Synthesis and structure of bis(2-phenylethyl) phosphine selenide

Bis(2-phenylethyl)phosphine selenide was obtained with 86% yield from bis(2-phenylethyl)phosphine and selenium. XRD, IR, UV, and multinuclear NMR spectroscopic studies revealed that the phosphorus atom in the bis(2-phenylethyl)phosphine selenide molecule is four-coordinated irrespective of the phase state (crystals or solution).     

Tris(2-ethylhexyl)phosphine oxide as an effective solvent mediator for constructing a serotonin-selective membrane electrode

A series of solvent mediators containing a phosphoryl (PO) group, such as tris(2-ethylhexyl)phosphate, bis(2-ethylhexyl) 2-ethylhexylphosphonate, 2-ethylhexyl bis(2-ethylhexyl)phosphinate, and tris(2-ethylhexyl)phosphine oxide, were used to construct serotonin-selective membrane electrodes. We found that replacing the alkoxy groups attached to phosphorus atoms in PO groups with alkyl groups strengthened the response of the electrode to serotonin, suppressing remarkably interference from inorganic cations, such as Na⁺. Thus, an electrode combining tris(2-ethylhexyl)phosphine oxide with an ion-exchanger, sodium tetrakis[3,5-bis(2-methoxyhexafluoro-2-propyl)phenyl]borate, gave a detection limit of 9 × 10⁻⁶ M with a slope of 55.2 mV per concentration decade in physiological saline containing 150 mM NaCl and 10 mM NaH₂PO₄/Na₂HPO₄ (pH 7.4). This is the best detection limit of any serotonin-selective electrode developed to date. The selectivity of this electrode for serotonin was over 10³ times that for inorganic cations, such as Na⁺ and K⁺, and lipophilic quaternary ammonium ions, such as acetylcholine and (C₂H₅)₄N⁺. Using the electrode, we measured the amount of serotonin released from platelets and found that the results agreed well with those obtained by a conventional fluorimetric assay of serotonin.     

PCl3- and organometallic-free synthesis of tris(2-picolyl)phosphine oxide from elemental phosphorus and 2-(chloromethyl)pyridine hydrochloride

In the superbase KOH/H₂O/toluene/phase-transfer catalyst system, 2-picolyl chloride, generated in situ from 2-(chloromethyl)pyridine hydrochloride, reacts with elemental phosphorus at 65–95?°C for 3?h to afford tris(2-picolyl)phosphine oxide in 50% yield. Single crystal X-ray analysis of the latter revealed one polymorph form of this tertiary phosphine oxide.     

Microwave synthesis of secondary phosphines and phosphine oxides from red phosphorus and allyl(methoxy)benzenes in KOH-DMSO

Bis[1-(methoxyphenyl)propan-2-yl]phosphines and bis[1-(methoxyphenyl)propan-2-yl]phosphine oxides were synthesized by phosphorylation of allyl(methoxy)benzenes in the system red phosphorus-KOH · 0.5 H₂O-DMSO under microwave irradiation.     

Reactions of Tris(diethylamino)phosphine with Some Quinones

Abstract

Tris(diethylamino)phosphine reacts with chloranil and 2,3-dichloro-4,5-dicyanoquinone to give products of addition to carbon with loss of chloride ion.