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G. A. Gazieva A. N. Kravchenko O. V. Lebedev Yu. A. Strelenko K. Yu. Chegaev 《Russian Chemical Bulletin》1998,47(8):1561-1564
The interaction of sulfonamides with 4,5-dihydroxyimidazolidin-2-ones was studied for the first time. The earlier unknown
4,4′-sulfonyldiiminobis(1,3-dialkylimidazolidin-2-ones) and 4(5)-aryl(alkyl)-sulfonyliminoimidazolidin-2-ones were synthesized.
A probable pathway of the reaction was proposed. 1,3-Diethyl-4,5-dihydroxyimidazolidin-2-one was isolated and described.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1604–1607, August, 1998. 相似文献
3.
A convenient synthesis of 5-alkylfuran-2(5H)-ones are described starting from 3-nitropropanoate and aldehydes, promoted by neutral alumina, in 35–60% overall yields, via a condensation–lactonization–elimination pathway. 相似文献
4.
在NaHSO4催化下,以苯甲醛和邻氨基苯甲酰胺为底物,在室温下合成了一系列2-芳基-2,3-二氢-4(1H)-喹唑啉酮类化合物,该反应产率高、操作简单、并且避免使用有毒的金属催化剂. 相似文献
5.
We describe a simple and efficient protocol for accessing some unsaturated heterocyclic compounds in a direct evaluation of allyl bromide as Z-ethyl 3-bromomethyl-4-oxopent-2-enoate. The latter reacts with primary amines via two successive nucleophilic substitutions followed by a 5-exo-trig cyclization to produce selectively 4-acetyl-1-alkyl-1H-pyrrol-2(5H)-ones in good yields. 相似文献
6.
A. A. Bogolyubov N. B. Chernysheva V. V. Nesterov M. Yu. Antipin V. V. Semenov 《Chemistry of Heterocyclic Compounds》2004,40(8):992-1001
The composition and yields of the products from the reaction of 4,4-dialkyl-5-methylene-1,3-dioxolan-2-ones with amidines depend on the structure of the initial amidine and on the reaction conditions. 2-Aminopyridines lead to 3-substituted 4-hydroxy-4-methyloxazolidin-2-ones and 4-methylene-oxazolidin-2-ones and also to sym-carbamides. 2-Amino-4,6-dimethylpyrimidine leads to the corresponding 4-methyleneoxazolidin-2-one. 3-Aminothiazoles give linear oxourethanes and sym-carbamides. 相似文献
7.
An atom-economic route to densely functionalized thiophenes has been developed via base-catalyzed rearrangement of 5-propargyl-2H-thiopyran-4(3H)-ones involving tandem retro-thio Michael addition, propargyl isomerization, and intramolecular thio-addition to allenes. 相似文献
8.
The interaction of different 3-acetylfuran-2(5H)-ones (1, 4) with dimethylformamide dimethyl acetal (DMF/DMA) has been investigated, and the condensed furopyridine system 3 was obtained. By means of interaction of compounds 4 and DMF/DMA via the 3-acetylfuran-2(5H)-one enamines, the heterocyclic substituted furanones are obtained. The condensation of 3-acetyl-4,5,5-trimethylfuran-2(5H)-one (1a) with veratraldehyde was realized. Through the interaction of 1a with malononitrile and further intramolecular condensation of the product, 6-amino-dihydroisobenzofuran-5-carbonitrile was also synthesized. 相似文献
9.
Rahhal El Ajlaoui Amiri Ouafa Souad Mojahidi Lahcen El Ammari Mohamed Saadi 《合成通讯》2013,43(17):2035-2042
AbstractThe reaction of 3-allylrhodanine with 2-arylidene-4-methyl-5-oxopyrazolidinium ylides proceeded unexpectedly to form novel 3-allyl-5-(arylidene)-2-thioxo-thiazolidin-4-ones 6a–k in good yields. All structures have been formulated on the basis of their spectral (IR, NMR, MS) data and elemental analyses. In addition, the structure of compound 6a was confirmed by means of x-ray crystallographic analysis. 相似文献
10.
Yu. M. Volovenko T. A. Volovnenko A. V. Dobrydnev 《Chemistry of Heterocyclic Compounds》2006,42(9):1137-1142
3-Cyano-3-hetaryl-2-oxopropyl-and 3-cyano-3-hetaryl-1-methyl-2-oxopropyl ethanethioates were obtained by the acylation of
2-azahetarylacetonitriles with (acetylthio)acetyl and α-(acetylthio)propionyl chlorides respectively. They are deacetylated
by the action of amines and undergo cyclization with the formation of 5-amino-4-hetarylthiophen-2(2H)-ones.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1314–1319, September, 2006. 相似文献
11.
Kamal A. Kandeel Ali M. Youssef Hany M. El-Bestawy Mohamed T. Omar 《Monatshefte für Chemie / Chemical Monthly》2002,45(8):1211-1219
N,N-Disubstituted 5-arylmethylidene-2-aminothiazol-4(5H)-ones reacted with diethyl malonate, ethyl benzoylacetate, acetylacetone, or cyclopentadiene in refluxing toluene and in presence of powdered sodium to give the respective 5-arylmethylidene-2′-amino-2,5′-bithiazolylidene-4,4′-dione derivatives in moderate yields. 5-Benzylidene-2-morpholin-4-yl-2-thiazol-4(5H)-one reacted with malononitrile in toluene and in presence of powdered sodium under mild conditions to afford the 1:1 adduct, benzylmalononitrile, and 2-morpholin-4-yl-2-thiazol-4(5H)-one. However, similar treatment of 5-(4-methoxyphenylmethylidene)-2-morpholin-4-yl-2-thiazol-4(5H)-one with malononitrile yielded the 2,5′-bithiazolylidene-4,4′-dione derivative together with 4-methoxyphenylmethylidene malononitrile. Treatment of 5-benzylidene- and 5-(4-methoxyphenylmethylidene)-2-morpholin-4-yl-2-thiazol-4(5H)-ones with 3-phenyl-4-oxo-2-thioxo-1,3-thiazolidine in refluxing toluene and in presence of powdered sodium produced 5-arylmethylidene-3-phenyl-4-oxo-2-thioxo-1,3-thiazolidines in good yields. The structures of all products were deduced from microanalytical and spectroscopic data, mechanistic details are discussed. 相似文献
12.
A. Yu. Egorova V. A. Sedavkina Z. Yu. Timofeeva 《Chemistry of Heterocyclic Compounds》2001,37(6):694-697
Conditions were developed for the synthesis and production of 1-aryl-5-alkyl(aryl)-3H- and 1-aryl-5-alkyl(aryl)-5H-pyrrolin-2-ones from the amides and esters of 4-oxoalkanoic acids. It was established that the yield and ratio of the 3H and 5H isomers depend on the substrate employed in the reaction. 相似文献
13.
V. O. Kozminykh D. B. Oborin V. I. Goncharov E. N. Kozminykh 《Chemistry of Heterocyclic Compounds》2007,43(8):978-980
3-Hydroxy-3-(2-oxoethyl)-6-phenyl-2,3-dihydropyridazin-4(1H)-ones were obtained by the reaction of methyl 3-oxo-5-phenylfuran-2(3H)-ylideneacetate
or 2-[2-(4-chlorophenyl)-2-oxoethylidene]-5-phenylfuran-3(2H)-one with benzoic or p-nitrobenzoic isopropylidenehydrazides.
Equilibrium C(5)H and C(5)H2 tautomeric forms were detected in solutions of the 4-chlorophenyl derivatives in DMSO-d6.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1156–1158, August, 2007. 相似文献
14.
G. A. Gazieva P. V. Lozhkin A. N. Kravchenko K. A. Lysenko N. G. Kolotyrkina N. N. Makhova 《Chemistry of Heterocyclic Compounds》2007,43(8):981-988
The reactions of 1,3-dialkyl-4,5-dihydroxyimidazolidin-2-ones with alkyl sulfamides have been studied and previously undescribed
1,3-dialkyl-4-(alkylaminosulfonylimino)imidazolidin-2-ones have been obtained. The structure of 1,3-dimethyl-4-(benzenesulfonylimino)imidazolidin-2-one
was investigated by X-ray structural analysis.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1159–1166, August, 2007. 相似文献
15.
N. B. Chernysheva A. A. Bogolyubov V. V. Semenov 《Chemistry of Heterocyclic Compounds》2003,39(8):1057-1064
The structure of the products of the reaction of 4-methylene-1,3-dioxolan-2-ones with hydrazines is a function of the structure of the starting hydrazine. 1,3,4-Oxadiazin-2-one derivatives are obtained from hydrazine hydrate. 3-Arylaminooxazolidin-2-ones are obtained from monoarylhydrazines, while mixtures of these derivatives are obtained from aliphatic monoalkylhydrazines. 相似文献
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Xing Zhou Li ;Xian Ping Dai ;Kang Ying Lai ;Li Li Wang ;Zhi Bing Zheng ;Song Li 《中国化学快报》2008,19(4):379-382
A series of 2,4,5-triaryl substituted 1H-pyrazol-3(2H)-ones,as ALK5 inhibitors,were desigened,synthesized and evaluated in vitro.Most compounds exhibited noticeable ALK5 inhibition activities at 1μmol/L and displayed no significant cytotoxicities at 30μmol/L. 相似文献
18.
Rima Laroum 《合成通讯》2018,48(14):1876-1882
In this work we describe a new, highly efficient method for the synthesis of 3-methyl-4-arylmethylidene-isoxazol-5(4H)-one derivatives by a three-component reaction between aromatic aldehydes, ethyl acetoacetate, and hydroxylamine hydrochloride under the influence by PPTS as a low-toxicity, inexpensive, commercially available and easy to handle catalyst. The advantages of this procedure are good yields, short reaction times, simplicity of implementation, and respect of the environment. 相似文献
19.
S. M. Ramsh A. G. Ivanenko N. L. Medvedskiy D. G. Lagerev D. B. Lazarev L. N. Belobrzeckaja Costa 《Chemistry of Heterocyclic Compounds》2006,42(8):1086-1093
It was found that the aminomethylation of 2-amino-5,5-bis(hydroxymethyl)-1,3-thiazol-4(5H)-one and its spiro analogs using
primary amines is accompanied by cyclization at the amidine fragment of the molecule with annelation of a tetrahydrotriazine
ring. When using secondary amines the aminomethylation occurs at the exocyclic nitrogen atom.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1252–1260, August, 2006. 相似文献
20.
A Selective Synthesis of 2-Alkylamino-5, 6, 7, 8-tetrahydrobenzothieno[2, 3-d]pyrimidin-4(3H)-ones 总被引:1,自引:0,他引:1
MingWuDING RuiJunXU JingXU YunFengCHEN 《中国化学快报》2005,16(2):189-192
2-Alkylamino-5, 6, 7, 8-tetrahydrobenzothieno [2,3-d] pyrimidin-4(3H)-ones 7 were synthesized by a new selective synthetic method, which includes aza-Wittig reaction of iminophosphorane 4 with aromatic isocynate to give carbodiimide 5 and subsequent reaction of 5 with various aliphatic primary amine in the presence of EtO^-Na^ . 相似文献