6-arylphthalates in good to excellent yields. 相似文献
3.
Madabhushi Sridhar Beeram C. Ramanaiah Chinthala Narsaiah Bellam Mahesh Mudam Kumaraswamy Kishore K.R. Mallu Vishnu M. Ankathi Pamulaparty Shanthan Rao 《Tetrahedron letters》2009,50(27):3897-6782
ZnCl2-catalyzed one-pot multicomponent synthesis of 2-amino-3,5-dicarbonitrile-6-thio-pyridines under microwave heating and conventional heating is described. 相似文献
4.
Maryam Oudi Kazem Sanchooli Tazeh Nourallah Hazeri Maryam Fatahpour Raheleh Ahmadi 《中国化学会会志》2019,66(12):1721-1728
In the present work, the catalytic activity of quinolinic acid (QUIN) was studied for the synthesis of spirochromene and pyranopyrazole derivatives from readily available materials. The salient features of these one‐pot multicomponent protocols are the clean reaction profile, easy isolation of products, no chromatographic separation techniques, high efficiency, short reaction time, and high yield of products plus using QUIN as a new, inexpensive, commercially available, and efficient organocatalyst. 相似文献
5.
One-step synthesis of ‘privileged medicinal scaffolds’, 2-amino-3,5-dicarbonitrile- 6-sulfanylpyridines, has been demonstrated via a multicomponent reaction of aldehydes, malononitrile, and thiols using silica nanoparticle (NP) as catalysts. The silica NP catalysts are very mild (nearly neutral in nature), effective, environmentally benign, and retain most of their activities after being reused for three times. 相似文献
6.
Parameshwara Chary Jilloju 《合成通讯》2018,48(14):1739-1746
A facile, one-pot three-component protocol for the synthesis of substituted 4-(benzylideneamino)-5-(3,5-dimethyl-1H-pyrazol-1-yl)-4H-1,2,4-triazole-3-thiols have been reported by the reaction of 4-amino-5-hydrazinyl-4H-1,2,4-triazole-3-thiol with acetyl acetone and various substituted benzaldehydes via multi component reaction. The newly synthesized derivatives were characterized by their elemental analysis and spectral data. The current strategy provides heterocyclic compounds in good yields with broad substrate scope. 相似文献
7.
室温离子液体催化“一锅法”合成3, 4-二氢嘧啶-2-酮 总被引:17,自引:0,他引:17
利用室温离子液体作催化剂,芳香醛、尿素和乙酰乙酯或乙酰丙酮三组分缩合制备3,4-二氢嘧啶-2-酮衍生物,反应条件温和,反应时间短,且不需另加有机溶剂,考察了不同取代基对芳香醛、尿素和乙酰乙酸乙酯或乙酰丙酮三组分缩合反应的影响。还考察了不同的室温离子液体的催化性能,发现1-丁基-3-甲基咪唑六氟磷酸盐较1-丁基-3-甲基咪唑四氟硼酸盐的催化效果略好。 相似文献
8.
Ranganathan Raja Dinesh Murugan Archana Sivasubramaniyan Jaabil George Sakthivel Perumal 《合成通讯》2016,46(11):942-948
Two different heterocycles, thiazole-2-imines and imidazole-2-thiones, have been conveniently synthesized by just altering the sequential order (1 + 2 + 3 or 1 + 3 + 2) when combining the same components [aryl amine (1), aryl isothiocyanate (2), and phenacyl bromide (3)] in one-pot, three-component protocols. The third possible sequential order of combination (2 + 3 + 1) chemoselectively affords thiazole-2-imine. The finding is a stepping stone in the synthetic applicability of sequential one-pot, three-component protocols. 相似文献
9.
Maryam Mirza-Aghayan Masoud Yarmohammadi Rabah Boukherroub 《Supramolecular chemistry》2013,25(5-6):442-449
A new approach is applied for the synthesis of novel acridine-calix[4]arene derivatives via a multicomponent reaction. These compounds have been characterised by 1H NMR, 13C NMR and HR-MS. Our binding studies between acridine-functionalised calix[4]arenes and calf thymus DNA (CT-DNA) via fluorescence titration show that these compounds have a good affinity to CT-DNA. 相似文献
10.
Mohammad Hosein Sayahi Seyyed Jafar Saghanezhad Saeed Bahadorikhalili Mohammad Mahdavi 《应用有机金属化学》2019,33(1)
A novel methodology is presented for the synthesis of 3‐substituted 2‐thioxo‐2,3‐dihydroquinazolin‐4(1H)‐one derivatives based on an efficient tandem multicomponent reaction using copper bromide as catalyst. This methodology is based on the multicomponent one‐pot reaction of methyl 2‐bromobenzoate, phenylisothiocyanate derivatives and sodium azide in the presence of copper bromide and l ‐proline under basic conditions. To show the generality of the method, various phenylisothiocyanates bearing electron‐donating or electron‐withdrawing functionalities were used and the desired products were obtained in high isolated yields. 相似文献
11.
The reactions of N-methylmorpholinium 6-amino-3,5-dicyano-1,4-dihydropyridine-2-thiolates with formaldehyde and primary aromatic amines produce
3,5,7,11-tetraazatricyclo[7.3.1.02,7]tridec-2-ene-1,9-dicarbonitrile derivatives.
For Part 1, see Ref. 1.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2605–2607, November, 2005. 相似文献
12.
In this investigation a new strategy involves the one-pot,three-component reaction of malononitrile,salycilaldehyde and phenol derivatives in the presence of high surface area of MgO is extended to the formation of chromeno[3,4-c]chromene derivatives in good to excellent yields in a short reaction time.Also,the three component reactions of an aldehyde such as salycilaldehyde and ketones with malononitril for the formation of chromeno[3,4-c]pyridines are investigated. 相似文献
13.
《Green Chemistry Letters and Reviews》2013,6(2):109-115
Abstract Polyethylene glycol (PEG)-mediated facile one-pot synthesis of polysubstituted-tetrahydropyrimidines have been developed under mild and green reaction conditions. The obtained products are interesting nitrogen heterocyclic molecules that contain α- and β-amino acid blocks. PEG can be reused with minimum loss of its activity. 相似文献
14.
4-Halo-1,8-naphthyridin-2(1H)-ones readily available from 2-chloronicotinic acid were subjected to the Suzuki coupling reaction with arylboronic acids to give a diversity of 4-aryl-1,8-naphthyridin-2(1H)-ones. 相似文献
15.
Hassan Sheibani 《Tetrahedron》2004,60(28):5931-5934
2-Pyrone derivatives were prepared in a one step procedure from readily available (chlorocarbonyl)phenyl ketene and 1,3-diketones such as 2,4-pentanedione, 1,3-diphenyl-1,3-propanedione, 1-phenyl-1,3-butanedione, 1,3-cyclohexanedione, 5,5-dimethyl-1,3-cyclohexanedione, 1,3-dimethyl-pyrimidine-2,4,6-trione and ethyl 2,4-dioxopentanoate. A mechanism is presented to account for the formation of the products. This method provides an easy route to prepare 3,4,5,6-tetrasubstituted 2-pyrones in good to excellent yields and in a short experimental time. 相似文献
16.
A simple, efficient and diastereoselective route to 2,3,6-trisubstituted 2,3-dihydro-4-pyridones from methyl 3,5-dioxohexanoate, aryl aldehydes and ammonium acetate is described. 相似文献
17.
The catalytic activity of l ‐arginine‐coated nano‐Fe3O4 particles (Fe3O4@l ‐arginine) proves they are a novel magnetic catalyst without the use of heat and reflux for the synthesis of 1,3‐diaryl‐2‐N‐azaphenalene derivatives and n‐acyl‐1,3‐diaryl‐2‐N‐azaphenylene derivatives in a one‐pot pseudo‐five‐component condensation reaction of compounds of 2,7‐naphthalene diol, aldehydes, and ammonia derivatives (ammonium acetate or ammonium hydrogen phosphate) and solvent (water and alcohol) with high yield and short reaction times, economical, and simple workup. The structure and magnetic properties of the obtained nanoparticles were characterized via Fourier transform infrared spectroscopy (IR) and field emission scanning electron microscopy (FE‐SEM). The results demonstrated that the average size of the synthesized magnetite nanoparticles is about 21 nm. In addition, the heterogeneous catalyst can be easily recovered magnetically and can be reused for further runs without significant loss of its catalytic activity. 相似文献
18.
We have discovered a unique stabilization condition for beta-amino ketone 7. With compound 7 as an unprecedented intermediate, omarigliptin 1 could be prepared in a highly efficient one-pot procedure with good yield. Also with this intermediate 7, some analogues of omarigliptin 1 were readily prepared for the first time. 相似文献
19.
Aminomethylation of 3,5-dicyano-6-oxo-1,4,5,6-tetrahydropyridine-2-thiolates upon treatment with primary amines and excess
formaldehyde leads to 3,7-diazabicyclo[3.3.1]nonane derivatives. N-Methylmorpholinium 4-(2-chlorophenyl)-3,5-dicyano-6-oxo-1,4,5,6-tetrahydropyridine-2-thiolate was obtained by the reaction
of (E)-3-(2-chlorophenyl)-2-cyanoprop-2-enethioamide with 1-cyanoacetyl-3,5-dimethylpyrazole and N-methylmorpholine in acetone in quantitative yield.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2397–2400, December, 2007. 相似文献
20.
R. L. Antipin E. K. Beloglazkina A. G. Magouga A. N. Chernysheva N. V. Zyk 《Chemistry of Heterocyclic Compounds》2008,44(9):1135-1137
It has been shown that bromination of 5-aryl-5-benzylidene-3,5-dihydro-4H-2-methylthioimidazol-4-one in methylene chloride
at room temperature leads to the addition of bromine at the double bond, but the the reaction of 5-aryl-3,5-dihydro-4H-2-methylthio-5-(2-pyridylmethylene)imidazol-4-one
gave complex compound of the starting materials. After boiling both of the compounds obtained in ethanol the corresponding
5-[bromo(aryl)methylene]imidazolidine-2,4-diones were obtained.
Dedicated to Academician B. A. Trofimov on his 70th jubilee.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, 1406–1408, September, 2008. 相似文献