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Valentina F. Sedova Viktor P. Krivopalov Oleg P. Shkurko 《Chemistry of Heterocyclic Compounds》2017,53(10):1163-1166
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Tayebeh Davodian Reza Ranjbar-Karimi Hossein Mehrabi 《Chemistry of Heterocyclic Compounds》2017,53(10):1120-1123
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G. M. Butov V. V. Burmistrov V. S. D’yachenko 《Russian Journal of Organic Chemistry》2017,53(7):977-980
Self-condensation of substituted adamantan-1-yl isocyanates in THF in the presence of DBU afforded 91–96% of symmetrical ureas as target-oriented soluble epoxide hydrolase (sEH) inhibitors. The described reaction avoids the use of the corresponding amine as counterpart. The obtained ureas are characterized by reduced melting points and improved solubility in water. 相似文献