IMP重离子治癌中的剂量计算方法

针对深部肿瘤重离子治疗临床试验的需求,首先在水介质中进行生物有效剂量的优化计算,然后根据CT图像中像素CT值与水等效长度转换系数之间的关系, 结合水中的深度剂量分布曲线对每个像素进行积分得到CT图像上的生物有效剂量分布。同时介绍了基于被动式束流配送系统适形照射时的剂量确定方式, 并提出二维适形放疗也应使用分层照射方式以适应治疗时的不同要求。 这些方法适合目前及今后在IMP进行的重离子治癌临床试验研究中治疗计划系统的需要。Basic algorithms of biological effective dose optimization and dose distribution on CT image for the heavy ion therapy project at the Institute of Modern Physics (IMP), Chinese Academy of Sciences (CAS) are reported in this paper. Firstly, biological effective dose optimization is conducted in water. According to the relationship between CT number and water equivalent path length, an integral algorithm is used to calculate the average dose within a pixel and then the dose distribution in tissue is derived. Secondly, the dose determination of layer stacking conformal irradiation is described and the layer stacking method is proposed to be applied in two dimensional conformal irradiation. These methods are sufficient to the requirements of the ongoing and future heavy ion clinical trials conducted at IMP.     

重离子治疗计划系统的构想

对重离子柬治癌的优势进行简要的回顾，并着重介绍了用于重离子放射治疗的治疗计划系统。治疗计划系统是一套软件系统，不同的硬件设施应有与其相匹配的软件系统，即治疗计划系统。在此基础上，针对兰州重离子加速器的特点提出一些关于治疗计划系统方面的构想。After a brief review concerning the advantages of heavy ions in radiotherapy, more interests are concentrated on treatment planning system （TPS） for heavy ion radiotherapy. Compared to the hardware devices such as accelerator and beam delivery system, the TPS is a set of software system, and different therapy facilities require their corresponding TPSs. Based on the specialities of the Heavy Ion Research Facility in Lanzhou （HIIRFL）, some suggestions on the TPS for tumor therapy at HIRFL finally are given.     

重离子治癌中的三维剂量成形方式

介绍了重离子治癌装置ＨＩＭＡＣ和ＨＩＴＡＧ的三维剂量成形方式;对一种正在设计中的重离子对肿瘤的照射方式进行了分析,旨在为ＨＩＲＦＬ及ＨＩＲＦＬ－ＣＳＲ所提供的离子束设计三维剂量成形方案． Three dimensional dose shaping methods in heavy-ion therapy facilities,HI MAC and HITAG are introduced.A new tumor irradiation pattern with heavy ion beam which is being designed is analyzed.It aims at choosing suitable three dimensional dose shaping planning for heavy ion beam supplied by HIRFL and the proposed HIRFL-CSR.     

重离子治癌终端的束流强度及剂量监测系统

为实现重离子肿瘤治疗临床实验中对照射束流状态的实时监测,研制了束流强度及剂量监测系统,包括积分电离室、后续电流频率转换电路及LabVIEW数据获取处理三部分。利用闪烁体探测器和标准剂量计测试了系统的线性响应和得到剂量的准确性,结果表明：系统在束流临床照射流强范围内的线性响应好于90%,其实时反馈的临床照射剂量偏差小于5%。同时束流强度及剂量监测系统与安全控制系统相结合,保证束流照射状态满足临床照射的安全要求。     

重离子治癌终端的束流强度及剂量监测系统

 为实现重离子肿瘤治疗临床实验中对照射束流状态的实时监测,研制了束流强度及剂量监测系统,包括积分电离室、后续电流频率转换电路及LabVIEW数据获取处理三部分。利用闪烁体探测器和标准剂量计测试了系统的线性响应和得到剂量的准确性,结果表明：系统在束流临床照射流强范围内的线性响应好于90%,其实时反馈的临床照射剂量偏差小于5%。同时束流强度及剂量监测系统与安全控制系统相结合,保证束流照射状态满足临床照射的安全要求。     

重离子治疗计划的生物有效剂量及其验证

介绍了重离子治疗计划中的生物有效剂量，以及基于局部效应模型的相对生物学效应的计算. 报告了用生物测试系统测得的实验结果，并与治疗计划的计算结果做了比较. 靶子内外结果的一致性显示了重离子治疗计划的可靠性及保护紧挨着靶的重要器官的能力.     

HIRFL浅层肿瘤重离子治疗终端束流配送系统性能的实验验证

详细介绍了兰州重离子研究装置(HIRFL)浅层肿瘤重离子治疗终端的被动式束流配送系统, 对该束流配送系统重要组成部件及其整体的性能进行了实验验证. Bragg峰展宽装置脊形过滤器及能量调节装置射程移位器测试结果显示该设备的性能指标达到设计要求. 为验证该被动式束流配送系统的整体性能, 进行了束流成形实验, 模拟对肿瘤靶区的三维适形照射. 结果表明: 利用该束流配送系统可实施对肿瘤的三维适形放射治疗. HIRFL浅层肿瘤治疗装置束流配送系统性能的验证为下一步开展肿瘤重离子束治疗临床试验奠定了基础.     

重离子治癌的磁扫描照射野形成法

在论述重离子治癌照射的基本思想及其特点的基础上,着重对磁扫描照射野形成的两种技术路线——点扫描和栅扫描的优缺点进行了分析阐述.初步给出了 HIRFL上的重离子治癌终端磁扫描相关参数. The basic principle and characteristic of irradiation in heavy ion radiotherapy are introduced. Based on the basic principle and characteristic of irradiation in heavy ion radiotherapy, two magnetic scan methods for creating uniform irradiation field--the spot scan and the raster scan, are compared briefly. The parameter requests to the magnetic scanning system of the heavy ion radiotherapy facility planned in IMP(Institute of Modern Physics) are presented.     

用于浅层肿瘤重离子治疗的终端束流诊断控制系统

 设计了中国科学院近代物理研究所利用兰州重离子研究装置（HIRFL）进行浅层肿瘤临床治疗试验研究中所使用的束流诊断安全控制系统。该系统包括束流强度监测及保护、剂量测量、扫描波形监测及保护3个部分。系统基于PXI系统及LabVIEW软件,给出了该系统的各部分结构。从系统建立时的多次测试结果以及实际临床治疗试验研究时的长期运行结果来看,该束流诊断控制系统在控制辐照剂量以及安全保护方面能够满足当前重离子加速器浅层肿瘤临床治疗试验的基本要求,为试验研究的顺利进行提供了可靠的保证。     

近物所在产生金属离子束方面的研究

Since 1998,many experiments for metallic ion production have been done on LECR2(Lanzhou ECR ion source NO.2),LECR3(Lanzhou ECR ion source NO.3)and SECRAL(Superconductiong ECB ion source Advanced design in Lanzhou)at Institute of Modern Physics.The very heavy metallic ion beams such as those of uranium were also produced by the plasma sputtering method,and supplied for HIRFL(Heavy Ion Research Facility in Lanzhou)accelerators successfully.During the test,11.SeμAU~(28 ),9eμAU~(24 ) were obtained.Some ion beams of the metal having lower melting temperature such as Ni and Mg ion beams were produced by oven method on LECR3 too.The consumption rate was controlled to be lower for ~(26)Mg ion beams production,and the minimum consumption was about 0.3mg per hour.In this paper,the main experimental results are given.Some discussions are made for some experimental phenomena and results,and some conclusions are drawn.     

用于中能重离子反应测量的塑料闪烁探测器阵列

描述了用于中能(10-100MeV/u)重离子核反应前角度(5°≤θ≤20°)测量的36单元phoswich闪烁探测器阵列.每个phoswich探测器单元由1mm厚的快塑料闪烁体NE102A和100mm厚的慢塑料闪烁体NE115组成,用传统的快、慢门控制的QDC积分方法,对Z=1-20范围的碎片得到了好的粒子鉴别,其粒子分辨能力Z/△Z～45.     

π弦在重离子碰撞实验中的效应

在能量为s=5.5TeV的LHCPb?Pb重离子碰撞实验中,研究了和手征相变相关的π弦的可观测效应.利用Kibble-Zurek机制讨论了π弦的产生和演化.在LHCPb-Pb重离子碰撞实验中,如果手征相变发生并且是二级相变,那么π弦将会产生然后衰变.π弦的主要效应是:π弦衰变成大量的末态π粒子,这些大量的π粒子,主要分布在动量为143MeV的低动量空间;同时π弦的衰变还伴随着大量中性π粒子,这些中性的π粒子主要分布在动量为21MeV的低动量空间.     

重离子束治疗肿瘤临床研究

文章综述了重离子束在物理学、生物学、临床治疗等方面的优势,以及在放射生物学方面的基础实验研究内容。分析总结了国内外重离子束辐照治疗肿瘤的临床研究结果。其中,日本已接受治疗了约6 000 名不同类型的肿瘤患者,并取得较高的局部控制率和生存率;德国在头颈部肿瘤临床治疗方面取得了巨大的成功;在兰州重离子研究装置(HIRFL) 肿瘤治疗终端上,中国科学院近代物理研究所联合甘肃省肿瘤医院及兰州军区总医院对肿瘤患者的重离子治疗已进入临床试验阶段。甘肃省肿瘤医院治疗结果显示:43 例患者通过影像学检查评价疗效,客观有效率(CR+PR)为71.4%,主要急性放射损伤为1-2 级皮肤反应(红斑形成和脱皮),发生率为61.9%,治疗1 个月后随访结果显示重离子束(12C6+)对深部肿瘤具有较好的局部控制作用,且无严重不良反应发生。This article reviews the advantages of heavy ion in physical, biological and clinical aspects, discusses the radio-biological basis of experiment research, and summarizes clinical results of heavy ion beam treatment on tumor at home and abroad. Japan has accepted and treated about 6000 cancer patients of different types with high local control rates and survival ones. Germany has achieved great success in head and neck tumor clinical treatment. Institute of Modern Physics, Chinese Academy of Sciences (IMP-CAS), Tumor Hospital of Gansu Province and Lanzhou General Hospital of PLA have begun clinical trial on heavy ion treatment of deep-seated tumors after the shallow-seated tumor therapy has been done at HIRFL (Heavy Ion Research Facility in Lanzhou). The treatment results of Tumor Hospital of Gansu Province show that the objective response rate (CR+PR) is 71.4% and the rate of 1-2 levels radiation injury to skin reactions (erythema and desquamation) is 61.9% when we evaluate the 43 patients by means of maging. The results of case follow-up after treatment in 1 month indicate that the deep-seated tumor therapy with heavy ion beam has high local control rates without severe adverse effect.     

重离子熔合反应与双核模型

简单介绍了兰州-北京-吉森合作组对合成超重核的重离子反应进行的初步研究。研究的重点是熔合阶段的反应机制。在原有双核模型的基础上做了一些改进,把耗散相对运动过程与核子转移过程耦合起来,从更微观的角度来描写双核系统向全熔合复合核的演化。在双核过程中的每一步求解主方程,不对驱动势做谐振子近似。同时,还探讨了原子核形变与相对取向对驱动势的影响,存活几率与复合核蒸发中子的奇偶效应,以及入射道中原子核非弹性激发对俘获截面的影响等。In recent years, the Lanzou-Beijing-Giessen collaboration has studied the heavy ion reactions which are lead to the formation of super-heavy nuclei. The study emphases the mechanism of the fusion stage of the reactions. Based on the so called Di-nuclear System Model, some improvements have been made. The main points are the coupling of the dissipation of relative motion energy, angular momentum with nucleon transfer, and solving the Master equation in every step of the nucleon transfer with exact driving potentials, in order to describe the evolution of the system more microscopically. At the same time, we also discussed the effects of nuclear deformation and their relative orientation on the driving potentials, and studied the survive probability of the compound nuclei and its old-even effects, as well as the influence of inelastic excitations of nuclei in entrance channels to the capture cross sections.