共查询到20条相似文献,搜索用时 46 毫秒
1.
Eva Eichler Clarence Stanley Rooney Haydn Windsor Richard Williams 《Journal of heterocyclic chemistry》1976,13(1):41-42
The synthesis of some 2-amino-1,8-naphthyridine derivatives substituted in the 5- and/or 7-positions with trifluoromethyl is described along with their conversions to the corresponding 1,8-naphthyridin-2(1H)ones. A modified procedure for oxidizing electron-deficient heterocyclic compounds to their N-oxides is presented. 相似文献
2.
William F. Goure 《Journal of heterocyclic chemistry》1993,30(1):71-80
The facile two step, one pot synthesis of heretofore unknown 2-hydroxy-4,6-bis(trifluoromethyl)-pyridine-5-carboxylates by condensation of 3-amino-4,4,4-trifluoro-2-butenoate with 4,4,4-trifluoroacetoacetyl chloride and subsequent intramolecular cyclization of the resultant enamineamide is described. Methodology for the introduction of electrophiles at the 3-position and elaboration of substituents at the 2- and 5-positions is also discussed. 相似文献
3.
Cyril Prknyi Hui Liang Yuan Meng-Kan Michael Tsai 《Journal of heterocyclic chemistry》1991,28(2):465-467
Two bis-(6-chloropurines) bridged by conformationally restricted tethers were synthesized as potential DNA bis-intercalating agents. Reduction of 4,6-dichloro-5-nitropyrimidine ( 1 ) afforded 5-amino-4,6-dichloropyrimidine ( 2 ) which was then used as the starting material. Reaction of 2 with 4,4′-diaminodiphenylmethane ( 3 ) and bis-(4-aminophenyl) ether ( 4 ) yielded bis-[4-(N-5-amino-4-chloro-6-pyrimidyl)aminophenyl]methane ( 5 ) and bis-[4-(N-5-amino-4-chloro-6-pyrimidyl)aminophenyl] ether ( 6 ), respectively. Acid-catalyzed condensation of the above pyrimidines, 5 and 6 , with triethyl orthoformate in N,N-dimethylacetamide gave bis-[4-(6-chloro-9-purinyl)phenyl]methane ( 7 ) and bis-[4-(6-chloro-9-purinyl)phenyl] ether ( 8 ). The spectral data on the new compounds will be discussed. 相似文献
4.
The 4,6-diamino-1,3-di(morpholin-4-yl)- and 5-amino-2,4-di(morpholin-4-yl)-1-nitro derivatives of benzene, which serve as
model compounds in studies of spatial structures and reactivities of monomer units of many polymers of practical importance,
have been studied by X-ray diffraction analysis. The morpholine rings are twisted so that they are virtually perpendicular
to the benzene ring. According to the results of AM1 calculations, the hydrogen atoms of the methylene groups of these substituents
carry noticeable positive charges. The introduction of different substituents into the benzene ring has no substantial effect
on the charge distribution in the morpholine rings due to the absence of conjugation between the lone electron pairs of the
nitrogen atoms of the ring and the π-system of the benzene ring.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 444–449, March, 1998. 相似文献
5.
Bheemanapalli LN Akkinepally RR Pamulaparthy SR 《Chemical & pharmaceutical bulletin》2008,56(9):1342-1348
A new series of 2,3,5,7-substituted-pyrido[2,3-d]pyrimidin-4(3H)-one derivatives were prepared from 2-amino-N,6-substituted phenyl-4-(trifluoromethyl or methyl)nicotinamides. The key intermediate 2-amino-N,6-substituted phenyl-4-(trifluoromethyl or methyl)nicotinamides were synthesized from 2-bromo-N,6-disubstituted phenyl-4-(trifluoromethyl or methyl)nicotinamides as well as from ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) coupling of 2-amino-4,6-substituted nicotinic acid and substituted arylamines. All the synthesized compounds were screened for antibacterial activity against Gram +ve and Gram -ve bacteria. Compound 7c showed better antibacterial activity against Gram +ve and Gram -ve bacteria. 相似文献
6.
Eva Eichler Clarence Stanley Rooney Haydn Windsor Richard Williams 《Journal of heterocyclic chemistry》1976,13(4):841-844
The syntheses of some 1,8-naphthyridines substituted in the 6-position with heterocyclic groups are described. A synthetic route to 6-amino-5,7-dimethyl-1,8-naphthyridin-2(1H)one is also presented. 相似文献
7.
Yuh-Wen Ho 《中国化学会会志》1999,46(6):955-962
Coupling the diazonium salt of 3-amino-2-cyano-4,6-dimethylthieno[2,3-b]pyridine 1 with malononitrile 2 gave 2-cyano-3-(hydrazonomalononitrile)-4,6-dimethylthieno[2,3-b]pyridine 3 which then reacted with hydrazine compounds 4a-4h to yield corresponding 2-cyano-3-(3,5-diamino-1-substituted-pyrazol-4-yl)azo-4,6-dimethylthieno[2,3-b]pyridines 5a-5h. The 2-cyano-3-(2-amino-5,7-disubstituted-pyrazolo-[1,5-a]pyrimidine-3-yl)azo-4,6-dimethylthieno[2,3-b]pyridines 7a-7f were obtained in good yield by the cyclocondensation reaction of 2-cyano-3-(3,5-diamino-pyrazol-4-yl)azo-4,6-dimethylthieno[2,3-b]pyridine 5a with the appropriate 1,3-diketones 6a-6f under acidic condition. 相似文献
8.
Carlos Seoane Jos L. Soto Pilar Zamorano Margarita Quinteiro 《Journal of heterocyclic chemistry》1981,18(2):309-314
Ring transformations of 4H-pyrans into pyridines are reported. Treatment of 2-amino-4,6-diaryl-3,5-dicyano-4H-pyrans (I) with nitrosylsulfuric acid brings about their transformation into 3,5-dicyano-4,6-diaryl-2-pyridones (VI) which can also be obtained from α-benzoylcinnamonitriles (IX) and cyanoacetamide. Similarly, 2-amino-4,6-diaryl-5-carbethoxy-3-cyano-4H-pyrans (II) lead to 4,6-diaryl-5-carbethoxy-3-cyano-2-pyridones (VII). Treatment of both series of pyrans with sulfuric acid results in the formation of the corresponding 3,4-dihydro-2-pyridones (IV and V). Reaction of pyrans II with ammonium acetate in acetic acid yields 2-amino-4,6-diaryl-5-carbethoxy-3-cyanopyridines (XII). Pyrans I undergo an entirely different type of reaction upon treatment with this reagent leading to 2,4,6-triaryl-3,5-dicyano-1,4-dihydropyridines (XV). 相似文献
9.
Natalia V. Loginova Tat’yana V. Koval’chuk Rimma A. Zheldakova Anna A. Chernyavskaya Nikolai P. Osipovich Gennady K. Glushonok Henry I. Polozov Victor L. Sorokin Oleg I. Shadyro 《Central European Journal of Chemistry》2006,4(3):440-457
Cu (II) complexes with the sterically hindered diphenol derivatives 3,5-di(tert-butyl)-1,2-benzenediol (I), 4,6-di(tert-butyl)-1,2,3-benzenetriol (II) and the sulfur-containing 4,6-di(tert-butyl)-3-(2-hydroxyethylsulfanyl)-1,2-benzenediol (III) and 2-[4,6-di(tert-butyl)-2,3-dihydroxyphenylsulfanyl]acetic acid (IV) have been synthesized and characterized by elemental analysis, TG/DTA, FT-IR, ESR, XPS, XPD and conductivity measurements.
Compounds I–III can coordinate in their singly deprotonated forms and act as bidentate ligands. These compounds yield Cu (II) complexes of the stoichiometry Cu(L)2, which have square planar geometry (g| > g⊥ > ge). Unlike them, compound IV behaves as a terdentate ligand, and its complex Cu(LIV)2 has distorted octahedral geometry. According to ESR data, only the Cu(LII)2 complex contains a very small amount of phenoxyl radicals. Antimicrobial activities of these ligands and their respective
Cu (II) complexes have been determined with respect to Gram-positive and Gram-negative bacteria, as well as on yeasts. Their
phytotoxic properties against Chlorella vulgaris 157 were also examined. 相似文献
10.
G. V. Loukova E. P. Olekhnovich M. E. Kletzky A. A. Bumber A. D. Garnovskii 《Russian Chemical Bulletin》1999,48(4):686-689
Electrochemical reduction of 1,2-di(2,4,6-triphenylpyridinium-l)ethane, 1,4-di(2,4,6-triphenylpyridinium-1)butane, 1,6-di(2,4,6-triphenylpyridinium-l)hexane, 1,4-di(N-methyl-4,6-diphenylpyridinium-2)benzene, and 2,7-di(N-methyl-4,6-diphenylpyridinium-2)fluorene in solutions of DMF and MeCN in the potential range from−0.8 to −1.7 V (SCE) was studied by CV. The successive formation of stable radical cations, biradicals, and dianions was investigated by semiempirical MO calculations at the PM3 level. 相似文献
11.
Shamoon Ahmad Siddiqui Abdullah M. M. 《Russian Journal of Physical Chemistry A, Focus on Chemistry》2018,92(10):1996-2002
Russian Journal of Physical Chemistry A - We have modeled multifunctional compounds from 4,6-di(2-furyl)pyrimidine, because 4,6-di(2-furyl)pyrimidine has alternate π-rich and π-poor... 相似文献
12.
V. V. Tkachev S. M. Aldoshin G. V. Shilov V. N. Komissarov Yu. A. Sayapin M. S. Korobov G. S. Borodkin V. I. Minkin 《Russian Chemical Bulletin》2007,56(2):276-280
The structure of the oxidation product of 4,6-di(tert-butyl)pyrogallol, viz., 6,10a-dihydroxy-3,4a, 7,9-tetra(tert-butyl)-1,2,4a,10a-tetrahydrodibenzo[b,e][1,4]dioxine-1,2-dione, was established by X-ray diffraction. Dimerization of intermediate 3-hydroxy-4,6-di(tert-butyl)-1,2-benzoquinone occurs by the mechanism of Diels—Alder heterocyclization.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 267–271, February, 2007. 相似文献
13.
Preparation of a number of derivatives of 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone (ABPP) including the 2-dialkylaminoalkylamino-, 2-hydroxyalkylamino-, 2-ethoxycarbonylamino- and 2-alkylaminocarbonyl-amino- groups substituted on the pyrimidine ring as well as preparation of 1-(alkylaminoalkyl)-4,6-dioxo-8-phenyl-2,3,4,6-tetrahydro-1H-pyrimido[1,2-α]pyrimidines and 3,5-dioxo-7-phenyl-1,2,3,5-tetrahydroimidazo-[1,2-α]pyrimidines with or without the bromo-substitution are reported. 相似文献
14.
Oxidation of 7-amino-8-hydroxyquinoline-5-sulfonic acid with silver oxide in dimethylformamide and in the presence of arylamines provided a series of 7-amino-5-arylimino-8(5H)-quinolones (VIIIb). Reaction of 8-dialkylamino-5,6-quinolinediones with triethyloxonium tetrafluoborate gave a series of unstable but synthetically useful enol ethers. These reacted with amines to give 6-amino-8-imino-5(8H)-quinolones, isolated and characterized as tetrafluoborate salts (XIa). Proton magnetic resonance studies showed these to be vinylogous amidinium salts, analogous to those previously obtained with 2-amino-1,4-naphthoquinone imines. 4,6-Dihydroxy-5,8-quinolinedione underwent free radical alkylation to give a 7-alkyl-4,6-dihydroxy-5,8-quinolinedione. Evaluation of the new compounds against various Plasmodium species in rodents, birds and mosquitoes revealed no significant antimalarial activity. 相似文献
15.
2,6-Dichloro-3-(trifluoromethyl)pyridine 3 was used to develop a six-step preparation of 7-amino-4-oxo-6-(trifluoromethyl)naphthyridines. The CF3 group deactivated the pyridine ring towards both nucleophiles and electrophiles. A new reagent for pyridone annulation, the aminomethylidenemalonate anion, is described, along with several strategies to manipulate the electron density of substituted pyridines. 相似文献
16.
Tetsuo Suami Yutaka Sato Yasushi Fukai Yukio Sakota 《Journal of heterocyclic chemistry》1969,6(5):663-665
Biologically active 1,3-dihydroxy-2-(6-substituted-9-purinyl)cyclohexanes (VI-X) were prepared by a reaction between trans-2-amino-1,3-cyclohexanediol (I) and 4,6-dichloro-5-amino-pyrimidine (II), followed by cyclization and nucleophilic substitution. Compounds VI and VII showed a weak inhibitory effect against Xanthomonas oryzae, a pathogenic bacteria of leaf blight of rice plant. 相似文献
17.
18.
Yuh-Wen Ho 《中国化学会会志》1999,46(6):947-953
The reaction of 3-amino-4,6-dimethyl-2-thieno[2,3-b]pyridine carbohydrazide ( 1 ) with appropriate 1,3-diketones 2a-2d in glacial acetic acid afforded 3-amino-2-[(3,5-disubstituted-pyrazo)-1-yl)carbonyl]-4,6-dimethylthieno[2,3-b]pyridines 3a-3d. 3-Amino-2-[(5-amino-3,4-disubstituted-pyrazol-1-yl)carbonyl]-4,6-dimethylthieno[2,3-b]pyridines 5a-5h were also prepared by treatment of carbohydrazide 1 with appropriate alkylethoxymethylenes and ketene dithioacetals 4a-4h , respectively. 相似文献
19.
A. V. Piskunov I. A. Aivazyan G. A. Abakumov V. K. Cherkasov O. V. Kuznetsova G. K. Fukin E. V. Baranov 《Russian Chemical Bulletin》2007,56(2):261-266
The exchange reactions of tin diorganohalides R2SnCl2 (R = Et, But, or Ph) with lithium amidophenolate APLi2 (AP is the 4,6-di(tert-butyl)-N-(2,6-diisopropylphenyl)-o-iminobenzo-quinone dianion) in tetrahydrofuran produced the new five-coordinate (Et2SnAP(THF) (3)) and four-coordinate (R2SnAP (R = But, Ph)) tin(IV) complexes. The reaction of Ph2SnCl2 with APLi2 in a nonpolar solvent (hexane or toluene) is accompanied by the additional redox process giving rise to the paramagnetic
complex Ph2Sn(ImSQ)Cl (6) (ImSQ is the 4,6-di(tert-butyl)-N-(2,6-diisopropylphenyl)-o-iminobenzoquinone radical anion). The molecular structures of complexes 3 and 6 were established by X-ray diffraction.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 253–258, February, 2007. 相似文献
20.
A. V. Popov A. V. Shastin E. L. Luzina A. N. Pushin T. N. Gavrishova 《Russian Chemical Bulletin》1999,48(8):1548-1552
A procedure was developed for the synthesis of substituted 2-amino-4,6-bis(nonafluoro-tert-butyl)-1,3,5-triazines from 2-chloro-4,6-bis(nonafluoro-tert-butyl)-1,3,5-triazine and aliphatic and aromatic amines. The data of19F NMR spectroscopy are indicative of the presence of a barrier to internal rotation.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1568–1572, August, 1999. 相似文献