共查询到20条相似文献,搜索用时 31 毫秒
1.
Xiqing Bian Meili Shao Huaqi Pan Kaibo Wang Shengdong Huang Xin Wu 《Natural product research》2016,30(2):125-130
A new 2(1H)-pyrazinone ring-containing natural product, paenibacillin A (1), together with five known diketopiperazine derivatives 2–6 and two known isoflavones 7–8, was isolated from the culture of an endophytic bacterium Paenibacillus sp. Xy-2. The structure of compound 1 was elucidated by extensive spectral methods, including UV, IR, HR-ESI-MS, 1D and 2D NMR and ECD experiments. Compound 1 exhibited moderate cytotoxicity against HL-60 cell line with IC50 value of 50.48 μM. 相似文献
2.
Anton Nikolaevich Yurchenko Dmitry V. Berdyshev Olga F. Smetanina Elena V. Ivanets Olesya I. Zhuravleva Anton B. Rasin 《Natural product research》2020,34(8):1118-1123
AbstractFour new diketopiperazine alkaloids, citriperazines A-D were isolated from algae-derived Penicillium sp. KMM 4672. The structures of compounds 1–4 were determined using spectroscopic methods. The absolute configurations of compounds 1 and 4 were established by comparison of calculated and experimental ECD spectra. The cytotoxicity of compounds 1–4 against several human prostate cell lines was evaluated. 相似文献
3.
A new diketopiperazine (DKP) derivative, (6R,3Z)-3-benzylidene-6-isobutyl-1-methyl piperazine-2,5-dione (1), as well as five known DKPs 2–6 was isolated from a deep sea-derived Streptomyces sp. SCSIO 04496. The structure of 1 was elucidated using a combination of 1D and 2D NMR, HR-ESI-MS and chiral-phase HPLC techniques. Compounds 1–6 did not show cytotoxic activity at a concentration of 100 μM in bioactivity assay. 相似文献
4.
Known diketopiperazine WIN 64821 and its asymmetric stereoisomers (1–3) had been isolated from the culture broth of a marine gut fungus Aspergillus sp. DX4H. The planar and stereochemistry for new compounds were determined by a suite of techniques including mass, NMR and CD spectra together with Marfey’s method. Their inhibitory activity against PC3 cell line had been tested. 相似文献
5.
Ai-Qun Lin Lin Du Yu-Chun Fang Fa-Zuo Wang Tian-Jiao Zhu Qian-Qun Gu Wei-Ming Zhu 《Chemistry of Natural Compounds》2009,45(5):677-680
A new natural product, iso-α-cyclopiazonic acid (1), together with its isomer α-cyclopiazonic acid (2); three mycotoxins: aflatoxin B1 (AFB1) (3), aflatoxin Q1 (AFQ1) (4), and O-methylsterigmatocystin (OMST) (5); two diketopiperazine alkaloids: ditryptophenaline (6) and 3-[(1H-indol-3-yl)methyl]-6-benzylpiperazine-2,5-dione (7), were isolated from the marine-derived fungus Aspergillus flavus. Their structures were determined by analysis of spectroscopic data. The cytotoxicities of compounds 1 and 2 were studied using HL-60, MOLT-4, A-549, and BEL-7402 cell lines. 相似文献
6.
Cong-Cong Liu Zhen-Zhen Zhang Yan-Yan Feng Qian-Qun Gu De-Hai Li 《Natural product research》2019,33(3):414-419
A new polyene compound (1) and a new diketopiperazine (2), as well as three known compounds (3–5), were isolated from the Antarctic marine-derived fungus Penicillium crustosum HDN153086. The structures of 1–5 were deduced based on MS, NMR and TD-DFT calculations of specific ECD spectra. These compounds were evaluated for their cytotoxic activities against K562 cell line and only compound 2 exhibited cytotoxicity against K562 cell, with IC50 value of 12.7 μM. 相似文献
7.
Chemical investigation of the cultures of a sponge-derived fungus Simplicillium sp. YZ-11 led to the isolation of a new minor diketopiperazine alkaloid cyclo-(2-hydroxy-Pro-Gly) (1) and a natural lactone (S)-dihydro-5-[(S)- hydroxyphenylmethyl]-2(3H)-furanone (2), together with five known ergostane-type sterols (3–7). Their structures were established based on extensive spectroscopic methods (1H and 13C NMR, 1H-1H COSY, HSQC and HMBC) and optical rotation analysis. 相似文献
8.
Franca J. M. van der Klein-de Gunst Jacques H. van Boom Rob M. J. Liskamp 《Journal of computer-aided molecular design》1992,6(1):33-46
Summary Intercalators are molecules capable of sliding between base pairs without disturbing the overall stacking pattern. In addition, there may exist molecules capable of inserting into a base pair thereby disrupting the hydrogen bonds and replacing them with new hydrogen bonds. A molecule probably capable of inserting, i.e., an insertor, is the diketopiperazine cyclo-[Gly-Gly] (1). A barbiturate (2), alloxan (3), a pyrimidine derivative (4) and a hydantoin (5) were also studied as possible insertors. Furthermore, molecules such as ethyleneurea (6), succinimide (7), as well as a malonamide derivative (8) and oxamide derivatives (9–11) were studied in order to investigate the arrangement and the number of hydrogen bonds necessary for insertion. Molecules 12–14 were designed and studied for their capacity to act as bisinsertors and/or bisintercalators. These molecules feature two diketopiperazine moieties which are connected via a diphenyl(thio)ether, i.e., 12 and 13, or a bisphenol A spacer, i.e., 14. The latter molecule (14) seems a promising candidate as a bisinsertor. 相似文献
9.
AbstractTwo diketopiperazines were isolated from a culture of the marine-derived actinomycete Streptomyces sp. ZZ446. Their structures were elucidated as maculosin (1) and maculosin-O-α-L-rhamnopyranoside (2) based on their NMR and HRESIMS data, specific rotation, and chemical degradation. Maculosin-O-α-L-rhamnopyranoside (2) is a new diketopiperazine glycoside, a structural class not reported previously from the natural sources. Both compounds showed antimicrobial activity against methicillin-resistant Staphylococcus aureus, Escherichia coli, and Candida albicans with MIC values in a range from 26.0 to 37.0?μg/mL. 相似文献
10.
Yan-Ni Shi Lian Yang Jin-Hua Zhao Yi-Ming Shi Yan Qu Hong-Tao Zhu 《Natural product research》2015,29(14):1372-1375
Fifteen known compounds including four triterpenoids (1–4), one sterol (5), one diketopiperazine alkaloid (6) and nine phenolics (7–15) were isolated from the stems of Piper wallichii. Their structures were elucidated by means of spectroscopic analysis, and acidic hydrolysis in case of the 2-oxo-3β,19α,23-trihydroxyurs-12-en-28-oic acid β-D-glucopyranosyl ester (1). The structure of compound 1 was fully assigned by 1D and 2D NMR experiments for the first time. All isolates were tested for their antibacterial, antifungal, anti-inflammatory and antiplatelet aggregation bioactivities. 相似文献
11.
Oxepine‐Containing Diketopiperazine Alkaloids from the Algal‐Derived Endophytic Fungus Paecilomyces variotii EN‐291
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Two new oxepine‐containing diketopiperazine‐type alkaloids, varioloids A and B ( 1 and 2 , resp.), were isolated from the algal‐derived fungus Paecilomyces variotii EN‐291. The structures and absolute configurations were determined by detailed interpretation of 1D‐ and 2D‐NMR spectroscopic data and by analysis of acidic hydrolysates. Compounds 1 and 2 exhibited potent activity against the plant‐pathogenic fungus Fusarium graminearum with MIC values of 8 and 4 μg/ml, respectively. 相似文献
12.
Li‐Na Zhou Tian‐Jiao Zhu Sheng‐Xin Cai Qian‐Qun Gu De‐Hai Li 《Helvetica chimica acta》2010,93(9):1758-1763
Three new indole‐containing diketopiperazine alkaloids, named variecolorins M–O ( 1 – 3 ), together with the eight known analogues 4 – 11 , were isolated from a deep‐ocean sediment‐derived fungus, Penicillium griseofulvum. Their structures were determined by analysis of the spectroscopic data. The 2,2‐diphenyl‐1‐picrylhydrazinyl (DPPH) radical‐scavenging activities and the cell‐proliferation inhibitory activities of the three new compounds 1 – 3 were investigated. 相似文献
13.
O. F. Smetanina A. I. Kalinovskii Yu. V. Khudyakova N. N. Slinkina M. V. Pivkin T. A. Kuznetsova 《Chemistry of Natural Compounds》2007,43(4):395-398
1,8-Dihydroxy-6-methoxy-3-methyl-9,10-anthracenedione (physcion, 1), 3,4-dihydro-3,6,9-trihydroxy-8-methoxy-3-methyl-1(2H)-anthraceneone (asperflavin, 2), and 2,5-dihydroxy-3-(3-methyl-2-butenyl)-6-[(1E)-1-heptenyl]-benzaldehyde (tetrahydroauroglaucin, 3) were shown to be the main pigments of the marine isolate of the fungus Eurotium repens. In addition to the pigments, the fungal metabolites included the diketopiperazine alkaloid echinulin (4). The structures of the compounds were identified using NMR spectroscopy and mass spectrometry. The cytotoxic activity of
1–3 toward sex cells of the sea urchin Strongylocentrotus intermedius was determined.
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Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 327–329, July–August, 2007. 相似文献
14.
Wei‐Guang Shan You‐Min Ying Hai‐Ning Yu Wen‐Hong Liu Zha‐Jun Zhan 《Helvetica chimica acta》2010,93(4):772-776
Cultivation of the fungus Penicillium spp. HS‐3, an endophytic fungus from the stems of Huperzia serrata, led to the isolation of a new diketopiperazine alkaloid, named as tryhistatin ( 1 ), together with three known ones, 2 – 4 , all of which share a similar backbone. The structure of 1 was established by detailed interpretation of the 1D‐ and 2D‐NMR spectra, and HR‐ESI‐MS data. Furthermore, 1D‐ and 2D‐NMR experiments were employed to elucidate the structure of 2 which was deduced previously only on the basis of the LC/MS method. In this article, we confirmed the correctness of the previously reported structure and made a complete assignment of the NMR signals of 2 for the first time. 相似文献
15.
Rachada Haritakun Pranee Rachtawee Somjit Komwijit Sutichai Nithithanasilp Masahiko Isaka 《Helvetica chimica acta》2012,95(2):308-313
Two new ergostane derivatives, 12β,15α,25,26‐tetrahydroxyergosta‐4,6,8(14),22‐tetraen‐3‐one ( 1 ) and 12β,15α,25,28‐tetrahydroxyergosta‐4,6,8(14),22‐tetraen‐3‐one ( 2 ), and a new aranotin‐type diketopiperazine, bisdethiobis(methylsulfanyl)apoaranotin ( 3 ), were isolated from the fungus Aspergillus terreus BCC 4651. The structures of the new compounds were elucidated by means of NMR spectroscopic and MS analyses. 相似文献
16.
AbstractIn continuation of the search for new compounds from the terrestrial fungus Aspergillus sp., one new butyrolactone, 3″-hydroxymethyl-butyrolactone II (1) was isolated. The chemical structure of 1 was confirmed by extensive 1D and 2D NMR and HR-ESI mass data analysis, and by comparison with literature data. The absolute configuration was also determined by ECD calculations. 相似文献
17.
Two new eremophilenolides, ligushicins A (1) and B (2), and two known compounds including β-sitosterol and ursolic acid were isolated from Ligulariopsis shichuana. The structures of new compounds were established on the basis of 1D and 2D NMR data and HRESIMS data interpretation. The absolute configuration of new compounds was assigned by ECD spectroscopy, and that of ligushicins A (1) was confirmed by X-ray diffraction analysis. The antifungal and antifeedant activities of new compounds were evaluated against four plant pathogenic fungi and third-instar larvae of Plutella xylostella, respectively. Ligushicins A (1) and B (2) exhibited potent antifungal activity against Botrytis cinerea and Fusarium oxysporum with minimum inhibitory concentration (MIC) values ranging from 50 to 100 mg/L, while they also exhibited weak antifeedant activities. 相似文献
18.
A new benzopyran derivative, malloapeltic acid (1), along with seven known compounds, was isolated from the roots of Mallotus apelta. The structure of the new compound 1 was elucidated by spectroscopic data analysis. The known compounds 2–8 were identified by comparison of their spectroscopic data with reported values in the literature. Compound 1 showed strong anti-HIV activity in vitro. 相似文献
19.
Mohamed Shaaban 《Natural product research》2020,34(7):1032-1036
AbstractIn continuation of the search for new compounds from the terrestrial fungus Penicillium purpurogenum MM, (3R,4S)-isostreptenol III (1), a further new natural compound is reported. The chemical structure of 1 was confirmed by extensive 1D and 2D NMR and ESI HR mass measurements, and by comparison with literature data. The absolute configuration was determined by ab initio calculations of ECD, ORD, and NMR data. The antimicrobial and cytotoxic activities of the crude extract and 1 were reported using a set of microorganisms and by the brine shrimp assay, respectively. 相似文献
20.
Yang-Hua Tang Ting-Ting Liang Ting-Ting Fan Lawrence Jordan Keen Xiao-Dan Zhang Lin Xu 《Natural product research》2020,34(15):2151-2156
AbstractNeo-debromoaplysiatoxin C (1), a new member of the aplysiatoxin family, was isolated from the marine cyanobacterium Lyngbya sp. The structure of 1 was elucidated based on spectroscopic data, and its stereochemistry was determined from NOESY spectrum and biosynthetic considerations. This new compound presents an intriguing 10-membered lactone ring skeleton derived from debromoaplysiatoxin by structural rearrangement, which is the first example in the aplysiatoxin family. Its biological properties were evaluated for cytotoxicity, PKCδ activation and inhibitory effects on potassium channel. 相似文献