Studies on chemical carcinogens and mutagens. XXVII alkylating property of mutagenic N-trimethylsilylmethyl-N-nitrosourea,a silicon-analogue of N-neopentyl-N-nitrosourea,in aqueous media

The kinetics for hydrolysis and the chemoselectivity toward nucleophiles of mutagenic N-trimethylsilylmethyl-N-nitrosourea, a silicon analogue of N-neopentyl-N-nitrosourea, were studied.     

Self-assembly of aniline oligomers in aqueous medium

By dissolving branched or linear aniline oligomers in polar solvent and introducing their stock solution into an aqueous acidic medium, sheet-like as well as wire-like supramolecular structures with well-defined morphology were obtained, respectively. These oligomeric supramolecular structures were constructed via a post-synthetic precipitation process, indicating that aniline oligomers are capable of self-assembling in an aqueous medium, which is similar to the reaction medium of aniline chemical polymerization. Possible formation mechanisms of these supramolecular structures were proposed, i.e., sheet-like products were probably constructed by collapsed molecular chains of aniline oligomers with branched units through π–π stacking and hydrogen bonding, whereas formation of the wire-like products was attributed to “oriented-attachment” of collapsed molecular chains of linear aniline oligomers. The findings obtained in this study are supposed to provide useful clues for uncovering the formation mechanism of polyaniline micro-/nanostructures.     

Some chemical transformations of carbohydrates in aqueous medium

The interest of combining the use of carbohydrates as synthons and the use of water as the reaction medium is emphasized by briefly reviewing some examples of contributions in this field achieved in our Lyon and Orsay laboratories.     

Green chemical synthesis of fluorinated 1,3,5-triaryl-s-triazines in aqueous medium under microwaves as potential antifungal agents

Reasonable pure fluorinated s-triazines were synthesized in quantitative yield (96-99%) in 2-3 min in aqueous medium under microwaves, by reaction of fluorinated anilines and aqueous formaldehyde. All synthesized compounds have been screened in vitro for their antifungal activity against Rhizoctonia solani, Fusarium oxysporum, and Collectotrichum capsici.     

Chemistry of 1,6-diazaphenalene. Reaction with alkylating and acylating agents

A study of the reactivity of 1,6-diazaphenalene ( 1 ) toward alkylating and acylating agents has been carried out in order to investigate the chemistry of this new heterocycle. Attempts to alkylate 1 were successfully completed by stirring the lithium stabilized anion of 1 with either methyl iodide or benzyl bromide to provide N-alkyldiazaphenalenes 4 and 5, respectively, whereas, experiments performed to alkylate 1 under conditions employed for alkylation of imidazole were unsuccessful. Studies directed toward acylation of 1 did not lead, in general, to isolable acyldiazaphenalenes; however, in one specific case successful acylation of 2-chloro-9-methoxy-1,6-diazaphenalene ( 10 ) did provide a characterisable amide ( 14 ). Where possible the chemistry of 1,6-diazaphenalene has been compared to that reported for imidazole.     

Anisotropy of chemical activity in graphite toward oxidizing agents

Problems related to the anisotropy of chemical reactivity in graphite are examined. Possible reasons are indicated for disagreement between experimental values for the anisotropy of the reactivity of graphite toward oxidizing agents and the theoretical anisotropy in the chemical reactivity of the peripheral and internal carbon atoms of the graphite crystal lattice.     

Studies on interaction of ferrofluid with ascorbic acid in aqueous acidic medium

The solution chemistry of the interaction of ferrofluid with ascorbic acid in dilute solutions has been investigated in the temperature range of 15–45°C. Kinetic, mechanistic and thermodynamic aspects of the reactions were studied by spectrophotometric and potentiometric techniques.